Article
Pharmacology & Pharmacy
Haocheng Zhou, Dingquan Zou, Bo Hong, Rong Hu, Tongbiao Yang, Xinning Li, Xin Li, Junjiao Hu, Ruixuan Wang, Yaping Wang
Summary: The aim of this study was to examine the distribution pattern of intrathecal drug delivery strategy for orofacial pain management. The distribution of contrast media through prepontine cisternal access was demonstrated in a patient with severe orofacial pain caused by sublingual gland tumor. The bilateral perfusion pattern observed in the MRI scans may provide insights into the analgesic mechanism of this novel intrathecal therapy.
Article
Clinical Neurology
I. E. Duman, T. Demerath, A. Stadler, S. Elsheikh, E. Raithel, C. Forman, T. Hildenbrand, M. Shah, J. Grauvogel, C. Scheiwe, H. Urbach, S. Meckel
Summary: Accurate identification of CSF leakage in patients with CSF rhinorrhea is crucial for surgical planning. The novel gadolinium-enhanced high-resolution 3D compressed-sensing T1 SPACE technique appears to be superior to CT cisternography for precise detection of CSF leaks.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. J. Lee, D. Kim, C. H. Suh, W. H. Shim, H. Heo, S. Jo, S. J. Chung, H. S. Kim, S. J. Kim
Summary: The study aimed to evaluate the detection rate of MR myelography without intrathecal gadolinium for CSF leakage in patients with newly diagnosed SIH and validate a published scoring system. The non-invasive MR myelography should be considered for detecting CSF leakage in patients with suspected SIH.
CLINICAL RADIOLOGY
(2022)
Article
Clinical Neurology
Ajay A. Madhavan, Carrie M. Carr, John C. Benson, Waleed Brinjikji, Felix E. Diehn, Dong Kun Kim, Vance T. Lehman, Greta B. Liebo, Pearse P. Morris, Darya P. Shlapak, Jared T. Verdoorn, Jonathan M. Morris
Summary: Intrathecal gadolinium magnetic resonance (MR) myelography can localize CSF-venous fistulas and distal nerve root sleeve tears, but has limited diagnostic yield, as shown in this study. It may be beneficial to consider other modalities before attempting intrathecal gadolinium MR myelography.
CLINICAL NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Oktay Algin, Ural Koc, Giyas Ayberk
Summary: This study investigated the value of 3D-T1W sequences in the diagnosis of cerebrospinal fluid (CSF) leakage and the severity of artifacts. The results showed that fat-saturated 3D-T1W-SPACE and 3D-T1W-VIBE sequences were most consistent with consensus diagnoses, while 3D-MPRAGE had the highest artifact scores. Therefore, 3D-SPACE and 3D-VIBE are more effective in evaluating CSF leakages compared to 3D-MPRAGE.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Alexander Emil Kaspersen, Pelle Hanberg, Magnus A. Hvistendahl, Mats Bue, Anne Vibeke Schmedes, Kristian Hoy, Maiken Stilling
Summary: Optimal antibiotic prophylaxis is crucial to prevent postoperative infection in spinal surgery. We assessed cefuroxime concentrations and fT > MIC of 4 mu g center dot ml(-1) for relevant bacteria in the intrathecal and extrathecal compartments of the lumbar spine. The results showed that fT > MIC for cefuroxime was lower in the intrathecal compartments than in the extrathecal compartment, suggesting a significant effect of the blood-brain barrier.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Physics, Multidisciplinary
Gary J. Cowin, Karine Mardon, Zachary H. Houston, Rajiv Bhalla, Damion H. R. Stimson, Kristofer J. Thurecht, Ian M. Brereton
Summary: The study utilized dynamic gadolinium-enhanced magnetic resonance - positron emission tomography to independently evaluate vascular delivery and blood brain barrier integrity in brain tumors. It also observed the dynamic changes of therapeutic agents. This method can provide important information on the alterations of therapeutic agent delivery and uptake.
FRONTIERS IN PHYSICS
(2022)
Article
Clinical Neurology
A. Sperre, I. Karsrud, A. H. S. Rodum, A. Lashkarivand, L. M. Valnes, G. Ringstad, P. K. Eide
Summary: This study found that intrathecal gadobutrol in doses up to 0.50 is safe, based on observations of 196 patients who received intrathecal contrast-enhanced imaging of the cerebrospinal fluid.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Medicine, General & Internal
Fotini Boufidou, Aigli G. Vakrakou, Maria Anagnostouli, Kostas Patas, Georgios Paraskevas, Stylianos Chatzipanagiotou, Leonidas Stefanis, Maria-Eleftheria Evangelopoulos
Summary: The performance of a new quantitative marker for intrathecal IgG synthesis was evaluated and compared with established markers used for the same purpose. A retrospective analysis was conducted on a cohort of 372 patients with central nervous system demyelination, who underwent lumbar puncture and oligoclonal bands (OCBs) detection. Auer's formula had lower sensitivity compared to Reiber's formula and IgG index, possibly due to the mathematical model used. The use of Reiber's hyperbolic formula and similar formulas are recommended for discriminating between CNS-derived and blood-derived molecules in clinical laboratories.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ensar Yekeler, Ganesh Krishnamurthy, Christopher L. Smith, Fernando A. Escobar, Erin Pinto, Jordan B. Rapp, Hansel J. Otero, Ammie M. White, Yoav Dori, David M. Biko
Summary: The study demonstrated the feasibility of using ferumoxytol for MR lymphangiography in children with renal disease, showing that ferumoxytol-enhanced DCMRL provides high-quality diagnostic images of the central lymphatic system with a safe profile based on the preliminary report of four cases.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Lin Sun, Luwen Mu, Jing Zhou, Wenjie Tang, Linqi Zhang, Sidong Xie, Jingbiao Chen, Jin Wang
Summary: The study aimed to predict CD8 cell density and PD-L1 expression in HCC using preoperative gadoxetic acid-enhanced MRI findings, and identified MRI features associated with PD-L1 positivity and high CD8 cell density in HCC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Engineering, Environmental
Jun Kobayashi, Keisuke Kuroda, Chinatsu Miyamoto, Yukiko Uchiyama, Kenshi Sankoda, Daisuke Nakajima
Summary: This study evaluated sewer exfiltration in groundwater in the Kumamoto area after the earthquakes by using multiple tracers, finding that the effect of the earthquakes on sewer exfiltration was small due to quick repairs of damaged sewers. The study demonstrated that a multiple-tracer approach is useful for evaluating sewer exfiltration after major earthquakes.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Veterinary Sciences
Mirja L. Pueschel, Fritjof Freise, Regina Carlson, Andrea Tipold, Jasmin Nessler
Summary: A quotient graph (Reibergram) based on CSF/serum quotient of albumin and IgA was developed to visualize intrathecal IgA synthesis and blood-CSF barrier dysfunction. The graph was validated and found to be effective in detecting blood-CSF barrier dysfunction and intrathecal IgA synthesis in most cases. It provides a feasible tool for routine CSF diagnostic testing.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yongkang Gai, Yuying Li, Shuangping Wu, Ling Xu, Yao Lu, Xiaoli Lan, Guangya Xiang, Xiang Ma
Summary: The aim of this study was to synthesize and characterize a new micelle-based TPGS gadolinium chelate as a biocompatible MRI contrast agent for prolonged blood circulation time and good tumor imaging contrast. The successfully prepared TPGS-L-NETA-Gd micelle exhibited improved cellular uptake in HepG2 cells and xenografts and high in vivo safety. The in vitro and in vivo properties of TPGS-L-NETA-Gd make it a favorable macromolecular MRI contrast agent for future in vivo imaging.
Article
Chemistry, Multidisciplinary
Mengxing Wei, Lulu Wang, Yanfang Wang, Tong Zhang, Chenchen Wang, Chengfan Wu, Changlin Tian, Gaolin Liang, Yue Yuan
Summary: Magnetic resonance imaging (MRI) is an excellent imaging technique with unlimited tissue penetration depth and superb spatiotemporal resolution. However, the use of intracellular self-assembled Gd-containing nanoparticles to enhance T-2-weighted MR contrast in vivo for precise tumor MRI is rarely reported. This study developed a CTSB-responsive small molecular contrast agent VC-Gd-CBT, which can self-assemble into large intracellular Gd-containing nanoparticles, and it has the potential to be used as a T-2 contrast agent for early-stage cancer diagnosis.
Article
Neuroimaging
Dominik F. Vollherbst, Rene Chapot, Marta Wallocha, Isil Saatci, Saruhan Cekirge, Aymeric Rouchaud, Charbel Mounayer, Naci Kocer, Osman Kizilkilic, Nader A. Sourour, Eimad Shotar, Marios N. Psychogios, Alex Brehm, Martin Bendszus, Markus A. Moehlenbruch
Summary: The new Scepter Mini dual-lumen microballoon catheter shows promise in the balloon-assisted embolization of cerebrospinal vascular malformations. It can be used for various applications, including embolization, balloon-occlusion, diagnostic angiography, and navigation support, with a high rate of navigability and success in complete occlusion. Technical failures were minimal, and no complications related to the Scepter Mini were observed in the study.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Neuroimaging
Christoph J. Griessenauer, Alejandro Enriquez-Marulanda, Sissi Xiang, Tao Hong, Hongqi Zhang, Philipp Taussky, Ramesh Grandhi, Muhammad Waqas, Vincent M. Tutino, Adnan H. Siddiqui, Elad Levy, Christopher S. Ogilvy, Ajith J. Thomas, Christian Ulfert, Markus A. Moehlenbruch, Leonardo Renieri, Nicola Limbucci, Carmen Parra-Farinas, Jan-Karl Burkhardt, Peter Kan, Lorenzo Rinaldo, Giuseppe Lanzino, Waleed Brinjikji, Julian Spears, Erasmia Mueller-Thies-Broussalis, Monika Killer-Oberpfalzer, Civan Islak, Naci Kocer, Michael Sonnberger, Tobias Engelhorn, Mandeep Ghuman, Victor X. D. Yang, Arsalaan Salehani, Mark R. Harrigan, Ivan Radovanovic, Vitor M. Pereira, Timo Krings, Charles C. Matouk, Karen Chen, Mohammad Ali Aziz-Sultan, Mohammad Ghorbani, Clemens M. Schirmer, Oded Goren, Shamsher S. Dalal, Matthew J. Koch, Christopher J. Stapleton, Aman B. Patel, Thomas Finkenzeller, Markus Holtmannspotter, Jan Hendrik Buhk, Paul Michael Foreman, Marshall Cress, Robert Hirschl, Wolfgang Reith, Andreas Simgen, Hendrik Janssen, Thomas R. Marotta, Adam A. Dmytriw
Summary: This study compared PED and FRED for the treatment of unruptured posterior circulation aneurysms and found no significant differences in aneurysm occlusion or neurological complications between the two devices. However, there were variations in functional outcomes, indicating the need for further investigations.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Clinical Neurology
Sebahat Nacar Dogan, Vefa Salt, Bora Korkmazer, Serdar Arslan, Civan Islak, Naci Kocer, Osman Kizilkilic
Article
Clinical Neurology
Johanna Maria Ospel, Nima Kashani, Arnuv Mayank, Petra Cimflova, Manraj Heran, Sachin Pandey, Lissa Peeling, Anil Gopinathan, Demetrius Lopes, Naci Kocer, Mayank Goyal
INTERVENTIONAL NEURORADIOLOGY
(2020)
Letter
Clinical Neurology
Naci Kocer
WORLD NEUROSURGERY
(2020)
Article
Neuroimaging
Petra Cimflova, Enes Ozluk, Bora Korkmazer, Ramiz Ahmadov, Elif Akpek, Osman Kizilkilic, Civan Islak, Naci Kocer
Summary: This study retrospectively reviewed 23 patients with MCA aneurysms in the M2 segment or beyond treated with flow diversion stent. It found that flow diversion of distally located aneurysms is technically feasible with low morbidity and mortality rates.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Clinical Neurology
Guilherme Dabus, Peter Kan, Carlos Diaz, Boris Pabon, Juan Andres-Mejia, Italo Linfante, Jonathan A. Grossberg, Brian M. Howard, Civan Islak, Naci Kocer, Osman Kizilkilic, Ajit S. Puri, Anna L. Kuhn, Viraj Moholkar, Santiago Ortega-Gutierrez, Edgar A. Samaniego, Michael W. McDermott
Summary: Our study shows that endovascular treatment for ACF DAVFs is safe and effective, with high rates of complete occlusion, particularly when using the transvenous approach. Whenever feasible, the transvenous approach should be preferred as the first line strategy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Burcu Gul, Cesur Samanci, Derya Ugurlu Uluduz, Deniz Alis, Ipek Midi, Naci Kocer, Civan Islak, Osman Kizilkilic
Summary: The study aimed to differentiate transverse sinus (TS) thrombosis from TS hypoplasia by establishing a cutoff value based on the ratio of bilateral jugular foramen (JF) diameters on MRI. Results showed that the JF diameter ratio was lower in patients with hypoplasia compared to those with thrombosis. Calculating the JF diameter ratio can be an efficient method to differentiate between TS thrombosis and hypoplasia.
Article
Clinical Neurology
N. Adeeb, M. Dibas, C. J. Griessenauer, H. H. Cuellar, M. M. Salem, S. Xiang, A. Enriquez-Marulanda, T. Hong, H. Zhang, P. Taussky, R. Grandhi, M. Waqas, A. S. Aldine, V. M. Tutino, A. Aslan, A. H. Siddiqui, E. Levy, C. S. Ogilvy, A. J. Thomas, C. Ulfert, M. A. Mohlenbruch, L. Renieri, J. D. Bengzon Diestro, G. Lanzino, W. Brinjikji, J. Spears, J. E. Vranic, R. W. Regenhardt, J. D. Rabinov, P. Harker, E. Mueller-Thies-Broussalis, M. Killer-Oberpfalzer, C. Islak, N. Kocer, M. Sonnberger, T. Engelhorn, A. Kapadia, V. X. D. Yang, A. Salehani, M. R. Harrigan, T. Krings, C. C. Matouk, S. Mirshahi, K. S. Chen, M. A. Aziz-Sultan, M. Ghorbani, C. M. Schirmer, O. Goren, S. S. Dalal, T. Finkenzeller, M. Holtmannspoetter, J-H Buhk, P. M. Foreman, M. C. Cress, R. A. Hirschl, W. Reith, A. Simgen, H. Janssen, T. R. Marotta, C. J. Stapleton, A. B. Patel, A. A. Dmytriw
Summary: This study retrospectively analyzed data from multiple international academic institutions to investigate the change in complication rates and treatment outcomes for posterior circulation aneurysms treated with flow diversion. The results showed a trend towards treating smaller vertebral artery aneurysms, fewer large vertebrobasilar aneurysms, and an increased usage of a single flow diverter, leading to a decrease in the rate of thromboembolic and hemorrhagic complications.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Kanullah Suleyman, Bora Korkmazer, Naci Kocer, Civan Islak, Osman Kizilkilic
Summary: This study evaluated the feasibility, safety, and efficacy of Y-stent-assisted coiling (Y-SAC) using LEO Baby(R) stents for the treatment of bifurcation aneurysms. The results showed that Y-SAC is a safe, durable, and effective method for treating wide-necked and complex bifurcation aneurysms.
Article
Clinical Neurology
D. F. Vollherbst, H. Luecking, J. DuPlessis, M. Sonnberger, C. Maurer, N. Kocer, M. Killer-Oberpfalzer, R. Rautio, L. Valvassori, A. Berlis, S. Gasser, S. Gatt, A. Doerfler, M. Bendszus, M. A. Moehlenbruch
Summary: This study aimed to investigate the safety and short-term efficacy of the new FRED X flow diverter. The FRED X was successfully implanted in all procedures, and the rate of major adverse events was 3.1%. Thrombotic events occurred in 4.3%, with only 1.2% leading to major adverse events. The rate of complete aneurysm occlusion after a mean follow-up of 7.0 months was 66%.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Rasmiranjan Padhi, Sathish Kandasamy, Balasenthil Kumaran, Naci Kocer, Harshith Karmadhari
Summary: This study reported a case of hypoglossal canal DAVF that was successfully embolized through the SOV approach, achieving complete resolution of symptoms. Hypoglossal canal DAVFs are rare and may require knowledge of complex venous anatomy for planning alternative treatment routes.
Article
Clinical Neurology
Eda Coban, Helin Cansu Serindag, Eda Salihoglu Kara, Hatem Hakan Selcuk, Fulya Eren, Vasfiye Burcu Albay, Aysun Soysal
Summary: Tularemia is a bacterial zoonotic disease caused by francisella tularensis, and the case presented here is the first reported vasculitis of the central nervous system due to tularemia.
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2021)
Article
Clinical Neurology
Gunay Gul, Mesude Ozerden, Zeynep Ozdemir, Cahit Keskinkilic, Hakan Selcuk, Batuhan Kara, Aysun Soysal
IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE
(2020)
Article
Medicine, General & Internal
Behlul Igus, Hakan Selcuk, Batuhan Kara, Ali Firat, Aysun Erbahceci Salik
MEDICAL JOURNAL OF BAKIRKOY
(2020)