Article
Clinical Neurology
Iris A. M. Huijben, Ruud J. G. van Sloun, Bertram Hoondert, Sylvie Dujardin, Angelique Pijpers, Sebastiaan Overeem, Merel M. van Gilst
Summary: Non-rapid eye movement parasomnia disorders, characterized by abnormal nocturnal behaviours, have been studied to understand the timing and probability of awakenings from slow-wave sleep. Patients with these disorders have a higher probability of waking up after a bout of slow-wave sleep, and this probability increases with the duration of the bout. The occurrence of behavioural episodes reduces over sleep cycles, and there is a difference in the duration of slow-wave sleep prior to behavioural and non-behavioural awakenings in patients.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Peripheral Vascular Disease
Rong Ren, Ye Zhang, Linghui Yang, Yuan Shi, Naima Covassin, Xiangdong Tang
Summary: This study aimed to quantify the independent association between arousals during REM/NREM sleep and prevalent hypertension. The results showed a significant dose-response relationship between arousal index during REM sleep and hypertension, while arousal index during NREM sleep was not a significant predictor of hypertension.
JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Luc Masset, Milan Nigam, Anne Ladarre, Marie Vidailhet, Smaranda Leu-Semenescu, Philippe Fossati, Isabelle Arnulf, Jean-Baptiste Maranci
Summary: Dreams during REM sleep can help reduce negative emotions, as shown by the study on emotional dynamics. Previous studies were limited to dream reports, but by studying individuals with REM sleep behavior disorder (RBD), researchers gained direct access to observe emotional dream behaviors. Analysis of 17 participants with RBD and 39.7 hours of REM sleep video revealed that emotional behaviors follow a biphasic temporal course, with an initial increase in frequency followed by a progressive decrease. Negative emotional behaviors occurred earlier than positive and neutral behaviors, and rapid succession of emotions of opposite valence was observed to prevent prolonged periods of negative emotions.
Article
Clinical Neurology
Sara M. Pani, Matteo Fraschini, Michela Figorilli, Ludovica Tamburrino, Raffaele Ferri, Monica Puligheddu
Summary: Research focused on subjects with sleep-related hypermotor epilepsy and non-rapid eye movement parasomnias revealed significant differences in the relative power of the gamma frequency band and the slope of the aperiodic component of the EEG signal between the two groups. This suggests that these measures may be helpful in distinguishing between individuals with different sleep-related disorders.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Multidisciplinary Sciences
Daniela C. Robler, Kris Kim, Massimo De Agro, Alex Jordan, C. Giovanni Galizia, Paul S. Shamble
Summary: This study demonstrates the presence of REM sleep-like state in a terrestrial invertebrate, the jumping spider. The spider exhibits periodic bouts of retinal movements, limb twitching, and leg curling behaviors during nocturnal resting. These findings challenge our understanding of REM sleep and provide insights into the visual brain and the origin, evolution, and function of REM sleep.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Geography
AbdouMaliq Simone
Summary: This article examines the emergence of collective identity through mutual witnessing and the coordination of heterogeneities in public space, based on Michael Sorkin's expansive concept. It focuses on the relays between the Tanah Tinggi district in Jakarta and the estates in Hackney and East London, exploring the challenges and instabilities of this collective identity, particularly in the context of a pandemic. Instead of viewing it as a matter of settlement, the relays offer an opportunity to conceptualize collective life in motion as an ongoing exploration of the public domain.
Article
Multidisciplinary Sciences
Charles W. Dickey, Ilya A. Verzhbinsky, Xi Jiang, Burke Q. Rosen, Sophie Kajfez, Brittany Stedelin, Jerry J. Shih, Sharona Ben-Haim, Ahmed M. Raslan, Emad N. Eskandar, Jorge Gonzalez-Martinez, Sydney S. Cash, Eric Halgren
Summary: Declarative memory encoding, consolidation, and retrieval require the integration of elements encoded in widespread cortical locations. The mechanism whereby such binding of different components of mental events into unified representations occurs is unknown. This study found that brief high-frequency oscillations, known as ripples, occur in different brain areas and play a crucial role in memory recall and consolidation. These ripples phase-lock, co-occur, and show high-frequency correlations between widely distributed cortical locations, even between hemispheres. The findings suggest that cortical ripple co-occurrence and phase synchrony are essential for memory retrieval and potentially cognitive processes in general.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Pao-Huan Chen, Cheng-Chih Chung, Shuen-Hsin Liu, Yu-Hsun Kao, Yi-Jen Chen
Summary: Lithium treatment can improve cardiac dysfunction caused by REM sleep deprivation and alleviate fibrosis. The potential mechanisms may involve the regulation of TGF-β, angiotensin II, and Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Marcus O. Harrington, Jennifer E. Ashton, Hong-Viet V. Ngo, Scott A. Cairney
Summary: This study manipulated theta activity during sleep using auditory closed-loop stimulation, showing that stimulation led to a short-term increase in theta power followed by a prolonged suppression, as well as an increase in beta power. These results highlight the potential of auditory stimulation in investigating REM sleep electrophysiology and its impact on behavior.
Article
Clinical Neurology
Ankur Singh, Stevie Williams, Angela Calabrese, Renata Riha
Summary: Previous studies have shown that rapid eye movement sleep without atonia can predict the risk of phenoconversion to neurodegenerative disease in patients with isolated rapid eye movement sleep behaviour disorder. This study aimed to determine the predictive value of different types of rapid eye movement sleep without atonia in patients with isolated rapid eye movement sleep behaviour disorder at the time of diagnosis.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Neurosciences
Han Qin, Ling Fu, Tingliang Jian, Wenjun Jin, Mengru Liang, Jin Li, Qianwei Chen, Xinyu Yang, Haoran Du, Xiang Liao, Kuan Zhang, Rui Wang, Shanshan Liang, Jiwei Yao, Bo Hu, Shuancheng Ren, Chunqing Zhang, Yanjiang Wang, Zhian Hu, Hongbo Jia, Arthur Konnerth, Xiaowei Chen
Summary: The hippocampal CA2 region is crucial for social memory, and sleep plays a vital role in the consolidation of social memory. Research has shown that hypothalamic neurons projecting to CA2 are highly active during REM sleep and silencing these neurons disrupts social memory consolidation.
Article
Neurosciences
Jiso Hong, David E. Lozano, Kevin T. Beier, Shinjae Chung, Franz Weber
Summary: This study reveals the important role of the medial prefrontal cortex (mPFC) in promoting REM sleep through its projections to the lateral hypothalamus. It demonstrates that cortical neurons can trigger REM sleep and regulate phasic events during this sleep stage.
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Cole D. Stang, Aidan F. Mullan, Mania Hajeb, Emanuele Camerucci, Pierpaolo Turcano, Peter Martin, Michelle M. Mielke, Keith A. Josephs, James H. Bower, Erik K. St Louis, Bradley F. Boeve, Rodolfo Savica
Summary: The study revealed that the prevalence of rapid eye movement (REM) sleep behavior disorder (RBD) increased over time in patients with alpha-synucleinopathies, with higher likelihood of developing RBD in male patients. However, RBD did not increase mortality risk within the cohort.
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Catherine Falla, Alan Young, Alun Pope, Denise M. O'Driscoll
Summary: Respiratory events during REM sleep are significantly associated with morning hypertensive blood pressure, while the relationship with evening hypertensive blood pressure is not significant. Age and BMI are independent factors influencing morning hypertension.
Review
Multidisciplinary Sciences
Zhiqiang Que, Cuifeng Zheng, Zhenhua Zhao, Yanhong Weng, Zhibao Zhu, Yuqi Zeng, Qinyong Ye, Fabin Lin, Guoen Cai
Summary: Clonazepam and melatonin are effective medications for RBD, with clonazepam improving sleep stage and melatonin improving sleep efficiency and quality. Ramelteon can reduce RWA, and pramipexole can increase total sleep time and reduce PLMS index. Pramipexole also has different effects on different types of RBD.
Article
Clinical Neurology
Benjamin S. Aribisala, Renata L. Riha, Maria Valdes Hernandez, Susana Munoz Maniega, Simon Cox, Ratko Radakovic, Adele Taylor, Alison Pattie, Janie Corley, Paul Redmond, Mark E. Bastin, John Starr, Ian Deary, Joanna M. Wardlaw
Article
Clinical Neurology
Elizabeth A. Hill, Donna M. Fairley, Ewan McConnell, Ian Morrison, Marta Celmina, Serafeim-Chrysovalantis Kotoulas, Renata L. Riha
Article
Clinical Neurology
C. L. A. Bassetti, W. Randerath, L. Vignatelli, L. Ferini-Strambi, A. -K. Brill, M. R. Bonsignore, L. Grote, P. Jennum, D. Leys, J. Minnerup, L. Nobili, T. Tonia, R. Morgan, J. Kerry, R. Riha, W. T. McNicholas, V. Papavasileiou
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Respiratory System
Maria R. Bonsignore, Winfried Randerath, Sofia Schiza, Johan Verbraecken, Mark W. Elliott, Renata Riha, Ferran Barbe, Izolde Bouloukaki, Alessandra Castrogiovanni, Oana Deleanu, Marta Goncalves, Damien Leger, Oreste Marrone, Thomas Penzel, Silke Ryan, Dan Smyth, Joaquin Teran-Santos, Cecilia Turino, Walter T. McNicholas
Summary: This report evaluates the epidemiology of motor vehicle accidents in patients with obstructive sleep apnoea, the mechanisms involved, the role of evaluating sleepiness and impaired vigilance through screening questionnaires, driving simulators and other techniques, as well as the impact of treatment on accident risk in affected drivers, highlighting evidence gaps in identifying OSA patients at risk of accidents.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Clinical Neurology
Renata L. Riha, Serafeim-Chrysovalantis Kotoulas, Athanasia Pataka, John Arthur Kvamme, Pavol Joppa, Jan Hedner
Summary: The study compared the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between OSA patients who had undergone tonsillectomy and those who had not. Patients who had undergone tonsillectomy presented with less severe OSA at the time of diagnosis, and had a lower prevalence of Type II diabetes mellitus and cardiovascular co-morbidities.
Review
Health Care Sciences & Services
Serafeim-Chrysovalantis Kotoulas, Paraskevi Katsaounou, Renata Riha, Ioanna Grigoriou, Despoina Papakosta, Dionysios Spyratos, Konstantinos Porpodis, Kalliopi Domvri, Athanasia Pataka
Summary: Research suggests that many EC compounds may contribute to the pathogenesis of asthma, therefore, asthmatic patients should avoid using electronic cigarettes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Respiratory System
Renata L. Riha
Summary: OSAS, as one of the most prevalent medical conditions in industrialized societies, has seen variations in its definition and difficulties in standardization, leading to uncertainties in the assessment of its severity and prevalence in clinical research settings. Efforts in precision medicine have focused on the pathophysiology of obstructed breathing during sleep, but less attention has been paid to the relationship between obstructed breathing and diurnal symptoms integral to the definition of OSAS.
Editorial Material
Respiratory System
Jason Weatherald, Renata L. Riha, Marc Humbert
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Developmental Biology
Emma C. Johns, Daniel L. Halligan, Triin Tammsalu, Elizabeth A. Hill, Renata L. Riha, Fiona C. Denison, Rebecca M. Reynolds
Summary: This study compared the gene expression differences in placenta between obese women with and without OSA. The study found downregulation of genes involved in O-linked glycosylation and Wnt signaling pathways in OSA placentae. Additionally, gene set enrichment analysis revealed an increase in genes related to the reversible hydration of carbon dioxide in OSA placentae, which may contribute to adverse pregnancy outcomes in women with OSA.
Review
Clinical Neurology
Kelsea Stewart, Nicholas Shakarishvili, Adriana Michalak, Emily L. Maschauer, Natalie Jenkins, Renata L. Riha
Summary: Traumatic brain injury (TBI) can cause sleep disturbances, and addressing these problems can have noticeable benefits, such as reducing the expression of inflammatory genes and alleviating other issues related to brain injury. However, the current evidence for interventions is limited, and further research is recommended.
SLEEP MEDICINE REVIEWS
(2022)
Article
Clinical Neurology
Manpreet Nijjar, Serafeim-Chrysovalantis Kotoulas, Jan Kerr, Renata L. Riha
Summary: This study compares individuals with floppy eyelid syndrome (FES) to individuals suspected of having obstructive sleep apnea (OSA) without FES, and finds that FES patients have a higher prevalence of comorbidities related to matrix metalloproteinase dysfunction, and significant improvement in daytime hypersomnolence with continuous positive airway pressure (CPAP) treatment.
SLEEP AND BREATHING
(2023)
Article
Respiratory System
Renata L. Riha, Marta Celmina, Brendan Cooper, Refika Hamutcu-Ersu, Athanasios Kaditis, Andrew Morley, Athanasia Pataka, Thomas Penzel, Luca Roberti, Warren Ruehland, Dries Testelmans, Annelies van Eyck, Gert Grundstroem, Johan Verbraecken, Winfried Randerath
Summary: For over three decades, type III devices have been used to diagnose sleep disordered breathing. While they are satisfactory in detecting obstructive and central sleep apnoea in populations with moderately high risk of symptoms, these devices lack standardization and can vary greatly in technical specifications. This technical standard summarizes type III studies published since 2007, aiming to provide a framework for considering the limitations and improving the use of these devices in the diagnosis of sleep disordered breathing.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Clinical Neurology
Ankur Singh, Stevie Williams, Angela Calabrese, Renata Riha
Summary: Previous studies have shown that rapid eye movement sleep without atonia can predict the risk of phenoconversion to neurodegenerative disease in patients with isolated rapid eye movement sleep behaviour disorder. This study aimed to determine the predictive value of different types of rapid eye movement sleep without atonia in patients with isolated rapid eye movement sleep behaviour disorder at the time of diagnosis.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Renata L. Riha, Sophie Dodds, Serafeim - Chrysovalantis Kotoulas, Ian Morrison
Summary: Sexualised behaviour in sleep (SBS) is a relatively rare parasomnia characterized by instinctive sexual behaviors during non-rapid-eye movement (NREM) sleep. This study aims to further understand the clinical features and onset of SBS, as well as its relationship with psychiatric co-morbidity, other sleep disorders, and adverse early life experiences. The study compared SBS patients with other NREM parasomnia patients to identify any distinguishing features.
Article
Clinical Neurology
Cara Walsh, Lee Mitchell, Maria Hrozanova, Serafeim-Chrysovalantis Kotoulas, Christopher Derry, Ian Morrison, Renata L. Riha
Summary: This study found differences in the phenotypes of childhood, adolescent, and adult-onset NREM parasomnias. Childhood and adolescent-onset groups were more likely to have a family history of NREM disorders, a wider range of NREM disorders, and a history of sleep-talking. Childhood-onset group had a higher prevalence of atopy and were more likely to arouse from N3 sleep. Adult-onset group had a higher comorbidity with psychiatric disorders. Childhood and adolescent-onset groups were more likely to have a history of trauma coinciding with the onset of NREM behaviors.
