Article
Clinical Neurology
Ilyas Yazici, Britta Krieger, Barbara Bellenberg, Theodoros Ladopoulos, Ralf Gold, Ruth Schneider, Carsten Lukas
Summary: In this study, we validated the estimation of brain parenchymal fraction (BPF) in multiple sclerosis (MS) patients using synthetic magnetic resonance imaging (SyMRI). We compared SyMRI with software tools from the FMRIB Software Library (FSL) and assessed longitudinal volume changes to determine the suitability of SyMRI for quantifying disease-specific changes.
Article
Neurosciences
Giordano Gentile, Mark Jenkinson, Ludovica Griffanti, Ludovico Luchetti, Matteo Leoncini, Maira Inderyas, Marzia Mortilla, Rosa Cortese, Nicola De Stefano, Marco Battaglini
Summary: In this study, a novel tool called BIANCA-MS is presented for brain white matter lesion segmentation in multiple sclerosis (MS). BIANCA-MS is able to generalize across different MRI acquisition protocols and heterogeneity of manually labeled data. It outperformed other available tools in high- and low-resolution images and provided comparable performance across different scanning protocols, sets of modalities, and image resolutions. The findings suggest that BIANCA-MS is a robust and accurate approach for automated MS lesion segmentation.
HUMAN BRAIN MAPPING
(2023)
Article
Immunology
Deepak Kumar Kaushik, Anindita Bhattacharya, Brian Mark Lozinski, V. Wee Yong
Summary: Pericytes play a critical role in mediating inflammation in multiple sclerosis (MS) and its models, seeking to restore blood-brain barrier (BBB) integrity through increased coverage but facilitating macrophages to enter the central nervous system when exposed to CSPGs, leading to elevated neuroinflammation in experimental autoimmune encephalomyelitis (EAE) and MS.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
P. Sorrentino, S. Petkoski, M. Sparaco, E. Troisi Lopez, E. Signoriello, F. Baselice, S. Bonavita, M. A. Pirozzi, M. Quarantelli, G. Sorrentino, V. Jirsa
Summary: Two structurally connected brain regions are more likely to interact, with the properties of the structural bundles and the topology of the structural connectome affecting the timing of the interactions. Using magneto/electroencephalography (MEG/EEG) and integrating them with the structural bundles, researchers measured functional delays across the entire human brain and created a topochronic map. The study also found that patients with multiple sclerosis had greater delays across the network compared to controls.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Helge Herthum, Stefan Hetzer, Michael Scheel, Mehrgan Shahryari, Juergen Braun, Friedemann Paul, Ingolf Sack
Summary: Recent studies using magnetic resonance elastography (MRE) found that the range of stiffness changes in white matter lesions due to multiple sclerosis (MS) is similar to the normal variability of white matter, suggesting that in vivo tissue sclerosis may not be a mechanical signature of MS.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Yong Li, Junlan Wu, Fenghua Liu, Xianjun Shao, Xiaohua Liang, Feifei Zhang, Yan Meng, Meihua Shen, Mianshun Pan
Summary: This study compared the efficacy of stereotactic radiotherapy (SRT) and stereotactic radiosurgery (SRS) for the treatment of brain metastases from colorectal cancer (CRC) and found that both methods are effective. The simultaneous use of bevacizumab may be one of the most important factors that affects the survival of these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Gabriela A. Bou, Sally El Sammak, Ling-Chen Chien, Julien J. Cavanagh, Spencer K. Hutto
Summary: This study retrospectively reviewed the uncommon manifestation of neurosarcoidosis, tumefactive brain parenchymal lesions. The study aimed to characterize the clinical features, management, and outcomes of these lesions. It found that tumefactive lesions are rare, typically associated with leptomeningitis, refractory to initial treatments, and have a high risk of relapse.
JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thien Huong Nguyen, Alexis Vaussy, Violette Le Gaudu, Jennifer Aboab, Sophie Espinoza, Irina Curajos, Emmanuel Heron, Christophe Habas
Summary: The study evaluated the FGATIR sequence for MRI identification of brainstem tracts and nuclei damage in MS patients. Results showed that FGATIR enabled precise visualization of structures and identification of inflammatory brainstem involvement in MS patients. Combination of FGATIR and PD/T2w sequences could help define MS injury patterns in brainstem structures for potential neural network training for automated lesion labeling.
INSIGHTS INTO IMAGING
(2021)
Article
Clinical Neurology
Matthew R. Brier, Zhuocheng Li, Maria Ly, Helmet T. Karim, Leda Liang, Weixin Du, John E. McCarthy, Anne H. Cross, Tammie L. S. Benzinger, Robert T. Naismith, Salim Chahin
Summary: Brain age, quantified using machine learning applied to structural MRI, is a clinically relevant biomarker that correlates with and predicts increasing disability in patients with multiple sclerosis (MS).
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Yaqiong Xiao, Liangjun Liao, Kaiyu Huang, Shun Yao, Lei Gao
Summary: This study investigates the relationship between hippocampal volumetric integrity and brain atrophy during AD progression, and finds that hippocampal atrophy is associated with cognitive decline. The study also reveals stronger connections between the hippocampus and other brain regions in MCI and AD patients. These findings have important clinical implications for the prognosis of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Elisa Colato, Ferran Prados, Jonathan Stutters, Alessia Bianchi, Sridar Narayanan, Douglas L. Arnold, Claudia Wheeler-Kingshott, Frederik Barkhof, Olga Ciccarelli, Declan T. Chard, Arman Eshaghi
Summary: Network-based measures of white and grey matter damage can predict disability progression and cognitive worsening in multiple sclerosis (MS). This study has important implications for identifying patients at risk of disease worsening and for stratifying cohorts in treatment trials.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Kolodziej, Karolina Chrabaszcz, Ewa Pieta, Natalia Piergies, Julia Rudnicka-Czerwiec, Halina Bartosik-Psujek, Czeslawa Paluszkiewicz, Marian Cholewa, Wojciech M. Kwiatek
Summary: Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system. The diagnosis of MS is crucial for successful treatment, and it typically involves clinical observation, MRI, and analysis of cerebrospinal fluid (CSF). In this study, the researchers propose using spectroscopy as an alternative diagnostic tool, specifically Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy. By analyzing blood plasma and serum samples from MS patients and healthy individuals, the researchers identified specific spectral patterns that can differentiate between MS samples and non-MS samples.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Jana Lizrova Preiningerova, Zuzana Jiraskova Zakostelska, Adhish Srinivasan, Veronika Ticha, Ivana Kovarova, Pavlina Kleinova, Helena Tlaskalova-Hogenova, Eva Kubala Havrdova
Summary: This article discusses the relationship between gut microbiota and the pathophysiology of multiple sclerosis (MS), emphasizing the importance of further research and understanding of the role of microbiota in MS treatment.
Article
Clinical Neurology
Britta Matusche, Ludmila Litvin, Ruth Schneider, Barbara Bellenberg, Mark Muehlau, Viola Pongratz, Achim Berthele, Sergiu Groppa, Muthuraman Muthuraman, Frauke Zipp, Friedemann Paul, Heinz Wiendl, Sven G. Meuth, Philipp Saemann, Frank Weber, Ralf A. Linker, Tania Kuempfel, Ralf Gold, Carsten Lukas
Summary: The aim of this study was to analyze the extent of pseudoatrophy in the upper spinal cord during the first 2 years after therapy initiation and compare this to the brain. The results suggest that pseudoatrophy occurs not only in the brain, but also in the spinal cord during the first year of interferon-beta treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Junghun Cho, Thanh D. Nguyen, Weiyuan Huang, Elizabeth M. Sweeney, Xianfu Luo, Ilhami Kovanlikaya, Shun Zhang, Kelly M. Gillen, Pascal Spincemaille, Ajay Gupta, Susan A. Gauthier, Yi Wang
Summary: Our study demonstrates the feasibility of whole brain oxygen extraction fraction mapping for measuring lesion-specific and regional abnormalities in multiple sclerosis patients. Comparing OEF and neural tissue susceptibility between MS patients and healthy controls revealed distinct differences in lesion areas and overall brain oxygen utilization, suggesting OEF as a potential quantitative marker for tissue oxygenation in MS.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Mathias Granqvist, Joachim Burman, Martin Gunnarsson, Jan Lycke, Petra Nilsson, Tomas Olsson, Peter Sundstrom, Anders Svenningsson, Magnus Vrethem, Thomas Frisell, Fredrik Piehl
MULTIPLE SCLEROSIS JOURNAL
(2020)
Article
Clinical Neurology
Gustavo Luna, Peter Alping, Joachim Burman, Katharina Fink, Anna Fogdell-Hahn, Martin Gunnarsson, Jan Hillert, Annette Langer-Gould, Jan Lycke, Petra Nilsson, Jonatan Salzer, Anders Svenningsson, Magnus Vrethem, Tomas Olsson, Fredrik Piehl, Thomas Frisell
Article
Clinical Neurology
Peter Alping, Johan Askling, Joachim Burman, Katharina Fink, Anna Fogdell-Hahn, Martin Gunnarsson, Jan Hillert, Annette Langer-Gould, Jan Lycke, Petra Nilsson, Jonatan Salzer, Anders Svenningsson, Magnus Vrethem, Tomas Olsson, Fredrik Piehl, Thomas Frisell
ANNALS OF NEUROLOGY
(2020)
Article
Clinical Neurology
J. Salzer, G. Granasen, P. Sundstrom, M. Vagberg, A. Svenningsson
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Endocrinology & Metabolism
Henrik Carlsson, Sandy Abujrais, Stephanie Herman, Payam Emami Khoonsari, Torbjorn Akerfeldt, Anders Svenningsson, Joachim Burman, Kim Kultima
Article
Clinical Neurology
Joakim Bergman, Joachim Burman, Tommy Bergenheim, Anders Svenningsson
Summary: The study evaluated the effect of intrathecally delivered rituximab on PMS and found that it was well tolerated but did not halt disease progression.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Henrik Carlsson, Niclas Rollborn, Stephanie Herman, Eva Freyhult, Anders Svenningsson, Joachim Burman, Kim Kultima
Summary: This study analyzed the metabolomes of healthy individuals' CSF and identified ten metabolites significantly associated with ageing, with eight increasing with age and two decreasing with age. These findings contribute to the field of ageing metabolomics and provide motivation for further in-depth research.
Editorial Material
Clinical Neurology
Victoria M. Leavitt, Ruth Dobson, Anders Svennigsson
Article
Clinical Neurology
Tim Spelman, Melinda Magyari, Fredrik Piehl, Anders Svenningsson, Peter Vestergaard Rasmussen, Matthias Kant, Finn Sellebjerg, Hanna Joensen, Jan Hillert, Jan Lycke
Summary: This study investigated the association between national differences in treatment strategies for RRMS and disability outcomes, finding that the Swedish treatment strategy was associated with reduced rates of disability worsening compared to the Danish strategy.
Article
Clinical Neurology
Anders Svenningsson, Thomas Frisell, Joachim Burman, Jonatan Salzer, Katharina Fink, Susanna Hallberg, Joakim Hambraeus, Markus Axelsson, Faiez Al Nimer, Peter Sundstrom, Martin Gunnarsson, Rune Johansson, Johan Mellergard, Igal Rosenstein, Ahmad Ayad, Irina Sjoblom, Anette Risedal, Pierre de Flon, Eric Gilland, Jonas Lindeberg, Fadi Shawket, Fredrik Piehl, Jan Lycke
Summary: Rifund-MS study provides evidence that rituximab is superior to dimethyl fumarate in preventing relapses in patients with early relapsing-remitting multiple sclerosis. Adverse events such as infusion reactions and gastrointestinal reactions were observed, but there were no safety concerns.
Editorial Material
Clinical Neurology
Jan Lycke, Anders Svenningsson
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Elisa Longinetti, Hannah Bower, Kyla A. McKay, Simon Englund, Joachim Burman, Katharina Fink, Anna Fogdell-Hahn, Martin Gunnarsson, Jan Hillert, Annette Langer-Gould, Jan Lycke, Petra Nilsson, Jonatan Salzer, Anders Svenningsson, Johan Mellergard, Tomas Olsson, Fredrik Piehl, Thomas Frisell
Summary: This study investigated the risks and associations with disease-modifying therapies in multiple sclerosis patients during the COVID-19 pandemic. The results showed that multiple sclerosis patients had increased risks for COVID-19 and other severe outcomes compared to population controls, but these risk increases were not significantly different from previous years. The risk conveyed by disease-modifying therapies was smaller than previously assumed, likely due to better control for confounding factors.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Medicine, General & Internal
Ida Petersson, Bjorn M. Hansen, Anders Svenningsson, Annika Lundstrom
Summary: Neuroradiological findings in COVID-19 patients can resemble cerebral small vessel disease (CSVD). We present a case of a severe COVID-19 patient who showed white matter abnormalities and restricted diffusion on MRI. The patient experienced significant clinical recovery but MRI showed progression of the white matter abnormalities.
Article
Clinical Neurology
H. Tedeholm, F. Piehl, J. Lycke, J. Link, L. Stawiarz, J. Burman, P. de Flon, K. Fink, M. Gunnarsson, J. Mellergard, P. Nilsson, P. Sundstrom, A. Svenningsson, H. Johansson, O. Andersen
Summary: This study examined the impact of disease-modifying therapies (DMTs) on the risk of transition to secondary progressive MS (SPMS) using nationwide population-based data in Sweden. The results showed that the introduction of DMTs significantly decreased the incidence of SPMS conversion. The age at onset played a role in determining the risk of SPMS, and this pattern was observed in both treated and untreated subgroups.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
L. Novakova, M. Axelsson, C. Malmestrom, H. Zetterberg, K. Blennow, A. Svenningsson, J. Lycke
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)