Article
Neurosciences
Reuben Rideaux, Mark Mikkelsen, Richard A. E. Edden
Summary: This study found that aligning MRS data to the creatine (Cr) signal can more accurately measure GABA concentration in grey matter and is more robust. The variability in performance is primarily caused by differences in the zero-order phase estimated by each alignment method, rather than frequency differences.
Article
Radiology, Nuclear Medicine & Medical Imaging
Huawei Liu, Adam W. Autry, Peder E. Z. Larson, Duan Xu, Yan Li
Summary: This study developed a time-efficient method for acquiring simultaneous, dual-slice MR spectroscopic imaging (MRSI) and demonstrated its feasibility. The method provides good signal-to-noise ratios and allows for multi-element analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaorui Su, Xibiao Yang, Huaiqiang Sun, Yanhui Liu, Ni Chen, Shuang Li, Zongyao Huang, Hanbing Shao, Simin Zhang, Qiyong Gong, Qiang Yue
Summary: This study aimed to evaluate the value of MRI biomarkers for the identification of IDH mutation and 1p/19q codeletion in adult patients with diffuse glioma. ADC and CBV models were built to determine the status of IDH mutation and 1p/19q codeletion, and the performance of these models was improved by incorporating metabolite concentrations. The results showed that the ADC model performed well in identifying IDH mutation status, while the CBV model outperformed in predicting 1p/19q codeletion.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Sana Vaziri, Huawei Liu, Emily Xie, Helene Ratiney, Michael Sdika, Janine M. Lupo, Duan Xu, Yan Li
Summary: This study evaluates the accuracy of machine learning models for automated quality control in 3D MR spectroscopic imaging, providing potential for clinical translation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
D. Kuetting, J. Luetkens, A. Faron, A. Isaak, U. Attenberger, C. C. Pieper, L. Meffert, C. Jansen, A. Sprinkart, F. Kuetting
Summary: This study aimed to investigate the diagnostic yield of rapid T1-mapping for differentiating malignant and non-malignant effusions in an ex-vivo set up, showing that MOLLI T1 relaxation times were able to distinguish between different types of fluids effectively.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Romergryko G. Geocadin, Sachin Agarwal, Adeline L. Goss, Clifton W. Callaway, Megan Richie
Summary: The association between brain injury after cardiac arrest and poor survival outcomes has created pessimism, but the case of Mr. Damar Hamlin's favorable neurologic recovery brings some optimism. His case emphasizes the need to implement neuroprotection strategies, redefine brain recovery, and incorporate neurorehabilitation for holistic recovery in all cardiac arrest patients.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Aimie L. Peek, Andrew M. Leaver, Sheryl Foster, Georg Oeltzschner, Nicolaas A. Puts, Graham Galloway, Michele Sterling, Karl Ng, Kathryn Refshauge, Maria-Eliza R. Aguila, Trudy Rebbeck
Summary: Treatment outcomes for migraine and chronic pain conditions show modest results with higher GABA+ levels identified in recent studies, particularly in the posterior cingulate gyrus (PCG). This study suggests that elevated GABA+ in the PCG may reflect an underlying mechanism of chronic headache and pain conditions, informing the development of treatments targeting aberrant brain neurochemistry to improve patient outcomes.
Article
Neurosciences
Claire Shyu, Sonja Elsaid, Peter Truong, Sofia Chavez, Bernard Le Foll
Summary: This study investigates the reproducibility of metabolite measurements in the insula using MRS on a 3T scanner, comparing different scanning sequences. The results show that MEGA-PRESS can reliably measure standard metabolites and GABA in the insula, with voxel placement inconsistencies not affecting reproducibility and no sex differences found.
Article
Pediatrics
Joanna Thomson, Matt Hall, Katherine Nelson, Juan Carlos Flores, Brigid Garrity, Danielle D. DeCourcey, Rishi Agrawal, Denise M. Goodman, James A. Feinstein, Ryan J. Coller, Eyal Cohen, Dennis Z. Kuo, James W. Antoon, Amy J. Houtrow, Lucia Bastianelli, Jay G. Berry
Summary: The study revealed that children with NI enrolled in Medicaid have a high prevalence of multimorbidity, which develops early in life and mainly affects the respiratory and digestive organ systems.
Article
Chemistry, Multidisciplinary
Guanghu Tong, Ryan A. Shenvi
Summary: The plant metabolite picrotoxinin (PXN) is commonly used in neuroscience to study GABAergic signaling. The hydrolysis of PXN in weakly alkaline media actually occurs at a closed lactone, contributing to a longstanding misunderstanding in the literature.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Silvia Schiro, Gianluca Milanese, Michele Maddalo, Francesco Ziglioli, Umberto Vittorio Maestroni, Carmenlinda Manna, Roberta Eufrasia Ledda, Giulio Negrini, Francesco Mastrapasqua, Rocco Cobelli, Giacomo Tamburino, Maria Elena Conti, Silvia Luceri, Ludovica Leo, Caterina Ghetti, Nicola Sverzellati
Summary: The study aimed to test the reproducibility and predictive value of a simplified score for assessing extraprostatic tumor extension (sEPE grade). By evaluating 65 patients who underwent multiparametric magnetic resonance imaging (mpMRI) and assessing by seven radiologists, it was found that the sEPE grade combined with the diameter of the index lesion accurately predicts extraprostatic tumor extension.
EUROPEAN RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Eric Ouvrard, Paul Voulleminot, Bertrand Mennecier, Caroline Bund, Izzie Jacques Namer
Summary: A 70-year-old man with a history of small cell lung carcinoma presented with suspected paraneoplastic limbic encephalitis. Brain (18)FDG PET/CT confirmed limbic encephalitis with bilateral amygdalian and hippocampal hypermetabolism, while whole-body (18)FDG PET/CT revealed metastatic recurrence of small cell lung carcinoma. Follow-up (18)FDG PET/CT after chemotherapy showed normalization of brain metabolism and partial metabolic response of the metastatic recurrence, consistent with good clinical neurological evolution. This case highlights the clinical-metabolic imaging correlation in paraneoplastic limbic encephalitis.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Walaa Hamada Abd-Allah, Mostafa Abd El-Mohsen Anwar, Eman R. Mohammed, Marawan A. Elbaset, Samir M. El Moghazy
Summary: A new series of derivatives were synthesized and tested for their anticonvulsant activity, neurotoxicity, liver enzymes, and neurochemical assay. The screening showed varying anticonvulsant potential, particularly in chemically induced seizures. Compound 6d and 6e exhibited the highest potency in ScPTZ test. Compound 6e was even more potent than the reference drugs phenobarbital and Ethosuximide. The results suggest that the newly synthesized compounds have potential for further development as anticonvulsants.
BIOORGANIC CHEMISTRY
(2023)
Article
Clinical Neurology
Monica E. Lemmon, Mary C. Barks, Sarah Bernstein, J. Kelly Davis, Megan G. Jiao, Erica C. Kaye, Hannah C. Glass, Debra Brandon, Peter A. Ubel
Summary: This study characterizes the content and role of prognostic discussion for infants with neurological conditions. It found that such discussions focus on anticipated impairments, inform decision-making, and help families prepare for home life.
ANNALS OF NEUROLOGY
(2022)
Article
Chemistry, Physical
Christian Bruns, Rainer Ringleb, Isabell Prediger, Frederike Euchner, Johannes Bernarding, Markus Plaumann
Summary: The interest in fluorinated substances has grown due to their diverse properties. NMR spectroscopy, an important analytical method, provides information on the structure and environment changes. Temperature plays a crucial role in most studies, however, measuring it is challenging in certain cases. Despite the difficulties, the potential applications in chemical reactors and medical fields are significant. Polyfluorinated molecules with separate 19F MR signals prove to be ideal for temperature determination without the need for a reference substance. The sensitivity of temperature is influenced by fluorine position and chemical environment.
Article
Oncology
Andrew J. Degnan, Shannon Tocchio, Waleed Kurtom, Sameh S. Tadros
PEDIATRIC BLOOD & CANCER
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew B. Rosenkrantz, Andrew J. Degnan, Richard Duszak
ABDOMINAL RADIOLOGY
(2018)
Review
Radiology, Nuclear Medicine & Medical Imaging
Xinrui Wang, Chengcheng Zhu, Yue Leng, Andrew J. Degnan, Jianping Lu
ACADEMIC RADIOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alison L. Chetlen, Andrew J. Degnan, Mark Guelfguat, Brent Griffith, Jason Itri, Hazem Matta, Angela Tong, Jonathan Flug, Dennis Toy, Nikita Consul, Eric Walker, Lucy Spalluto, Andrew D. Smith, Elizabeth A. Krupinski
ACADEMIC RADIOLOGY
(2018)
Article
Clinical Neurology
C. Zhu, X. Tian, A. J. Degnan, Z. Shi, X. Zhang, L. Chen, Z. Teng, D. Saloner, J. Lu, Q. Liu
AMERICAN JOURNAL OF NEURORADIOLOGY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew J. Degnan, Chul Y. Chung, Amisha J. Shah
Letter
Pediatrics
Andrew J. Degnan, Mark D. Alson, Richard Duszak
PEDIATRIC RADIOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew J. Degnan, Emily H. Ghobadi, Peter Hardy, Elizabeth Krupinski, Elena P. Scali, Lindsay Stratchko, Adam Ulano, Eric Walker, Ashish P. Wasnik, William F. Auffermann
ACADEMIC RADIOLOGY
(2019)
Letter
Clinical Neurology
C. Zhu, X. Tian, A. J. Degnan, J. Lu, Q. Liu
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Editorial Material
Pediatrics
Andrew J. Degnan, William W. Fox, Huayan Zhang, David Saul
PEDIATRICS AND NEONATOLOGY
(2019)
Article
Clinical Neurology
C. Zhu, X. Wang, L. Eisenmenger, B. Tian, Q. Liu, A. J. Degnan, C. Hess, D. Saloner, J. Lu
AMERICAN JOURNAL OF NEURORADIOLOGY
(2019)
Article
Pediatrics
Andrew J. Degnan, Victor M. Ho-Fung, Jie C. Nguyen, Christian A. Barrera, I. Todd R. Lawrence, Summer L. Kaplan
PEDIATRIC RADIOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew J. Degnan, Paul H. Yi, Nathan Kim, John Swietlik, Eric Huh, Jie C. Nguyen
CURRENT PROBLEMS IN DIAGNOSTIC RADIOLOGY
(2020)
Article
Clinical Neurology
Y. Jiang, W. Peng, B. Tian, C. Zhu, L. Chen, X. Wang, Q. Liu, Y. Wang, Z. Xiang, A. J. Degnan, Z. Teng, D. Saloner, J. Lu
AMERICAN JOURNAL OF NEURORADIOLOGY
(2017)
Review
Radiology, Nuclear Medicine & Medical Imaging
Andrew J. Degnan, Sameh S. Tadros, Shannon Tocchio
AMERICAN JOURNAL OF ROENTGENOLOGY
(2017)
