Article
Medicine, General & Internal
Xianjing Xie, Dan Chen, Xingyu Yang, Yunyun Cao, Yuna Guo, Weiwei Cheng
Summary: This study aimed to determine whether the combination of pregnancy-associated endothelial cell-specific molecule 1 (ESM-1), the placental growth factor (PLGF) in the first- and second-trimester maternal serum, and the uterine artery Doppler pulsatility index (PI) in the second trimester can predict preeclampsia (PE). The results showed that levels of ESM-1 and PLGF, as well as PI, were associated with PE. The combination of these biomarkers improved the screening efficiency of PE prediction, especially for severe preeclampsia (SPE).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Jiang-Nan Wu, Ming-Qing Li, Feng Xie, Bin Zhang
Summary: The study found that the second-trimester measured UtA indices had a satisfactory performance at the 9th week in predicting subsequent preeclampsia. The right UtA-RI was the first choice in ruling out preeclampsia, while the left UtA-PI showed the best authenticity of the prediction.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Droima Stevens, Veronique Schiffer, Carmen Severens-Rijvers, Johnny de Nobrega Teixeira, Ashlee van Haren, Marc Spaanderman, Salwan Al-Nasiry
Summary: The study revealed that histologic decidual vasculopathy is associated with abnormal uterine artery Doppler, independent of clinical phenotype during pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Medicine, Research & Experimental
Zhonglu Ren, Yunfei Gao, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang
Summary: The study found that early-onset severe preeclampsia and late-onset severe preeclampsia have different molecular mechanisms, with the former associated with metabolism-related pathways and the latter with immune-related pathways. Some key transcription factors may be driving the widespread gene dysregulation in both early-onset and late-onset patients.
Article
Education, Scientific Disciplines
Ananya Trongpisutsak, Vorapong Phupong
Summary: This study demonstrated that a combination of serum micro RNA-210 and uterine artery Doppler is effective in predicting preeclampsia in the second trimester.
Article
Radiology, Nuclear Medicine & Medical Imaging
Keerthi Chilumula, Pradip Kumar Saha, Tanuja Muthyala, Subhas Chandra Saha, Venkataseshan Sundaram, Vanita Suri
Summary: Pregnancies with early-onset preeclampsia and abnormal uterine artery Doppler findings are at high risk for both maternal and neonatal complications, while those with late-onset preeclampsia and abnormal Doppler findings have an increased risk of perinatal complications.
JOURNAL OF ULTRASOUND
(2021)
Article
Obstetrics & Gynecology
Luiza Meelhuysen Sousa Aguiar, Lumena Goncalves Machado Zanotto, Carlos Henrique Mascarenhas Silva, Marianna Amaral Pedroso
Summary: A retrospective study showed that using both transverse and longitudinal Doppler techniques during the first trimester morphological examination can reliably measure the pulsatility index of uterine arteries in pregnant women, without affecting the final outcome of preeclampsia screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Eman Mohamed Ibraheim Moawad, Amr Samir Fouad Tammam, Maha Mohamed Mosaad, Hadeer Mashaal El Sayed, Adel Atef
Summary: The study found that fetal Doppler can effectively predict adverse outcomes in severe late onset preeclampsia. Umbilical artery Doppler was identified as the best indicator to predict such outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medicine, Research & Experimental
Qing Liu, Zhihong Zhu, Wen Cai, Liu Yang, ShuangDi Li, Jiarong Zhang
Summary: This study aimed to evaluate the potential of triglyceride (TG) concentrations at the time of oral lipid tolerance test (OLTT) measurement in the second trimester to predict preeclampsia and elucidate the lipid metabolic changes related to these diseases. The study found that pregnant women who subsequently developed preeclampsia had higher concentrations of 4-hour postprandial TG than those who remained normotensive. In linear logistic regression analyses, mid-trimester 4-hour postprandial TG concentrations at the time of OLTT measurement were significantly higher in preeclamptic cases than in controls.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Michelle Broekhuizen, Emilie Hitzerd, Thierry P. P. van den Bosch, Jasper Dumas, Robert M. Verdijk, Bas B. van Rijn, A. H. Jan Danser, Casper H. J. van Eijck, Irwin K. M. Reiss, Dana A. M. Mustafa
Summary: This study revealed distinct immunological alterations in early-onset preeclampsia compared to late-onset preeclampsia, with reduced expression of complement and Toll-like receptor associated genes, as well as decreased numbers of mast cells and M2 macrophages in early-onset preeclampsia placentas. Tailored treatments for each subtype may be desirable based on the differing immune profiles observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Suchada Erjongmanee, Vorapong Phupong
Summary: This study aimed to determine the predictive value of first-trimester serum SHARP1 level and second-trimester uterine artery Doppler in singleton pregnancy for the prediction of preeclampsia. The study demonstrated that combining the first-trimester serum SHARP1 level with the second-trimester uterine artery PI had good sensitivity to predict preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Amir Naeh, Alexandra Berezowsky, Shimrit Salem Yaniv, Howard Berger, Swati Agrawal, Joel G. Ray
Summary: This cohort study conducted at St. Michael's Hospital in Toronto, Canada, examined risk factors for placental insufficiency in singleton pregnancies. The findings suggested that pregnancies complicated by preeclampsia and/or IUGR had higher umbilical artery pulsatility index (UA PI) at 18-22 weeks' gestation compared to unaffected pregnancies. However, by 6 weeks post-partum, there was no significant difference in UA PI values between the two groups, indicating potential differences in the physiological recovery of umbilical artery flow in pregnancies affected by placental insufficiency.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Developmental Biology
Yue Pan, Miaojuan Chen, Gendie E. Lash
Summary: This study focuses on the role and molecular mechanism of osteopontin in uterine spiral artery remodeling. This process is critical for successful pregnancy and the deficiency in remodeling can affect placental blood perfusion, leading to impacts on fetal nutritional supply and growth.
Article
Obstetrics & Gynecology
Nana Yang, Qianghua Wang, Biao Ding, Yingying Gong, Yue Wu, Junpei Sun, Xuegu Wang, Lei Liu, Feng Zhang, Danli Du, Xiang Li
Summary: This study identified distinct gene expression profiles and functions in early-onset and late-onset preeclampsia. Ferroptosis may play a significant role in the pathogenesis of early-onset preeclampsia, with genes mainly involved in hypoxia and iron-related pathways. Further research is needed to explore placental ferroptosis and its role in the pathogenesis of early-onset preeclampsia.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Biochemistry & Molecular Biology
Tamara Antonic, Daniela Ardalic, Sandra Vladimirov, Aleksandra Zeljkovic, Jelena Vekic, Marija Mitrovic, Jasmina Ivanisevic, Tamara Gojkovic, Jelena Munjas, Vesna Spasojevic-Kalimanovska, Zeljko Mikovic, Aleksandra Stefanovic
Summary: A specific feature of dyslipidemia in pregnancy is increased HDL cholesterol concentration, but preeclampsia is associated with low HDL cholesterol. This study aimed to investigate changes in HDL metabolism in risky pregnancies and those with late-onset preeclampsia. The findings suggest that reduced capacity for intestinal HDL synthesis, decreased LCAT activity, and impaired capacity for HDL-mediated cholesterol efflux could contribute to lower HDL cholesterol in late-onset preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Elena Contro, Laura Cattani, Anna Balducci, Daniela Prandstraller, Antonella Perolo, Laura Larcher, Maria Letizia Bacchi-Reggiani, Antonio Farina, Andrea Donti, Gaetano Domenico Gargiulo, Gianluigi Pilu
Summary: In a retrospective cohort study at S. Orsola Hospital in Bologna, Italy, 140 fetuses suspected of CoA were evaluated using fetal echocardiography. Arch hypoplasia showed the highest correlation with postnatal CoA, with affected neonates having lower Z scores of the ascending aorta and aortic isthmus. An odds ratio-based multiparametric model was developed to build a scoring system (AUC 0.89) for better identification of affected fetuses.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Maria Gaia Dodaro, Elisa Montaguti, Anna Balducci, Antonella Perolo, Emanuela Angeli, Jacopo Lenzi, Lorenzo Lombardo, Andrea Donti, Gaetano Gargiulo, Gianluigi Pilu
Summary: The study suggests that the use of e-STIC technology can improve the reproducibility of ventricular deformation analysis, especially for left ventricular global strain. Additionally, e-STIC shows better reliability in measuring left ventricular ejection fraction compared to 2D analysis.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Federica Bellussi, Daniele Di Mascio, Ginevra Salsi, Tullio Ghi, Andrea Dall'Asta, Fabrizio Zullo, Gianluigi Pilu, Joana G. Barros, Diogo Ayres-de-Campos, Vincenzo Berghella
Summary: This study indicates that sonographic assessment of fetal occiput position before operative vaginal delivery does not reduce the incidence of failed operative vaginal deliveries, despite better accuracy in occiput position diagnosis compared to clinical assessment.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Elisa Montaguti, Roberta Rizzo, Josefina Diglio, Gaetana Di Donna, Elena Brunelli, Maria Cofano, Anna Seidenari, Jacopo Lenzi, Cesare Battaglia, Gianluigi Pilu
Summary: This study found that a transverse view of the fetal head can accurately detect increased nuchal translucency during 11 to 13 weeks of gestation. The time required to obtain transverse measurements was shorter than for sagittal measurements, but the results were similar. Increased nuchal translucency can be reliably identified using transverse views, and in some cases, this may be technically advantageous.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Andrea Dall'Asta, Giuseppe Rizzo, Tullio Ghi
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Acoustics
Andrea Dall'Asta, Monica Minopoli, Ruben Ramirez Zegarra, Elvira Di Pasquo, Tullio Ghi
Summary: Pre-eclampsia and fetal growth restriction have traditionally been attributed to primary placental dysfunction, but emerging evidence suggests that suboptimal maternal cardiovascular adaptation may be a key factor. This review summarizes the current understanding of maternal cardiac hemodynamics in these conditions and discusses different approaches for antihypertensive treatment based on observed hemodynamic phenotypes.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Review
Acoustics
R. Ramirez Zegarra, T. Ghi
Summary: Deep learning is leading the way in image analysis and has particular significance in medical imaging, including obstetric ultrasound. While ultrasound is the preferred method for detecting fetal malformations, it is reliant on operator experience and can be unreliable in inexperienced hands. Deep learning models have been proposed as a solution to support sonographers and improve the accuracy of ultrasound. This review provides a comprehensive explanation of the fundamentals of deep learning in fetal imaging, focusing on its clinical applicability.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Editorial Material
Acoustics
A. Dall'Asta, C. Melito, G. Morganelli, C. Lees, T. Ghi
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Elisa Montaguti, Maria Cofano, Josefina Diglio, Marta Fiorentini, Anita Pellegrino, Jacopo Lenzi, Cesare Battaglia, Gianluigi Pilu
Summary: This study aimed to evaluate the relationship between maternal hemodynamics and pregnancy outcomes. It was found that both gestational hypertension/preeclampsia and fetal growth restriction were associated with increased uterine artery pulsatility index and significant differences in hemodynamic parameters. The uterine artery pulsatility index was found to be useful in predicting fetal growth restriction, while hemodynamic parameters were associated with the development of hypertensive disorders. Further research is needed to assess the value of hemodynamics evaluation in screening protocols of preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Marta Fiorentini, Bianca Nedu, Fabrizio Dapoto, Elena Brunelli, Gianluigi Pilu, Aly Youssef
Summary: This study aimed to investigate the clinical presentation, maternal and perinatal outcomes, and treatment of Wernicke encephalopathy (WE) in women with hyperemesis gravidarum (HG). A systematic review of the literature identified 82 cases of WE due to HG, showing diverse clinical manifestations including ocular signs, ataxia, confusion, dysarthria, muscular weakness, impaired reflexes, and memory impairment. Thiamin administration treatment was commonly used, but there was a lack of data regarding the clinical course and perinatal outcomes.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Letter
Acoustics
A. Dall'Asta, R. Ramirez Zegarra, F. Figueras, G. Rizzo, C. Lees, T. Frusca, T. Ghi
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Letter
Acoustics
M. S. Scalia, C. Lees, G. Zamagni, T. Ghi, A. Bhide, L. Monasta, G. Ricci, G. Maso, H. Valensise, T. Stampalija
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
E. Contro, N. Volpe, L. Larcher, A. Dall'Asta, M. A. Penas da Costa, G. Vairo, E. di Pasquo, I. Giorgini, T. Ghi
Summary: This study aimed to describe the appearance and size of the ganglionic eminence (GE) in normal fetuses using three-dimensional (3D) neurosonography and to investigate the association between GE alterations (cavitation or enlargement) and malformation of cortical development (MCD). The study included normal fetuses and retrospective analysis of pathological cases with MCD. The results showed that the systematic assessment of the GE in fetuses at 19-22 weeks of gestation is feasible and reproducible on 3D neurosonography. Cavitation or enlargement of the GE can be observed in fetuses with MCD.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Editorial Material
Acoustics
A. Youssef
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Silvia Martini, Arianna Aceti, Anna Nunzia Della Gatta, Isadora Beghetti, Concetta Marsico, Gianluigi Pilu, Luigi Corvaglia
Summary: The detrimental effects of oxidative stress (OS) can start as early as after conception. Preterm infants are particularly susceptible to oxidative damage due to their physiological immaturity of antioxidant defenses and increased exposure to free radicals. This narrative review provides a detailed overview of the OS-related pathophysiological mechanisms in the preterm population during pregnancy and the early postnatal period, focusing on pregnancy disorders associated with preterm birth and specific postnatal complications.
