Article
Virology
Emel Yilmaz, Carina Eklund, Camilla Lagheden, Karin Dahlin Robertsson, Marina Lilja, Miriam Elfstrom, Laila Sara Arroyo Muhr, Joakim Dillner
Summary: This study provides the first global overview of the proficiency of HPV testing services for cervical cancer screening. The results indicate a high level of sensitivity and few false positives, but specificity still needs further improvement.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Review
Medicine, General & Internal
Paddy Ssentongo, Jennifer S. McCall-Hosenfeld, William A. Calo, Jennifer Moss, Eugene J. Lengerich, Vernon M. Chinchilli, Djibril M. Ba
Summary: This study found that HPV vaccination is associated with higher rates of cervical cancer screening, suggesting that vaccinated individuals are more likely to engage in preventive health behaviors.
Article
Public, Environmental & Occupational Health
Jingran Li, Ruifang Wu, Xinfeng Qu, Xia Huang, Ling Li, Zhixin Lin, Zhijun Zhang, Jihong Deng, Rong Liu, Xiaofeng Zhao, Songling Zhang, Bei Lin, Ruifang An, Chao Zhao, Mingzhu Li, Yun Zhao, Lihui Wei
Summary: This study evaluated the feasibility of using self-sampling for HPV testing as a primary cervical cancer screening method, combined with the internet, in low-resource settings. The results showed that self-sampling was well accepted by the participants, with a high percentage of women willing to choose self-sampling for cervical cancer screening and to introduce it to others. Self-sampling can be used as a supplement to conventional screening, particularly in outlying areas with limited medical resources.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Ali Can Gunes, Nejat Ozgul, Murat Turkyilmaz, Fatih Kara, Fahriye Unlu, Ali Ayhan, Murat Gultekin
Summary: The study evaluated colposcopy performance in the HPV DNA screening program in Turkey and found high rates of unnecessary colposcopies, as well as a high percentage of multiple and random punch biopsies and endocervical curettage (ECC).
Article
Multidisciplinary Sciences
Yvonne T. Nartey, Kwabena H. Amo-Antwi, Philip M. Hill, Edward Dassah, Richard O. Asmah, Kofi Nyarko, Ramatu Agambire, Thomas Konney, Joel Yarney, Nelson Damale, Brian Cox
Summary: This study aimed to compare the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women with and without cervical cancer in order to develop a population-based prevention strategy for cervical cancer in Ghana. The results showed that the most common HR-HPV genotypes among women with cervical cancer were 16, 18, 45, 35, and 52, while 66, 52, 35, 43, and 31 were frequently detected in women without cancer. HPV DNA testing and multivalent vaccines targeting HPV 16, 18, 45, and 35 genotypes are crucial for cervical cancer control in Ghana.
Article
Multidisciplinary Sciences
Kathryn L. Hopkins, Maya Jaffer, Khuthadzo E. Hlongwane, Kennedy Otwombe, Janan Dietrich, Mireille Cheyip, Jacobus Olivier, Tanya Doherty, Glenda E. Gray
Summary: A screening center in Soweto, South Africa investigated high-risk HPV, HIV, and cervical cancer risk among women. The study found high prevalence of HR-HPV infection in South African women, low coverage of cervical cancer screening, and that younger women are more susceptible to LSIL and other HR-HPV infections. It suggests implementing HPV-based primary screening starting from age 25.
Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Article
Oncology
Leonardo I. Green, Christopher S. Mathews, Jo Waller, Henry Kitchener, Matejka Rebolj
Summary: The study found that while there were differences in attendance based on deprivation and age groups, the overall attendance at early recall and colposcopy was reassuringly high. Women from more deprived areas and older age groups were more likely to attend early recall and colposcopy screenings.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Valeria Denninghoff, Felicitas von Petery, Cristobal Fresno, Mercedes Galarza, Florencia Torres, Alejandra Avagnina, Vanina Fishkel, Hugo Krupitzki, Angel Fiorillo, Fernando Monge
Summary: The HPV test is crucial for preventing cervical cancer, and a screening program using co-testing can help reduce the burden of the disease.
Article
Medicine, General & Internal
Yanxia Zhao, Heling Bao, Lan Ma, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Hai-Jun Wang, Jiuling Wu
Summary: The study evaluated the effectiveness of HPV testing in the national cervical cancer screening programme in China. Results showed that HPV testing had higher CIN2+ detection rate and PPV compared to cytology, with colposcopy referrals differing by income status in different regions.
Article
Obstetrics & Gynecology
C. Acuti Martellucci, S. Nomura, D. Yoneoka, P. Ueda, J. M. L. Brotherton, K. Canfell, M. Palmer, L. Manzoli, P. Giorgi Rossi, A. De Togni, C. Palmonari, A. Califano, E. Saito, M. Hashizume, K. Shibuya
Summary: This retrospective cohort study in Italy assessed the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities detected during subsequent screenings. Results showed that women who received at least one dose of the HPV vaccine were significantly less likely to have abnormal cervical cytology. Overall, catch-up HPV vaccination almost halved the risk of cytological abnormalities in organized cervical screening programmes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Oncology
Maria Hortlund, Laila Sara Arroyo Muhr, Camilla Lagheden, Anders Hjerpe, Joakim Dillner
Summary: Regular laboratory audits of cervical samples taken before CIN3+ can ensure the expected performance of the laboratory in a real-life screening program, and globally recommended public health policy for cervical screening is primary human papillomavirus (HPV) screening.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
David Robert Grimes, Edward M. A. Corry, Talia Malagon, Ciaran O'Riain, Eduardo L. Franco, Donal J. Brennan
Summary: The study compared different cervical cancer screening modalities on a simulated population of women aged >= 25 years, considering the increasing uptake of the HPV vaccine. HPV-based modalities outperformed LBC-based approaches, with reflex approaches and appropriate test intervals maximizing therapeutic efficacy. Increasing HPV vaccination rates resulted in fewer unnecessary colposcopies with HPV-based screening approaches.
Editorial Material
Oncology
Eduardo Franco
Summary: The American Cancer Society (ACS) believes that the time has come for primary human papillomavirus (HPV) screening in the United States, but it requires educating the public and healthcare providers and overcoming logistical barriers. ACS is taking the lead by utilizing its resources to promote primary HPV screening in the US and sharing best practices from other countries through its Primary HPV Screening Initiative.
Article
Obstetrics & Gynecology
K. F. Bennett, J. Waller, E. McBride, A. S. Forster, G. Di Gessa, H. Kitchener, L. A. Marlow
Summary: The study found that receiving an HPV-positive result following primary HPV testing can cause short-term psychosexual distress, especially among women with HPV-positive and normal or abnormal cytology results.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Oncology
Sarah Dilley, Britt K. Erickson, Caroline E. Phillips, Caroline R. Kennemer, Bin Zhang, Tasnia Matin, Jovana Y. Martin, Monjri S. Shah, J. Michael Straughn, Charles A. Leath
GYNECOLOGIC ONCOLOGY
(2018)
Article
Obstetrics & Gynecology
Akila Subramaniam, Christina T. Blanchard, Britt K. Erickson, Jeff Szychowski, Charles A. Leath, Joseph R. Biggio, Warner K. Huh
OBSTETRICS AND GYNECOLOGY
(2018)
Article
Immunology
Abigail M. Schnaith, Erica M. Evans, Caleb Vogt, Andrea M. Tinsay, Thomas E. Schmidt, Katelyn M. Tessier, Britt K. Erickson
Article
Oncology
Anne R. Van Arsdale, Rebecca C. Arend, Maria J. Cossio, Britt K. Erickson, Yanhua Wang, David W. Doo, Charles A. Leath, Gary L. Goldberg, Gloria S. Huang
Article
Obstetrics & Gynecology
Alexandra M. Schefter, John Fischer, Britt K. Erickson
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2018)
Article
Oncology
Camille C. Gunderson, Britt K. Erickson, Ivy Wilkinson-Ryan, Sara K. Vesely, Charles A. Leath, Paola A. Gehrig, Kathleen N. Moore
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2019)
Article
Oncology
Akila Subramaniam, Brett D. Einerson, Christina T. Blanchard, Britt K. Erickson, Jeff Szychowski, Charles A. Leath, Joseph R. Biggio, Warner K. Huh
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Sabrina M. Bedell, Chloe Hedberg, Anna Griffin, Hannah Pearson, Annelise Wilhite, Nathan Rubin, Britt K. Erickson
GYNECOLOGIC ONCOLOGY
(2019)
Article
Obstetrics & Gynecology
Annelise M. Wilhite, Makinna C. Oestreich, Megan Olson, Sabrina M. Bedell, Danielle Westenberg, Ananta Bangdiwala, Salman Ikramuddin, Monica Sanchez-Avila, Robert D. Madoff, Mahmoud A. Khalifa, Britt K. Erickson
OBSTETRICS AND GYNECOLOGY
(2019)
Article
Oncology
Artur A. Serebrenik, Prokopios P. Argyris, Matthew C. Jarvis, William L. Brown, Martina Bazzaro, Rachel I. Vogel, Britt K. Erickson, Sun-Hee Lee, Krista M. Goergen, Matthew J. Maurer, Ethan P. Heinzen, Ann L. Oberg, Yajue Huang, Xiaonan Hou, S. John Weroha, Scott H. Kaufmann, Reuben S. Harris
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Valentino Clemente, Asumi Hoshino, Mihir Shetty, Andrew Nelson, Britt K. Erickson, Ruth Baker, Nathan Rubin, Mahmoud Khalifa, S. John Weroha, Emil Lou, Martina Bazzaro
Summary: Targeting glutamine metabolism has been proposed as a therapeutic strategy for ovarian cancer, and the kidney isoform of glutaminase, GLS1, has emerged as a potential target. CB839, a first-in-class GLS1 inhibitor, has shown promise in clinical trials and is being investigated in platinum-resistant ovarian cancer patients. In OCCC, the presence of ARID1A mutations has been suggested to drive GLS1 expression and metabolism reprogramming. However, our study found that GLS1 overexpression was not correlated with ARID1A loss in clinical specimens of OCCC, and was associated with better clinical outcomes. This suggests that blockade of GLS1 may not be beneficial for OCCC patients.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Jennifer Hagen, Annelise Wilhite, Maryna Tarbunova, Britt Erickson
GYNECOLOGIC ONCOLOGY REPORTS
(2019)
Article
Obstetrics & Gynecology
Emily M. Hartsougha, Britt K. Erickson, Anil Chauhan, Mahmoud A. Khalifa
GYNECOLOGIC ONCOLOGY REPORTS
(2019)
Article
Obstetrics & Gynecology
Khalid Amin, Beatrice Brumley, Britt K. Erickson, Mahmoud A. Khalifa
GYNECOLOGIC ONCOLOGY REPORTS
(2018)
Article
Obstetrics & Gynecology
Laura R. Daily, Britt K. Erickson, Daniel N. Pasko, J. Michael Straughn, Warner K. Huh, Charles A. Leath
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2018)
