Article
Urology & Nephrology
Andrew Z. Fenves, Michael Emmett
Summary: The anion gap is a useful calculation that helps differentiate different types of metabolic acidosis and identify potential diseases. By comparing the AG with changes in bicarbonate concentration, other potential acid-base balance issues can be identified.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Nick Schoenmann, Nicholas Tannenbaum, Ryan M. Hodgeman, Raghavan Pillai Raju
Summary: Dichloroacetate (DCA), a naturally occurring xenobiotic, has been used as an investigational drug for over 50 years. It serves primarily as a pyruvate dehydrogenase kinase inhibitor, reversing the preference for glycolysis over oxidative phosphorylation and increasing available energy. This review examines the potential and clinical application of DCA in various diseases including cancer, metabolic disorders, cerebral ischemia, trauma, and sepsis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Medicine, General & Internal
Oladapo O. Yeku, Arielle J. Medford, Andrew Z. Fenves, Sacha N. Uljon
Summary: A 76-year-old woman with a history of multiple diseases presented with symptoms of nausea, abdominal cramps, and nonbloody diarrhea. Blood tests revealed abnormal levels of creatinine and lactic acid.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Toxicology
Fanny de Landsheere, Franck Saint-Marcoux, Vincent Haufroid, Sylvain Dulaurent, Joseph P. Dewulf, Lidvine Boland, Pierre-Francois Laterre, Philippe Hantson
Summary: This article reports a case of metabolic acidosis caused by toxic alcohol ingestion and highlights the treatment approach and contributing factors.
JOURNAL OF MEDICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Muqun Yang, Mingyang Liu, Jing Cheng, Han Wang
Summary: A movable type bioelectronics printing method is proposed for fabricating biosensors by directly transferring bioelectronic materials onto various substrates using pre-fabricated molds. This simple, low-cost method allows for on-demand printing of master molds of partial or complete circuits on both rigid or flexible substrates. With advantages of repeatability, flexibility and low cost, this technology greatly promotes small-scale production of biosensors by facilitating direct transfer printing of bioactive materials.
SCIENTIFIC REPORTS
(2021)
Review
Critical Care Medicine
Kosuke Yagi, Tomoko Fujii
Summary: This article is one of ten selected reviews from the Annual Update in Intensive Care and Emergency Medicine 2021, with additional articles available online. The reviews cover the latest developments in the field of intensive care and emergency medicine in 2021.
Article
Oncology
Ubonrat Thamrongwaranggoon, Kanji Kuribayashi, Hirotaka Araki, Yuko Hino, Tomoaki Koga, Wunchana Seubwai, Sopit Wongkham, Mitsuyoshi Nakao, Shinjiro Hino
Summary: The high glycolytic activity of cancer cells leads to lactic acidosis in the tumor microenvironment, which not only is a consequence of metabolic activities but also has functional roles in metabolic reprogramming and cancer progression. Long-term lactic acidosis reprograms the metabolic phenotype of cholangiocarcinoma cells and enhances their migratory activity.
Article
Medicine, General & Internal
Abdullah Ibrahim, Burcu Bayramoglu, Nihat Mujdat Hokenek, Davut Tekyol
Summary: The study found that lactate clearance during the first 2 hours after admission to the emergency department can be used to predict the 30-day mortality of patients diagnosed with diabetic ketoacidosis (DKA). Significant differences were observed in age, pH, osmolarity, HCO3-, sodium levels, lactate level after 2 hours, and lactate clearance between groups with different mortality rates.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Editorial Material
Medicine, Research & Experimental
Marjan Gucek, Michael N. Sack
Summary: By analyzing blood and urine samples from patients with MELAS syndrome, researchers have identified proteins and metabolites related to NADH-reductive stress, which may serve as important biomarkers for future management of the disease. These circulating biomarkers have intriguing clinical potential that could implicate disease pathophysiology and guide therapeutic efficacy monitoring.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biology
Xiaoxu Chen, Mingyue Chen, Yuqing Zhu, Haifeng Sun, Yue Wang, Yuan Xie, Lianfu Ji, Cheng Wang, Zhibin Hu, Xuejiang Guo, Zhengfeng Xu, Jun Zhang, Shiwei Yang, Dong Liang, Bin Shen
Summary: A proof-of-concept study demonstrates the potential of using a screened DdCBE pair to correct homoplasmic mitochondrial mutations and restore mitochondrial function in induced pluripotent stem cells.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, General & Internal
Jae Hyoung Im, Jin-Soo Lee, Moon-Hyun Chung, Hea Yoon Kwon, Man-Jong Lee, Ji Hyeon Baek
Summary: Regular monitoring of serum lactate in patients treated with linezolid is recommended, as it can lead to early detection of lactatemia and improve the detection rate of critical illnesses, enabling rapid rescue.
Article
Emergency Medicine
Brit Long, Skyler Lentz, Alex Koyfman, Michael Gottlieb
Summary: Euglycemic diabetic ketoacidosis is a rare but serious endocrine emergency in diabetic patients with relative euglycemia and acidosis. The condition is often misdiagnosed due to the low serum glucose levels. Treatment involves addressing the underlying cause and management with intravenous fluids, insulin, and glucose.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Health Care Sciences & Services
Rachel Jaber Chehayeb, Ysabel C. Ilagan-Ying, Christopher Sankey
Summary: We present a case of a young woman with diabetic ketoacidosis and persistently elevated lactate levels during the COVID-19 pandemic. Misinterpretation of the elevated lactate led to an extensive infectious workup instead of considering thiamine deficiency. We discuss the clinical patterns, etiologies, and cognitive biases related to elevated lactate levels, and provide guidance for appropriate thiamine administration.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jaskamal Padda, Khizer Khalid, Varsha Kakani, Ayden Charlene Cooper, Gutteridge Jean-Charles
Summary: Leukemia remains a leading cause of mortality worldwide, especially among children. The Warburg effect is associated with cancer, particularly in leukemia. The exact role and mechanisms of the Warburg effect in leukemia are still under investigation.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Biology
Rabina Mainali, Manal Zabalawi, David Long, Nancy Buechler, Ellen Quillen, Chia-Chi Key, Xuewei Zhu, John S. Parks, Cristina Furdui, Peter W. Stacpoole, Jennifer Martinez, Charles E. McCall, Matthew A. Quinn
Summary: Metabolic reprogramming occurs in the immune system during sepsis, particularly in the liver, with changes in lipid metabolism, mitochondrial energy, and redox balance. Targeting mitochondrial energy metabolism can rebalance the transcriptional and metabolic manifestations of sepsis in the liver.