期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 38, 页码 21295-21304出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b05619
关键词
mechanized silica nanoparticles; multimodal controlled release; supramolecular nanovalves; acid-cleavable; voltage stimulation
资金
- Fundamental Research Funds for the Central Universities [30915011312, 2013-ZiJin-0102]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The major challenges of current drug delivery systems for combination chemotherapy focus on how to efficiently transport drugs to target sites and release multiple drugs in a programmed manner. Herein, we report a novel multidrug delivery system, MSNPs 1, based on mechanized silica nanopartides, which were constructed through functionalization of mesoporous silica nanopartides with the acid-cleavable intermediate linkages and the monoferrocene functionalized beta-cyclodextrin (Fc-beta-CD) as supramolecular nanovalves. MSNPs 1 achieved zero premature release in the physiological pH solution and realized two different release modalities. In modality 1, MSNPs 1 released the encapsulated drugs gemcitabine (GEM) and doxorubicin (DOX) in sequence when they were successively applied to voltage and acid stimuli. The release time and dosage of GEM were precisely controlled via external voltage. The subsequent acid-triggered release of DOX was attributed to breakage of the intermediate linkages containing ketal groups. Modality 2 is the concurrent release of these two drugs directly upon acid exposure. Furthermore, the cell viability experiments demonstrated that MSNPs 1 had an improved cytotoxicity to MCF7 cells in comparison with single DOX- or GEM-loaded mechanized silica nanopartides. We envisage that MSNPs 1 will play an important role in research and development for a new generation of controlled-release drug delivery system.
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