Article
Surgery
Catherine McManus, Aaron Oh, James A. Lee, Chin Hur, Jennifer H. Kuo
Summary: Combining cinacalcet with PTX before kidney transplant is the most cost-effective strategy for treating tertiary hyperparathyroidism in patients with end-stage renal disease.
Article
Health Care Sciences & Services
Po-Cheng Su, Cai-Mei Zheng, Chien-Chou Chen, Li-Yun Chiu, Hao-Yun Chang, Meng-Hsu Tsai, Chia-Te Liao, Chih-Chin Kao, Yung-Ho Hsu, Che-Chou Shen, Chih-Cheng Hsu, Mai-Szu Wu, Yen-Chung Lin
Summary: There are differences in survival rates between PD and HD in ESKD patients. PD shows better survival advantage in younger non-DM patients, while both PD and HD are suitable dialysis modalities for younger ESKD patients without the risk of cardiovascular disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Gabriela A. Duchesne, Jennifer L. Waller, Stephanie L. Baer, Lufei Young, Wendy B. Bollag
Summary: Pressure ulcers are associated with multiple comorbidities and pose a significant risk of mortality, contributing to approximately 60,000 deaths per year in the US. A retrospective analysis of the US Renal Data System (USRDS) database revealed that pressure ulcer diagnosis is independently associated with mortality in patients with end-stage renal disease (ESRD). The study also identified several comorbidities as potential risk factors for pressure ulcers in the ESRD population.
Article
Primary Health Care
Noah Wouk
Summary: End-stage renal disease (ESRD) treatment options include kidney transplantation, dialysis, and palliative care. Prior to dialysis, optimal disease management is essential and initiation should be decided through shared decision-making. Vaccination, blood pressure control, salt restriction, and adequate dialysis are recommended for ESRD patients to optimize treatment outcomes.
AMERICAN FAMILY PHYSICIAN
(2021)
Article
Peripheral Vascular Disease
Suveenkrishna Pothuru, Wan-Chi Chan, Harsh Mehta, Mohinder R. Vindhyal, Sagar Ranka, Jinxiang Hu, Sri G. Yarlagadda, Mark A. Wiley, Eric Hockstad, Peter N. Tadros, Kamal Gupta
Summary: This study retrospectively observed the incidence, clinical characteristics, admission trends, and outcomes of hypertensive crisis in end-stage kidney disease patients on maintenance dialysis. The study found that hospitalization rates for hypertensive crisis have increased during the past decade in these patients, but mortality and readmission rates have shown improvement.
Article
Endocrinology & Metabolism
Hui-Teng Cheng, Xiaoqi Xu, Paik Seong Lim, Kuan-Yu Hung
Summary: The study compared the incidence of diabetes-related end-stage renal disease globally from 2000 to 2015, finding significant geographic variation in the risk of diabetic patients reaching ESRD in different regions during the study period.
Article
Public, Environmental & Occupational Health
Rachel Wilf-Miron, Vicki Myers, Mor Saban, Ilya Novikov, Lizie Kimron, Arnona Ziv, Ofra Kalter-Leibovici
Summary: The incidence of end-stage renal disease (ESRD) is higher in Israel than the European average. Socio-economic factors and ethnicity, particularly Arab ethnicity, are associated with an increased risk of ESRD, especially due to diabetes. Allocation of health resources and culturally appropriate interventions are necessary to improve control of modifiable risk factors for chronic renal failure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ryoichi Maenosono, Tatsuo Fukushima, Daisuke Kobayashi, Tomohisa Matsunaga, Yusuke Yano, Shunri Taniguchi, Yuya Fujiwara, Kazumasa Komura, Hirofumi Uehara, Maki Kagitani, Hajime Hirano, Teruo Inamoto, Hayahito Nomi, Haruhito Azuma
Summary: Patients with ESRD are at risk of malnutrition and high mortality. The study found an association between unplanned hemodialysis and low GNRI scores with mortality risk.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Mark Sulkowski, Laura E. Telep, Massimo Colombo, Francois Durand, K. Rajender Reddy, Eric Lawitz, Marc Bourliere, Nelson Cheinquer, Stacey Scherbakovsky, Liyun Ni, Lindsey Force, Heribert Ramroth, Anuj Gaggar, Anand P. Chokkalingam, Meghan E. Sise
Summary: In clinical trials, patients with chronic kidney disease did not experience worsening of estimated glomerular filtration rate during treatment with sofosbuvir, and sofosbuvir was not associated with an increased risk of end-stage renal disease in patients with CKD in a nationally-representative administrative claims database.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Elzbieta Dembowska, Aleksandra Jaron, Joanna Raslawska-Socha, Ewa Gabrysz-Trybek, Joanna Bladowska, Szymon Gacek, Grzegorz Trybek
Summary: This study assessed the extent of gingivitis and periodontitis in hemodialysis patients compared to healthy subjects. The study found that hemodialysis patients had a higher incidence and severity of gingivitis and periodontitis than the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Urology & Nephrology
Li Yang, Yanwei He, Xiaoming Li
Summary: This study conducted a meta-analysis to explore the relationship between physical functional performance and all-cause mortality in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) undergoing dialysis. The results showed that poor physical functional performance was significantly associated with higher all-cause mortality in these patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zixiang Ye, Yaxin Wu, Yimin Tu, Mulei Chen, Yanxiang Gao, Linying Shi, Peizhao Li, Enmin Xie, Ziyu Guo, Qing Li, Xiaozhai Yu, Yike Li, Wenquan Niu, Jingyi Ren, Jingang Zheng
Summary: This study demonstrates that blood group O may be negatively associated with the risk and severity of coronary artery disease (CAD) in end-stage renal disease (ESRD) patients undergoing dialysis, while blood groups A, B, and AB may be positively associated with the severity of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Haruna Fukuzaki, Junichiro Nakata, Shuko Nojiri, Yuki Shimizu, Yuka Shirotani, Takuya Maeda, Toshiki Kano, Maiko Mishiro, Nao Nohara, Hiroaki Io, Yusuke Suzuki
Summary: The importance of shared decision-making (SDM) is widely recognized. This study aimed to clarify the effectiveness and long-term medical benefits of SDM in renal replacement therapy (RRT) for patients with end-stage renal disease (ESRD). The findings demonstrate the association between visiting an ESRD clinic, improved survival in ESRD patients, and the choice of different RRT modalities.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Lina A. Dahabiyeh, Refat M. Nimer, Khalid M. Sumaily, Mohamad S. Alabdaljabar, Minnie Jacob, Essa M. Sabi, Maged H. Hussein, Anas Abdel Rahman
Summary: Chronic kidney disease (CKD) is a severe public health problem that can lead to end-stage renal disease (ESRD) requiring dialysis or transplantation. This study identified altered metabolites and biochemical reactions between ESRD and CKD, offering potential new biomarkers for monitoring CKD progression. Inhibition of the kynurenine pathway may be a promising target for delaying CKD progression, and metabolites with high discriminative ability could complement current markers to better indicate kidney damage status.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Thomas Robert, Rodolphe Jantzen, Alexandra Cambier, Matthieu Jamme, Cecile Couchoud, Philippe Brunet, Stephanie Gentile, Eric Rondeau, Laurent Mesnard, Nathanael Lapidus
Summary: In France, IgAN is the most common glomerulonephritis related to ESRD, with patients being the youngest, having the fewest comorbidities, and using peritoneal dialysis the most frequently. Patients with IgAN have the best prognosis among primary and secondary GN, with those awaiting transplantation after dialysis seeming to have a more favorable prognosis compared to ADPKD patients. The reasons for the difference in treatment modalities between these two groups should be further investigated to improve survival rates in renal disease.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Philippa Davie, Debra Bick, Sergio A. Silverio, Joseph Chilcot
Summary: This study examines whether the perceptions and practices of infant feeding are different among women who give birth to larger birthweight infants. The results suggest that larger infant birthweight may be a protective factor against breastfeeding difficulties, alleviating maternal concerns, but not reducing the demands of breastfeeding.
PSYCHOLOGY & HEALTH
(2023)
Article
Nursing
Frances Waite, Joseph Chilcot, Rona Moss-Morris, Ken Farrington, Federica Picariello
Summary: This study highlights the importance of understanding fatigue and accepting the treatment model for the acceptability and engagement with a cognitive-behavioural therapy-based intervention for fatigue. Overall, there is an indication that such an intervention is acceptable to patients and the mechanisms of change align with the proposed biopsychosocial model of fatigue. However, it needs to be delivered in a way that is appealing and practical to patients, while acknowledging the burdens of illness and treatment.
JOURNAL OF RENAL CARE
(2023)
Review
Psychiatry
Lindsay Bottoms, Montserrat Prat Pons, Naomi A. A. Fineberg, Luca Pellegrini, Oliver Fox, David Wellsted, Lynne M. M. Drummond, Jemma Reid, David S. S. Baldwin, Ruihua Hou, Samuel Chamberlain, Nick Sireau, Dominique Grohmann, Keith R. R. Laws
Summary: This systematic review and meta-analysis found that exercise is effective in reducing OCD symptoms, anxiety, and depression. However, the quality of the included trials was low and there was a risk of bias. Further well-designed RCTs are needed to evaluate the role of exercise as an intervention for OCD.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Review
Nursing
Christina J. Pearce, Natalie Hall, Joanna L. Hudson, Ken Farrington, Madeleine J. Ryan Tucker, David Wellsted, Julia Jones, Shivani Sharma, Sam Norton, Paula Ormandy, Nick Palmer, Anthony Quinnell, Lauren Fitzgerald, Sophie Griffiths, Joseph Chilcot
Summary: Depression is common among patients with Chronic Kidney Disease and is associated with poor outcomes. The most effective interventions and care pathways for depression in this population are still uncertain. This scoping review aimed to investigate how depression is identified and managed in adults with Chronic Kidney Disease.
JOURNAL OF RENAL CARE
(2023)
Article
Psychiatry
Naomi A. Fineberg, Eduardo Cinosi, Megan V. A. Smith, Amanda D. Busby, David Wellsted, Nathan T. M. Huneke, Kabir Garg, Ibrahim H. Aslan, Arun Enara, Matthew Garner, Robert Gordon, Natalie Hall, Daniel Meron, Trevor W. Robbins, Solange Wyatt, Luca Pellegrini, David S. Baldwin
Summary: This study compared the effects of transcranial direct current stimulation (tDCS) on two different targets for the treatment of obsessive compulsive disorder (OCD). The results showed that stimulation of the left orbitofrontal cortex (L-OFC) had a greater effect and additional therapeutic effects compared to the supplementary motor area (SMA). The study concluded that tDCS is a feasible and acceptable treatment for OCD, with the L-OFC being the most promising target.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Urology & Nephrology
Rajnish Mehrotra, Sara N. Davison, Ken Farrington, Jennifer E. Flythe, Marjorie Foo, Magdalena Madero, Rachael L. Morton, Yusuke Tsukamoto, Mark L. Unruh, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Edwina A. Brown, Conference Participants
Summary: Patients with kidney failure undergoing maintenance dialysis often experience a high symptom burden that affects functioning and life satisfaction. The focus of nephrology care has traditionally been on laboratory targets and outcomes, with limited attention to symptom assessment and management. A conference was held in May 2022 to address the optimal means for diagnosing and managing symptom-based complications in dialysis patients, outlining foundational principles and identifying research priorities.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
C. G. Walklin, Hannah M. L. Young, E. Asghari, S. Bhandari, R. E. Billany, N. Bishop, K. Bramham, J. Briggs, J. O. Burton, J. Campbell, E. M. Castle, J. Chilcot, N. Cooper, V Deelchand, M. P. M. Graham-Brown, A. Hamilton, M. Jesky, P. A. Kalra, P. Koufaki, K. McCafferty, A. C. Nixon, H. Noble, Z. L. Saynor, C. Sothinathan, M. W. Taal, J. Tollitt, D. C. Wheeler, T. J. Wilkinson, J. H. Macdonald, S. A. Greenwood
Summary: The Kidney BEAM trial aims to evaluate whether a self-management program called Kidney BEAM can improve the health-related quality of life for people with chronic kidney disease (CKD). The study is a randomized controlled trial that will provide evidence on the cost-effectiveness of the program in enhancing the mental and physical well-being of CKD patients.
Article
Urology & Nephrology
Sharlene A. Greenwood, Benjamin A. Oliveira, Elham Asgari, Salma Ayis, Luke A. Baker, Nicholas Beckley-Hoelscher, Aicha Goubar, Debasish Banerjee, Sunil Bhandari, Joseph Chilcot, James O. Burton, Philip A. Kalra, Courtney J. Lightfoot, Iain C. Macdougall, Kieran McCafferty, Thomas H. Mercer, Darlington O. Okonko, Chante Reid, Fiona Reid, Alice C. Smith, Pauline A. Swift, Anastasios Mangelis, Emma Watson, David C. Wheeler, Thomas J. Wilkinson, Kate Bramham
Summary: This trial evaluated the effects of iron supplementation on exercise capacity of nonanemic patients with CKD. The results showed that IV iron therapy did not improve exercise capacity at 4 weeks. A larger study is needed to confirm the benefits of IV iron in iron-deficient non-dialysis CKD patients.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Psychology, Multidisciplinary
Joseph Chilcot, Ruth A. Hackett
Summary: This study found that higher levels of optimism were associated with a reduced risk of stroke. Individuals with more conscientious and open personality types also had a lower risk of stroke. However, the strongest effect was seen for optimism, where optimistic individuals had a lower stroke risk regardless of their clinical risk or health behaviors. It is still unclear why optimism may help reduce the risk of stroke, but the study suggests that optimism may be related to higher levels of physical activity, which in turn helps reduce the risk of stroke. Further research is needed to understand the relationship between personality, health behaviors, and stroke risk reduction.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Surgery
Mira Zuchowski, Nizam Mamode, Heather Draper, Peter Gogalniceanu, Sam Norton, Joseph Chilcot, Timothy Auburn, Alexis Clarke, Lynsey Williams, Lisa Burnapp, Paul McCrone, Hannah Maple
Summary: This is the first in-depth qualitative study of attitudes of transplant professionals towards unspecified kidney donation (UKD). The study identified five themes: staff's conception of the ethics of UKD; presence of the known recipient in the donor-recipient dyad; need for better management of patient expectations; managing visceral reactions about the typical unspecified kidney donor; complex attitudes toward a promising new practice.
TRANSPLANT INTERNATIONAL
(2023)
Article
Surgery
Hannah Maple, Petrut Gogalniceanu, Rebecca Gare, Lisa Burnapp, Heather Draper, Joseph Chilcot, Sam Norton, Nizam Mamode
Summary: This study investigates the perspectives of UK transplant professionals towards unspecified kidney donors (UKDs) and identifies potential barriers. The majority of professionals had a positive experience with UKDs and were comfortable with them undergoing major surgery. However, concerns include the time-consuming nature of UKDs and the need for mental health assessments.
TRANSPLANT INTERNATIONAL
(2023)
Review
Urology & Nephrology
Claire Carswell, Clodagh Cogley, Kate Bramham, Joseph Chilcot, Helen Noble, Najma Siddiqi
Summary: There is an increased risk of chronic kidney disease among people with severe mental illness, and they face significant health inequalities in kidney care. Further research is needed to understand the factors contributing to this relationship and improve clinical outcomes and access to kidney care for these individuals.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Elizabeth Ralston, Priscilla Smith, Katherine Clark, Kate Wiles, Kate RaDaR CKD Pregnancy Grp, Joseph Chilcot, Kate Bramham
Summary: This study examined the perception of pregnancy risk and its impact on pregnancy intention among women with Chronic Kidney Disease (CKD). The findings showed that clinical characteristics were not associated with women's perception of pregnancy risk and intention, while the severity of CKD and attending pre-pregnancy counseling were independent predictors of perceived pregnancy risk.
JOURNAL OF NEPHROLOGY
(2023)
Article
Neurosciences
Iris Knoop, Annie S. K. Jones, Nicholas Gall, Joseph Chilcot, William Pascoe, Rona Moss-Morris
Summary: This study aims to evaluate the psychometric properties of the OGS and SSS as effective measurement instruments for patients with suspected and confirmed POTS.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2023)
