Article
Clinical Neurology
Mikkel K. E. Nygaard, Martin Langeskov-Christensen, Ulrik Dalgas, Simon F. Eskildsen
Summary: The study found that cortical diffusion and thalamic volume are closely associated with walking and cognitive performance in patients with relapsing-remitting multiple sclerosis (RRMS), and are highly affected by the presence of white matter lesions.
JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiyoon Yoo, Leevi Kerkela, Patrick W. Hales, Kiran K. Seunarine, Christopher A. Clark
Summary: This study successfully implemented a multidimensional diffusion-encoding protocol to image the microstructure of the healthy hippocampus at high resolution, revealing orientation dispersion in hippocampal tissue. The reproducibility of q-space trajectory imaging metrics was comparable to DTI, providing reference values for microstructural metrics in the healthy hippocampus.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Vito A. G. Ricigliano, Matteo Tonietto, Raffaele Palladino, Emilie Poirion, Alberto De Luca, Francesca Branzoli, Geraldine Bera, Elisabeth Maillart, Bruno Stankoff, Benedetta Bodini
Summary: The study demonstrates that reduced thalamic ADC(tCr) is associated with damage to thalamo-cortical tracts in multiple sclerosis (MS) patients, indicating a correlation between pathological changes in thalamic energy metabolism and structural degeneration of connected fibers.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Neurosciences
Min-Chien Tu, Sheng-Min Huang, Yen-Hsuan Hsu, Jir-Jei Yang, Chien-Yuan Lin, Li-Wei Kuo
Summary: The study found that DKI metrics may be more sensitive than DTI metrics in reflecting microstructural changes within the gray matter, providing complementary information for the pathogenesis of SIVD and AD.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Monika Gloor, Michaela Andelova, Laura Gaetano, Athina Papadopoulou, Federico Burguet Villena, Till Sprenger, Ernst-Wilhelm Radue, Ludwig Kappos, Oliver Bieri, Meritxell Garcia
Summary: This study analyzed the potential of magnetization transfer imaging (MTI) and diffusion tensor imaging (DTI) for the detection and evolution of new multiple sclerosis (MS) lesions. The results showed that MTI provides more information than DTI and can detect tissue changes 2 to 4 months prior to their appearance on MRI.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Diana Valdes Cabrera, Penelope Smyth, Gregg Blevins, Derek Emery, Christian Beaulieu
Summary: DTI and volumetric MRI revealed white matter and deep grey matter abnormalities in the limbic system of MS patients. The fornix, thalamus, and hippocampus displayed atrophy and/or abnormal diffusion metrics, with the fornix showing the most extensive changes, mainly in those with cognitive impairment. These findings suggest a strong correlation between microstructural abnormalities in the limbic system and cognitive deficits in MS.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiali Shao, Xuewei Zhang, Wenrui Xu, Zhe Zhang, Jieying Zhang, Hua Guo, Tao Jiang, Weihong Zhang
Summary: The study found that NODDI has good reliability in evaluating epileptogenic tubers in TSC patients. ICVF showed advantages in detecting subtle epileptogenic tubers, and NODDI parameters have the potential to identify epileptogenicity.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Sooyoung Kim, Eun Kyoung Lee, Chang June Song, Eunhee Sohn
Summary: This study investigates the clinical significance of iron rim lesions (IRLs) in differentiating multiple sclerosis (MS) from other central nervous system (CNS) demyelinating diseases. The presence of IRLs seems to be specific to MS and may serve as a reliable imaging biomarker for diagnosing MS. Furthermore, the presence of IRLs in MS patients is associated with a higher number of total white matter lesions, more frequent recurrence, and more extensive use of second-line immunosuppressive agents.
Article
Neuroimaging
Carolyn Lou, Pascal Sati, Martina Absinta, Kelly Clark, Jordan D. Dworkin, Alessandra M. Valcarcel, Matthew K. Schindler, Daniel S. Reich, Elizabeth M. Sweeney, Russell T. Shinohara
Summary: The study introduces a fully automated technique named APRL for detecting paramagnetic rim lesions using standard T1 and FLAIR sequences and a T2*phase sequence obtained on 3T MR images. The classification algorithm using radiomic features showed a good ability in classifying lesions.
NEUROIMAGE-CLINICAL
(2021)
Article
Biophysics
Diana Valdes Cabrera, Gregg Blevins, Penelope Smyth, Derek Emery, Kevin Grant Solar, Christian Beaulieu
Summary: High-resolution DTI and T2 mapping revealed abnormalities in the hippocampus of patients with multiple sclerosis. In patients with cognitive impairment, higher MD and T2 values and lower FA and volume were observed. These abnormalities may be associated with demyelination, neuron loss, and/or inflammation.
NMR IN BIOMEDICINE
(2023)
Review
Clinical Neurology
Nandakumar Nagaraja
Summary: DWI is a widely used imaging technique for evaluating patients with stroke, but it has potential pitfalls to be recognized, such as false negative results and ischemic stroke mimics that may occur during interpretation. Advanced diffusion imaging techniques like Diffusion Kurtosis Imaging and Diffusion Tensor Imaging are being studied to evaluate ischemic core.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Moein Amin, Daniel Ontaneda
Summary: Multiple sclerosis (MS) results in thalamic volume loss, which affects cognitive function such as processing speed and memory. Thalamic atrophy is a significant predictor of cognitive impairment (CI) in MS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Matthias Grothe, Katharina Jochem, Sebastian Strauss, Soenke Langner, Michael Kirsch, Kai Hoffeld, Iris Katharina Penner, Guy Nagels, Kai Klepzig, Martin Domin, Martin Lotze
Summary: The study found that the structural integrity of frontoparietal white matter tracts is associated with processing speed in MS patients, with frontoparietal tracts playing a crucial role in information processing speed. Additionally, disease disability and total white matter volume were the main factors associated with processing speed.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Olivia Foesleitner, Volker Sturm, Jennifer Hayes, Markus Weiler, Georges Sam, Brigitte Wildemann, Wolfgang Wick, Martin Bendszus, Sabine Heiland, Laura Bettina Jaeger
Summary: The study provides evidence of peripheral nerve involvement in multiple sclerosis at initial diagnosis, with a characteristic pattern indicating predominant demyelination and suggesting primary coaffection of the peripheral nervous system in MS. The use of DKI for peripheral nerves in this human study shows potential and clinical feasibility in providing novel biomarkers.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
BingYang Bian, BoXu Zhou, ZhiQing Shao, XiaoNa Zhu, YiGe Jie, Dan Li
Summary: This study aimed to use diffusion kurtosis imaging (DKI) to assess gray matter, white matter, lesions, and therapeutic effect in multiple sclerosis (MS). The DKI metrics showed significant differences between MS and healthy individuals, as well as between patients with and without T2 hyperintensity in the cervical spinal cord. The study results indicate that DKI metrics can detect and quantitatively evaluate the changes in micropathological structure of the cervical spinal cord.
Article
Neuroimaging
Josue Luiz Dalboni da Rocha, Gabriel Coutinho, Ivanei Bramati, Fernanda Tovar Moll, Ranganatha Sitaram
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Infectious Diseases
Carolina da S. G. Pedrosa, Leticia R. Q. Souza, Tiago A. Gomes, Caroline V. F. de Lima, Pitia F. Ledur, Karina Karmirian, Jimena Barbeito-Andres, Marcelo do N. Costa, Luiza M. Higa, Atila D. Rossi, Maria Bellio, Amilcar Tanuri, Arnaldo Prata-Barbosa, Fernanda Tovar-Moll, Patricia P. Garcez, Flavio A. Lara, Renato J. R. Molica, Stevens K. Rehen
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Psychiatry
Premika S. W. Boedhoe, Daan van Rooij, Martine Hoogman, Jos W. R. Twisk, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Anatoly Anikin, Alan Anticevic, Celso Arango, Paul D. Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Tobias Banaschewski, Alexander Baranov, Marcelo C. Batistuzzo, Sarah Baumeister, Ramona Baur-Streubel, Marlene Behrmann, Mark A. Bellgrove, Francesco Benedetti, Jan C. Beucke, Joseph Biederman, Irene Bollettini, Anushree Bose, Janita Bralten, Ivanei E. Bramati, Daniel Brandeis, Silvia Brem, Brian P. Brennan, Geraldo F. Busatto, Sara Calderoni, Anna Calvo, Rosa Calvo, Francisco X. Castellanos, Mara Cercignani, Tiffany M. Chaim-Avancini, Kaylita C. Chantiluke, Yuqi Cheng, Kang Ik K. Cho, Anastasia Christakou, David Coghill, Annette Conzelmann, Ana Cubillo, Anders M. Dale, Sara Dallaspezia, Eileen Daly, Damiaan Denys, Christine Deruelle, Adriana Di Martino, Ilan Dinstein, Alysa E. Doyle, Sarah Durston, Eric A. Earl, Christine Ecker, Stefan Ehrlich, Benjamin A. Ely, Jeffrey N. Epstein, Thomas Ethofer, Damien A. Fair, Andreas J. Fallgatter, Stephen Faraone, Jennifer Fedor, Xin Feng, Jamie D. Feusner, Jackie Fitzgerald, Kate D. Fitzgerald, Jean-Paul Fouche, Christine M. Freitag, Egill A. Fridgeirsson, Thomas Frodl, Matt C. Gabel, Louise Gallagher, Tinatin Gogberashvili, Ilaria Gori, Patricia Gruner, Deniz A. Gursel, Shlomi Haar, Jan Haavik, Geoffrey B. Hall, Neil A. Harrison, Catharina A. Hartman, Dirk J. Heslenfeld, Yoshiyuki Hirano, Pieter J. Hoekstra, Marcelo Q. Hoexter, Sarah Hohmann, Marie F. Hovik, Hao Hu, Chaim Huyser, Neda Jahanshad, Maria Jalbrzikowski, Anthony James, Joost Janssen, Fern Jaspers-Fayer, Terry L. Jernigan, Dmitry Kapilushniy, Bernd Kardatzki, Georgii Karkashadze, Norbert Kathmann, Christian Kaufmann, Clare Kelly, Sabin Khadka, Joseph A. King, Kathrin Koch, Gregor Kohls, Kerstin Konrad, Masaru Kuno, Jonna Kuntsi, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Sara Lera-Miguel, Klaus-Peter Lesch, Liesbeth Hoekstra, Yanni Liu, Christine Lochner, Mario R. Louza, Beatriz Luna, Astri J. Lundervold, Charles B. Malpas, Paulo Marques, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Paulo Mattos, Hazel McCarthy, Jane McGrath, Mitul A. Mehta, Jose M. Menchon, Maarten Mennes, Mauricio Moller Martinho, Pedro S. Moreira, Astrid Morer, Pedro Morgado, Filippo Muratori, Clodagh M. Murphy, Declan G. M. Murphy, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Leyla Namazova-Baranova, Janardhanan C. Narayanaswamy, Rosa Nicolau, Joel T. Nigg, Stephanie E. Novotny, Erika L. Nurmi, Eileen Oberwelland Weiss, Ruth L. O'Gorman Tuura, Kirsten O'Hearn, Joseph O'Neill, Jaap Oosterlaan, Bob Oranje, Yannis Paloyelis, Mara Parellada, Paul Pauli, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Kerstin J. Plessen, Olga Puig, J. Antoni Ramos-Quiroga, Y. C. Janardhan Reddy, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G. P. Rosa, Katya Rubia, Oana Georgiana Rus, Yuki Sakai, Anouk Schrantee, Lena Schwarz, Lizanne J. S. Schweren, Jochen Seitz, Philip Shaw, Devon Shook, Tim J. Silk, H. Blair Simpson, Norbert Skokauskas, Juan Carlos Soliva Vila, Anastasia Solovieva, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Gustavo Sudre, Philip R. Szeszko, Leanne Tamm, Margot J. Taylor, David F. Tolin, Michela Tosetti, Fernanda Tovar-Moll, Aki Tsuchiyagaito, Theo G. M. van Erp, Guido A. van Wingen, Alasdair Vance, Ganesan Venkatasubramanian, Oscar Vilarroya, Yolanda Vives-Gilabert, Georg G. von Polier, Susanne Walitza, Gregory L. Wallace, Zhen Wang, Thomas Wolfers, Yuliya N. Yoncheva, Je-Yeon Yun, Marcus Zanetti, Fengfeng Zhou, Georg C. Ziegler, Kathrin C. Zierhut, Marcel P. Zwiers, Paul M. Thompson, Dan J. Stein, Jan Buitelaar, Barbara Franke, Odile A. van den Heuvel
AMERICAN JOURNAL OF PSYCHIATRY
(2020)
Editorial Material
Obstetrics & Gynecology
Adriana Melo, Patricia S. Oliveira-Szejnfeld, Gustavo Malinger, Jousilene S. Tavares, Fabiana O. Melo, Larissa Cristina Q. M. Coutinho, Gabriela L. Gama, Fernanda T. Moll, Renato S. Aguiar, Amilcar Tanuri, Melania M. Amorim
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2020)
Article
Neurosciences
Diego Szczupak, Cirong Liu, Cecil C. C. Yen, Sang-Ho Choi, Fernanda Meireles, Caroline Victorino, Linda Richards, Roberto Lent, Afonso C. Silva, Fernanda Tovar-Moll
Editorial Material
Neurosciences
Fernanda G. De Felice, Fernanda Tovar-Moll, Jorge Moll, Douglas P. Munoz, Sergio T. Ferreira
TRENDS IN NEUROSCIENCES
(2020)
Article
Pediatrics
Heloisa Viscaino Fernandes Souza Pereira, Stella Pinto dos Santos, Ana Paula Rodrigues Lazzari Amancio, Patricia Soares de Oliveira-Szejnfeld, Edneusa Oliveira Flor, Jousilene de Sales Tavares, Rayssa Vieira Brandao Ferreira, Fernanda Tovar-Moll, Melania Maria Ramos de Amorim, Adriana Melo
LANCET CHILD & ADOLESCENT HEALTH
(2020)
Article
Neurosciences
Diego Szczupak, Cecil C. Yen, Cirong Liu, Xiaoguang Tian, Roberto Lent, Fernanda Tovar-Moll, Afonso C. Silva
FRONTIERS IN NEURAL CIRCUITS
(2020)
Article
Psychiatry
Yanli Zhang-James, Emily C. Helminen, Jinru Liu, Barbara Franke, Martine Hoogman, Stephen Faraone
Summary: Using deep learning neural network classification models, this study found neuroanatomical differences in children and adult ADHD patients, with better prediction performance and effect sizes in the child sample. The results support the continuity of ADHD's brain differences from childhood to adulthood.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Developmental
Ting Li, Daan van Rooij, Nina Roth Mota, Jan K. Buitelaar, Martine Hoogman, Alejandro Arias Vasquez, Barbara Franke
Summary: This study aimed to investigate the heterogeneity of ADHD using subcortical brain volumes as a basis for discerning patient subgroups. Results showed that there is neuroanatomic heterogeneity in subcortical volumes regardless of ADHD diagnosis, with more pronounced case-control differences seen in some subgroups. Male participants could be separated into four communities, with significant case-control differences observed in boys but not in men. Comorbidities were more frequent in affected men in certain communities.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Article
Psychology, Developmental
Merel C. Postema, Martine Hoogman, Sara Ambrosino, Philip Asherson, Tobias Banaschewski, Cibele E. Bandeira, Alexandr Baranov, Claiton H. D. Bau, Sarah Baumeister, Ramona Baur-Streubel, Mark A. Bellgrove, Joseph Biederman, Janita Bralten, Daniel Brandeis, Silvia Brem, Jan K. Buitelaar, Geraldo F. Busatto, Francisco X. Castellanos, Mara Cercignani, Tiffany M. Chaim-Avancini, Kaylita C. Chantiluke, Anastasia Christakou, David Coghill, Annette Conzelmann, Ana I. Cubillo, Renata B. Cupertino, Patrick de Zeeuw, Alysa E. Doyle, Sarah Durston, Eric A. Earl, Jeffery N. Epstein, Thomas Ethofer, Damien A. Fair, Andreas J. Fallgatter, Stephen V. Faraone, Thomas Frodl, Matt C. Gabel, Tinatin Gogberashvili, Eugenio H. Grevet, Jan Haavik, Neil A. Harrison, Catharina A. Hartman, Dirk J. Heslenfeld, Pieter J. Hoekstra, Sarah Hohmann, Marie F. Hovik, Terry L. Jernigan, Bernd Kardatzki, Georgii Karkashadze, Clare Kelly, Gregor Kohls, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Sara Lera-Miguel, Klaus-Peter Lesch, Mario R. Louza, Astri J. Lundervold, Charles B. Malpas, Paulo Mattos, Hazel McCarthy, Leyla Namazova-Baranova, Rosa Nicolau, Joel T. Nigg, Stephanie E. Novotny, Eileen Oberwelland Weiss, Ruth L. O'Gorman Tuura, Jaap Oosterlaan, Bob Oranje, Yannis Paloyelis, Paul Pauli, Felipe A. Picon, Kerstin J. Plessen, J. Antoni Ramos-Quiroga, Andreas Reif, Liesbeth Reneman, Pedro G. P. Rosa, Katya Rubia, Anouk Schrantee, Lizanne J. S. Schweren, Jochen Seitz, Philip Shaw, Tim J. Silk, Norbert Skokauskas, Juan C. Soliva Vila, Michael C. Stevens, Gustavo Sudre, Leanne Tamm, Fernanda Tovar-Moll, Theo G. M. van Erp, Alasdair Vance, Oscar Vilarroya, Yolanda Vives-Gilabert, Georg G. von Polier, Susanne Walitza, Yuliya N. Yoncheva, Marcus V. Zanetti, Georg C. Ziegler, David C. Glahn, Neda Jahanshad, Sarah E. Medland, Paul M. Thompson, Simon E. Fisher, Barbara Franke, Clyde Francks
Summary: Recent large-scale analysis found no evidence of altered caudate nucleus asymmetry in ADHD, but children with ADHD showed less rightward asymmetry of total hemispheric surface area. Adults with ADHD also exhibited altered globus pallidus asymmetry. However, the effects were small and not significant after correcting for multiple testing, suggesting that altered structural brain asymmetry may not serve as a useful biomarker for ADHD.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Livia Goto-Silva, Michele Martins, Jimmy Rodriguez Murillo, Leticia R. Q. Souza, Gabriela Vitoria, Julia T. Oliveira, Juliana M. Nascimento, Erick Correia Loiola, Fabio C. S. Nogueira, Gilberto B. Domont, Marilia Zaluar P. Guimaraes, Fernanda Tovar-Moll, Stevens Kastrup Rehen, Magno Junqueira
Summary: This study identified quantitative changes in the proteome of neurospheres during differentiation, showing that human neurospheres have a molecular profile resembling the fetal brain. Upregulated pathways during differentiation include neuronal development, differentiation, cell adhesion, and axonal guidance, while cell proliferation pathways are downregulated.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2021)
Article
Neurosciences
Mychael Lourenco, Felipe C. Ribeiro, Luis E. Santos, Danielle Beckman, Helen M. Melo, Felipe K. Sudo, Claudia Drummond, Naima Assuncao, Bart Vanderborght, Fernanda Tovar-Moll, Fernanda G. De Felice, Paulo Mattos, Sergio T. Ferreira
Summary: The study aimed to determine concentrations of multiple cytokines, chemokines, and neurotransmitters in the cerebrospinal fluid (CSF) of AD and LBD patients. Results showed alterations in levels of noradrenaline, homovanillic acid, and vascular endothelial growth factor in the CSF of these patients, suggesting possible pathogenic features and diagnostic tools for these disorders. Further studies are needed to replicate these findings in larger, multicenter cohorts.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Letter
Ophthalmology
Daniel Araujo Ferraz, Fernanda Tovar-Moll, Rubens Belfort
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
(2021)
Article
Clinical Neurology
Mychael Lourenco, Felipe C. Ribeiro, Felipe K. Sudo, Claudia Drummond, Naima Assuncao, Bart Vanderborght, Fernanda Tovar-Moll, Paulo Mattos, Fernanda G. De Felice, Sergio T. Ferreira
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2020)