Article
Cardiac & Cardiovascular Systems
Yunlong Lu, Zhen Wang, Marios K. Georgakis, Hefeng Lin, Liangrong Zheng
Summary: The genetic liability to depression is associated with higher risks of coronary artery disease (CAD) and myocardial infarction, partly mediated by type 2 diabetes mellitus and smoking.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Veronika A. Myasoedova, Stefano Genovese, Laura Cavallotti, Alice Bonomi, Mattia Chiesa, Jeness Campodonico, Maurizio Rondinelli, Nicola Cosentino, Damiano Baldassarre, Fabrizio Veglia, Mauro Pepi, Francesco Alamanni, Gualtiero Colombo, Giancarlo Marenzi, Paolo Poggio
Summary: The study found that AVSc is frequently detected in high-risk CAD patients and is associated with long-term mortality. AVSc may be an underestimated marker of systemic cardiovascular risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Giulia Magnani, Serena Bricoli, Maddalena Ardissino, Giuseppe Maglietta, Adam Nelson, Caterina Disisto, Patrizia Celli, Maurizio Ferrario, Umberto Canosi, Carlo Cernetti, Francesco Negri, Marco Tubaro, Carlo Berzuini, Chiara Manzalini, Gianfranco Ignone, Carlo Campana, Luigi Moschini, Elisabetta Ponte, Roberto Pozzi, Raffaela Fetiveau, Silvia Buratti, Elvezia Paraboschi, Rosanna Asselta, Andrea Botti, Domenico Tuttolomondo, Federico Barocelli, Andrea Biagi, Rosario Bonura, Tiziano Moccetti, Antonio Crocamo, Giorgio Benatti, Giorgia Paoli, Emilia Solinas, Elisabetta Moscarella, Paolo Calabr, Stefano Duga, Giampaolo Niccoli, Diego Ardissino
Summary: MINOCA is common in patients with early-onset MI, and although there is a lower rate of cardiovascular death, the long-term risk is not significantly different from that of patients with obstructive coronary artery disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Arnav Katira, Ravish Katira
Summary: Colchicine may play a key role in the prevention of cardiovascular events in patients with stable and unstable coronary artery disease, as it is associated with a reduction in the rate of myocardial infarction and other major cardiovascular outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Regitze Skals, Maria Lukacs Krogager, Emil Vincent R. Appel, Theresia M. Schnurr, Christian Theil Have, Gunnar Gislason, Henrik Enghusen Poulsen, Lars Kober, Thomas Engstrom, Steen Stender, Torben Hansen, Niels Grarup, Christina Ji-Young Lee, Charlotte Andersson, Christian Torp-Pedersen, Peter E. Weeke
Summary: Among patients referred for coronary angiography, only a strong genetic predisposition to insulin resistance was associated with risk of coronary artery disease and with a greater disease burden.
Article
Cardiac & Cardiovascular Systems
Ryan Wereski, Philip Adamson, Nur Shazlin Shek Daud, Michael McDermott, Caelan Taggart, Anda Bularga, Dorien M. Kimenai, Mathew T. H. Lowry, Chris Tuck, Atul Anand, David J. Lowe, Andrew R. Chapman, Nicholas L. Mills
Summary: The study aimed to evaluate the role of cardiac troponin testing in risk stratification of patients with chronic coronary artery disease. The results showed that higher levels of cardiac troponin were associated with an increased risk of myocardial infarction or cardiovascular death in patients with coronary artery disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Donald M. Lloyd-Jones, Cora E. Lewis, Pamela J. Schreiner, James M. Shikany, Stephen Sidney, Jared P. Reis
Summary: The CARDIA study began in 1985-1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 from 4 US communities. Over 35 years, CARDIA has contributed fundamentally to our understanding of cardiovascular health and disease, as well as associations between neighborhood environment, lifestyle behaviors, and biological risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Afrose Liaquat, Ameerdad Khan, Saeed Ullah Shah, Hania Iqbal, Safa Iqbal, Atif Iqbal Rana, Habib Ur Rahman
Summary: This study investigates the use of coronary artery calcium scoring (CACS) as a tool for coronary artery disease (CAD) risk stratification and its association with conventional cardiovascular risk factors. The results demonstrate a strong positive correlation between CACS and coronary artery stenosis, indicating the potential of CACS as a useful tool for CAD risk assessment.
Article
Multidisciplinary Sciences
Lin Sun, Lin Zhao, Kunqi Yang, Zuozhi Li, Yan Wang, Tianjie Wang, Man Wang, Yan Zeng, Xianliang Zhou, Weixian Yang
Summary: This study evaluates the potential predictive value of total bilirubin (TBIL) for one-year prognosis in patients with coronary artery disease (CAD) and psoriasis. The results show that lower TBIL levels are associated with the severity of coronary artery calcification, and patients with lower TBIL levels have a significantly higher incidence of major adverse cardiac and cerebrovascular events (MACCEs) in one-year follow-up.
Article
Hematology
An Young, Mariana Garcia, Samaah M. Sullivan, Chang Liu, Kasra Moazzami, Yi-An Ko, Amit J. Shah, Jeong Hwan Kim, Brad Pearce, Irina Uphoff, J. Douglas Bremner, Paolo Raggi, Arshed Quyyumi, Viola Vaccarino
Summary: The study found that peripheral microvascular dysfunction is associated with an increased risk of major adverse cardiovascular events (MACE) in patients with stable coronary artery disease (CAD), suggesting the role of microvascular disease in the adverse outcomes of CAD patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Diana N. Vikulova, Mark Trinder, G. B. John Mancini, Simon N. Pimstone, Liam R. Brunham
Summary: This study assessed the prevalence of FH, FCHL, and elevated Lp(a) in patients with premature CAD and their impact on treatment and achievement of lipid targets. The results showed that these conditions are common in patients with premature CAD and have differing impacts on individualized management and achievement of lipid targets.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ibrahim Al-Sawalha, Dalia Alzoubi
Summary: Coronary artery calcium score (CACs) is a method for measuring calcification in coronary arteries using a computed tomography scan, which can predict myocardial infarction. However, neglecting ethnicity in the study may affect the findings.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Engineering, Biomedical
Bilge Han Tozlu, Cemaleddin Simsek, Onder Aydemir, Yusuf Karavelioglu
Summary: Electronic noses are devices that can detect the presence of chemicals in odors through gas sensors. Research shows that using an electronic nose to analyze exhaled breath can accurately diagnose myocardial infarction and stable coronary artery disease.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Medicine, General & Internal
Iain S. Forrest, Ben O. Petrazzini, Aine Duffy, Joshua K. Park, Carla Marquez-Luna, Daniel M. Jordan, Ghislain Rocheleau, Judy H. Cho, Robert S. Rosenson, Jagat Narula, Girish N. Nadkarni, Ron Do
Summary: This study developed and validated a machine learning-based predictive marker for coronary artery disease, which can quantitatively measure atherosclerosis and risk of death, as well as identify undiagnosed individuals.
Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Article
Biochemistry & Molecular Biology
Shuo-Ming Ou, Ming-Tsun Tsai, Huan-Yuan Chen, Fu-An Li, Kuo-Hua Lee, Wei-Cheng Tseng, Fu-Pang Chang, Yao-Ping Lin, Ruey-Bing Yang, Der-Cherng Tarng
Summary: Plasma galectin-3 is associated with organ fibrosis, and this study explored the potential of urinary galectin-3 as a biomarker for kidney disease progression. Patients with higher urinary galectin-3 levels had lower eGFRs and higher proteinuria levels. Higher levels of urinary galectin-3 were also associated with more severe renal fibrosis. The study suggests that urinary galectin-3 levels may be useful for identifying patients at high risk of kidney disease progression and renal fibrosis.
Article
Cardiac & Cardiovascular Systems
Shuo-Ming Ou, Chieh-Ju Chao, Ming-Tsun Tsai, Kuo-Hua Lee, Wei-Cheng Tseng, Pin-Jie Bin, Yao-Ping Lin, Chien-Yi Hsu, Der-Cherng Tarng
Summary: Heart failure is prevalent in patients with chronic kidney disease (CKD), and its impact on renal function and long-term outcomes in different subtypes of heart failure remains uncertain. This study found that heart failure is associated with worse clinical outcomes, and patients with HFrEF have the highest risk.
Article
Dermatology
Yu-Wen Chen, Yi-Ling Chang, Chun-Ying Wu, Yi-Ju Chen
JOURNAL OF DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Ching-Chi Chi, Yen-Wen Wu, Ting-Hsing Chao, Chih-Chiang Chen, Yi-Ju Chen, Hao-Min Cheng, Hsien-Yi Chiu, Yu-Wei Chiu, Wen-Hung Chung, Tsu-Yi Hsieh, Po-Hsun Huang, Yu-Huei Huang, Shang-Hung Lin, Tsung-Hsien Lin, Kwo-Chang Ueng, Chun-Chieh Wang, Yu-Chen Wang, Nan-Lin Wu, Charles Jia-Yin Hou, Tsen-Fang Tsai
Summary: Psoriatic disease, a chronic inflammatory disorder with skin and joint manifestations, is associated with an increased risk of cardiovascular diseases due to the shared pathogenic mechanisms between psoriatic and CV diseases. Therefore, attention to cardiovascular comorbidities is crucial in the management of psoriasis, particularly in screening, primary prevention, and treatment selection. The collaboration between dermatology, cardiology, and rheumatology experts has led to consensus expert recommendations for the management of patients with psoriatic disease with a focus on CV comorbidities.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Hsiao-Tien Liu, Chia-Yu Lai, Jian-Jhou Liao, Yi-Ju Chen, Shao-Bin Cheng, Cheng-Chung Wu
Summary: This retrospective study aimed to investigate the benefit of postoperative parenteral anticoagulation in patients with acute mesenteric ischemia and bowel gangrene who underwent intestinal resection. The results showed that immediate postoperative parenteral anticoagulant therapy was associated with lower 30-day mortality and higher 2-year survival rate.
BMC GASTROENTEROLOGY
(2023)
Article
Mathematical & Computational Biology
Shuo-Ming Ou, Ming-Tsun Tsai, Kuo-Hua Lee, Wei-Cheng Tseng, Chih-Yu Yang, Tz-Heng Chen, Pin-Jie Bin, Tzeng-Ji Chen, Yao-Ping Lin, Wayne Huey-Herng Sheu, Yuan-Chia Chu, Der-Cherng Tarng
Summary: This study aimed to develop predictive models for the risk of developing ESRD in newly diagnosed T2DM patients using machine learning. XGBoost was found to be the best model with high discriminative ability. These models can be used as risk assessment tools for clinical decision-making and early intervention strategies.
Article
Pediatrics
Chun-Ying Wu, Li -Lin Liang, Hsiu J. Ho, Chen-Te Hsu, Hsiu-Tao Hsu, Chon-Kit Ao, Chen-Yi Wu, Yi-Hsian Lin, Yi-Fang Chuang, Yao-Chun Hsu, Yi-Ju Chen, Siew C. Ng
Summary: This study investigated the association between physical fitness and the risk of inflammatory bowel disease (IBD) among children and adolescents in Taiwan. The results showed that better cardiorespiratory endurance was inversely associated with IBD risk, while other measures of physical fitness were not independently associated with IBD risk.
Article
Biochemistry & Molecular Biology
Ya-Chu Hsieh, Yuan-Chang Dai, Kur-Ta Cheng, Wei-Ting Yang, Modukuri V. Ramani, Gottumukkala V. Subbaraju, Yi-Ju Chen, Chia-Che Chang
Summary: Colorectal cancer (CRC) is the third most prevalent human cancer globally, and current chemotherapy has limited effectiveness. This study found that Dehydroxyhispolon methyl ether (DHME) has a strong cytotoxic effect on CRC cells while being less toxic to normal colon epithelial cells. DHME induces CRC cell apoptosis by blocking the SRC/STAT3/BCL-2 axis, suggesting its potential as a CRC chemotherapy agent.
Article
Medicine, General & Internal
Teng-Yu Lee, Yao-Chun Hsu, Hsiu J. Ho, Jaw-Town Lin, Yi-Ju Chen, Chun-Ying Wu
Summary: Aspirin therapy is significantly associated with a reduced risk of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients.
Article
Pediatrics
Chun-Ying Wu, Li-Lin Liang, Hsiu J. Ho, Chen-Te Hsu, Hsiu-Tao Hsu, Chon-Kit Ao, Chen-Yi Wu, Yi-Hsian Lin, Yi-Fang Chuang, Yao-Chun Hsu, Yi-Ju Chen, Siew C. Ng
Summary: This study investigated the association between physical fitness and the risk of inflammatory bowel disease (IBD) among children and adolescents in Taiwan. The results showed that better cardiorespiratory endurance (CE) was inversely associated with IBD risk, while musculoskeletal endurance (ME), musculoskeletal power (MP), and flexibility fitness (FF) were not independently associated with IBD risk. This study provides valuable insights for further exploring the mechanisms underlying this relationship.
Article
Medical Laboratory Technology
Ming-Tsun Tsai, Ruey-Bing Yang, Shuo-Ming Ou, Wei-Cheng Tseng, Kuo-Hua Lee, Chih-Yu Yang, Fu -Pang Chang, Der-Cherng Tarng
Summary: Plasma galectin-9 levels are associated with varying stages of chronic kidney disease (CKD), and high levels are correlated with older age, decreased renal function, increased proteinuria, and greater interstitial fibrosis. In renal tissue, galectin-9 expression is positively correlated with plasma galectin-9 levels and is mainly expressed in macrophages.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Review
Dermatology
Yu-Ching Weng, Yi-Ju Chen
Summary: This systematic review explores the role of skin microbiota in acne vulgaris, skin aging, and rosacea, and identifies potential therapeutic targets. However, further research is needed to understand the mechanisms of microbial interaction in these diseases.
DERMATOLOGICA SINICA
(2022)
Article
Immunology
Teng-Li Lin, Yi-Hsuan Fan, Yi-Ling Chang, Hsiu J. Ho, Li-Lin Liang, Yi-Ju Chen, Chun-Ying Wu
Summary: Early-life antibiotic exposure is associated with the occurrence of varicella and breakthrough infections, regardless of vaccine administration. The use of certain antibiotics during infancy is positively correlated with the incidence of varicella.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Allergy
Teng-Li Lin, Chun-Ying Wu, Yi-Ju Chen
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
