Article
Multidisciplinary Sciences
Gal Cohen, Maya Shavit, Netanella Miller, Rimon Moran, Yael Yagur, Omer Weitzner, Michal Ovadia, Hanoch Schreiber, Gil Shechter-Maor, Tal Biron-Shental
Summary: The study aimed to determine the benefit of 17P treatment in preventing the recurrence of sPTB. The results suggest that 17P treatment can delay preterm delivery and reduce the risk of complications associated with preterm birth for patients with a previous sPTB.
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: Vaginal progesterone significantly decreased the risk of preterm birth <37 and <34 weeks, as well as the risk of admission to the neonatal intensive care unit, but did not have significant effects on other adverse perinatal and maternal outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Sophie Vanhaesebrouck, Alexandra Zecic, Linde Goossens, Annelies Keymeulen, Lara Garabedian, Julie De Meulemeester, Pauline Naessens, Kris De Coen, Koenraad Smets
Summary: This retrospective study analyzed trends in mortality and morbidity rates as well as pre-, peri-, and postnatal characteristics of very low birth weight infants over a 20-year period. The results showed a significant increase in survival rates, but an increase in major morbidities such as retinopathy of prematurity and bronchopulmonary dysplasia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Toma Fukuda, Hyo Kyozuka, Tsuyoshi Murata, Shun Yasuda, Akiko Yamaguchi, Keiya Fujimori
Summary: The study found that weekly injections of 125 mg of 17-OHPC significantly reduced the risk of recurrent preterm birth among pregnant women.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Medicine, General & Internal
Agnes Grill, Monika Olischar, Michael Weber, Lukas Unterasinger, Angelika Berger, Harald Leitich
Summary: In preterm infants, clinical sepsis is more common than culture-proven sepsis and is equally valuable in predicting mortality and mortality or severe morbidity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Rafael B. Galvao, Renato T. Souza, Matias C. Vieira, Dharmintra Pasupathy, Jussara Mayrink, Francisco E. Feitosa, Edilberto A. Rocha Filho, Debora F. Leite, Janete Vettorazzi, Iracema M. Calderon, Maria H. Sousa, Jose G. Cecatti
Summary: This study evaluated the diagnostic performance of different birthweight charts for detecting small-for-gestational-age neonates among nulliparas and found poor performance in identifying related neonatal adverse outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Saeed Baradwan, Sahar Hassan Abdulghani, Mohammed Abuzaid, Khalid Khadawardi, Majed Saeed Alshahrani, Abdulrahman Al-Matary, May A. AlRasheed, Najlaa Talat Miski, Aroob Abdulhalim, Yousra Mansour Alturki, Ahmed Abu-Zaid
Summary: A systematic review and meta-analysis of randomized controlled trials showed that 17-alpha hydroxyprogesterone caproate (17OHPC) may decrease the risks of recurrent preterm birth and reduce the rate of neonatal death among singleton pregnant women with a previous history of preterm birth.
OBSTETRICS & GYNECOLOGY SCIENCE
(2021)
Article
Obstetrics & Gynecology
Emily Fay, Oliver Hugh, Andre Francis, Ronit Katz, Kristin Sitcov, Vivienne Souter, Jason Gardosi
Summary: This study assesses the performance of two international birthweight standards in identifying perinatal morbidity and mortality indicators associated with small for gestational age infants at term. The results show that compared to INTERGROWTH-21st, GROW identifies more small for gestational age infants with adverse outcomes.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
Devlynne S. Ondusko, Jessica Liu, Brigit Hatch, Jochen Profit, Emily Hawkins Carter
Summary: This study compares prenatal factors, access to care, and health outcomes for very-low birthweight infants in isolated rural areas. The findings show that survival without major morbidity decreases with increasing rural residence.
JOURNAL OF PERINATOLOGY
(2022)
Review
Obstetrics & Gynecology
Moti Gulersen, Erez Lenchner, Kypros H. Nicolaides, Katsufumi Otsuki, Orion A. Rust, Sietske Althuisius, Eran Bornstein, Vincenzo Berghella
Summary: This study aimed to determine whether cervical cerclage reduces the risk of preterm birth in singleton pregnancies with a short cervical length detected after 24 weeks of gestation. Data from 4 randomized controlled trials were analyzed, and the results showed that cervical cerclage did not reduce or increase the rate of preterm birth in these pregnancies.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Review
Obstetrics & Gynecology
Rupsa C. Boelig, Mariavittoria Locci, Gabriele Saccone, Elisabetta Gragnano, Vincenzo Berghella
Summary: Vaginal progesterone is more effective than 17-alpha-hydroxyprogesterone caproate in preventing preterm birth at <34 weeks in singleton pregnancies with previous spontaneous preterm birth, but the evidence supporting this conclusion is no longer statistically significant in high-quality studies.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
Inshirah Sgayer, Yara Nakhleh Francis, Dan Miron, Elizabeta Shprits, Vered Fleisher Sheffer, Hagai Rechnitzer, Lior Lowenstein, Maya Frank Wolf
Summary: This study aimed to compare the efficacy of two antibiotic regimens in prolonging the latency period in women with premature rupture of membranes. The results showed that cefuroxime + roxithromycin combination prolonged pregnancy in primiparas and reduced the incidence of maternal and neonatal infections compared to ampicillin. Although there are some limitations, the study suggests that CEF + ROX could be a better treatment option.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Medicine, Research & Experimental
Katja Cehovin, Ajda Gortnar, Ivan Verdenik, Miha Lucovnik, Lilijana Kornhauser-Cerar, Stefan Grosek
Summary: This retrospective population-based study analyzed data to compare neonatal morbidity and mortality following spontaneous and medically indicated preterm births. The study found that neonatal mortality was significantly lower following spontaneous preterm birth at extremely to very preterm gestational age. However, there was no significant correlation between preterm birth type and neonatal morbidity.
MEDICAL SCIENCE MONITOR
(2023)
Article
Obstetrics & Gynecology
Roser Porta, Paula Sol Ventura, Gemma Ginovart, Fermin Garcia-Munoz, Alejandro Avila-Alvarez, Montserrat Izquierdo
Summary: In Spain, a more active approach is being taken towards treating infants born at 23 weeks. However, the survival rate of actively managed infants has remained stable around 25-30% during the study period. A multidisciplinary effort is needed to improve outcomes in this population.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)