Review
Obstetrics & Gynecology
Sarah Buckley, Kerstin Uvnas-Moberg, Zada Pajalic, Karolina Luegmair, Anette Ekstrom-Bergstrom, Anna Dencker, Claudia Massarotti, Alicja Kotlowska, Leonie Callaway, Sandra Morano, Ibone Olza, Claudia Meier Magistretti
Summary: Synthetic oxytocin increases maternal plasma oxytocin levels during labor, but does not affect newborn oxytocin levels. However, its use during labor can change uterine contraction patterns, potentially harming the fetus and increasing maternal pain and stress.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Barbara Baranowska, Anna Kajdy, Iwona Kiersnowska, Dorota Sys, Urszula Tataj-Puzyna, Deirdre Daly, Michal Rabijewski, Grazyna Baczek, Maria Wegrzynowska
Summary: The study found no effect of the mean cumulative dose of oxytocin on short-term perinatal outcomes and a high rate of non-compliance with national guidelines for oxytocin administration during labor induction and augmentation. Cooperation between different professional groups in maternity care should be considered in developing national guidelines.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Jennifer A. McCoy, Lauren Walheim, Meaghan G. McCabe, Lisa D. Levine
Summary: This study aimed to evaluate the rates of cesarean delivery in patients with prolonged labor who received intravenous propranolol compared with placebo. The results showed no significant difference in cesarean delivery rate between the propranolol group and the placebo group.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Tusar Giri, Jia Jiang, Zhiqiang Xu, Ronald McCarthy, Carmen M. Halabi, Eric Tycksen, Alison G. Cahill, Sarah K. England, Arvind Palanisamy
Summary: By creating and validating a high-fidelity pregnant rat model, researchers have successfully simulated the process of labor induction with oxytocin and conducted experimental studies on labor-related issues. Their findings suggest that there is no significant oxidative stress in the newborn brain during labor induction with oxytocin.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Ines Nunes, Corinne Dupont, Susanna Timonen, Diogo Ayres de Campos, Vanessa Cole, Christiane Schwarz, Anneke Kwee, Branka Yli, Christophe Vayssiere, Georges-Emmanuel Roth, Elko Gliozheni, Yuliya Savochkina, Marina Ivanisevic, Petr Janku, Susanna Timonen, George Daskalakis, Artur Beke, Susana Santo, Mirjam Druskovic, J. J. Duvekot, Alex Farr, Michel Dreyfus
Summary: The use of oxytocin for labor induction and augmentation should be carefully considered in appropriate conditions with continuous cardiotocography monitoring and administration of standard doses through intravenous infusion. Regular auditing of oxytocin use is recommended for quality assurance.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Hillary Bracken, Kate Lightly, Shuchita Mundle, Robbie Kerr, Brian Faragher, Thomas Easterling, Simon Leigh, Mark Turner, Zarko Alfirevic, Beverly Winikoff, Andrew Weeks
Summary: This study aims to compare a labor induction protocol using misoprostol alone with the standard protocol of misoprostol plus oxytocin in pregnant women with hypertensive disease in pregnancy. The primary outcome will be the rate of caesarean births, with secondary outcomes evaluating efficacy, maternal and fetal complications, and patient acceptability. The study also plans to conduct cost-effectiveness analysis and qualitative assessment of women's experience.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Helena Litorp, Avinash K. Sunny, Ashish Kc
Summary: A cohort study in 12 public hospitals in Nepal involving nearly 80,000 women found that the use of oxytocin to augment labor resulted in different risks and outcomes compared to women who did not receive oxytocin. While oxytocin may have some benefits, its use also comes with increased risks of adverse perinatal outcomes, indicating a need for cautious use in low-resource settings.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Obstetrics & Gynecology
Rehab Abdelhamid Aboshama, Ahmed Mohamed Abdelhakim, Mohammad Abrar Shareef, Abdulhadi A. AlAmodi, Mohammad Sunoqrot, Nourhan M. Alborno, Mohamed Gadelkarim, Ahmed M. Abbas, Mohamed Sobhy Bakry
Summary: When comparing high dose and low dose oxytocin for labor augmentation, high dose oxytocin did not reduce cesarean delivery rate or increase spontaneous vaginal delivery rate, but did reduce labor duration. On the other hand, low dose oxytocin was associated with lower rates of uterine hyperstimulation and tachysystole.
JOURNAL OF PERINATAL MEDICINE
(2021)
Article
Nursing
Stine Bernitz, Ana Pilar Betran, Nina Gunnes, Jun Zhang, Ellen Blix, Pal Oian, Torbjorn Moe Eggebo, Rebecka Dalbye
Summary: This study investigated the association between labour duration, oxytocin augmentation, and postpartum hemorrhage. The findings showed that both oxytocin use and prolonged labour duration were associated with postpartum hemorrhage. A maximum dose of oxytocin >=20 mU/min and a labour duration >=16 hours were independently associated with postpartum hemorrhage.
Article
Obstetrics & Gynecology
Melese Gezahegn Tesemma, Demisew Amenu Sori, Desta Hiko Gemeda
Summary: The study found that pregnant mothers who received high dose oxytocin for labor induction had higher rates of adverse perinatal outcomes compared to those who received low dose oxytocin. Risk factors associated with adverse perinatal outcomes included high dose oxytocin use, caesarean birth, instrumental birth, and antepartum hemorrhage. The study recommended the use of low dose oxytocin for better perinatal outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Cecilia Bruggemann, Sara Carlhall, Hanna Grundstrom, Marie Blomberg
Summary: The study found that oxytocin augmentation at cervical dilatation <= 5 cm increased the risk of cesarean section, while no increased risk of operative birth was found at 6-10 cm of cervical dilatation. Additionally, a decreased risk of operative birth was observed at full cervical dilatation, with a high rate of negative birthing experience across all groups.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Nutrition & Dietetics
Junki Imaizumi, Shuhei Kamada, Miyu Taniguchi, Tatsuro Sugimoto, Takaaki Maeda, Ryosuke Arakaki, Shota Yamamoto, Aya Shirakawa, Ayuka Mineda, Atsuko Yoshida, Takeshi Iwasa, Takashi Kaji
Summary: Changes in oxytocin levels and oxytocin receptor mRNA expression were observed in rats with intrauterine undernutrition. These changes could potentially affect nutritional and metabolic regulation systems and contribute to the mechanisms underlying DOHaD.
Article
Obstetrics & Gynecology
James Owen Drife
Summary: The mean duration of human pregnancy is 280 days with a wide range; labour induction was mainly used for pelvic deformity in the 18th and 19th centuries; induction methods became more reliable in the 20th century.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Editorial Material
Neurosciences
Richard G. Dickson, Matthew W. Jacobs, Euiseok J. Kim
Summary: In this study, Inada et al. investigate the changes in brain-wide connectivity and synaptic plasticity of hypothalamic oxytocin+ neurons in male mice, and their contribution to parental behaviors.
Article
Multidisciplinary Sciences
Heidi Kruit, Irmeli Nupponen, Seppo Heinonen, Leena Rahkonen
Summary: This study compared the outcomes of low-dose and high-dose oxytocin induction protocols. The results showed that the implementation of the new high-dose protocol resulted in a higher rate of vaginal delivery and a lower rate of maternal and neonatal infections.