Article
Cardiac & Cardiovascular Systems
Mohamed Khalfallah, Ayman Elsheikh, Ahmad Eissa, Basma Elnagar
Summary: This study found that resistant hypertension (RH) is prevalent among adult Egyptians, and patients with RH are at higher risk for major cardiovascular events compared to those with controlled blood pressure. Advanced age, chronic kidney disease, obesity, and NSAID use are the main predictors impacting the cardiovascular outcomes of RH.
Article
Endocrinology & Metabolism
Ahmed Saadi, Mohamed Ali Bedoui, Selim Zaghbib, Hamza Boussaffa, Seif Mokaddem, Ibtissem Ben Nacef, Haroun Ayed, Amine Derouiche, Karima Khiari, Marouene Chakroun, Riadh Ben Slama
Summary: This study retrospectively analyzed the medical records of 71 Tunisian patients who underwent surgery for UPA. The complete clinical success rate was 48% and the partial clinical success rate was 43%. Absence of diabetes, low BMI, high plasma ARR, and high ARS were identified as the main predictors of complete resolution of hypertension.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Bartosz Symonides, Jacek Lewandowski, Wojciech Marcinkowski, Jacek Zawierucha, Tomasz Prystacki, Jolanta Malyszko
Summary: This study aimed to assess the prevalence, characteristics, and determinants of apparent treatment-resistant hypertension (aTRH) in a large population of end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD). Prevalence rates of hypertension and aTRH were determined using pre- and post-dialysis blood pressure criteria. The results showed that aTRH in ESKD HD patients appears to be multifactorial, influenced by patient-related factors rather than dialysis-related factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Nicholas Chiu, Julie Lauffenburger, Jessica Franklin, Niteesh Choudhry
Summary: Research shows that patients with true resistant hypertension are at higher risk of cardiovascular and mortality events, especially among those who are black, have macroalbuminuria, chronic kidney disease, a history of stroke, higher baseline systolic blood pressure, and are taking more baseline antihypertensive medications.
HYPERTENSION RESEARCH
(2021)
Article
Peripheral Vascular Disease
John Jui Ping Yeo, Leh Siang Yeo, Shirley Siang Ning Tan, Dayang Diana Rozana Aini Delailah, Shaun Wen Huey Lee, Anna Ting Huey Hu, Diana Hui Ping Foo, Faiz Sahiran, Ivan Kok Seng Yap, Alan Yean Yip Fong
Summary: Resistant hypertension is a commonly encountered clinical challenge, and its definition and epidemiology in Asia remain unclear. This study found that a high proportion of Asian adults referred for uncontrolled hypertension met the criteria for true resistant hypertension, with up to two-thirds meeting the criteria according to American guidelines. Additional findings revealed that a quarter of those with resistant hypertension had refractory hypertension, indicating elevated blood pressure despite treatment with at least 5 antihypertensive medications.
HYPERTENSION RESEARCH
(2023)
Article
Infectious Diseases
Youssef Madney, Shaimaa Aboubakr, Reham Khedr, Hanafy Hafez, Naglaa Ahmed, Khaled Elsheshtawy, Mervat Elanany, Abdelhamid Salahelden, Lobna Shalaby, Ola Galal Behairy
Summary: Carbapenem-resistant Enterobacteriaceae (CRE) poses a significant threat to pediatric cancer patients, with a high mortality rate. A retrospective study in Egypt from 2013 to 2017 identified 254 pediatric cancer patients with CRE bloodstream infections (BSIs). The main risk factors for acquiring CRE-BSI included previous antibiotics exposure, profound neutropenia, prolonged steroid use, previous colonization with a resistant pathogen, ICU admission within 90 days, and central venous catheter use. E. coli and Klebsiella pneumoniae were the most common pathogens, and all isolates were resistant to carbapenem. The overall mortality rate was 57%, and predictors of poor outcome were carbapenem resistance with high MIC and associated complications.
Article
Medicine, General & Internal
Hussein Alhawari, Sameeha AlShelleh, Hussam Alhawari, Saif Aldeen AlRyalat, Asim N. Khanfar, Osama Alzoubi
Summary: This study investigated the prevalence of undiagnosed hypertension in the healthy Jordanian population, finding that nearly 70% of previously healthy Jordanians met the criteria for hypertension diagnosis. The study also identified age, BMI, and family history of CAD as predictors of high systolic blood pressure, while female gender was associated with lower systolic blood pressure; for diastolic blood pressure, BMI and family history of CAD were significantly associated with higher readings, while female gender and exercise were significantly associated with lower diastolic blood pressure.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Maximillian T. Bourdillon, Rebecca J. Song, Ibrahim Musa Yola, Vanessa Xanthakis, Ramachandran S. Vasan
Summary: The prevalence of hypertension subtypes varies with age, and they exhibit dynamic changes during short-term follow-up and have distinct prognoses. This highlights the importance of blood pressure subtyping.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Pariya Panchavinnin, Sirisawat Wanthong, Weranuj Roubsanthisuk, Damras Tresukosol, Peera Buranakitjaroen, Chavalit Chotruangnapa, Wattana Watanapa, Rungtiwa Pongakasira, Nattawut Wongpraparut
Summary: The study aimed to determine the long-term outcome of renal denervation (RDN) in patients with resistant hypertension. Patients were followed up at different time points up to 9 years, and the effectiveness of RDN was observed to be >80% during the entire follow-up period.
HYPERTENSION RESEARCH
(2022)
Article
Pediatrics
Delicia Shu Qin Ooi, Siong Gim Ong, Owen Ming Hao Lee, Yiong Huak Chan, Yvonne Yijuan Lim, Cindy Wei Li Ho, Veronica Tay, K. Vijaya, Kah Yin Loke, Andrew Anjian Sng, Yung Seng Lee
Summary: In a multi-ethnic Asian cohort of severely obese children, adiposity measures are not associated with metabolically healthy obese (MHO) phenotype, but younger age, maternal healthy metabolic status, absence of paternal obesity, Malay and Indian ethnicity are independent predictors for MHO phenotype. Parental influence is important in predicting metabolic health in obese individuals.
PEDIATRIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Fabio Bioletto, Martina Bollati, Chiara Lopez, Stefano Arata, Matteo Procopio, Federico Ponzetto, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: Primary aldosteronism is recognized as the most common cause of secondary hypertension, associated with high-risk phenotypes and increased cardiovascular morbidity. Excessive aldosterone secretion can contribute to the development of hypertension and drug resistance through various mechanisms and worsen end-organ damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Aseel AbuSara, Nabiha Tayyeb, Lujain Matalka, Bayan Almomani, Haneen Abaza, Lama Nazer
Summary: The study aimed to evaluate the prevalence and predictors of multi-drug resistant organisms (MDROs) in cancer patients with urinary tract infections (UTIs) in the ambulatory setting. Retrospective analysis showed that more than half of the urine cultures from cancer patients treated for UTIs in the ambulatory setting were positive for MDROs, with extended-spectrum-beta-lactamase producing organisms being the most common. Having had a UTI with MDRO within the past 6 months was the only significant predictor for subsequent MDRO UTIs.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Peripheral Vascular Disease
Lingkan Barua, Mithila Faruque, Shagoofa Rakhshanda, Palash Chandra Banik, Riffat Ara Shawon, Saidur Rahman Mashreky
Summary: This study found that one-fourth of rural adults in Bangladesh had prehypertension and hypertension, with common significant predictors being age, family history of hypertension, physical inactivity, obesity, and diabetes.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Review
Medicine, General & Internal
Gabrielle Bourque, Swapnil Hiremath
Summary: Resistant hypertension, a common condition, increases the risk of cardiovascular and renal events. This review provides an overview of the definition, diagnosis, evaluation, and management of resistant hypertension. The association between medication non-adherence and resistant hypertension, as well as non-pharmacological interventions, are discussed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Amitai Segev, Yishay Wasserstrum, Michael Arad, Jose M. Larranga Moreira, Cristina Martinez-Veira, Roberto Barriales-Villa, Avi Sabbag
Summary: This study retrospectively analyzed the incidence and predictors of sustained ventricular arrhythmias (VTAs) in patients with hypertrophic cardiomyopathy (HCM). The study found that VT is the most common arrhythmia in HCM patients and is associated with decreased left ventricular ejection fraction and increased left ventricular diameters. Antitachycardia pacing (ATP) was effective in terminating VT events.
Article
Cardiac & Cardiovascular Systems
Bernard R. Chaitman, Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, Renato D. Lopes, Marcin Demkow, Gian Piero Perna, Robert K. Riezebos, Edward O. McFalls, Subhash Banerjee, Akshay Bagai, Gilbert Gosselin, Sean M. O'Brien, Frank W. Rockhold, David D. Waters, Kristian A. Thygesen, Gregg W. Stone, Harvey D. White, David J. Maron, Judith S. Hochman
Summary: The ISCHEMIA trial showed that an initial invasive strategy did not reduce cardiovascular events or all-cause mortality in patients with stable ischemic heart disease. Procedural MI rates were higher with the invasive strategy compared to conservative strategy, with the use of the secondary MI definition.
Review
Cardiac & Cardiovascular Systems
Toshiki Kuno, Yujiro Yokoyama, Alexandros Briasoulis, Makoto Mori, Masao Iwagami, Tomo Ando, Hisato Takagi, Sripal Bangalore
Summary: This study compared the outcomes of single antiplatelet therapy versus 3- or 6-month DAPT following TAVR. Results showed that the risk of major bleeding was significantly higher in the 3- and 6-month DAPT groups compared to the single antiplatelet therapy group, with similar rates of stroke and all-cause mortality among the three groups.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Irbaz Hameed, Antonino Di Franco, Ajita Naik, Michelle Demetres, Giuseppe Biondi-Zoccai, Sripal Bangalore
Summary: This study conducted a systematic review and meta-analysis to compare the efficacy of percutaneous coronary intervention and coronary artery bypass grafting stratified by SYNTAX score. The results showed no significant association between SYNTAX score and the comparative effectiveness of the two procedures.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Franz H. Messerli, Chirag Bavishi, Sripal Bangalore
Article
Cardiac & Cardiovascular Systems
Sripal Bangalore, John A. Spertus, Susanna R. Stevens, Philip G. Jones, G. B. John Mancini, Jonathon Leipsic, Harmony R. Reynolds, Matthew J. Budoff, Cameron J. Hague, James K. Min, William E. Boden, Sean M. O'Brien, Robert A. Harrington, Jeffrey S. Berger, Roxy Senior, Jesus Peteiro, Neeraj Pandit, Leonid Bershtein, Mark A. de Belder, Hanna Szwed, Rolf Doerr, Lorenzo Monti, Khaled Alfakih, Judith S. Hochman, David J. Maron
Summary: The study found that intermediate left main disease (LMD) was associated with cardiovascular events. An invasive strategy can reduce nonprocedural MI and improve angina-related quality of life.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Monil Majmundar, Gabriel Ibarra, Ashish Kumar, Rajkumar Doshi, Palak Shah, Roxana Mehran, Grant W. Reed, Rishi Puri, Samir R. Kapadia, Sripal Bangalore, Ankur Kalra
Summary: Invasive management is associated with lower mortality and major adverse cardiovascular events in NSTEMI-CKD patients compared to medical management, with minimal increase in in-hospital complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sonal Pruthi, Sripal Bangalore
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Article
Cardiac & Cardiovascular Systems
Muhammad Haisum Maqsood, Samir Pancholy, Kristin A. A. Tuozzo, Nicole Moskowitz, Sunil V. V. Rao, Sripal Bangalore
Summary: For patients undergoing transradial access procedures, a hemostasis duration of 2 hours offers the best balance between preventing radial artery occlusion and reducing the risk of access site bleeding or hematoma.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Letter
Cardiac & Cardiovascular Systems
Monil Majmundar, Rajkumar Doshi, Rhythm Vasudeva, Kunal N. Patel, Ashish Kumar, Sripal Bangalore, Ankur Kalra
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert S. Zhang, Usman Alam, Muhammad H. Maqsood, Yuhe Xia, Rafael Harari, Norma Keller, Lindsay Elbaum, Sunil V. Rao, Carlos L. Alviar, Sripal Bangalore
Summary: In this study, percutaneous vegetation debulking was found to be a feasible, effective, and safe treatment option for patients with tricuspid valve infective endocarditis refractory to medical therapy.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Toshiki Kuno, Atsuyuki Watanabe, Satoshi Shoji, Tomohiro Fujisaki, Hiroki Ueyama, Hisato Takagi, Pierre Deharo, Thomas Cuisset, Sripal Bangalore, Roxana Mehran, Gregg W. Stone, Shun Kohsaka, Deepak L. Bhatt
Summary: In patients with acute coronary syndrome, unguided de-escalation is associated with the lowest risk of major adverse cardiovascular events and major or minor bleeding outcomes, while short DAPT followed by P2Y12 inhibitor is associated with the lowest risk of major bleeding and all-cause death.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Peripheral Vascular Disease
Muhammad Haisum Maqsood, Franz H. Messerli, Adam H. Skolnick, Jonathan D. Newman, Jeffrey S. Berger, Sripal Bangalore
Summary: This study compared the efficacy of morning versus evening dosing of antihypertensive drugs and found that evening dosing significantly reduced ambulatory blood pressure parameters and cardiovascular events, but this effect was mainly driven by trials by the Hermida group. Therefore, the timing of antihypertensive drug administration should be chosen based on convenience and minimizing undesirable effects.
Article
Cardiac & Cardiovascular Systems
Zainali S. Chunawala, Melissa C. Caughey, Deepak L. Bhatt, Michael Hendrickson, Sameer Arora, Sripal Bangalore, John P. Erwin, Justin P. Levisay, Jonathan R. Rosenberg, Mark J. Ricciardi, Ron Blankstein, Kunihiro Matsushita, Sidney Smith, Arman Qamar
Summary: AMI is not rare among individuals without SMuRFs. The clinical characteristics and prognosis of SMuRFless individuals are not well described. Therefore, personalized prevention and treatment strategies need to be developed for this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Orly Leiva, Eugene Yuriditsky, Radu Postelnicu, Eric H. Yang, Vikramjit Mukherjee, Allison Greco, James Horowitz, Carlos Alviar, Sripal Bangalore
Summary: Among cancer patients with intermediate or high-risk PE, treatment with CBT was associated with a lower risk of in-hospital death or cardiac arrest but a higher risk of bleeding.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
