Article
Oncology
Yuehui Su, Yingcui Zhang, Yutong Tong, Luoman Zhang, Panpan Li, Huiping Zhang, Xiaodong Zhang, Yujie Tang, Lihong Qin, Yan Shen, Bingjie Wang, Yingying Zhou, Lili Cao, Mengzhen Zhang, Ting Zhang
Summary: 5-ALA-PDT is a non-invasive, effective, and safe therapy for treating CIN & VAIN. However, its efficacy is relatively poor in patients with endocervical canal lesions involvement, atypical vessels, and HPV16/18 and other hrHPV infection.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Yi Chen, Ying Xu, Zhengrong Zhang, Zhenhong Xiong, Dan Wu
Summary: This study shows that ALA-PDT is effective in treating HPV-infected CIN and promotes HPV clearance. The HPV clearance rate and LSIL reversal rate in the ALA-PDT group are significantly higher compared to the laser therapy group. There are no significant differences in treatment outcomes based on lesion location and different HPV types, but partially visible transformation zones have lower HPV negative conversion rate and LSIL residual/recurrence rate. The control group has a higher incidence of complications compared to the experimental group.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Infectious Diseases
Hong-Fang Zhi, Liu-Feng Yang, Jing Ge, Xuan-Tao Yang
Summary: This study analyzed the status of human papillomavirus (HPV) infections in women in Yunnan, China and their correlation with the grade of cervical intraepithelial neoplasia (CIN). The study found that HPV infection in Yunnan was dominated by single infection and high-risk HPV types. Patients aged 30 to 45 years had a higher incidence of high-grade squamous intraepithelial lesions (HSIL), and the most common high-risk HPV subtypes were HPV16, HPV58, and HPV52.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Marta del Pino, Isabel Matas, Pilar Carrillo, Cristina Marti, Ariel Glickman, Nuria Carreras-Dieguez, Lorena Marimon, Adela Saco, Natalia Rakislova, Aureli Torne, Jaume Ordi
Summary: Women with anal HPV infection treated for HSIL/CIN2-3 should be re-tested for anal HPV after treatment. Those who have persisting anal HPV infection after treatment are at high risk of developing HSIL/AIN and may benefit from anal exploration. Additionally, women with anal HPV infection treated for HSIL/CIN might have a higher risk of recurrent cervical HPV infection.
Article
Obstetrics & Gynecology
Afsaneh Tehranian, Akram Ghahghaei-Nezamabadi, Akram Seifollahi, Parisa Mansouri, Arezoo Maleki-Hajiagha, Reyhaneh Aghajani
Summary: This study found no correlation between abnormal cervical cytology, dysplasia, or cervical high-risk HPV with anal abnormal cytology.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Dermatology
Junyu Xu, Jian Zhao, Ying Dong, Xia Zhao, Rui Chen, Yun Shi, Jining Tao, Feng Cao, Yimin Cui, Wenpei Bai
Summary: This study evaluated photodetection and safety of 5-ALA-induced porphyrin in CIN tissues, concluding that 10%-30% concentration of 5-ALA is safe for patients with CIN, recommending the application of 20% 5-ALA 6 hours before treatment.
LASERS IN SURGERY AND MEDICINE
(2021)
Article
Oncology
Wei Cang, Liying Gu, Zubei Hong, Anyue Wu, Wen Di, Lihua Qiu
Summary: The study showed that ALA-PDT is effective in eliminating cervical hrHPV infection in HPV-positive women without cervical lesions. HPV16/18 positive cases benefit the most from ALA-PDT. Women infected with multiple types of HPV require more sessions of ALA-PDT to eradicate hrHPV infection.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Marina Dudea-Simon, Dan Mihu, Laura Ancuta Pop, Razvan Ciortea, Andrei Mihai Malutan, Doru Diculescu, Cristina Alexandra Ciocan, Roxana Maria Cojocneanu, Vasile Simon, Carmen Bucuri, Radu Mocan-Hognogi, Cornelia Braicu, Ioana Berindan-Neagoe
Summary: Cervical cancer is a common and deadly form of cancer in women. Detecting the precursor, CIN, can prevent cervical cancer. This study found that certain genes, such as MEG3, DAPK1, MLH1, MALAT1, TIMP3, and SOX1, had abnormal expression levels in both CIN and cancer samples compared to normal samples. Lower expression of MEG3 and miR-205-5p could serve as early warning signals for the development of invasive cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yingxin Han, Liyan Ji, Yanfang Guan, Mengya Ma, Pansong Li, Yinge Xue, Yinxin Zhang, Wanqiu Huang, Yuhua Gong, Li Jiang, Xipeng Wang, Hong Xie, Boping Zhou, Jiayin Wang, Junwen Wang, Jinghua Han, Yuliang Deng, Xin Yi, Fei Gao, Jian Huang
Summary: Cervical cancer is the second leading cause of cancer death among women globally. Epigenetic dysregulation through DNA methylation and hydroxymethylation plays a crucial role in tumorigenesis. This study found genome-wide hypo-methylation and hypo-hydroxymethylation in CC, along with local hyper-methylation and hyper-hydroxymethylation. Additionally, novel differentially methylated/hydroxymethylated-associated genes were identified as potential epigenetic biomarkers for CC prognosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Suibin Lin, Bin Zhang, Yixia Lin, Yueping Lin, Xiaoyu Zuo
Summary: This study aimed to investigate the dysbiosis of the cervical and vaginal microbiota in Chinese women with CIN. The results showed a greater shift in microbial diversity in the cervix compared to the vagina for CIN patients, especially in CIN 1. Less dysbiosis was found between CIN patients and healthy controls, in both the vagina and cervix. The study also identified distinct patterns of perturbed bacteria in the vaginal and cervical microbiota, suggesting potential microbial migration in the reproductive tract.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Chaohui Bao, Na An, Hong Xie, Ling Xu, Boping Zhou, Jun Luo, Wanqiu Huang, Jian Huang
Summary: By conducting whole-exome sequencing and systematic bioinformatics analysis, we identified C>T transitions in both CINs and CCs, with significantly higher somatic mutations in CCs compared to CINs. Additionally, potential driver genes were identified and new neoantigens were found, providing a solid foundation for further research on the pathogenesis of CC and the development of novel immunotherapeutic approaches.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Rachael H. Dodd, Erin Cvejic, Katy Bell, Kirsten Black, Deborah Bateson, Megan A. Smith, Olivia A. Mac, Kirsten J. McCaffery
Summary: The study found that for the management of CIN2, most women of childbearing age tend to prefer active surveillance over surgery. Participants who had not yet had children, planned to have children in the future, had no family history of cancer or endometriosis, had adequate health literacy, and trusted their GP were more likely to choose active surveillance. Conversely, those who were more predisposed to seek health care for minor problems were less likely to choose active surveillance.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Y. Y. Zhang, R. Xia, D. Chen, X. Zhang
Summary: This study aimed to explore the risk factors for and prevent misdiagnosis of cervical intraepithelial neoplasia (CIN) coexisting with vaginal intraepithelial neoplasia (VaIN). The results indicated that menopausal status and HPV load were related to the occurrence of VaIN in CIN patients, with menopausal patients at higher risk.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Andrea Ciavattini, Jacopo Di Giuseppe, Chiara Marconi, Luca Giannella, Giovanni Delli Carpini, Michela Paolucci, Mariasole Fichera, Rosa Pasqualina De Vincenzo, Giovanni Scambia, Maria Teresa Evangelista, Giorgio Bogani, Francesca Bertolina, Francesco Raspagliesi, Barbara Gardella, Arsenio Spinillo, Mattia Dominoni, Ermelinda Monti, Carlo Antonio Liverani, Paolo Vercellini, Maria Iorio, Domenico Vitobello, Rosalba Portuesi, Gianluigi Bresciani, Massimo Origoni, Francesco Cantatore, Antonio Maurizio Pellegri, Lorenzo Moriconi, Matteo Serri, Andrea Chiari, Francesco Sopracordevole, Maggiorino Barbero, Fabio Parazzini
Summary: There has been a significant increase in the number of hysterectomies performed for CIN in the past decade. However, this procedure carries risks of complications, the onset of vaginal lesions, and overtreatment, which highlights the importance of proper counseling before making a decision.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)