Article
Biology
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce
Summary: CRH plays a role in regulating multiple biological systems, and is also associated with reproduction, neuropsychiatric, gastrointestinal, immune disorders, and tumor development. Further research on the physiological functions of CRH will help determine its role in human diseases and may serve as novel therapeutic targets.
Article
Environmental Sciences
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang
Summary: In the neuroendocrine system, corticotropin-releasing hormone (CRH) activates CRHRs and plays a vital role in the HPA/HPI axis. Two CRHR1 subtypes, LcCRHR1-1 and LcCRHR1-2, were identified in Larimichthys crocea genome and were found to be highly homologous to known teleost CRHRs. These receptors were found to be localized in the cell membrane and respond to LcCRH by increasing cAMP, Ca2+ and mitogen-activated protein kinase phosphorylation. LcCRHR1s were expressed in various tissues, with high expression in the brain and ovaries, and shown to be specifically localized in ovarian follicle cells. This study suggests that the CRH/CRHR1 system may be involved in the neuroendocrine regulation of reproduction in L. crocea.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Clinical Neurology
Alexandros N. Vgontzas, Julio Fernandez-Mendoza, Kristina Puzino Lenker, Maria Basta, Edward O. Bixler, George P. Chrousos
Summary: Insomnia, especially when associated with objective sleep disturbance, was found to be related to activation of the hypothalamic-pituitary-adrenal axis. Men with insomnia demonstrated shorter total sleep time and lower sleep efficiency on polysomnography, as well as lower levels of adrenocorticotropic hormone and cortisol after exposure to stress, suggesting a disrupted hypothalamic-pituitary-adrenal axis function in this population.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Environmental Sciences
Emily S. Barrett, Matthew Corsetti, Drew Day, Sally W. Thurston, Christine T. Loftus, Catherine J. Karr, Kurunthachalam Kannan, Kaja Z. LeWinn, Alicia K. Smith, Roger Smith, Frances A. Tylavsky, Nicole R. Bush, Sheela Sathyanarayana
Summary: Phthalates may disrupt the endocrine pathways in pregnant women, impacting pregnancy outcomes and fetal development. This study found associations between phthalate mixtures and changes in plasma pCRH levels, with differing effects observed among women with gestational diabetes and gestational hypertension.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Cell Biology
Hong Zhou, Aqin Chen, Weiqun Lu
Summary: The study showed that CRH is expressed in the zebrafish ovary and can partly inhibit steroidogenesis by activating the p38 MAPK signaling pathway, resulting in reduced estradiol synthesis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Gersende Maugars, Xavier Mauvois, Patrick Martin, Salima Aroua, Karine Rousseau, Sylvie Dufour
Summary: This study reveals the patterns of duplication and loss of CRH genes in different vertebrates, as well as the functional diversification of different CRH paralogs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Michael H. Riad, Kwanghoon Park, Ines Ibanez-Tallon, Nathaniel Heintz
Summary: The study reveals the role of neuromodulatory substances in the medial prefrontal cortex (mPFC). It shows that a specific class of mPFC interneurons releases corticotropin-releasing hormone (CRH) to enhance excitability of pyramidal cells, leading to increased novelty exploration in male mice. The effect of CRH is influenced by sex and does not affect anxiety-related behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Xiaoshuai Liu, Qing Gao, Shuai Wu, Haifeng Qin, Tiange Zhang, Xianchuang Zheng, Baojun Li
Summary: Neutrophils, as the first line of defense against pathogens, have the ability to eliminate foreign agents and migrate to infected tissues. By integrating neutrophils with scanning optical tweezers, an optically manipulated neutrophil microcraft was developed for controlled medical tasks in vivo, such as targeted delivery and debris elimination.
ACS CENTRAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Erin Faught, Mathilakath M. Vijayan
Summary: The study demonstrates that the CRH/CRHR1 system mediates stress-induced hyperactivity, while the temporal activation of cortisol production and associated GR/MR signaling are crucial for prolonging stressor-induced hyperactivity.
NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Christina L. Herrera, Kaushik Maiti, Roger Smith
Summary: Preterm birth is a significant cause of neonatal morbidity and mortality, and its exact mechanisms remain unclear. It is a multifactorial syndrome, making individual predictive measures less effective. Corticotrophin-releasing hormone (CRH) synthesized by the placenta is proposed as a pathway for preterm birth, as it activates the myometrium through the production of estriol and the transcription factor nuclear factor-kappa B.
Article
Medicine, General & Internal
Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab, Ai -Min Bao
Summary: Increased expression of OXT in PVN and OXTR in DLPFC are characteristic for male BD patients. Stimulation of PVN-OXT neurons induced mood changes in mice, in a pattern different from BD.
Article
Endocrinology & Metabolism
Emily S. Barrett, Tomomi Workman, Marnie F. Hazlehurst, Sophie Kauderer, Christine Loftus, Kurunthachalam Kannan, Morgan Robinson, Alicia K. Smith, Roger Smith, Qi Zhao, Kaja Z. LeWinn, Sheela Sathyanarayana, Nicole R. Bush
Summary: In this study, modest evidence of association was found between OH-PAHs, particularly 2-OH-PHEN, and pCRH levels. The associations tended to be stronger in early pregnancy. Further research is needed to confirm these findings and investigate alternative mechanisms linking PAHs and timing of birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Hua Zhang, Jing-Jing Zhou, Jian-Ying Shao, Zhao-Fu Sheng, Jingxiong Wang, Peiru Zheng, Xunlei Kang, Zhenguo Liu, Zixi Jack Cheng, David D. Kline, De -Pei Li
Summary: Elevated levels of CRH and CRHR1 in the PVN are associated with increased sympathetic outflow in primary hypertension, potentially contributing to the hyperactivity of PVN presympathetic neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Xin-Ya Qin, Qing-Hong Shan, Hui Fang, Yu Wang, Peng Chen, Zhi-Qi Xiong, Dick F. Swaab, Jiang-Ning Zhou
Summary: The study observed an increased density of PSD-93-CRH co-localized neurons in the hypothalamic PVN of major depression patients, showing that PSD-93 regulates excitatory synaptic activity in CRH neurons leading to depression-like behaviors. PSD-93 overexpression heightened HPA axis activity, while PSD-93 knockdown alleviated depression phenotypes.
ACTA NEUROPATHOLOGICA
(2021)
Article
Endocrinology & Metabolism
Weigang Cai, Michaela Egertova, Cleidiane G. Zampronio, Alexandra M. Jones, Maurice R. Elphick
Summary: This study provides the first insights into the expression and function of CRH-type neuropeptides in the unique context of the pentaradially symmetrical body plan of an echinoderm. The neuropeptide ArCRH was found to have a widespread pattern of expression in the central nervous system and locomotory organs of the starfish Asterias rubens.
NEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Clare A. Flannery, Farrah L. Saleh, Gina H. Choe, Daryl J. Selen, Pinar H. Kodaman, Harvey J. Kliman, Teresa L. Wood, Hugh S. Taylor
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2016)
Article
Obstetrics & Gynecology
Humberto Azpurua, Edmund F. Funai, Luisa M. Coraluzzi, Leo F. Doherty, Isaac E. Sasson, Merwin Kliman, Harvey J. Kliman
AMERICAN JOURNAL OF PERINATOLOGY
(2010)
Article
Obstetrics & Gynecology
Elizabeth Kagan Arleo, Robert N. Troiano, Raphaella da Silva, Daniella Greenbaum, Harvey J. Kliman
AMERICAN JOURNAL OF PERINATOLOGY
(2014)
Article
Neurosciences
Cheryl K. Walker, Kaitlin W. Anderson, Kristin M. Milano, Saier Ye, Daniel J. Tancredi, Isaac N. Pessah, Irva Hertz-Picciotto, Harvey J. Kliman
BIOLOGICAL PSYCHIATRY
(2013)
Article
Immunology
Duncan I. Mackie, Fuad Al Mutairi, Reema B. Davis, Daniel O. Kechele, Natalie R. Nielsen, Joshua C. Snyder, Marc G. Caron, Harvey J. Kliman, Jonathan S. Berg, John Simms, David R. Poyner, Kathleen M. Caron
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Obstetrics & Gynecology
Harvey J. Kliman, M. Sammar, Y. I. Grimpel, S. K. Lynch, K. M. Milano, E. Pick, J. Bejar, A. Arad, J. J. Lee, H. Meiri, R. Gonen
REPRODUCTIVE SCIENCES
(2012)
Letter
Cell Biology
Harvey J. Kliman
SCIENCE TRANSLATIONAL MEDICINE
(2014)
Article
Multidisciplinary Sciences
Mihaela Pavlicev, Andreja Moset Zupan, Amanda Barry, Savannah Walters, Kristin M. Milano, Harvey J. Kliman, Gunter P. Wagner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Reshef Tal, Shafiq Shaikh, Pallavi Pallavi, Aya Tal, Francesc Lopez-Giraldez, Fang Lyu, Yuan-Yuan Fang, Shruti Chinchanikar, Ying Liu, Harvey J. Kliman, Myles Alderman, Nicola Pluchino, Jehanzeb Kayani, Ramanaiah Mamillapalli, Diane S. Krause, Hugh S. Taylor
Article
Developmental Biology
Julia Katz, Parker H. Holzer, Harvey J. Kliman
Summary: The study found that monozygotic twins showed significantly less variation in the average number of TIs per slide compared to dizygotic twins, suggesting that TIs are intrinsic to the genetics of the fetus rather than the uterine environment.
Article
Multidisciplinary Sciences
Daniel Feliciano, Carolyn M. Ott, Isabel Espinosa-Medina, Aubrey V. Weigel, Lorena Benedetti, Kristin M. Milano, Zhonghua Tang, Tzumin Lee, Harvey J. Kliman, Seth M. Guller, Jennifer Lippincott-Schwartz
Summary: The study reveals that post-fusion plasma membrane diminution causes transient nutrient stress, inhibiting YAP1 activity and reducing proliferation-promoting transcription.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Morgan R. Firestein, Harvey J. Kliman, Ayesha Sania, Lucy T. Brink, Parker H. Holzer, Katherine M. Hofmann, Kristin M. Milano, Nicolo Pini, Lauren C. Shuffrey, Hein J. Odendaal, William P. Fifer
Summary: Objective trophoblast inclusions are associated with adverse birth outcomes and specific placental pathologies. The presence of trophoblast inclusions is significantly higher in preterm and stillborn deliveries compared to full-term liveborn deliveries. These findings suggest the need for further investigation into the complex mechanisms underlying trophoblast inclusions.
Article
Public, Environmental & Occupational Health
K. G. Salvante, K. Milano, H. J. Kliman, P. A. Nepomnaschy
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2017)
Article
Obstetrics & Gynecology
Mary D. Stephenson, Dana McQueen, Michelle Winter, Harvey J. Kliman
FERTILITY AND STERILITY
(2017)