Article
Medicine, General & Internal
Anne Karge, Silvia M. Lobmaier, Bernhard Haller, Bettina Kuschel, Javier U. Ortiz
Summary: This study evaluated the association between CPR and mUtA-PI with adverse perinatal outcomes in VSGA and SGA fetuses, finding that CPR had predictive value for adverse perinatal outcomes in SGA, while VSGA fetuses were more frequently affected by adverse perinatal outcomes regardless of Doppler values.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Stephen Contag, Silvia Visentin, Katherine Goetzinger, Erich Cosmi
Summary: The study compared the effectiveness of cerebral-placental ratio (CPR) and cerebral-renal ratio (CRR) in predicting adverse neonatal outcomes among growth-restricted fetuses. The results showed that the umbilical artery pulsatility index performed the best in detecting composite adverse neonatal outcomes, with no additional benefit from using CRR compared to CPR. The data did not support the use of renal artery Doppler as a useful clinical test for identifying fetuses at risk for adverse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Jose Morales-Rosello, Asma Khalil, Alicia Martinez-Varea
Summary: The study aimed to propose a risk-based approach for managing pregnancies with normal EFW but abnormal CPR near term. By dividing pregnancies into four groups based on CPR and EFW, the study found that fetuses in pregnancies complicated by FRGP are likely to benefit from being delivered at 39 weeks of gestation.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Acoustics
A. Grzyb, J. Szymkiewicz-Dangel
Summary: This study examined Doppler parameters in the middle cerebral artery (MCA) and umbilical artery (UA) in fetuses with transposition of the great arteries (TGA) and evaluated their potential in predicting the need for urgent balloon atrial septostomy (BAS) in neonates. The results showed that the Doppler parameters in TGA fetuses were generally within normal limits, and the presence of a ventricular septal defect did not significantly affect these parameters. Additionally, the peak systolic velocity (PSV) in the MCA increased after 35 weeks, and a low MCA-PSV value measured at 38 weeks or later could predict the need for urgent BAS.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Cecilia Villalain, Alberto Galindo, Daniele Di Mascio, Danilo Buca, Jose Morales-Rossello, Gabriela Loscalzo, Filomena Giulia Sileo, Alessandra Finarelli, Emma Bertucci, Fabio Facchinetti, Giuseppe Rizzo, Roberto Brunelli, Antonella Giancotti, Ludovico Muzii, Giuseppe Maria Maruotti, Luigi Carbone, Alice D'Amico, Sara Tinari, Roberta Morelli, Chiara Cerra, Luigi Nappi, Pantaleo Greco, Marco Liberati, Francesco D'Antonio, Ignacio Herraiz
Summary: The cerebroplacental (CPR) and umbilicocerebral (UCR) ratios were found to be poor predictors of adverse perinatal outcomes (APO) in both appropriate for gestational age (AGA) fetuses and those affected by late fetal growth restriction (FGR), regardless of fetal weight.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
R. Cruz-Martinez, A. Gamez-Varela, M. Cruz-Lemini, M. Martinez-Rodriguez, J. Luna-Garcia, H. Lopez-Briones, F. Chavelas-Ochoa, E. Chavez-Gonzalez, K. Aguilar-Vidales, J. Chavez-Vega, A. Castelo-Vargas, P. Rivera-Carrillo, E. Hernandez-Andrade
Summary: In this study, changes in fetal Doppler parameters during open fetal microneurosurgery for open spina bifida repair were described. The results showed that a small hysterotomy, reduced fetal manipulation, and maintenance of normal amniotic fluid volume during surgery seemed to prevent severe fetal Doppler abnormalities. Mild Doppler changes observed during surgery may be a result of fetal adaptation to the stress of the surgery.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Clinical Neurology
Tharani Thirugnanachandran, Richard Beare, Melissa Mitchell, Chloe Wong, Jason Vuong, Shaloo Singhal, Lee-Anne Slater, James Hilton, Mathew Sinnott, Velandai Srikanth, Henry Ma, Thanh Phan
Summary: The study investigated the role of the circle of Willis and leptomeningeal anastomoses in modifying infarct topography following anterior cerebral artery occlusion. Results showed that these anatomical structures play a crucial role, especially in distal artery occlusions. Specific brain regions were identified with varying probabilities of infarction, with superior frontal gyrus and anterior cingulate gyrus having the highest probabilities.
Article
Obstetrics & Gynecology
L. Mecke, A. Ignatov, A. Redlich
Summary: This study aimed to investigate the validity of cerebroplacental ratio (CPR) as a Doppler sonographic parameter in obstetric assessment. The results showed that decreased CPR in appropriate for gestational age (AGA) fetuses was associated with impaired neonatal outcome and secondary cesarean section due to fetal distress.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Multidisciplinary Sciences
Jezid Miranda, Cristina Paules, Guillaume Noell, Lina Youssef, Angel Paternina-Caicedo, Francesca Crovetto, Nicolau Canellas, Maria L. Garcia-Martin, Nuria Amigo, Elisenda Eixarch, Rosa Faner, Francesc Figueras, Rui Simos, Fatima Crispi, Eduard Gratacos
Summary: This study used machine learning to conduct cluster analysis of FGR, confirming the existence of two distinct subtypes with different molecular and clinical features. The clusters generated by machine learning outperformed single data subtype analysis in predicting adverse maternal and neonatal outcomes, supporting the current clinical classification.
Article
Clinical Neurology
Wei Wei, Chong Song, Xuqin Li, Dianshi Jin
Summary: The study found that CT perfusion (CTP) imaging has high clinical value in vertebral artery stenosis stenting, providing effective evaluation for both preoperative and postoperative situations. CTP can sensitively reflect brain perfusion and significantly improve postoperative imaging in the majority of patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Jara Pascual-Mancho, Pilar Pintado-Recarte, Jorge C. Morales-Camino, Carlos Romero-Roman, Concepcion Hernandez-Martin, Coral Bravo, Julia Bujan, Melchor Alvarez-Mon, Miguel A. Ortega, Juan De Leon-Luis
Summary: This study examines the potential link between FGR fetuses and neurodevelopmental alterations. The results show a decrease in cord blood levels of BDNF in FGR fetuses, particularly in those with UA PI > 95th percentile. Further studies should be conducted to understand the implications of BDNF in FGR subjects with MCA PI < 5th percentile.
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Mengke Ban, Xue Han, Wanli Bao, Hongli Zhang, Ping Zhang
Summary: This study demonstrates that CBV and CBF ratios based on CTP measurements can quantitatively evaluate collateral status in stroke patients, and the CBV ratio is a significant predictor of clinical outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Obstetrics & Gynecology
Efraim Zohav, Eyal Zohav, Mark Rabinovich, Simon Shenhav, Yaniv Ovadia, Eyal Anteby, Leonti Grin
Summary: The study aimed to evaluate the predictive value of local versus external cerebroplacental ratio (CPR) reference ranges for delivery outcomes in low-risk pregnancies. Findings showed that a CPR model based on local reference ranges and <5th percentile cutoffs had the highest positive predictive value for urgent cesarean delivery (CD) and operative delivery (OD).
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kristina Norvilaite, Diana Ramasauskaite, Daiva Bartkeviciene, Aleksandra Sliachtenko, Juozas Kurmanavicius
Summary: This study conducted detailed Doppler examinations and monitoring of 53 late-onset intrauterine fetal growth restriction (IUGR) fetuses. The results showed that the TA-PI increased gradually from the 35th week, while the UA-PI remained stable. The MCA-PI and CPR decreased progressively from inclusion to delivery, with abnormalities observed from the 37th week onwards. These observations can contribute to the development of guidelines for detecting deteriorating signs and intervention timing in late pregnancies with IUGR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pediatrics
C. Murphy, S. Baskind, N. Aladangady, J. Banerjee
Summary: The gut plays a crucial role in postnatal nutrition and growth. However, compromised gut perfusion can lead to complications such as necrotizing enterocolitis in preterm infants. Additionally, feeding difficulties due to gut dysmotility can be a challenge in high-risk infants. The use of SMA Doppler can aid clinicians in feeding strategies and monitoring high-risk infants.
FRONTIERS IN PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Nuria Banos, Xavier P. Burgos-Artizzu, Brenda Valenzuela-Alcaraz, David Coronado-Gutierrez, Alvaro Perez-Moreno, Julia Ponce, Eduard Gratacos, Montse Palacio
Summary: This study evaluated the reproducibility of ultrasound cervical length (CL) measurement in the second trimester and found moderate agreement among intra- and inter-observers. However, wide disagreements were observed when using specific cutoffs to classify patients, highlighting the importance of training and quality assessments when considering the universal application of CL measurement for screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Immunology
Iolanda Jordan, Mariona Fernandez de Sevilla, Victoria Fumado, Quique Bassat, Elisenda Bonet-Carne, Claudia Fortuny, Aleix Garcia-Miquel, Cristina Jou, Cristina Adroher, Maria Mele Casas, Monica Girona-Alarcon, Maria Hernandez Garcia, Gemma Pons Tomas, Sara Ajanovic, Sara Arias, Nuria Balanza, Barbara Baro, Pere Millat-Martinez, Rosauro Varo, Sergio Alonso, Enric Alvarez-Lacalle, Daniel Lopez, Joana Claverol, Marta Cubells, Pedro Brotons, Anna Codina, Daniel Cuadras, Patricia Bruijning-Verhagen, Saul Faust, Alasdair Munro, Carmen Munoz-Almagro, Marti Catala, Clara Prats, Juan Jose Garcia-Garcia, Eduard Gratacos
Summary: The transmission rate of SARS-CoV-2 infection among children and adult staff in summer schools in Barcelona was lower than the general population, indicating that schools under strict preventive measures are unlikely to be significant sources of transmission.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Francesca Crovetto, Fatima Crispi, Elisa Llurba, Rosalie Pascal, Marta Larroya, Cristina Trilla, Made Camacho, Carmen Medina, Carlota Dobano, Maria Dolores Gomez-Roig, Francesc Figueras, Eduard Gratacos
Summary: This study found that pregnancy complications in women with SARS-CoV-2 infection were similar to those of noninfected women overall, but symptomatic COVID-19 was associated with modest increases in preterm delivery and intrapartum fetal distress.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Acoustics
M. Perez-Cruz, O. Gomez, M. Gibert, N. Masoller, E. Marimon, D. Lip-Sosa, M. Bennasar, E. Bonet-Carne, M. D. Gomez-Roig, J. M. Martinez-Crespo, E. Gratacos, E. Eixarch
Summary: The study aimed to evaluate corpus callosum size in fetuses with isolated major congenital heart defects using neurosonography. Findings revealed that fetuses with major CHD had a smaller corpus callosum compared to controls, particularly in the subgroup with expected poorer brain oxygen supply. This suggests sonographic corpus callosum size could serve as a clinically feasible marker of abnormal white matter development in congenital heart defects.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Talita Micheletti, Elisenda Eixarch, Mar Bennasar, Ximena Torres, Josep Maria Martinez-Crespo, Jan Deprest, Eduard Gratacos
Summary: This study found that the occurrence of PPROM after CO in MCDA pregnancies is associated with an increased risk of preterm delivery. The risk of PPROM is higher when CO is used to treat TTTS.
FETAL DIAGNOSIS AND THERAPY
(2021)
Article
Genetics & Heredity
Rebecca N. Spencer, Kurt Hecher, Gill Norman, Karel Marsal, Jan Deprest, Alan Flake, Francesc Figueras, Christoph Lees, Steve Thornton, Kathleen Beach, Marcy Powell, Fatima Crispi, Anke Diemert, Neil Marlow, Donald M. Peebles, Magnus Westgren, Helena Gardiner, Eduard Gratacos, Jana Brodszki, Albert Batista, Helen Turier, Mehali Patel, Beverley Power, James Power, Gillian Yaz, Anna L. David
Summary: This study aimed to improve safety monitoring for developing pregnancy drugs, devices, and interventions by creating AE terminology. An international multidisciplinary group filled gaps in definitions and severity grading through a modified Delphi process, allowing systematic consistent AE assessment in pregnancy trials.
PRENATAL DIAGNOSIS
(2022)
Article
Genetics & Heredity
Lennart Van der Veeken, Francesca M. Russo, Ewelina Litwinska, Olga Gomez, Doaa Emam, Liesbeth Lewi, David Basurto, Stephen Van der Veeken, Luc De Catte, Eduard Gratacos, Elisenda Eixarch, Kypros Nicolaides, Jan Deprest
Summary: Fetuses with isolated left-sided CDH exhibit a small cerebellum and reduced MCA peak systolic velocity. Disease severity is correlated to changes in TCD and MCA Doppler values. Follow-up studies are needed to determine the impact of these changes on neurodevelopment.
PRENATAL DIAGNOSIS
(2022)
Article
Obstetrics & Gynecology
Ben Van Calster, Alexandra Benachi, Kypros H. Nicolaides, Eduard Gratacos, Christoph Berg, Nicola Persico, Glenn J. Gardener, Michael Belfort, Yves Ville, Greg Ryan, Anthony Johnson, Haruhiko Sago, Przemyslaw Kosinski, Pietro Bagolan, Tim Van Mieghem, Philip L. J. DeKoninck, Francesca M. Russo, Stuart B. Hooper, Jan A. Deprest
Summary: This analysis suggests that fetoscopic endoluminal tracheal occlusion improves survival in cases of moderate and severe lung hypoplasia. The timing of balloon insertion may impact the treatment effect, but further research is needed to determine its precise influence due to the limited sample size and confounding factors. In particular, early insertion of the balloon greatly increases the risk of preterm delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Carlota Dobano, Selena Alonso, Mariona Fernandez de Sevilla, Marta Vidal, Alfons Jimenez, Gemma Pons Tomas, Chenjerai Jairoce, Maria Mele Casas, Rocio Rubio, Maria Hernandez Garcia, Gemma Ruiz-Olalla, Monica Girona-Alarcon, Diana Barrios, Rebeca Santano, Robert A. Mitchell, Laura Puyol, Leonie Mayer, Jordi Chi, Natalia Rodrigo Melero, Carlo Carolis, Aleix Garcia-Miquel, Elisenda Bonet-Carne, Joana Claverol, Marta Cubells, Claudia Fortuny, Victoria Fumado, Cristina Jou, Carmen Munoz-Almagro, Luis Izquierdo, Quique Bassat, Eduard Gratacos, Ruth Aguilar, Juan Jose Garcia-Garcia, Gemma Moncunill, Iolanda Jordan
Summary: Saliva antibody testing is a valuable tool for screening pediatric populations during viral epidemics, as it can detect low viral load exposures and show higher antibody conversion rates compared to RT-PCR screening. The study in Barcelona suggests that antibody profiling, including multiple antigens and isotypes, can help identify asymptomatic carriers and guide public health policies during pandemics.
Article
Multidisciplinary Sciences
Sergio Alonso, Marti Catala, Daniel Lopez, Enric Alvarez-Lacalle, Iolanda Jordan, Juan Jose Garcia-Garcia, Victoria Fumado, Carmen Munoz-Almagro, Eduard Gratacos, Nuria Balanza, Rosauro Varo, Pere Millat, Barbara Baro, Sara Ajanovic, Sara Arias, Joana Claverol, Mariona Fernandez de Sevilla, Elisenda Bonet-Carne, Aleix Garcia-Miquel, Ermengol Coma, Manuel Medina-Peralta, Francesc Fina, Clara Prats, Quique Bassat
Summary: The reopening of schools in Catalonia appeared to be safe and the preventive measures in place were effective in detecting and containing transmission. The risk of transmission within schools was found to be relatively low.
Letter
Acoustics
E. Eixarch, E. Gratacos
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Correction
Multidisciplinary Sciences
Xavier P. Burgos-Artizzu, David Coronado-Gutierrez, Brenda Valenzuela-Alcaraz, Elisenda Bonet-Carne, Elisenda Eixarch, Fatima Crispi, Eduard Gratacos
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Carlota Dobano, Selena Alonso, Marta Vidal, Alfons Jimenez, Rocio Rubio, Rebeca Santano, Diana Barrios, Gemma Pons Tomas, Maria Mele Casas, Maria Hernandez Garcia, Monica Girona-Alarcon, Laura Puyol, Barbara Baro, Pere Millat-Martinez, Sara Ajanovic, Nuria Balanza, Sara Arias, Natalia Rodrigo Melero, Carlo Carolis, Aleix Garcia-Miquel, Elisenda Bonet-Carne, Joana Claverol, Marta Cubells, Claudia Fortuny, Victoria Fumado, Anna Codina, Quique Bassat, Carmen Munoz-Almagro, Mariona Fernandez de Sevilla, Eduard Gratacos, Luis Izquierdo, Juan Jose Garcia-Garcia, Ruth Aguilar, Iolanda Jordan, Gemma Moncunill
Summary: COVID-19 has a lesser impact on children compared to adults, but they can still get infected and transmit the virus. A study evaluated the use of high-throughput Luminex assays to measure SARS-CoV-2 antibodies in saliva and compared them to serum/plasma samples in infected children and adults. The results showed a correlation between saliva and serum/plasma antibody levels, and infected children had higher antibody levels, suggesting stronger clinical immunity. Therefore, measuring saliva antibodies could be a useful tool to determine COVID-19 prevalence and transmission in pediatric populations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Lina Youssef, Francesca Crovetto, Rui Vasco Simoes, Jezid Miranda, Cristina Paules, Miquel Blasco, Marta Palomo, Hector Garcia-Caldero, Olga Tura-Ceide, Ana Paula Dantas, Virginia Hernandez-Gea, Pol Herrero, Nuria Canela, Josep Maria Campistol, Joan Carles Garcia-Pagan, Maribel Diaz-Ricart, Eduard Gratacos, Fatima Crispi
Summary: This study utilized metabolomic analysis to investigate the pathophysiological pathways involved in early-onset severe preeclampsia, revealing six altered metabolic pathways that may play a role in the development of this condition.
Article
Medicine, General & Internal
Laura Nogue, Olga Gomez, Nora Izquierdo, Cristina Mula, Narcis Masoller, Josep M. Martinez, Eduard Gratacos, Greggory Devore, Fatima Crispi, Mar Bennasar
Summary: This study evaluated the feasibility and reproducibility of 4D-STIC speckle tracking echocardiography (STE) using FetalHQ(R), and compared it to 2D STE. The results showed that 4D-STIC is feasible and reproducible for assessing cardiac morphometry and function.
JOURNAL OF CLINICAL MEDICINE
(2022)