Editorial Material
Hematology
Jorg P. Halter
Summary: The study by Cutler et al. shows promising results in treating patients with inadequately controlled chronic graft-versus-host disease (cGVHD) using the ROCK2 inhibitor belumosudil.
Editorial Material
Anesthesiology
Tim M. Cook, Michael F. Aziz
Summary: Recent evidence suggests that universal use of videolaryngoscopy in anaesthesia can improve the efficiency and safety of tracheal intubation. A study found that increased use of videolaryngoscopy was associated with a significant decrease in difficult airways and the use of airway rescue techniques. Further research should investigate the effectiveness of videolaryngoscopy in different settings.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Editorial Material
Genetics & Heredity
Angeline S. Ferdinand, Jane S. Hocking, Justin T. Denholm, Benjamin P. Howden, Deborah A. Williamson
Summary: Improving communication of pathogen genomic data in accordance with healthcare ethics requires educating healthcare professionals, developing ethical frameworks for reporting results to individuals, responsible media reporting guidelines, and providing pathogen genetic counselling for individuals.
Review
Oncology
Chiara Corti, Pier P. M. B. Giachetti, Alexander M. M. Eggermont, Suzette Delaloge, Giuseppe Curigliano
Summary: The use of the immune system as a weapon against cancer, particularly through immune checkpoint inhibitors (ICIs), has revolutionized cancer treatment. However, the effectiveness of ICIs in treating breast cancer (BC) is limited, except for certain subsets of triple-negative BCs. The tumor microenvironment (TME), which is immune-suppressive in BC, plays a crucial role in the poor response to immunotherapy. Cancer vaccines (CVs), as active immunotherapy, have regained attention due to technological advancements and the COVID-19 pandemic, with a focus on neoantigens as preferred targets. Lipid nanoparticles have also shown promise as effective delivery vehicles for CVs. Past clinical trials mainly focused on metastatic disease, where the TME is more likely compromised by inhibitory mechanisms. Promising strategies include using CVs as monotherapy in premalignant or adjuvant settings, and combining CVs with ICIs in late-stage disease. This review provides a comprehensive overview of the current landscape of breast cancer vaccines.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Obstetrics & Gynecology
Anja Pinborg, Christophe Blockeel, Alison Campbell, Giovanni Coticchio, Juan A. Garcia-Velasco, Pietro Santulli, Christian De Geyter, Christine Wyns
Summary: The European IVF-Monitoring Consortium, the Society for Assisted Reproductive Technology in the USA, and the Australia/New Zealand Assisted Reproduction Database collect data on assisted reproductive technology (ART) treatments to ensure quality and safety. The legal framework for ART surveillance affects the completeness and reliability of the datasets.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Biochemistry & Molecular Biology
Nienke M. Stege, Rudolf A. de Boer, Maarten P. van den Berg, Herman H. W. Sillje
Summary: Screening for pathogenic variants has become common practice for patients with genetic cardiomyopathies, allowing early detection of disease onset. Monitoring relies on a combination of plasma biomarkers, imaging techniques, and electrocardiography. Further research is needed to explore the potential of biomarkers in distinguishing primary cardiac disease from secondary organ dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Rosaria Ciriminna, Richard M. M. Laine, Mario Pagliaro
Summary: This study provides an updated perspective on the bio-based production of high-purity silicon and silica, taking into account the societal, economic, and environmental trends reshaping chemical processes. It summarizes the key aspects of green chemistry technologies that have the potential to transform current production methods, while also discussing selected industrial and economic aspects. Finally, it offers insights into how these technologies could reshape current chemical and energy production.
Article
Clinical Neurology
A. Sperre, I. Karsrud, A. H. S. Rodum, A. Lashkarivand, L. M. Valnes, G. Ringstad, P. K. Eide
Summary: This study found that intrathecal gadobutrol in doses up to 0.50 is safe, based on observations of 196 patients who received intrathecal contrast-enhanced imaging of the cerebrospinal fluid.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Management
Lynn Varagona, Nancy M. Ballard, Margot (Lisa) Hedenstrom
Summary: This article aims to summarize and evaluate the existing literature on nursing virtue ethics, and propose a new framework for understanding and developing virtuous healthcare teams. The study underscores the importance of applying virtue ethics in nursing leadership to rebuild healthy practice environments, especially in the post-COVID-19 era.
JOURNAL OF NURSING MANAGEMENT
(2022)
Review
Clinical Neurology
Vanessa Salasky, Matthew N. Jaffa, Melissa Motta, Gunjan Y. Parikh
Summary: The purposes of this review were to identify evidence for post-intensive care syndrome (PICS) and post-intensive care syndrome-family (PICS-F) in the neurologically injured population and to characterize existing models for neurorecovery clinics. It was found that while there are post-ICU clinics for general critical care patients, there is a lack of such clinics for brain injured patients. It is proposed to establish a neuro-ICU transitional care clinic modeled after transitional care provided to other brain injured populations.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Engineering, Electrical & Electronic
Doug Jorgesen, Christopher Marki
Summary: The outstanding fabrication tolerances and scalability of IC processes have made MMICs the preferred technology for almost all planar microwave components. However, fixed filters have not been impacted by the MMIC revolution due to outdated assumptions about performance and availability. In this article, we examine the filter landscape and explain why MMIC should be the technology platform of choice for many filter applications.
Article
Surgery
Anne M. Huml, John R. Sedor, Emilio Poggio, Rachel E. Patzer, Jesse D. Schold
Summary: Numerous clinical trials and policy changes have attempted to reduce disparities in access to kidney transplantation for patients with kidney failure, but have not yielded lasting results. Therefore, disruptive change is necessary to increase access to kidney transplants.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Biotechnology & Applied Microbiology
Chunbao Charles Xu, Luana Dessbesell, Yongsheng Zhang, Zhongshun Yuan
Summary: Driven by the commercial availability of kraft lignin and hydrolysis lignin, there is a pressing need to valorize lignin for high-value chemical and material products. The engineering approach developed involves depolymerizing lignin into de-polymerized lignin and utilizing it to substitute petroleum-based compounds in the production of bio-based resins and foams, demonstrating technical and economic feasibility with a payback period of around 3 years for a commercial capacity of 40,000 t/y. This approach shows that lignin valorization beyond energy use can be profitable, marking a potential shift in the perception of lignin's value.
BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR
(2021)
Article
Education & Educational Research
Zahava L. Friedman, Denise Nash-Luckenbach
Summary: An increasing number of neurodivergent learners are attending higher education, requiring the examination of best-fit learning models to support them. This study proposes a novel learning framework for neurodivergent college students based on neurodiversity-affirming practice. Through qualitative analysis of interviews with American university faculty and framework comparison, three themes were identified: pedagogy vs. andragogy, self-determination, and interdependency. The study highlights the potential of implementing and assessing heutagogical, pedagogical, and andragogical principles in higher education settings.
Editorial Material
Obstetrics & Gynecology
Robert J. Norman
Summary: Despite previous difficulties, recent advancements in understanding natural oocyte maturation, culture media, and clinical approaches have increased the potential for a wider use of in vitro maturation in human IVF.
FERTILITY AND STERILITY
(2023)