Article
Chemistry, Multidisciplinary
Qilin Zou, Luan Passini, Laure Gibot, Delphine Lagarde, Jie Hu, Haomiao Zhu, Franck Desmoulin, Pierre Sicard, Nitchawat Paiyabhroma, Marc Verelst, Robert Mauricot, Clement Roux
Summary: This study presents a versatile strategy for synthesizing ultrasmall rare-earth oxysulfide (RE2O2S) nanoparticles ranging from 3 to 10 nm. The stability of PVP-coated Gd0.8Nd1.2O2S nanoparticles with a size of 6 nm in culture medium is investigated. The results demonstrate the potential of these nanoparticles for applications in various imaging techniques, including magnetic resonance, X-ray computed tomography, photoacoustic, ultrasound, and second near-infrared fluorescence imaging. This study lays the foundation for further research on the bioapplications of ultrasmall RE2O2S nanoparticles.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Pharmacology & Pharmacy
Luca Pasquini, Antonio Napolitano, Matteo Pignatelli, Emanuela Tagliente, Chiara Parrillo, Francesco Nasta, Andrea Romano, Alessandro Bozzao, Alberto Di Napoli
Summary: The development of 'virtual' and 'augmented' contrasts in biomedical imaging using artificial intelligence techniques has enabled the generation of synthetic post-contrast images through computational modeling, reducing the risks and limitations associated with traditional contrast media in clinical practice.
Review
Chemistry, Multidisciplinary
Mike Jeon, Mackenzie Halbert, Zachary R. Stephen, Miqin Zhang
Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Shange Liu, Yuxing Jiang, Pengcheng Liu, Yu Yi, Dayong Hou, You Li, Xiao Liang, Yifan Wang, Zhi Li, Jia He, Hongpan Rong, Dingsheng Wang, Jiatao Zhang
Summary: This study introduces a single-atom gadolinium nano-contrast agent (Gd-SA) that enhances tumor magnetic resonance imaging (MRI). Gd atoms are atomically dispersed on a hollow carbon nanosphere, reducing the risk of toxic gadolinium ion leakage. Gd-SA shows excellent T1-weighted magnetic resonance enhancement and outperforms the commercial gadolinium-diethylenetri-amine pentaacetic acid (Gd-DTPA) in terms of spatial resolution and imaging time window for tumors.
Review
Chemistry, Multidisciplinary
Ruth Antwi-Baah, Yajing Wang, Xiaoqin Chen, Kui Yu
Summary: Metal-based nanoparticles, especially gadolinium, manganese, and iron, have shown potential as MRI contrast agents due to their desirable properties. However, most nanoparticles have not been translated into clinical applications yet.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Yongkang Gai, Yuying Li, Shuangping Wu, Ling Xu, Yao Lu, Xiaoli Lan, Guangya Xiang, Xiang Ma
Summary: The aim of this study was to synthesize and characterize a new micelle-based TPGS gadolinium chelate as a biocompatible MRI contrast agent for prolonged blood circulation time and good tumor imaging contrast. The successfully prepared TPGS-L-NETA-Gd micelle exhibited improved cellular uptake in HepG2 cells and xenografts and high in vivo safety. The in vitro and in vivo properties of TPGS-L-NETA-Gd make it a favorable macromolecular MRI contrast agent for future in vivo imaging.
Review
Chemistry, Medicinal
Zelong Chen, Zheng Han, Guanshu Liu
Summary: CEST MRI is an attractive approach that allows for the direct use of low-concentration, exchangeable proton-containing agents to generate MRI contrast, helping to rapidly translate newly developed MRI agents into clinical use. The ability to utilize diamagnetic compounds has been widely applied to detect clinical compounds, including FDA-approved drugs and X-ray/CT contrast agents.
Article
Materials Science, Biomaterials
Xingtai Huang, Zihan Wang, Shujie Li, Shiqi Lin, Lirong Zhang, Zhaowei Meng, Xuejun Zhang, Shao-Kai Sun
Summary: In this study, a non-invasive diagnosis method for acute kidney injury using contrast-enhanced magnetic resonance imaging (CE-MRI) based on manganese-doped carbon dots (Mn-CDs) was developed. The synthesized Mn-CDs possess small size, good biocompatibility, and high T1 relaxation rate, which can effectively enhance kidney signal and clearly show kidney structures. In an acute kidney injury model, Mn-CDs-based CE-MRI can accurately and intuitively reveal the site of kidney injury and reflect the functional changes in the injured kidney.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Richard Botar, Eniko Molnar, Zoltan Garda, Eniko Madarasi, Gyorgy Trencsenyi, Janos Kiss, Ferenc K. Kalman, Gyula Tircso
Summary: A new potential MRI contrast agent candidate has been synthesized, which shows high thermodynamic stability, inertness, and efficient binding to proteins, allowing for visualization in vivo.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Inorganic & Nuclear
Rocio Uzal-Varela, Aurora Rodriguez-Rodriguez, Huan Wang, David Esteban-Gomez, Isabel Brandariz, Eric M. Gale, Peter Caravan, Carlos Platas-Iglesias
Summary: This research developed a method for predicting Gd(III)-ligand formation constant and pGd at pH 7.4 using known stability constants and structural descriptors, showing strong predictive power and potential for screening potential ligands.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Connor M. Ellis, Daohe Yuan, Ferenc E. Mozes, Jack J. Miller, Jason J. Davis
Summary: Paramagnetically-doped polymer micelles with ionizable poly(acrylic acid) (PAA) block enable high-contrast MR imaging at clinically relevant field strengths with strong pH sensitivity. The reversible switch in polymer strand charge directly affects the local rigidity and rotational correlation time characteristics of the integrated Gd-chelate, resulting in a 50% amplitude switch in positive contrast.
CHEMICAL COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Changqiang Wu, Liang Du, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: Compared to traditional branched polymers, branched polymers with Gd(III) chelates as the internal skeleton show higher kinetic stability and better relaxivity enhancement for MRI contrast agents. Different poly-DOTA branched polymers were synthesized and the Gd(III) chelates displayed excellent stability and high T1 relaxivities. In vivo studies showed that P4-Gd had the best performance in terms of MRA effect, vascular stenosis detection, and longer observation window compared to Gd-DOTA. Overall, poly-DOTA branched polymers with Gd(III) chelates are promising candidates for MRI probes with improved relaxivity enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai, Jinhao Gao, Hongyu Lin
Summary: This study reports a new strategy to improve the performance of nanoparticle-based T1 contrast agents by utilizing the photoinduced super-hydrophilic assistance (PISA) effect. By doping gadolinium into citrate-coated titanium dioxide ellipsoidal nanoparticles (GdTi-SC NPs), the r1 value of the nanoparticles significantly increases upon UV irradiation. The existence of the PISA effect is confirmed by the reduced water contact angle and increased surface hydroxyl groups, leading to enhanced paramagnetic relaxation enhancement (PRE) efficiency and improved imaging performance. In vivo MRI experiments on rats demonstrate that GdTi-SC NPs can serve as a high-performance contrast agent for sensitive imaging of blood vessels and accurate diagnosis of vascular lesions, indicating the success of the proposed strategy.
Article
Chemistry, Inorganic & Nuclear
Camille Gosee, Juliette Moreau, Cyril Cadiou, Maite Callewaert, Celine Henoumont, Lionel Larbanoix, Michael Molinari, Sorina N. Voicu, Christophe Portefaix, Sophie Laurent, Francoise Chuburu
Summary: The challenge of imaging is to combine resolution and sensitivity in order to gain accuracy in diagnosis. No single modality can provide comprehensive information. Then, the solution is to design probes that are able to gather on a single platform the best features of the different imaging modalities. To achieve this objective, we have combined two types of probes, one associated with photoacoustic imaging (PAI) and the other with magnetic resonance imaging (MRI), within polysaccharide-based nanohydrogels.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Camille Gosee, Juliette Moreau, Cyril Cadiou, Maite Callewaert, Celine Henoumont, Lionel Larbanoix, Michael Molinari, Sorina N. Voicu, Christophe Portefaix, Sophie Laurent, Francoise Chuburu
Summary: The challenge in imaging is to achieve accurate diagnosis by combining resolution and sensitivity. To overcome the limitations of single modality imaging, a solution is to design probes that combine the best features of different imaging modalities. In this study, we successfully combined photoacoustic imaging and magnetic resonance imaging within polysaccharide-based nanohydrogels to create an 'all in one' bimodal imaging system. The nanohydrogels showed significant signals in both MSOT and MRI experiments, demonstrating their potential for accurate imaging.
INORGANIC CHEMISTRY FRONTIERS
(2023)
