Article
Gastroenterology & Hepatology
Edward H. Tsoi, Puneet Mahindra, Georgina Cameron, Richard Williams, Richard Norris, Paul Desmond, Spiro Raftopoulos, Darren Pavey, Arti Rattan, Luke F. Hourigan, Richard Lee, Michael J. Bourke, Naaz Sidhu, Rajvinder Singh, Andrew Chan, Sudarshan Krishnamurthi, Andrew C. F. Taylor
Summary: This study aimed to determine the proportion of prevalent HGD or EAC detected in Barrett's esophagus (BE) patients referred from the community with a recent diagnosis of low-grade dysplasia (LGD). The results showed that BERU assessment endoscopy identified more visible lesions than community referral endoscopy and identified HGD or EAC in 27% of patients referred from the community with a recent diagnosis of LGD. Reported progression rates from LGD to HGD or EAC may be overestimated.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Francesco Maione, Alessia Chini, Rosa Maione, Michele Manigrasso, Alessandra Marello, Gianluca Cassese, Nicola Gennarelli, Marco Milone, Giovanni Domenico De Palma
Summary: Barrett's Esophagus is a common condition associated with chronic gastroesophageal reflux disease and has a higher risk of developing esophageal adenocarcinoma. Low and high-grade dysplasia precede neoplastic transformation in this condition. The evaluation of low-grade dysplastic esophageal mucosa is still controversial, but endoscopic surveillance and minimally invasive endoscopic treatments such as endoscopic mucosal resection and radiofrequency ablation are available options. Cryotherapy ablation and argon plasma coagulation are novel endoscopic treatments with high eradication rates and fewer complications and post-procedural pain.
Article
Surgery
Jenifer Barrie, Fady Yanni, Mohamed Sherif, Asha K. Dube, Anand P. Tamhankar
Summary: The study found that nearly 20% of dysplasia in BE occurs in BE < 1 cm, and over 40% occurs in BE < 3 cm. Similarly, approximately 20% of EAC occurs within 1 cm of GEJ and 40% within 3 cm. The majority of dysplasia diagnosed within 3 cm of the GEJ is found on index endoscopy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Mamoru Tokunaga, Kenichiro Okimoto, Naoki Akizue, Kentaro Ishikawa, Yosuke Hirotsu, Kenji Amemiya, Masayuki Ota, Keisuke Matsusaka, Motoi Nishimura, Kazuyuki Matsushita, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Tetsuhiro Chiba, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Jun-ichiro Ikeda, Masao Omata, Naoya Kato
Summary: This study investigated the genetic characteristics of nondysplastic Barrett's esophagus (NDBE) to early esophageal adenocarcinoma (EAC) in the Japanese population. The results showed that the genetic variants of TP53 in Japanese early EAC were similar to those in western countries, and TP53 putative drivers were even detected in Japanese patients with nondysplastic short-segment Barrett's esophagus, indicating a potential higher risk of progression. Proper follow-ups may be necessary for patients with short-segment Barrett's esophagus to monitor the risk of progression to high-grade dysplasia or EAC.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yue Chen, Chenyu Sun, Yile Wu, Xin Chen, Sujatha Kailas, Zeid Karadsheh, Guangyuan Li, Zhichun Guo, Hongru Yang, Lei Hu, Qin Zhou
Summary: The use of PPI is negatively associated with the risk of progression to HGD/EAC in BE patients, and the risk of HGD/EAC can be reduced with the prolonged use of PPI. Sensitivity analysis showed the stable results of this meta-analysis, and no publication bias was detected.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Robert D. Odze, John Goldblum, Vivek Kaul
Summary: Barrett's esophagus (BE) is a premalignant condition that can be effectively monitored and managed using the Wide-area transepithelial sampling with computer-assisted three-dimensional analysis (WATS(3D)) technique, which has shown to significantly increase detection rates of dysplasia and intestinal metaplasia in BE patients.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Blake Jones, J. Lucas Williams, Srinadh Komanduri, V. Raman Muthusamy, Nicholas J. Shaheen, Sachin Wani
Summary: Black patients with Barrett's esophagus have lower diagnosis rates, are less likely to be recommended appropriate surveillance intervals, and are less likely to follow the Seattle biopsy protocol compared to white patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Yizi Wang, Bin Ma, Shize Yang, Wenya Li, Peiwen Li
Summary: Radiofrequency ablation (RFA) reduces the risk of progression from low-grade dysplasia (BE-LGD) to high-grade dysplasia (BE-HGD). RFA treatment is associated with a higher rate of complete eradication of dysplasia and intestinal metaplasia, but also a slightly higher rate of adverse events.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Claire A. Beveridge, Chetan Mittal, V. Raman Muthusamy, Amit Rastogi, Vladimir Kushnir, Mariah Wood, Sachin Wani, Srinadh Komanduri
Summary: This study aimed to assess the rate of visible lesion (VL) detection by academic and community endoscopists using high-definition white-light endoscopy (HD-WLE) and narrow-band imaging (NBI). Participants identified VLs using HD-WLE and NBI, and the results showed that 28% and 31% of VLs were not identified using HD-WLE and NBI respectively. The study also found that the rate of VL detection was associated with the endoscopist's experience and the number of surveillance endoscopies performed each month.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Chengjiao Yao, Yilin Li, Lihong Luo, Qin Xiong, Xiaowu Zhong, Fengjiao Xie, Peimin Feng
Summary: The study identified differentially expressed miRNAs (DEMs) and genes (DEGs) between EAC and BE tissue samples, performed pathway and functional enrichment analysis, and identified enriched functions and pathways. Some hub genes, such as GART and TNFSF11, as well as highly connected miRNAs like hsa-miR-143 and hsa-miR-133b were determined. This research provides insights into the development mechanism of BE and EAC.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsin-Yu Fang, Stefan Stangl, Sabrina Marcazzan, Marcos J. Braz Carvalho, Theresa Baumeister, Akanksha Anand, Julia Strangmann, Julia Slotta Huspenina, Timothy C. Wang, Roland M. Schmid, Marcus Feith, Helmut Friess, Vasilis Ntziachristos, Gabriele Multhoff, Dimitris Gorpas, Michael Quante
Summary: This study evaluated the use of a highly specific Hsp70-specific contrast agent in guided fluorescence molecular endoscopy biopsy, showing promising potential to improve tumor surveillance in BE patients, especially in cases with dysplasia and EAC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)