Review
Nutrition & Dietetics
Helene Roumes, Pierre Goudeneche, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Polyphenols, including resveratrol, have potential neuroprotective effects against neonatal hypoxia-ischemia-induced damage due to their anti-apoptotic, anti-inflammatory, and anti-oxidative properties, and may enhance brain energy metabolism. Maternal supplementation at nutritional doses shows promising results and could be a novel prophylactic treatment for neonatal hypoxia-ischemia.
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Article
Biochemistry & Molecular Biology
Ewelina Bratek-Gerej, Apolonia Ziembowicz, Jakub Godlewski, Elzbieta Salinska
Summary: The study established the neuroprotective and antioxidant potential of KYNA in an experimental model of neonatal hypoxia-ischemia, showing significant reduction in brain damage and oxidative stress.
Article
Biochemistry & Molecular Biology
Eduardo Sanches, Yohan van de Looij, Dini Ho, Laura Modernell, Analina da Silva, Stephane Sizonenko
Summary: Combining early oral administration of lactoferrin with whole body hypothermia can enhance neuroprotection in neonatal hypoxic-ischemic encephalopathy, preventing lactate accumulation, reducing inflammation, and mitigating brain damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Sarah Kolnik, Thomas R. Wood
Summary: Vitamin E has potential as a neuroprotectant in newborn infants with brain injury, but its effectiveness in clinical settings is still uncertain. Recent studies have shown that fat emulsions containing higher levels of Vitamin E can improve outcomes in neonatal co-morbidities, leading to a reconsideration of Vitamin E administration as a potential therapeutic modality. This review discusses the structure, mechanism(s) of action, evidence in animal models, and association with health outcomes in neonates, highlighting the need for further research and assessment of safety profiles before large clinical trials.
Review
Neurosciences
L. E. Duran-Carabali, F. K. Odorcyk, E. F. Sanches, M. M. de Mattos, F. Anschau, C. A. Netto
Summary: Neonatal hypoxia-ischemia (HI) is a major cause of mortality and morbidity in newborns, and there is currently no definitive treatment for this condition. This study conducted a systematic review and meta-analysis of articles on environmental enrichment (EE) in HI rodent models. The results showed that EE had a beneficial impact on neurodevelopmental reflexes, motor and cognitive function, as well as brain damage. Factors such as study quality, age at injury, and duration of EE exposure influenced the positive effects of EE. Overall, EE showed promise as a therapeutic strategy for HI.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gorane Beldarrain, Enrique Hilario, Idoia Lara-Celador, Marc Chillida, Ana Catalan, Antonia Angeles Alvarez-Diaz, Daniel Alonso-Alconada
Summary: Neonatal hypoxia-ischemia (HI) can lead to a neurological condition called hypoxic-ischemic encephalopathy (HIE) in newborns, resulting in overall disability. The current treatment for affected neonates is therapeutic hypothermia, but it is not always effective in preventing the harmful effects of HI. Therefore, cannabinoids are being researched as potential new therapies. Modulating the endocannabinoid system (ECS) may reduce brain damage and stimulate cell proliferation. This study examined the middle- and long-term effects of 2-AG, the most abundant endocannabinoid, after neonatal HI in rats, and found that it reduced brain injury and promoted cell proliferation, suggesting long-lasting neuroprotective effects.
Article
Nutrition & Dietetics
Helene Roumes, Stephane Sanchez, Imad Benkhaled, Valentin Fernandez, Pierre Goudeneche, Flavie Perrin, Luc Pellerin, Jerome Guillard, Anne-Karine Bouzier-Sore
Summary: Polyphenols extracted in an eco-sustainable manner have neuroprotective effects and can prevent brain lesions and associated deficits in a rat model of neonatal hypoxia-ischemia.
Article
Endocrinology & Metabolism
Helene Roumes, Ursule Dumont, Stephane Sanchez, Leslie Mazuel, Jordy Blanc, Gerard Raffard, Jean-Francois Chateil, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Lactate has shown neuroprotective effects in a neonatal hypoxia-ischemia model, reducing brain lesion volume rapidly and efficiently. Lactate metabolism plays a key role in this protection, and lactate administration holds promise as an effective therapy for neonatal HI insult.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
E. F. Sanches, T. M. Dos Santos, F. Odorcyk, H. Untertriefallner, E. Rezena, E. Hoeper, T. Avila, A. P. Martini, G. T. Venturin, J. C. da Costa, S. Greggio, C. A. Netto, A. T. Wyse
Summary: Swimming exercise during pregnancy can prevent mitochondrial dysfunction and improve spatial memory in offspring exposed to neonatal hypoxia-ischemia, with a sex-specific benefit for male rats, highlighting mitochondria as a potential therapeutic target for cognitive impairments in such conditions.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joanne O. Davidson, Lotte G. van den Heuij, Simerdeep K. Dhillon, Suzanne L. Miller, Rebecca Lim, Graham Jenkin, Alistair J. Gunn, Laura Bennet
Summary: This study aimed to investigate whether early infusion of hAECs could reduce brain damage after ischemia in near-term fetal sheep. The results showed that a single intravenous administration of hAECs did not reduce the brain damage after global cerebral ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
L. E. Duran-Carabali, J. L. Da Silva, A. C. M. Colucci, C. A. Netto, L. S. De Fraga
Summary: Sex steroid hormones, such as progesterone and 17 beta estradiol, have been shown to have positive effects on reducing brain damage in neonatal hypoxia-ischemia. This systematic review and meta-analysis confirmed their efficacy in reducing cerebral infarction size, cell death, neuroinflammatory responses, and astrocyte reactivity, while only showing a small effect on cognitive function. However, further research is needed to examine neurological function during hypoxia-ischemia recovery and to standardize methodological aspects to avoid spurious findings.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Immunology
Kerstin Muelling, Alexa Josephine Fischer, Elena Siakaeva, Mathis Richter, Sharareh Bordbari, Ilona Spyra, Christian Koester, Dirk M. Hermann, Matthias Gunzer, Ursula Felderhoff-Mueser, Ivo Bendix, Jadwiga Jablonska, Josephine Herz
Summary: This study found that neutrophils in the neonatal brain are rapidly activated after experimental hypoxia-ischemia, producing reactive oxygen species and showing an increased proportion of hyperactivated/aged cells compared to peripheral neutrophils. Delayed neutrophil depletion led to reduced cellular neurodegeneration and decreased microglial and astroglial activation, offering new possibilities for therapeutic approaches in post-hypoxic brain injury.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Obstetrics & Gynecology
Subrata Sarkar, Seetha Shankaran, Abbot R. Laptook, Beena G. Sood, Barbara Do, Barbara J. Stoll, Krisa P. Van Meurs, Edward F. Bell, Abhik Das, John Barks
AMERICAN JOURNAL OF PERINATOLOGY
(2015)
Article
Clinical Neurology
Renee A. Shellhaas, Juhi S. Kushwaha, Melissa A. Plegue, David T. Selewski, John D. E. Barks
JOURNAL OF CHILD NEUROLOGY
(2015)
Article
Pediatrics
Max D. Sokoloff, Melissa A. Plegue, Ronald D. Chervin, John D. E. Barks, Renee A. Shellhaas
PEDIATRIC RESEARCH
(2015)
Review
Pediatrics
Subrata Sarkar, John Barks
SEMINARS IN FETAL & NEONATAL MEDICINE
(2015)
Review
Obstetrics & Gynecology
Laura R. Ment, Ulrika Aden, Charles R. Bauer, Henrietta S. Bada, Waldemar A. Carlo, Jeffrey R. Kaiser, Aiping Lin, Charles Michael Cotten, Jeffrey Murray, Grier Page, Mikko Hallman, Richard P. Lifton, Heping Zhang
SEMINARS IN PERINATOLOGY
(2015)
Article
Endocrinology & Metabolism
John D. Barks, Yiqing Liu, Yu Shangguan, Zora Djuric, Jianwei Ren, Faye S. Silverstein
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Pediatrics
Megan A. Coughlin, Nicole L. Werner, Robert Gajarski, Samir Gadepalli, Ronald Hirschl, John Barks, Marjorie C. Treadwell, Maria Ladino-Torres, Jeannie Kreutzman, George B. Mychaliska
JOURNAL OF PEDIATRIC SURGERY
(2016)
Article
Pediatrics
Jennifer Levy, Fauziya Hassan, Melissa A. Plegue, Max D. Sokoloff, Juhi S. Kushwaha, Ronald D. Chervin, John D. E. Barks, Renee A. Shellhaas
PEDIATRIC PULMONOLOGY
(2017)
Review
Pediatrics
Alistair J. Gunn, Abbot R. Laptook, Nicola J. Robertson, John D. Barks, Marianne Thoresen, Guido Wassink, Laura Bennet
PEDIATRIC RESEARCH
(2017)
Article
Pediatrics
Rebecca J. Vartanian, Cagri G. Besirli, John D. Barks, Chris A. Andrews, David C. Musch
Article
Medicine, Research & Experimental
Claudia Pedroza, Jon E. Tyson, Abhik Das, Abbot Laptook, Edward F. Bell, Seetha Shankaran
Article
Medicine, General & Internal
Seetha Shankaran, Abbot R. Laptook, Athina Pappas, Scott. A. McDonald, Abhik Das, Jon E. Tyson, Brenda B. Poindexter, Kurt Schibler, Edward F. Bell, Roy J. Heyne, Claudia Pedroza, Rebecca Bara, Krisa P. Van Meurs, Carolyn M. Petrie Huitema, Cathy Grisby, Uday Devaskar, Richard A. Ehrenkranz, Heidi M. Harmon, Lina F. Chalak, Sara B. DeMauro, Meena Garg, Michelle E. Hartley-McAndrew, Amir M. Khan, Michele C. Walsh, Namasivayam Ambalavanan, Jane E. Brumbaugh, Kristi L. Watterberg, Edward G. Shepherd, Shannon E. G. Hamrick, John Barks, C. Michael Cotten, Howard W. Kilbride, Rosemary D. Higgins
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2017)
Article
Pediatrics
Seetha Shankaran, Edward F. Bell, Abbot R. Laptook, Shampa Saha, Nancy S. Newman, S. Nadya J. Kazzi, John Barks, Barbara J. Stoll, Rebecca Bara, Jenna Gabrio, Kirsten Childs, Abhik Das, Rosemary D. Higgins, Waldemar A. Carlo, Pablo J. Sanchez, David P. Carlton, Lara Pavageau, William F. Malcolm, Carl T. D'Angio, Robin K. Ohls, Brenda B. Poindexter, Gregory M. Sokol, Krisa P. Van Meurs, Tarah T. Colaizy, Ayman Khmour, Karen M. Puopolo, Meena Garg, Michele C. Walsh
JOURNAL OF PEDIATRICS
(2019)
Article
Environmental Sciences
Elizabeth Marchlewicz, Carolyn McCabe, Zora Djuric, Mark Hoenerhoff, John Barks, Lu Tang, Peter X. Song, Karen Peterson, Vasantha Padmanabhan, Dana C. Dolinoy
Summary: Perinatal diet and BPA exposure have a greater impact on metabolic outcomes in offspring than on hepatic steatosis. Alterations in dam phenotype by diet and BPA exposure appear to impact offspring health trajectory.
Article
Pediatrics
John D. E. Barks, Yiqing Liu, Ian A. Dopp, Faye S. Silverstein
Summary: The study showed that AZ improves sensorimotor function, survival, brain tissue preservation, and composite scores in two neonatal rat models of inflammation-amplified HI brain injury. The benefits of AZ treatment increased with higher doses and decreased with longer initiation delays. The findings support further evaluation of AZ as a candidate treatment for neonatal neuroprotection, even with a 2-hour delay in initiation.
PEDIATRIC RESEARCH
(2022)
