Article
Peripheral Vascular Disease
Daniela Ravizzoni Dartora, Adrien Flahault, Carolina N. R. Pontes, Ying He, Alyson Deprez, Anik Cloutier, Gael Cagnone, Perrine Gaub, Gabriel Altit, Jean-Luc Bigras, Jean-Sebastien Joyal, Thuy Mai Luu, Yan Burelle, Anne Monique Nuyt
Summary: This study found that neonatal hyperoxia in rats resulted in impaired left ventricle mitochondrial structure and function, and lower levels of humanin in preterm adults. These findings suggest that preterm birth-related conditions may lead to cardiac changes and increased risk for heart health.
Article
Multidisciplinary Sciences
Xue Yu, Chunhua He, Yanping Wang, Leni Kang, Lei Miao, Jian Chen, Qihui Zhao, Xiaona Huang, Jun Zhu, Juan Liang, Qi Li, Meixian Wang, Hanmin Liu
Summary: This study analyzed the epidemic characteristics of neonatal mortality due to preterm birth at 28-36 weeks gestation in different regions of China from 2009 to 2018. The study found that preterm birth was the main cause of neonatal deaths, with a significant downward trend in preterm neonatal mortality rates, and there were regional differences in the proportion of preterm neonatal deaths, as well as in the delivery patterns of preterm neonates among different regions.
Review
Nutrition & Dietetics
Nikoletta Lis, Demetris Lamnisos, Aikaterini Bograkou-Tzanetakou, Elena Hadjimbei, Irene P. Tzanetakou
Summary: Preterm birth is a global epidemic and factors such as maternal nutrition and placental-infant TL influence the risk of PTB. Maternal nutrition affects PTB risk through its influence on maternal TL. PTB also independently affects TL regulation in offspring. However, the strength of these associations and the influence of other factors remain unclear. Whether maternal TL is simply a biomarker of maternal nutrition status and PTB risk or a causative factor of PTB is yet to be determined.
Article
Multidisciplinary Sciences
Alina Luca, Angela Vinturache, Ciprian Ilea, Andreea Avasiloaiei, Luminita Paduraru, Alexandru Carauleanu, Ioana Sripcariu, Demetra Socolov
Summary: This study compared birth injuries between spontaneous vaginal and caesarean section deliveries in preterm and term pregnancies. The results showed that while spontaneous vaginal deliveries had a higher incidence of all types of birth trauma, there was no difference in the risk of major birth trauma between preterm babies delivered vaginally and those delivered by caesarean section.
Article
Obstetrics & Gynecology
Alexandra C. Sundermann, Tiara D. Aldridge, Katherine E. Hartmann, Sarah H. Jones, Eric S. Torstenson, Digna R. Velez Edwards
Summary: The study found no significant association between fibroids and preterm birth during pregnancy, even after accounting for confounding factors. This suggests that the presence of fibroids may not be a major risk factor for preterm birth as previously believed.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Biochemistry & Molecular Biology
Emma E. Don, Anadeijda J. E. M. C. Landman, Guus Vissers, Ekaterina S. Jordanova, Emiel D. Post Uiterweer, Christianne J. M. de Groot, Marjon A. de Boer, Judith A. F. Huirne
Summary: Recent studies indicate that uterine fibroids increase the risk of preterm birth. It is hypothesized that fibroid necrosis may induce preterm birth through an inflammatory response, similar to spontaneous preterm birth. This new hypothesis opens up possibilities for future research and preventive strategies for preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Alice Hoffsten, Laszlo Markasz, Katharina Ericson, Leif D. Nelin, Richard Sindelar
Summary: Autopsy determined the final cause of death in one-third of cases, and necrotizing enterocolitis as a cause of death increased significantly during the study period. The autopsy rate did not change significantly between the two study periods.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sandra E. Juul, Thomas R. Wood, Bryan A. Comstock, Krystle Perez, Semsa Gogcu, Mihai Puia-Dumitrescu, Sara Berkelhamer, Patrick J. Heagerty
Summary: Understanding the causes and circumstances of death in extremely preterm infants is crucial for healthcare practitioners. This study retrospectively examined a cohort of infants born between 24 and 27 weeks of gestation to determine the risk factors, causes, timing, and circumstances of death. The study found that respiratory distress or failure, pulmonary hemorrhage, necrotizing enterocolitis, catastrophic intracranial hemorrhage, sepsis, and sudden unexplained death were the primary causes of death. The risk of death decreased over time, and preterm labor was associated with a decreased hazard of death. Clinical factors such as low birth weight, low Apgar score, sick appearance at birth, necrotizing enterocolitis, pulmonary hemorrhage, severe intracranial hemorrhage, and severe sepsis were also associated with death.
Article
Peripheral Vascular Disease
Leandro De Oliveira, James M. Roberts, Arundhathi Jeyabalan, Kasey Blount, Christopher W. Redman, Lucilla Poston, Paul T. Seed, Lucy C. Chappell, Marcos Augusto Bastos Dias
Summary: The implementation of a risk stratification model based on biomarkers and clinical factors did not lead to reductions in preterm deliveries. Further training and development of additional risk stratification methods are needed before adopting this intervention into clinical practice.
Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Ophthalmology
Mukhit Kulmaganbetov, Myra Leung, Jane M. Alsweiler, Joanna Black, Frank H. Bloomfield, Greg D. Gamble, Jane E. Harding, Yannan Jiang, Tanya Poppe, Anna C. Tottman, Trecia A. Wouldes, Benjamin Thompson
Summary: This study aimed to assess the effect of increased protein intake on ophthalmic and visual development in school-age children born very preterm. The results showed that there were subtle and complex associations between early neonatal nutrition and visual development at school age.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Psychology, Multidisciplinary
Gozde Gokce Isbir, Figen Inci, Burcu Komurcu Akik, Wilson Abreu, Gill Thomson
Summary: This study aimed to investigate factors associated with birth-related post-traumatic stress disorder (PTSD) among women who had preterm birth in Turkey. The results showed that older age, positive impact from mother's birth experience, absence of traumatic experiences during pregnancy and postnatal period, lower stress level after traumatic events during birth, not feeling at risk during birth, amniotomy, psychological well-being after childbirth, not being negatively affected by witnessing other parents' happy moments with their babies, absence of infant illness, and positive interactions with healthcare team were associated with decreased likelihood of birth-related PTSD.
CURRENT PSYCHOLOGY
(2023)
Article
Medicine, Research & Experimental
Katja Cehovin, Ajda Gortnar, Ivan Verdenik, Miha Lucovnik, Lilijana Kornhauser-Cerar, Stefan Grosek
Summary: This retrospective population-based study analyzed data to compare neonatal morbidity and mortality following spontaneous and medically indicated preterm births. The study found that neonatal mortality was significantly lower following spontaneous preterm birth at extremely to very preterm gestational age. However, there was no significant correlation between preterm birth type and neonatal morbidity.
MEDICAL SCIENCE MONITOR
(2023)
Article
Obstetrics & Gynecology
Maryam Najjarzadeha, Sakineh Mohammad-Alizadeh-Charandabi, Shamsi Abbasalizadeh, Mohammad Asghari-Jafarabadi, Mojgan Mirghafourvand
Summary: This prospective cohort study aimed to determine the technology-free predictors of preterm birth in singleton women with threatened preterm labor. Seven variables were determined as predictors: rupture of membranes, cervical dilation, gravidity, psychological violence during pregnancy, medical problems in pregnancy onset, vaginal bleeding/spotting, and woman age. These factors seem to have moderate power in predicting preterm birth in singleton pregnant women.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Computer Science, Information Systems
Ameur Soualmi, Christophe Ducottet, Hugues Patural, Antoine Giraud, Olivier Alata
Summary: We propose a method for 3D pose estimation of infants using fine-tuning of 2D human pose estimation networks on a large dataset. Our approach significantly reduces pose estimation error compared to existing 2D infant pose estimation methods.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)
