Article
Multidisciplinary Sciences
Clement A. Adebamowo, Imran O. Morhason-Bello, Sally N. Adebamowo
Summary: Self-report of uterine fibroids underestimates the prevalence of UF and is not accurate enough for epidemiological research. Future studies should use population-based designs and more accurate diagnostic tools such as TVUS.
SCIENTIFIC REPORTS
(2023)
Review
Obstetrics & Gynecology
Edgardo Somigliana, Marco Reschini, Valentina Bonanni, Andrea Busnelli, Letizia Li Piani, Paolo Vercellini
Summary: Available evidence from IVF studies indicates a detrimental effect of submucosal and intramural fibroids on embryo implantation, but this should not be extrapolated to natural fertility. Current research on the impact of fibroids on natural fertility is inadequate, and further investigation is needed to understand the association between fibroids and infertility.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Physiology
Elizabeth A. Stewart, Romana A. Nowak
Summary: Uterine fibroids are a common condition in women that can cause serious health issues. The mechanisms behind their growth and development are currently not well understood and require further research.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David A. Resto, Peter Sang Uk Park, Thomas J. Werner, Poul F. Hoilund-Carlsen, Abass Alavi
Summary: This report presents a case of incidentally detected calcifying uterine leiomyoma using F-18-NaF PET/CT scans in a postmenopausal 61-year-old woman, with a follow-up image 2 years later. The findings highlight the potential of F-18-NaF in monitoring both the molecular and structural progression of uterine leiomyomas.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
George-Alexandru Rosu, Cringu Antoniu Ionescu, Florin Daniel Calin, Mihai Dimitriu, Liana Ples, Alexandra Matei, Dan-Bogdan Navolan
Summary: The location and size of submucosal fibroids are predictive factors of impaired fertility, with different types of fibroids having varying effects on fertility. Uterine cavity distortion is an important factor that alters the normal development of a pregnancy and the birth rate.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Editorial Material
Obstetrics & Gynecology
Carlos M. Parra, Taraneh Shirazian
Summary: This study provided the first video demonstration of laparoscopic removal of bilateral uterine remnants in a patient with Mullerian agenesis. The surgery successfully alleviated the symptoms and highlighted the importance of laparoscopic surgery in the treatment of this condition.
FERTILITY AND STERILITY
(2022)
Review
Obstetrics & Gynecology
Pasquapina Ciarmela, Giovanni Delli Carpini, Stefania Greco, Alessandro Zannotti, Nina Montik, Luca Giannella, Lucia Giuliani, Camilla Grelloni, Francesca Panfoli, Michela Paolucci, Gloria Pierucci, Federica Ragno, Pamela Pellegrino, Felice Petraglia, Andrea Ciavattini
Summary: Understanding the vascular network and angiogenesis in uterine fibroids is crucial for predicting treatment effectiveness, differentiating from other conditions, and developing new therapeutic approaches. This review explores the current knowledge on fibroid vascularization and its implications in clinical manifestations, highlighting the role of ultrasound in evaluating vascularization.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Gregory Shifrin, Matthias Engelhardt, Phyllis Gee, Gregor Pschadka
Summary: The study found that transcervical fibroid ablation is an effective single-stage treatment option for non-pedunculated submucous myomata, as well as larger or deeper uterine fibroids (including fibroid clusters) for which hysteroscopic treatment is not suitable.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Review
Cell Biology
Mohamed Ali, Michal Ciebiera, Somayeh Vafaei, Samar Alkhrait, Hsin-Yuan Chen, Yi-Fen Chiang, Ko-Chieh Huang, Stepan Feduniw, Shih-Min Hsia, Ayman Al-Hendy
Summary: Uterine fibroids are a significant benign neoplastic threat to women's health globally, affecting up to 80% of premenopausal women and causing symptoms such as heavy menstrual bleeding, pain, and infertility. Progesterone signaling is crucial for the development and growth of uterine fibroids, promoting cell proliferation through genetic and epigenetic pathways. This review discusses the role of progesterone signaling in uterine fibroid pathogenesis and explores the therapeutic potential of compounds that modulate progesterone signaling, including selective progesterone receptor modulator drugs and natural compounds. Further research is needed to ensure safety and understand the exact molecular mechanisms of selective progesterone receptor modulator drugs, while clinical trials are necessary to confirm the effectiveness of natural compounds as a potential long-term treatment option, particularly for women planning pregnancy.
Article
Biochemistry & Molecular Biology
Tsai-Der Chuang, Jianjun Gao, Derek Quintanilla, Hayden McSwiggin, Drake Boos, Wei Yan, Omid Khorram
Summary: Recent studies have found that somatic mutations in exon 2 of MED12 gene occur at a frequency of up to 80% and play a functional role in leiomyoma development. This study aimed to investigate the expression profile of RNA transcripts in leiomyomas with and without these mutations, as well as in their paired myometrium. Using next-generation RNA sequencing, the researchers found that there were 394 genes differentially and aberrantly expressed only in the mutated tumors. These genes mostly regulated the components of the extracellular matrix. Additionally, although the myometrium did not have MED12 mutations, there were significant differences in the transcriptome landscape compared to non-mutated specimens, with genes related to the response to oxygen-containing compounds being most affected.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Tsai-Der Chuang, Derek Quintanilla, Drake Boos, Omid Khorram
Summary: This study investigated the expression profile of SE-lncRNAs and associated mRNAs in leiomyomas and paired myometrium, revealing that differential expression of SE contributes to dysregulation of protein coding genes in leiomyomas. The study also found that race and MED12 mutation can influence the expression of certain SE-lncRNAs.
REPRODUCTIVE SCIENCES
(2022)
Article
Genetics & Heredity
Jacqueline A. Piekos, Jacklyn N. Hellwege, Yanfei Zhang, Eric S. Torstenson, Gail P. Jarvik, Ozan Dikilitas, Iftikhar J. Kullo, Daniel J. Schaid, David R. Crosslin, Sarah A. Pendergrass, Ming Ta Michael Lee, Dan Roden, Josh C. Denny, Todd L. Edwards, Digna R. Velez Edwards
Summary: In this study, the first polygenic risk score (PRS) for uterine fibroids (UF) was developed and validated. The PRS showed predictive ability for UF and captured the genetic architecture associated with increased risk for UF. This study is of great importance for further research.
Review
Radiology, Nuclear Medicine & Medical Imaging
Rishi Philip Mathew, Swati Francis, Vinayak Jayaram, Shameema Anvarsadath
Summary: Uterine leiomyomas, or fibroids, are common neoplasms in women, with a significant percentage of patients being asymptomatic. Typical leiomyomas are easily diagnosed on imaging, but larger, extrauterine, or degenerate tumors can pose challenges for diagnosis. Understanding the imaging appearance of atypical leiomyomas and their differential diagnosis is crucial for effective patient management.
ABDOMINAL RADIOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Walter Osorio, Natalia Posada, John Cano, Sergio Tamayo, Juan Giraldo
Summary: A new double-lumen intracervical cannula was used for single-step hysteroscopic cold myomectomy to extract nonfragmented fibroids. The surgical procedure was successful, with minimal pain and high patient satisfaction reported postoperatively. This technique allows efficient and complete extraction of fibroids without the need for resectoscope, electrosurgery, or hypo-osmolar uterine distension media.
FERTILITY AND STERILITY
(2021)
Review
Immunology
Lidia Korczynska, Natalia Zeber-Lubecka, Magdalena Zgliczynska, Elzbieta Zarychta, Kornelia Zareba, Cezary Wojtyla, Michalina Dabrowska, Michal Ciebiera
Summary: The long-held belief that the uterus is a sterile organ has been challenged by the growing evidence of a relationship between the gut and uterine microbiome. This systematic review explores the link between intestinal and uterine dysbiosis and uterine fibroids, a common yet poorly understood condition. The analysis of 16 studies suggests that dysbiosis in the gut microbiota may play a role in the development of uterine fibroids, calling for further research and possible microbiome modulations for prevention and treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Obstetrics & Gynecology
Nicole Robertson, Satomi Okano, Cameron Hurst, Sailesh Kumar
Summary: Excessive daytime sleepiness in pregnant women may be associated with sleep disordered breathing and adverse obstetric and neonatal outcomes. This study used the Epworth questionnaire and ultrasound examination to assess sleep propensity in pregnant women and found an increase in ESS scores across gestation. However, in low risk pregnancies, ESS scores during pregnancy were not correlated with fetal Doppler parameters, but only with higher birth weight.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Linda A. Gallo, Tania F. Gallo, Danielle J. Borg, Karen M. Moritz, Vicki L. Clifton, Sailesh Kumar
Summary: The study found that planned moderate/late preterm births significantly decreased during the COVID-19 lockdown, while there was no impact on extremely or very preterm infants, spontaneous preterm births, or stillbirth rates. A non-significant spike in spontaneous preterm births was observed from late April to early May 2020.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Alison Lee-Tannock, Karen Hay, Sailesh Kumar
Summary: The study found that biomarkers of cardiac dysfunction are elevated in infants of diabetic and obese mothers, and are correlated with increased interventricular septum thickness.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Wendy Chaboyer, David Ellwood, Lukman Thalib, Sailesh Kumar, Kassam Mahomed, Evelyn Kang, Brigid M. Gillespie
Summary: This study aimed to identify the cumulative incidence and predictors of surgical site infection in women with a pre-pregnancy BMI >= 30 kg/m(2) who gave birth by elective CS. The results showed that higher BMI, multiple previous pregnancies, and lack of pre-CS vaginal cleansing were associated with increased risk of SSI. These findings could help in counseling and decision-making for planned elective CS in women with higher pre-pregnancy BMI.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Acoustics
V. Schreiber, C. Hurst, F. da Silva Costa, R. Stoke, J. Turner, S. Kumar
Summary: This study compared the screening performance of SMFM biometric criteria with ISUOG/Delphi consensus criteria for fetal growth restriction (FGR) detection. The results showed that both criteria were effective in predicting infants with low birth weight, but had limited predictive ability for adverse neonatal outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Environmental Sciences
Felix Rafael De Bie, David Basurto, Sailesh Kumar, Jan Deprest, Francesca Maria Russo
Summary: Sildenafil has been investigated for various conditions during pregnancy, but its use remains controversial. Current studies are mainly based on in vitro experiments and animal models, and more clinical research is needed to determine its safety and efficacy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Developmental Biology
Christopher Edwards, Erika Cavanagh, Sailesh Kumar, Vicki L. Clifton, Danielle J. Borg, Jacob Priddle, Marie -Luise Wille, Christopher Drovandi, Davide Fontanarosa
Summary: This study aimed to analyze the influence of placental position on shear wave elastography (SWV) measures. The results showed that placental position does not affect the accuracy or reliability of SWV measurements.
Article
Obstetrics & Gynecology
Rosie Stoke, Veronika Schreiber, Kaycee Hocking, Luke Jardine, Sailesh Kumar
Summary: This study aimed to investigate key antecedents of moderate and severe hypoxic ischaemic encephalopathy (HIE) in newborns. The study found that nulliparity, type 1 diabetes mellitus, and maternal intensive care unit admission were associated with increased odds of moderate/severe HIE. Intrapartum risk factors included emergency caesarean birth, intrapartum haemorrhage, and intrapartum sentinel events. Neonatal risk factors included male sex, late preterm gestation, low Apgar score, severe respiratory distress, and severe acidosis at birth.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Alexa Bendall, Veronika Schreiber, Kylie Crawford, Sailesh Kumar
Summary: The aim of this study was to evaluate the association of a low cerebroplacental ratio (CPR) with hypoxic ischaemic encephalopathy (HIE), severe neonatal morbidity (SNM) and perinatal mortality (PNM). The study found that a low CPR was significantly associated with SNM, but not with HIE or PNM. These findings have important implications for the clinical management of infants.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Jennifer A. Whitty, Adam P. Wagner, Evelyn Kang, David Ellwood, Wendy Chaboyer, Sailesh Kumar, Vicki L. Clifton, Lukman Thalib, Brigid M. Gillespie
Summary: This study assessed the cost-effectiveness of closed incision negative pressure wound therapy (ci-NPWT) compared to standard dressings for preventing surgical site infections (SSIs) in obese women undergoing caesarean section (CS). The results showed that although ci-NPWT can reduce the occurrence of SSIs in obese women, it is associated with higher costs and does not improve quality of life. Therefore, routine use of ci-NPWT for preventing SSIs in obese women undergoing CS is currently not recommended.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Cynthia Wong, Veronika Schreiber, Kylie Crawford, Sailesh Kumar
Summary: While male infants are born with higher birthweights, they have higher rates of neonatal mortality and morbidity compared to female infants. This study examined obstetric and perinatal outcomes in a large Australian birth cohort and found significant disparities in clinical outcomes by infant sex.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Medicine, Research & Experimental
Jesrine Hong, Sailesh Kumar
Summary: Fetal growth restriction (FGR) leading to low birth weight (LBW) is a major cause of neonatal morbidity and mortality worldwide. Failure in normal placental development leads to placental dysfunction and related placental diseases. Early recognition of at-risk pregnancies and the development of screening tests based on maternal biomarkers can potentially prevent adverse maternal and perinatal outcomes. Among the current biomarkers, placental growth factor and soluble fms-like tyrosine kinase 1 show promise for predicting FGR and placental dysfunction.
Article
Nutrition & Dietetics
Sophie M. Leech, Morgan C. Gilbert, Vicki L. Clifton, Sailesh Kumar, Kym M. Rae, Danielle Borg, Marloes Dekker Nitert
Summary: Using shotgun metagenomic sequencing, the researchers assessed the microbes present in expressed breastmilk at six weeks postpartum and found that the microbial load was low and similar to controls. The microbes identified were mostly consistent with skin and oral microbes, with some samples having no identifiable bacterial sequences. The results do not provide convincing evidence for the existence of a breastmilk microbiota at six weeks postpartum, suggesting that the microbes present in breastmilk may come from the infant's mouth and surrounding skin, as well as contamination during sampling and processing.
Article
Obstetrics & Gynecology
Kylie Crawford, Jesrine Hong, Sailesh Kumar
Summary: This study aimed to investigate the effect of known causal risk factors for stillbirth and identify those that have a large proportion of their risk mediated through small for gestational age birth. The results showed that factors such as young age, low socioeconomic status, smoking, and multiple pregnancy increased the odds of stillbirth, with a significant proportion of the risk mediated through small for gestational age.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Nutrition & Dietetics
Linda A. Gallo, Sarah E. Steane, Sophia L. Young, Susan de Jersey, Danielle A. J. M. Schoenaker, Danielle J. Borg, Jack Lockett, Clare E. Collins, Anthony V. Perkins, Sailesh Kumar, Vicki L. Clifton, Shelley A. Wilkinson
Summary: Multiple micronutrient (MMN) supplementation during pregnancy is common in high-income countries, and is associated with private obstetric care, private health insurance, and alignment with meat/vegetarian alternatives recommendations. There is a high reliance on supplements to meet the recommended intake of folate, iodine, and iron, which raises concerns about excessive nutrient intake. Effective strategies for optimizing nutrient intake during pregnancy, including promoting whole food diets and appropriate use of MMN supplements, need to be defined.
MATERNAL AND CHILD NUTRITION
(2023)