Article
Clinical Neurology
Kang Min Park, Keun Tae Kim, Dong Ah Lee, Yong Won Cho
Summary: This study used graph theory and diffusion tensor imaging (DTI) to evaluate the changes in brain structural connectivity in patients with restless legs syndrome (RLS). The results showed that RLS patients had decreased segregation in the brain network compared to healthy controls, and the severity of clinical symptoms was correlated with structural connectivity measures.
Article
Clinical Neurology
J. Kikuta, K. Kamagata, M. Abe, C. Andica, Y. Saito, K. Takabayashi, W. Uchida, H. Naito, H. Tabata, A. Wada, Y. Tamura, R. Kawamori, H. Watada, S. Aoki
Summary: This study used advanced MR imaging techniques to investigate the effect of arterial stiffness on the white matter microstructure of older adults. The results showed that arterial stiffness may be associated with demyelination rather than axonal degeneration. This finding is important for understanding the relationship between arterial stiffness and brain structure.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Medicine, Research & Experimental
Eva Matt, Lisa Kaindl, Saskia Tenk, Anicca Egger, Teodora Kolarova, Nejla Karahasanovic, Ahmad Amini, Andreas Arslan, Kardelen Saricicek, Alexandra Weber, Roland Beisteiner
Summary: Ultrasound-based brain stimulation techniques show potential in treating neurological and psychiatric disorders, with evidence suggesting an increase in global efficiency within the stimulated brain network, improved axonal status in the stimulated area, and enhanced functional and structural coupling in specific brain regions up to one week post-stimulation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Fengzhao Zhu, Yulong Wang, Xiangchuang Kong, Yuan Liu, Lian Zeng, Xirui Jing, Sheng Yao, Kaifang Chen, Lian Yang, Xiaodong Guo
Summary: The combination of conventional MRI with DTI-DTT is a valid diagnostic approach for acute traumatic cervical SCI. Lower intramedullary lesion length and intramedullary hemorrhage length, and higher fractional anisotropy value and connection rates of fiber tractography are linked to better neurological outcomes.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Olof Lindberg, Felicia Ahlner, Theofanis Tsevis, Joana B. Pereira, Eric Westman, Ingmar Skoog, Lars-Olof Wahlund
Summary: This study investigated the impact of different levels of weekly alcohol consumption on the brain structure of 70-year-old individuals. The results showed that alcohol consumption exceeding 250 g/week was associated with cortical thinning and decreased white matter integrity, but had no effect on subcortical gray matter structures.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Critical Care Medicine
Jonas Stenberg, Live Eikenes, Kent Goran Moen, Anne Vik, Asta K. Haberg, Toril Skandsen
Summary: This prospective cohort study investigated the associations between acute diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics and persistent post-concussion symptoms (PPCS) 3 months after mild traumatic brain injury (mTBI). Patients who developed PPCS had poorer white matter microstructural integrity acutely after the injury, compared with patients who recovered and healthy controls. Differences became less pronounced when cognitive reserve was controlled for, suggesting that pre-existing individual differences in axonal integrity accounted for some of the observed differences.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Yuwen Hung, Marlee Vandewouw, Zahra Emami, Sonya Bells, Nicole Rudberg, Leodante da Costa, Benjamin T. Dunkley
Summary: Using multi-modality imaging methods, this study found disruptions in brain-behavior interactions related to working memory in patients with mild traumatic brain injury (mTBI), particularly in the hippocampal-prefrontal and amygdala circuits. These disruptions may leave mTBI patients vulnerable to increased environmental demands exerting memory resources, leading to cognitive and emotional psychopathologies.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Xiang Liu, Zhipeng Wei, Liting Chen, Wenfeng Duan, Haijun Li, Linghong Kong, Yongqiang Shu, Panmei Li, Kunyao Li, Wei Xie, Yaping Zeng, Ling Huang, Ting Long, Dechang Peng
Summary: The study reveals that patients with untreated obstructive sleep apnea (OSA) exhibit abnormal changes in white matter (WM) fibers, which are associated with cognitive impairment. However, short-term continuous positive airway pressure (CPAP) therapy does not result in reversible changes in WM microstructure.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Hamidreza Jamalabadi, Tim Hahn, Nils R. Winter, Erfan Nozari, Jan Ernsting, Susanne Meinert, Elisabeth J. Leehr, Katharina Dohm, Jochen Bauer, Julia-Katharina Pfarr, Frederike Stein, Florian Thomas-Odenthal, Katharina Brosch, Marco Mauritz, Marius Gruber, Jonathan Repple, Tobias Kaufmann, Axel Krug, Igor Nenadic, Tilo Kircher, Udo Dannlowski, Birgit Derntl
Summary: This study investigates the impact of parenthood on brain controllability and finds that parenthood can counteract the effects of aging on brain controllability, especially in mothers.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Dongrong Xu, Guojun Xu, Zhiyong Zhao, M. Elizabeth Sublette, Jeffrey M. Miller, J. John Mann
Summary: Research on major depressive disorder patients showed differences in network indices based on disease duration and subgroups, with certain brain regions displaying varying clustering coefficients in short and long-term disease subgroups. Network resilience analysis indicated that the MDDS group had more randomized networks compared to healthy controls.
HUMAN BRAIN MAPPING
(2021)
Review
Clinical Neurology
Nandakumar Nagaraja
Summary: DWI is a widely used imaging technique for evaluating patients with stroke, but it has potential pitfalls to be recognized, such as false negative results and ischemic stroke mimics that may occur during interpretation. Advanced diffusion imaging techniques like Diffusion Kurtosis Imaging and Diffusion Tensor Imaging are being studied to evaluate ischemic core.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Substance Abuse
Mallory A. Kisner, Lauren Sussman, Thushini Manuweera, Erica N. Grodin, Samantha J. Fede, Joelle E. Sarlls, Reza Momenan
Summary: This study aimed to investigate sex differences in the white matter microstructure of individuals with alcohol use disorder (AUD) and healthy controls. The results showed widespread differences between AUD and control subjects, but no impact of sex on these differences. Furthermore, age was found to have significant impacts on white matter microstructure, particularly in individuals with AUD.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Neurosciences
Sharmila Sagnier, Igor Sibon
Summary: The developments in human brain stroke imaging over the last two decades have brought about new MRI biomarkers that play a crucial role in the acute management and prediction of poststroke outcome. Along with stroke location, the analysis of brain parenchyma has highlighted the importance of prestroke cerebral status. Additionally, the analysis of normal-appearing brain parenchyma provides new biomarkers and targets for therapeutic follow-up.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Hematology
Brooke Tornifoglio, Alan J. Stone, Christian Kerskens, Caitriona Lally
Summary: This study investigates the potential of ex vivo diffusion tensor imaging to understand the microstructural composition and morphological arrangement of aged human atherosclerotic carotid arteries. The results indicate that diffusion tensor imaging has the potential to identify characteristics of arterial disease progression at early and late stages.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)