Review
Physiology
Gustavo Jose Justo da Silva, Raffaele Altara, George W. Booz, Alessandro Cataliotti
Summary: Atrial natriuretic peptide is a crucial cardiac hormone that helps maintain heart function through potent natriuretic, diuretic, and vasodilating actions. Its main effects involve promoting the function of different tissues and organs in the body, and it shows potential in cardiorenal protective actions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michal Kacprzak, Magdalena Brzeczek, Marzenna Zielinska
Summary: The study examined the association between atrial infarction (AI) and the prognostic value of N-terminal proANP (NT-proANP) in patients with myocardial infarction (MI) treated with primary percutaneous coronary intervention (PCI). The results showed that AI did not affect the prognosis of patients with MI, while NT-proANP was identified as a strong predictor of death.
Article
Cell Biology
Fei Sun, Ke Zhou, Ke-yong Tian, Xin-yu Zhang, Wei Liu, Jie Wang, Cui-ping Zhong, Jian-hua Qiu, Ding-jun Zha
Summary: Strategies using bioactive molecules that regulate neurite regeneration and neuronal survival to reestablish connections between auditory epithelium or implanted electrodes and SGN neurites would become attractive therapeutic candidates for sensorineural hearing loss.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Marcelo Roberto Choi, Belisario Enrique Fernandez
Summary: Atrial natriuretic peptide, part of the natriuretic peptide family, has natriuretic, diuretic, and vasodilator effects that oppose the renin-angiotensin system. It also exerts nephroprotective effects due to its antioxidant and anti-inflammatory properties, making it a beneficial agent against acute and chronic kidney diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Veterinary Sciences
Zohreh Khaki, Parviz Nooshirvani, Darioush Shirani, Majid Masoudifard
Summary: This study aimed to assess the serum concentrations of ANP, BNP, and lipoproteins in dogs with MMVD and evaluate their correlation. The results showed that serum BNP has a greater diagnostic value than serum ANP in dogs with MMVD, and it can be used to determine the subclinical stages of B1 and B2 MMVD. Additionally, dogs with subclinical MMVD showed an increase in BNP, a decrease in HDL-C, and an increase in LDL-C, which are known risk factors for cardiovascular diseases in humans.
BMC VETERINARY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Zhenjiang Yang, Tuerdi Subati, Kyungsoo Kim, Matthew B. Murphy, Owen P. Dougherty, Isis L. Christopher, Joseph C. Van Amburg, Kaylen K. Woodall, Joey Barnett, Katherine T. Murray
Summary: Natriuretic peptide oligomers increase susceptibility to atrial arrhythmia, and the accelerated formation of oligomers by mutANP is associated with familial atrial fibrillation mutations. Oligomers inhibit mitochondrial function and regulate ion currents in atrial cells.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Malgorzata Szaroszyk, Badder Kattih, Abel Martin-Garrido, Felix A. Trogisch, Gesine M. Dittrich, Andrea Grund, Aya Abouissa, Katja Derlin, Martin Meier, Tim Holler, Mortimer Korf-Klingebiel, Katharina Volker, Tania Garfias Macedo, Cristina Pablo Tortola, Michael Boschmann, Nora Huang, Natali Froese, Carolin Zwadlo, Mona Malek Mohammadi, Xiaojing Luo, Michael Wagner, Julio Cordero, Robert Geffers, Sandor Batkai, Thomas Thum, Nadja Bork, Viacheslav O. Nikolaev, Oliver J. Muller, Hugo A. Katus, Ali El-Armouche, Theresia Kraft, Jochen Springer, Gergana Dobreva, Kai C. Wollert, Jens Fielitz, Stephan von Haehling, Michaela Kuhn, Johann Bauersachs, Joerg Heineke
Summary: This study investigated the role of a muscle hormone called Musclin in heart failure. The results showed that decreased expression of Musclin in muscle exacerbates cardiac dysfunction and myocardial fibrosis, while its overexpression in muscle attenuates these symptoms. Mechanistically, Musclin enhances the levels of C-type natriuretic peptide (CNP), which promotes cardiomyocyte contractility through different signaling pathways and inhibits fibroblast activation. Additionally, reduced expression of OSTN, the gene encoding Musclin, was found in skeletal muscle of heart failure patients, suggesting that increasing Musclin levels could be a potential therapeutic strategy.
NATURE COMMUNICATIONS
(2022)
Article
Physiology
Shuxia Cao, Chengyong Han, Chunhua Xuan, Xiangdan Li, Jing Wen, Dongyuan Xu
Summary: This study explored the potential mechanisms of rapid atrial pacing (RAP) in regulating atrial natriuretic peptide (ANP) secretion. The results showed that NPR-A interacts with ANP to regulate particulate guanylate cyclase (PGC) expression and influence cyclic guanosine monophosphate (cGMP) expression during RAP, involving the Akt/GSK-3 beta signaling pathway.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Hematology
Felix Hofer, Andreas Hammer, Matthias Steininger, Niema Kazem, Lorenz Koller, Barbara Steinlechner, Gunther Laufer, Martin Andreas, Rodrig Marculescu, Christian Hengstenberg, Johann Wojta, Alexander Niessner, Patrick Sulzgruber
Summary: Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, and the study found that mid-region proANP (MR-proANP) levels were significantly associated with the development of POAF, making it a strong and independent predictor.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Multidisciplinary Sciences
Shuyu Li, Heng Pei, Yaomeng Huang, Da Liu, Liqun Yang, Qi Zhang, Zhijun Wang
Summary: An animal model of atrial fibrillation was constructed to observe the effect of acute atrial fibrillation on renal water and sodium metabolism in mice. The expression of TGF-beta and type III collagen in atrial myocardium, as well as the levels of CRP and IL-6 in blood, were examined. Additionally, the protein expression of NF-kappa B, TGF-beta, type III collagen, AQP2, AQP3, ENaC-beta, ENaC-gamma, SGK1, and NKCC in the kidneys were observed. The results showed that acute atrial fibrillation led to renal inflammatory response and fibrosis, hindering water and sodium metabolism, which was associated with the up-regulation of NKCC, ENaC, and AQPs in the kidneys.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Martin A. Daniels, Pamela Fischer-Posovszky, Michael Boschmann, Reiner Jumpertz-von Schwartzenberg, Timo D. Mueller, Leontine Sandforth, Sabine Frank-Podlech, Sonja Huelskaemper, Andreas Peter, Martin Wabitsch, Jens Jordan, Andreas L. Birkenfeld
Summary: This study investigated the effect of ANP on the levels of the anorexigenic adipokine leptin in healthy humans. The results showed that ANP infusion led to a significant decrease in plasma leptin levels and an increase in free fatty acids, indicating enhanced lipolysis. Additionally, ANP was found to suppress leptin release in human SGBS adipocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Maurizio Forte, Simona Marchitti, Flavio Di Nonno, Rosita Stanzione, Leonardo Schirone, Maria Cotugno, Franca Bianchi, Sonia Schiavon, Salvatore Raffa, Danilo Ranieri, Salvatore Fioriniello, Floriana Della Ragione, Maria Rosaria Torrisi, Roberto Carnevale, Valentina Valenti, Francesco Versaci, Giacomo Frati, Carmine Vecchione, Massimo Volpe, Speranza Rubattu, Sebastiano Sciarretta
Summary: NPPA plays a critical role in the cardiovascular system by activating autophagy to protect cardiomyocytes, reduce cardiac fibrosis, and promote vascular integrity.
Article
Physiology
Elizabeth O. Harrington, Ashok Kumar, Verida Leandre, Zachary S. Wilson, Brianna Guarino, Julie Braza, Craig T. Lefort, James R. Klinger
Summary: Atrial natriuretic peptide protects against acute lung injury, and NPR-C does not mediate the protective effect of ANP on endothelial cell permeability in settings of PA103-induced injury but may mediate the effect of ANP on inhibition of the recruitment of neutrophils to the lung and thereby attenuate the release of inflammatory cytokines.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Gaetano Pacinella, Federica Todaro, Rosaria Pecoraro, Antonino Tuttolomondo
Summary: Natriuretic peptides are a complex molecular network with pleiotropic effects on various organs and tissues, primarily maintaining cardiovascular homeostasis and regulating water-salt balance. Increasing knowledge of their receptors, molecular mechanisms, and discovery of new peptides has led to a better understanding of their physiological and pathophysiological roles, with potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Meteorology & Atmospheric Sciences
Jerome J. Maleski, Christopher J. Martinez
INTERNATIONAL JOURNAL OF CLIMATOLOGY
(2017)
Article
Meteorology & Atmospheric Sciences
Jerome J. Maleski, Christopher J. Martinez
INTERNATIONAL JOURNAL OF CLIMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Huey T. Nguyen, Darrell R. Sawmiller, Qi Wu, Jerome J. Maleski, Ming Chen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2012)
Article
Neurosciences
Ming Chen, Jerome J. Maleski, Darrell R. Sawmiller
JOURNAL OF ALZHEIMERS DISEASE
(2011)
Article
Engineering, Civil
Christopher J. Martinez, Jerome J. Maleski, Martin F. Miller
JOURNAL OF HYDROLOGY
(2012)
Article
Environmental Sciences
Jerome J. Maleski, David D. Bosch, Ray G. Anderson, Alisa W. Coffin, William F. Anderson, Timothy C. Strickland
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)