Review
Immunology
Nicki L. Boddington, Isabelle Pearson, Heather Whitaker, Punam Mangtani, Richard G. Pebody
Summary: This systematic review found that the effectiveness of influenza vaccine against hospitalization in children varies by influenza subtype and vaccine type, with an overall seasonal IVE of 53.3%. IVE was highest against influenza A/H1N1pdm09 and lowest against influenza A/H3N2.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Jill M. Ferdinands, Manjusha Gaglani, Emily T. Martin, Arnold S. Monto, Donald Middleton, Fernanda Silveira, Helen K. Talbot, Richard Zimmerman, Manish Patel
Summary: The effectiveness of influenza vaccine decreases with time since vaccination, with an absolute decline of about 8%-9% per month postvaccination.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Daniel Owusu, Fatimah S. Dawood, Eduardo Azziz-Baumgartner, Yeny Tinoco, Giselle Soto, Oswaldo Gonzalez, Santiago Cabrera, Richard Florian, Edwin Llajaruna, Danielle Rentz Hunt, Meredith G. Wesley, Tat Yau, Carmen S. Arriola
Summary: This study estimated the effectiveness of the 2018 Southern Hemisphere influenza vaccine among pregnant women in Peru. The results showed that participants who were vaccinated against influenza had more than 50% lower incidence of confirmed influenza illness. Although the findings did not reach statistical significance, they provide additional evidence about the value of maternal influenza vaccination in middle-income countries.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Emily T. Martin, Caroline Cheng, Joshua G. Petrie, Elif Alyanak, Manjusha Gaglani, Donald B. Middleton, Shekhar Ghamande, Fernanda P. Silveira, Kempapura Murthy, Richard K. Zimmerman, Arnold S. Monto, Christopher Trabue, H. Keipp Talbot, Jill M. Ferdinands
Summary: The study evaluated the vaccine effectiveness against A(H3N2) during the 2016-2017 and 2017-2018 influenza seasons, finding relatively low effectiveness against the A(H3N2) vaccine virus, especially A/Hong Kong/4801/2014. This suggests ongoing changes in H3N2 antigenic epitopes may impact the vaccine efficacy.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Jill M. Ferdinands, Manjusha Gaglani, Shekhar Ghamande, Emily T. Martin, Donald Middleton, Arnold S. Monto, Fernanda Silveira, Helen K. Talbot, Richard Zimmerman, Emily R. Smith, Manish Patel
Summary: The study estimated vaccine effectiveness for prevention of influenza-associated hospitalizations in adults during the 2018-2019 influenza season. The results showed positive effectiveness against influenza A(H1N1)pdm09 but no protection against influenza A(H3N2), with significant differences by age group noted.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Mar Fornaguera, Oleguer Pares-Badell, Ingrid Carbones-Fargas, Cristina Andres, Jose Angel Rodrigo-Pendas, Blanca Borras-Bermejo, Lluis Armadans-Gil, Gabriela Tejada, David Guananga, Marti Vivet-Escale, Arnau Penalver-Pinol, Irene Torrecilla-Martinez, Arnau del Oso, Xavier Martinez-Gomez, Andres Anton, Susana Otero-Romero
Summary: This study aimed to estimate the influenza vaccine effectiveness against hospitalization and its determinants in a Spanish tertiary hospital in the 2021/22 season. The results showed non-significant vaccine effectiveness for this season.
Article
Immunology
Mark W. Tenforde, H. Keipp Talbot, Christopher H. Trabue, Manjusha Gaglani, Tresa M. McNeal, Arnold S. Monto, Emily T. Martin, Richard K. Zimmerman, Fernanda P. Silveira, Donald B. Middleton, Samantha M. Olson, Rebecca J. Garten Kondor, John R. Barnes, Jill M. Ferdinands, Manish M. Patel
Summary: This study evaluated the effectiveness of the 2019-2020 influenza vaccine against influenza-associated hospitalization in the United States, showing a 41% reduction in risk of hospitalized influenza illness. Among the two major A(H1N1)pdmO9 subgroups, one subgroup had a vaccine effectiveness of 59%, while no effectiveness was observed in the other subgroup.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Abram L. Wagner, Lionel Gresh, Nery Sanchez, Guillermina Kuan, John Kubale, Roger Lopez, Sergio Ojeda, Eduardo Azziz-Baumgartner, Angel Balmaseda, Aubree Gordon
Summary: The study found that a large proportion of children under 2 years old in Nicaragua contract influenza, with partially vaccinated children experiencing milder symptoms. However, the vaccination rate is low, with few children being fully vaccinated. Future studies should focus on the effectiveness of a two-dose vaccination schedule.
Review
Immunology
Yiwen Xie, Xuebin Tian, Xiaodi Zhang, Hangping Yao, Nanping Wu
Summary: Vaccines have been successful in controlling infectious diseases, but influenza and COVID-19 vaccines face challenges due to the variability of the viral proteins. Immune imprinting and repeated vaccinations can negatively influence vaccine effectiveness, and co-administration of multiple vaccines can also interfere with their effectiveness. Future development of COVID-19 vaccines should focus on inducing cross-reactive T-cell responses and naive B-cell responses, while the strategy of co-administering influenza and COVID-19 vaccines needs more careful consideration and further clinical data.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Helena C. Maltezou, Sofoklis Stavros, George Asimakopoulos, Vasilios Pergialiotis, Vasilios Raftopoulos, Michael A. Talias, Androula Pavli, George Daskalakis, Michael Sindos, Pelopidas Koutroumanis, Marianna Theodora, Panagiotis Antsaklis, Evangelos Kostis, Evangelia Stratiki, Athanasios Kossyvakis, Maria Theodoridou, Andreas Mentis, Petros Drakakis, Dimitrios Loutradis, Alexandros Rodolakis
Summary: The quadrivalent inactivated influenza vaccine (QIV) was found to be effective in reducing the risk of influenza in pregnant women and their infants.
EXPERT REVIEW OF VACCINES
(2022)
Article
Immunology
Mark W. Tenforde, Jessie Chung, Emily R. Smith, H. Keipp Talbot, Christopher H. Trabue, Richard K. Zimmerman, Fernanda P. Silveira, Manjusha Gaglani, Kempapura Murthy, Arnold S. Monto, Emily T. Martin, Huong Q. McLean, Edward A. Belongia, Lisa A. Jackson, Michael L. Jackson, Jill M. Ferdinands, Brendan Flannery, Manish M. Patel
Summary: This study compared the effectiveness of influenza vaccination between inpatient and outpatient networks in the US, finding that inpatients were older and had more high-risk conditions than outpatients. The overall vaccine effectiveness across seasons was 31% for outpatients and 36% for inpatients, with some differences observed in strain-specific VE between the two groups.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Henrique Andrade R. Fonseca, Remo Holanda M. Furtado, Andre Zimerman, Pedro A. Lemos, Marcelo Franken, Frederico Monfardini, Rodrigo P. Pedrosa, Rodrigo de Lemos S. Patriota, Luiz Carlos S. Passos, Frederico Toledo C. Dall'Orto, Conrado R. Hoffmann Filho, Bruno Ramos Nascimento, Felipe A. Baldissera, Cesar Augusto C. Pereira, Paulo Ricardo A. Caramori, Pedro Beraldo de Andrade, Carlos Esteves, Elke Ferreira Salim, Jefferson Henrique da Silva, Izabela Chave Pedro, Mariana Castaldi R. Silva, Ewerton Hernandes de Pedri, Ana Carla R. D. Carioca, Luciana Pereira A. de Piano, Camila Santos N. Albuquerque, Diogo D. F. Moia, Roberta Grazzielli R. A. P. Momesso, Felipe P. Machado, Lucas P. Damiani, Ronaldo Vicente P. Soares, Guilherme P. Schettino, Luiz Rizzo, Jose Carlos Nicolau, Otavio Berwanger
Summary: This study aimed to evaluate whether double-dose influenza vaccination during hospitalization for acute coronary syndrome (ACS) would further reduce the risk of major cardiopulmonary events. The results showed that double-dose influenza vaccination before discharge did not reduce cardiopulmonary outcomes compared with standard-dose vaccination in the outpatient setting.
EUROPEAN HEART JOURNAL
(2022)
Article
Immunology
Joshua D. Doyle, Lauren Beacham, Emily T. Martin, H. Keipp Talbot, Arnold Monto, Manjusha Gaglani, Donald B. Middleton, Fernanda P. Silveira, Richard K. Zimmerman, Elif Alyanak, Emily R. Smith, Brendan L. Flannery, Melissa Rolfes, Jill M. Ferdinands
Summary: The study found that during two US influenza seasons, the effectiveness of high-dose influenza vaccine for preventing influenza hospitalizations in adults aged >= 65 years was low to moderate, with high-dose vaccine offering greater effectiveness compared to standard-dose vaccine. None of these findings were statistically significant.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Pere Godoy, Manuel Garcia-Cenoz, Cristina Rius, Carmen Munoz-Almagro, Gloria Carmona, Miquel Alseda, Mireia Jane, Maria-Jose Vidal, Raquel Rodriguez, Josep Alvarez, Neus Camps, Sofia Minguell, Monica Carol, Maria-Rosa Sala, Jesus Castilla, Angela Dominguez
Summary: Maternal pertussis vaccination during pregnancy is highly effective in reducing pertussis in infants aged < 2 months, with a vaccine effectiveness of 88%. Vaccination before and after the 32nd week of pregnancy are equally effective in reducing the risk of pertussis.
JOURNAL OF INFECTION
(2021)
Article
Immunology
Hiroshi Yokomichi, Reiji Kojima, Sayaka Horiuchi, Tadao Ooka, Yuka Akiyama, Kunio Miyake, Mie Mochizuki, Sanae Otawa, Ryoji Shinohara, Zentaro Yamagata
Summary: A study in a large Japanese birth cohort found that influenza vaccination can significantly reduce the risk of new infection, especially for children with siblings or attending nursery school.