Review
Medicine, General & Internal
Stepan Feduniw, Zuzanna Gaca, Olga Malinowska, Weronika Brunets, Magdalena Zgliczynska, Marta Wlodarczyk, Anna Wojcikiewicz, Michal Ciebiera
Summary: This study reviews the challenges and treatment options for preterm premature rupture of the membranes at the limit of viability, and proposes possible directions for future development.
Article
Obstetrics & Gynecology
Lu Zhuang, Zhan-Kui Li, Yuan-Fang Zhu, Rong Ju, Shao-Dong Hua, Chun-Zhi Yu, Xing Li, Yan-Ping Zhang, Lei Li, Yan Yu, Wen Zeng, Jie Cui, Xin-Yu Chen, Jing-Ya Peng, Ting Li, Zhi-Chun Feng
Summary: This study conducted a prospective study on 1001 preterm infants born from mothers with pPROM and identified several important factors associated with SNO risk. A predicting model was developed and showed good discrimination and calibration performance.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Akaninyene Eseme Ubom, Manu Vatish, Eytan R. Barnea
Summary: Preterm labor occurs in around 10% of pregnancies worldwide and efforts must be made to reduce morbidity and mortality. Access to neonatal intensive care is limited in LMICs and rural areas. The Prep-for-Labor triage method by FIGO can help identify low- and high-risk patients and guide appropriate management. The goal is to minimize morbidity and mortality associated with preterm labor and PPROM.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Il-Yeo Jang, Hye-Ji Jung, Ji-Hee Sung, Suk-Joo Choi, Soo-Young Oh, Jung-Sun Kim, Cheong-Rae Roh
Summary: The indication for preterm delivery may affect the severity of placental inflammatory pathology and neonatal morbidity.
Article
Obstetrics & Gynecology
Ichchha Madan, Frank I. I. Jackson, Reinaldo Figueroa, Ray Bahado-Singh
Summary: This study aimed to investigate the effects of gestational age at delivery on the outcomes of maternal and neonatal in preterm prelabor rupture of membranes (PPROM). The study also examined various predictors of neonatal and infant mortality in these pregnancies. The results showed that there was a decrease in neonatal complications and death with advancing gestational age in PPROM. Gestational age at delivery was found to be the strongest predictor of mortality risk in PPROM.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Medicine, General & Internal
Luiz Gustavo dos Anjos Borges, Jana Pastuschek, Yvonne Heimann, Kristin Dawczynski, Ekkehard Schleussner, Dietmar H. Pieper, Janine Zollkau
Summary: This study aims to evaluate the vaginal microbial composition of PPROM patients and its development under standard antibiotic therapy, as well as to assess the usefulness of vaginal microbiota for the prediction of EONS. The study also examines the neonatal microbiota at birth as a possible reflection of in utero microbiota. The findings suggest that analyzing vaginal and neonatal microbiota through 16S rRNA gene sequencing can be a basis for individualized risk assessment for consecutive EONS.
Article
Obstetrics & Gynecology
Alisa Kachikis, Christie L. Walker, Ryan M. McAdams, Cynthia Gyamfi-Bannerman, Kristina M. Adams Waldorf
Summary: The study aimed to determine if PPROM imparts a differentially greater risk for neonatal BPD than sPTL, with results showing no significant difference between the two. Additionally, in univariate analysis, neonates in the PPROM group had lower rates of pneumonia, neonatal sepsis, and PDA requiring therapy compared to those in the sPTL group, but this difference was not significant in the multivariate analysis. Neonatal respiratory outcomes may have a similar phenotypic overlap regardless of whether preterm birth follows PPROM or sPTL.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Clara Murillo, Silvia Ferrero, Teresa Cobo, Montse Izquierdo Renau, Victoria Aldecoa, Laia Grau, Julia Ponce, Claudia Rueda, Montse Palacio
Summary: This study evaluated the outcomes of pregnant women with preterm prelabor rupture of membranes (PPROM) eligible for outpatient care. The results showed that women eligible for outpatient management had better prognosis and the neonatal outcomes were significantly better in the outpatient group.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Michal Fishel Bartal, Lynda G. Ugwu, William A. Grobman, Jennifer L. Bailit, Uma M. Reddy, Ronald J. Wapner, Michael W. Varner, John M. Thorp, Steve N. Caritis, Mona Prasad, Alan T. N. Tita, George R. Saade, Dwight J. Rouse
Summary: The rate of preterm premature rupture of membranes (PROM) and the likelihood of composite maternal or neonatal morbidity after preterm PROM were similar for twin and singleton gestations in a large, diverse cohort.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Giuseppe Chiossi, Mariarosaria Di Tommaso, Francesca Monari, Sara Consonni, Noemi Strambi, Sofia Gambigliani Zoccoli, Viola Seravalli, Chiara Comerio, Marta Betti, Anna Cappello, Patrizia Vergani, Fabio Facchinetti, Anna Locatelli
Summary: Expectant management of late preterm pPROM or LpPROM patients can reduce the burden of prematurity, especially between 34 and 36 weeks of gestation. Factors such as gestational age and PROM to delivery interval can affect neonatal outcomes, and antibiotics may have beneficial effects on newborns.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Laila Ezzat Abdelfattah, Rehab Abdelhamid Aboshama, Amr S. Abdelbadie, Mohamed H. Abulhasan, Mohamed A. Anan, Ibraheem I. Abdelaal
Summary: This study evaluated the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. The results showed that a higher dose of azithromycin was associated with a longer latency period, higher mean gestational age at delivery, but also increased rates of postpartum endometritis and respiratory distress syndrome.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Jacky Herzlich, Laurence Mangel, Ariel Halperin, Daniel Lubin, Ronella Marom
Summary: This retrospective study aimed to examine the outcomes of preterm infants born to women with preterm premature rupture of membranes (PPROM). The study found that the survival rate of infants born after prolonged rupture of membrane at gestational week less than 24 weeks was 79.2%, and they did not have a higher incidence of major morbidities compared to infants born following membrane rupture at gestational week 24 to 27.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Hanna Mueller, Ann-Christin Staehling, Nora Bruns, Christel Weiss, Maria Ai, Angela Koeninger, Ursula Felderhoff-Mueser
Summary: In expectantly and carefully managed pregnancies, the latency duration of PPROM was not associated with adverse neonatal outcomes, but respiratory distress syndrome was pronounced. The treatment for pronounced respiratory distress syndrome can be surfactant preparations, which did not lead to an increased rate of bronchopulmonary dysplasia.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Esra Can, Suleyman Cemil Oglak, Fatma Olmez
Summary: This study aimed to investigate the effects of expectant management for previable PPROM before 24 weeks of gestation on maternal and fetal outcomes, as well as analyze the risk estimates of potential confounders.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Ga Young Park, Won Soon Park, Se In Sung, Min Sun Kim, Myung Hee Lee, Ga Won Jeon, Sung Shin Kim, Yun Sil Chang
Summary: The outcomes of very low birth weight infants (VLBWIs) are significantly influenced by maternal mid-trimester prolonged preterm premature rupture of membranes (PPROM) and subsequent early pulmonary hypertension (PH), impacting survival rates, bronchopulmonary dysplasia (BPD), and severe intraventricular hemorrhage (IVH).
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Editorial Material
Pediatrics
Lucy Hare, Elaine Boyle
Editorial Material
Public, Environmental & Occupational Health
Jennifer Zeitlin, Rolf F. Maier, Marina Cuttini, Ulrika Aden, Klaus Boerch, Janusz Gadzinowski, Pierre-Henri Jarreau, Jo Lebeer, Mikael Norman, Pernille Pedersen, Stavros Petrou, Johanna M. Pfeil, Liis Toome, Arno van Heijst, Patrick Van Reempts, Heili Varendi, Henrique Barros, Elizabeth S. Draper
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2020)
Editorial Material
Pediatrics
Carina Rodrigues, Jennifer Zeitlin, Emilija Wilson, Liis Toome, Marina Cuttini, Rolf F. Maier, Veronique Pierrat, Henrique Barros
Editorial Material
Pediatrics
Amy Keir, Nicolas Bamat, Elaine Boyle, Omar ElKhateeb, Clyde Wright
Article
Pediatrics
Neora Alterman, Samantha Johnson, Claire Carson, Stavros Petrou, Oliver Rivero-Arias, Jennifer J. Kurinczuk, Alison Macfarlane, Elaine Boyle, Maria A. Quigley
Summary: The study found that children born prematurely are more likely to have special educational needs (SEN), especially those born before 32 weeks. Additionally, both preterm and early term births (37-38 weeks) are associated with an increased risk of SEN.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Article
Multidisciplinary Sciences
Sharon Morad, David Pitches, Alan Girling, Beck Taylor, Vikki Fradd, Christine MacArthur, Sara Kenyon
Summary: Overall, the introduction of 24/7 resident consultant obstetrician presence in a large obstetric unit did not result in a change in the existing trend of increasing adverse infant outcomes. However, this change was associated with a reversal in the increasing adverse outcomes for term babies.
Letter
Obstetrics & Gynecology
Rachel Rowe, Elizabeth S. Draper, Sara Kenyon, Charlotte Bevan, Joanne Dickens, Mandy Forrester, Rachel Scanlan, Derek Tuffnell, Jennifer J. Kurinczuk
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Medicine, Research & Experimental
Edmund Juszczak, Oliver Hewer, Christopher Partlett, Madeleine Hurd, Vasha Bari, Ursula Bowler, Louise Linsell, Jon Dorling
Summary: Incentive experiments in infant follow-up surveys have shown that offering unconditional incentives in advance significantly increases response rates, which is important for ensuring research results and improving questionnaire response rates.
Editorial Material
Pediatrics
Hema Gandecha, Elaine M. Boyle
Review
Pediatrics
Viraraghavan Vadakkencherry Ramaswamy, Thangaraj Abiramalatha, Tapas Bandyopadhyay, Elaine Boyle, Charles Christoph Roehr
Summary: Evidence suggests that surfactant therapy may decrease mortality in late preterm and term infants with RDS. However, there is uncertainty regarding its use in this population, indicating a need for further research.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Nursing
Farina Kokab, Eleanor Jones, Laura Goodwin, Beck Taylor, Sara Kenyon
Summary: This study explored the views and experiences of community midwives delivering postnatal care through focus group discussions, highlighting the challenges, strategies, and increasing demand for flexible care in managing complex situations. The findings suggest that community midwives are responding to women's needs and service pressures by implementing various approaches to provide care, indicating a potential for further improvement in care and outcomes with wider implementation of specific strategies.
Article
Multidisciplinary Sciences
Victoria Coathup, Claire Carson, Jennifer J. Kurinczuk, Alison J. Macfarlane, Elaine Boyle, Samantha Johnson, Stavros Petrou, Maria A. Quigley
Summary: The study found that preterm birth is associated with higher rates of infection-related hospital admissions in childhood, with children born before 40 weeks still at higher risk at 7-10 years of age. Different types of infections showed variations in their relationship with gestational age, with a focus on reducing the number and severity of lower respiratory tract infections for effective infection prevention strategies.
Article
Environmental Sciences
Caitlin Notley, Tracey J. Brown, Linda Bauld, Elaine M. Boyle, Paul Clarke, Wendy Hardeman, Richard Holland, Marie Hubbard, Felix Naughton, Amy Nichols, Sophie Orton, Michael Ussher, Emma Ward
Summary: This study aimed to explore intervention measures to promote smoke-free homes in neonatal intensive care units (NICUs). The study found that both parents and healthcare professionals recognized the need for intervention and suggested that it should include cessation support, support to maintain a smoke-free environment, and guidance on discussing smoking issues with family and visitors. The findings informed the development of an intervention based on the '3As' approach.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Eleanor Cosstick, Rachel Nirmal, Fiona Cross-Sudworth, Marian Knight, Sara Kenyon
Summary: The background reasons for ethnic disparities in maternal death in the UK are unclear. This study suggests that neither social risk factors nor engagement with maternity services are underlying factors contributing to the disparities in maternal mortality. Improvements are needed in the management of complex social factors and the provision of interpreter services.
Article
Medicine, General & Internal
Marian Knight, Kathryn Bunch, Nicola Vousden, Anita Banerjee, Philippa Cox, Fiona Cross-Sudworth, Mandish K. Dhanjal, Jenny Douglas, Joanna Girling, Sara Kenyon, Rohit Kotnis, Roshni Patel, Judy Shakespeare, Derek Tuffnell, Meg Wilkinson, Jennifer J. Kurinczuk
Summary: This research reveals the existence of multiple structural and other biases in maternity care in the UK. Some ethnic minority women experience lack of nuanced care, microaggressions, and clinical, social, and cultural complexity during the care process. Further study on the impact of microaggressions is needed.