Article
Endocrinology & Metabolism
Oana P. Zaharia, Martin Schoen, Luca Loeffler, Klaus Strassburger, Clara Moeser, Iryna Yurchenko, Kalman Bodis, Sofia Antoniou, Yanislava Karusheva, Julia Szendroedi, Volker Burkart, Michael Roden
Summary: This study compared endothelial function during the early stage of type 1 and type 2 diabetes and found that endothelial function decreases in patients with type 2 diabetes, which is associated with baseline adipose tissue insulin resistance and indices of liver fibrosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Charlotte Loessner, Anna Multhaup, Thomas Lehmann, Ekkehard Schleussner, Tanja Groten
Summary: The evaluation of endothelial function during pregnancy is becoming increasingly important, as impaired adaptation in early pregnancy is associated with an increased risk of preeclampsia and fetal growth restriction. To standardize risk assessment and incorporate vascular function evaluation into routine pregnancy care, a suitable, accurate, and easy-to-use method is needed. Flow-mediated dilatation (FMD) of the brachial artery assessed by ultrasound is considered the gold standard for measuring vascular endothelial function. However, the challenges of FMD measurement have hindered its introduction into clinical practice. The VICORDER(R) device allows for automated determination of flow-mediated slowing (FMS), but its equivalence to FMD has not been proven in pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Marianne Riou, Walid Oulehri, Cedric Momas, Olivier Rouyer, Fabienne Lebourg, Alain Meyer, Irina Enache, Cristina Pistea, Anne Charloux, Christophe Marcot, Frederic de Blay, Olivier Collange, Michel Mertes, Emmanuel Andres, Samy Talha, Bernard Geny
Summary: The coronavirus disease 2019 (COVID-19) pandemic has caused over two million deaths worldwide, with evidence suggesting vascular endothelial dysfunction plays a critical role. However, impaired brachial artery flow-mediated dilatation (FMD) in COVID-19 patients three months after infection does not appear to be associated with disease severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Fong-Yu Cheng, Yuan-Yow Chiou, Shih-Yuan Hung, Tsun-Mei Lin, Hao-Kuang Wang, Chi-Wei Lin, Hung-Hsiang Liou, Min-Yu Chang, Hsi-Hao Wang, Yi-Che Lee
Summary: The study found that vitamin D-loaded magnetic nanoparticles show potential advantages in treating PD-related peritoneal damage, with better targeting of the peritoneum compared to vitamin D3, effectively alleviating peritoneal fibrosis and reducing side effects such as hypercalcemia.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pediatrics
Britt Engan, Mette Engan, Gottfried Greve, Maria Vollsaeter, Karl Ove Hufthammer, Elisabeth Leirgul
Summary: The study found that young adults born very preterm or with extremely low birthweight have significantly lower vascular endothelial function, indicating an increased risk of cardiovascular disease.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, Research & Experimental
Wenyan Su, Zuoyu Hu, Xiaohong Zhong, Ansheng Cong, Ying Zhang, Zhanmei Zhou, Jianyi Li, Cailing Su, Yujie Huang, Wei Cao
Summary: This study found that the fibrosis in peritoneal dialysis patients is associated with decreased fatty acid oxidation and carnitine palmitoyltransferase 1A expression. Overexpression of carnitine palmitoyltransferase 1A can reverse the fibrosis process.
Article
Cardiac & Cardiovascular Systems
Ruihua Liu, Yuan Peng, Haishan Wu, Xiangwen Diao, Hongjian Ye, Xuan Huang, Chunyan Yi, Haiping Mao, Fengxian Huang, Xueqing Yu, Xiao Yang
Summary: The study found that in peritoneal dialysis patients, a high uric acid/high-density lipoprotein cholesterol ratio (UHR) was associated with cardiovascular mortality, particularly in patients aged 65 years and older, with malnutrition, diabetes, and a history of cardiovascular disease.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Urology & Nephrology
Naoki Sugano, Yukio Maruyama, Iwao Ohno, Atsushi Wada, Takashi Shigematsu, Ikuto Masakane, Takashi Yokoo, Kosaku Nitta
Summary: This study found a U-shaped relationship between UA levels and all-cause mortality among Japanese PD patients, where both lower and higher UA levels were associated with higher mortality. Additionally, lower BMI significantly enhanced the effect of UA levels on mortality.
PERITONEAL DIALYSIS INTERNATIONAL
(2021)
Review
Cardiac & Cardiovascular Systems
Zhi-qiang Liu, Zhi-wen Huang, Shu-ling Kang, Chan-chan Hu, Fa Chen, Fei He, Zheng Lin, Feng Yang, Zhi-jian Hu
Summary: High SUA levels are associated with an increased risk of all-cause mortality in PD patients compared to middle SUA levels. SUA levels may not be associated with cardiovascular mortality. More high-level studies, especially randomized controlled trials, are needed to determine the association between SUA levels and cardiovascular or all-cause mortality in PD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Respiratory System
Anouk W. Vaes, Patrick De Boever, Frits M. E. Franssen, Nicole H. M. K. Uszko-Lencer, Lowie E. G. W. Vanfleteren, Martijn A. Spruit
Summary: This article summarizes the current knowledge on endothelial function in COPD patients, indicating that COPD patients have impaired endothelial function, and higher age, worse severity of airflow obstruction, and current smoking are significantly associated with impaired endothelial function.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Review
Geriatrics & Gerontology
Fuli Kang, Qi Zou, Jiazhen Huang
Summary: A systematic review and meta-analysis evaluated the effect of Raloxifene on endothelial function and inflammation in postmenopausal women. The results showed that Raloxifene treatment had positive effects on vascular function and inflammation, including a decrease in carotid intima-media thickness, C-reactive protein, and vascular cell adhesion molecule 1 levels, as well as an increase in flow-mediated dilatation.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Nutrition & Dietetics
Rosalind Baynham, Samuel R. C. Weaver, Catarina Rendeiro, Jet J. C. S. Veldhuijzen van Zanten
Summary: This study examined the impact of high-fat meal consumption on the negative effects of mental stress on vascular function. The results indicated that high-fat diet attenuates the recovery of endothelial function following mental stress.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Mao-Hung Lo, Ying-Jui Lin, Hsuan-Chang Kuo, Yi-Hua Wu, Tse-Yi Li, Ho-Chang Kuo, I. -Chun Lin
Summary: This study explored the endothelial function and clinical characteristics of patients with previous Kawasaki disease (KD). The results showed that patients with coronary arterial aneurysms (CAA) had impaired vascular endothelial function, while other parameters were not significantly different. Flow-mediated dilation (FMD) may be a useful indicator of endothelial dysfunction for long-term follow-up of KD patients.
BIOMEDICAL JOURNAL
(2023)
Article
Sport Sciences
James Shelley, Lynne Boddy, Zoe Knowles, Claire Stewart, Freddy Frost, Dilip Nazareth, Martin Walshaw, Ellen Dawson
Summary: Understanding of physical activity (PA) and its associated health benefits is limited in adults with Cystic Fibrosis (CF). This study compared PA between CF patients and non-CF peers and examined its associations with vascular function and health outcomes. CF patients engaged in less moderate-to-vigorous PA and had lower overall PA compared to non-CF peers. Vigorous activity was positively associated with lung function and quality of life.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Environmental Sciences
Jennifer Byrne, Caitriona Murphy, Jennifer B. Keogh, Peter M. Clifton
Summary: Evidence suggests that there is a connection between low magnesium intake and coronary heart disease, as well as magnesium intake and endothelial function. However, the study found that one week of magnesium supplementation did not improve endothelial function in a healthy population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
