Review
Gastroenterology & Hepatology
Maxime Ronot, Pierre Nahon, Jordi Rimola
Summary: Current surveillance recommendations for hepatocellular carcinoma (HCC) involve semiannual liver ultrasound, but this method's sensitivity is suboptimal for early-stage tumors, particularly in obese patients. MRI has shown excellent detection rates for liver lesions, but full contrast-enhanced MRI is not feasible due to limited availability and cost. Abbreviated MRI (AMRI) involves acquiring a limited number of sequences and has shown potential benefits of reduced acquisition time and improved cost-effectiveness compared to conventional MRI. However, caution should be exercised when interpreting published studies, as most were retrospective and focused on specific populations. Direct comparison studies and the development of tailored strategies based on HCC risk factors and AMRI availability are still needed.
Article
Medicine, General & Internal
Mattias Lissing, Daphne Vassiliou, Ylva Floderus, Pauline Harper, Matteo Bottai, Marianna Kotopouli, Hannes Hagstrom, Eliane Sardh, Staffan Wahlin
Summary: This study confirmed a high risk of primary liver cancer in patients with acute hepatic porphyrias (AHP), particularly in those with clinical and biochemical activity of acute intermittent porphyria (AIP). Regular surveillance for primary liver cancer is recommended for patients older than 50 years with a history of active AIP.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Monika Zajkowska, Barbara Mroczko
Summary: The liver plays crucial functions in the human body, but it is susceptible to damage from various factors, leading to liver diseases such as primary liver cancer. Chemokines have been found to play a significant role in the development of liver cancer, making them useful in detecting and monitoring the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Critical Care Medicine
Iona Cheng, Juan Yang, Chiuchen Tseng, Jun Wu, Salma Shariff-Marco, Sung-Shim Lani Park, Shannon M. Conroy, Pushkar P. Inamdar, Scott Fruin, Timothy Larson, Veronica W. Setiawan, Mindy C. DeRouen, Scarlett Lin Gomez, Lynne R. Wilkens, Loic Le Marchand, Daniel O. Stram, Jonathan Samet, Beate Ritz, Anna H. Wu
Summary: The study found a positive association between traffic-related air pollution and lung cancer risk in racially, ethnically, and socioeconomically diverse populations, mainly among African American and Latino American groups. Residents in low socioeconomic status neighborhoods had an increased risk of lung cancer associated with nitrogen oxides, while no association was observed among those in high socioeconomic status neighborhoods.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Tali Shaltiel, Serena Zheng, Cleo Siderides, Elizabeth M. Gleeson, Jacquelyn Carr, Eric R. Pletcher, Noah A. Cohen, Benjamin J. Golas, Deepa R. Magge, Daniel M. Labow, Andrea D. Branch, Umut Sarpel
Summary: Black patients with HCV exposure develop HCC at earlier stages of liver disease with more aggressive tumor features. Nearly one-third of Black patients do not meet the common HCC screening criteria, suggesting a need to revise guidelines to be more inclusive. Further molecular studies are needed to characterize the biological properties of tumors in Black patients.
Article
Gastroenterology & Hepatology
Nicole J. Kim, Anne Cravero, Trang VoPham, Philip Vutien, Rotonya Carr, Rachel B. Issaka, Janet Johnston, Brian McMahon, Jorge Mera, George N. Ioannou
Summary: HCC is the most common form of primary liver cancer and the fastest rising cause of cancer-related death in the United States. It disproportionately affects racial and ethnic minorities in the country. A practical framework is needed to address the complex factors driving these disparities and guide future research initiatives towards health equity in HCC care.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Harriet Rumgay, Melina Arnold, Jacques Ferlay, Olufunmilayo Lesi, Citadel J. Cabasag, Jerome Vignat, Mathieu Laversanne, Katherine A. McGlynn, Isabelle Soerjomataram
Summary: The burden of liver cancer varies across the world, and it is a major cause of death in many countries. The number of liver cancer cases and deaths is predicted to increase, with a significant rise expected by 2040.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Harriet Rumgay, Jacques Ferlay, Catherine de Martel, Damien Georges, Amal Samy Ibrahim, Rongshou Zheng, Wenqiang Wei, Valery E. P. P. Lemmens, Isabelle Soerjomataram
Summary: This study provides worldwide, regional, and national estimates of the incidence of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). The results show that HCC contributes the largest burden of liver cancer globally, with the highest rates in Eastern Asia, Northern Africa, and Southeastern Asia. iCCA rates are highest in Southeastern Asia, Eastern Asia, Northern Europe, the Caribbean and Central America, and Oceania.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Maomao Cao, He Li, Dianqin Sun, Siyi He, Changfa Xia, Lin Lei, Ji Peng, Wanqing Chen
Summary: A user-friendly primary screening method was developed to estimate the 3-year absolute risk of liver cancer and identify extremely high-risk individuals among the population with HBV.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chenxi Li, Wen-Qiang He
Summary: This study aimed to compare estimates of primary liver cancer mortality from the World Health Organization (WHO), Global Burden Disease (GBD), and Global Cancer Observatory (GCO). The study found that while the age-standardized rates (ASR) of primary liver cancer mortality were comparable across the three data sources, the most similar estimates were found between WHO and GCO. Concerns were raised about the true patterns of liver cancer mortality in certain countries due to opposite trends between WHO and GBD in some cases.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Amit G. Singal, T. Tara Ghaziani, Neil Mehta, Kali Zhou, Lauren T. Grinspan, Jihane N. Benhammou, Andrew M. Moon, Ju Dong Yang, Reena Salgia, Anjana Pillai, Elizabeth Zheng, Nicole E. Rich, Purva Gopal, Prasun Jalal, Elizabeth Verna, Sruthi Yekkaluri, Samuel Phen, Jonathan Melendez-Torres, Omar Alshuwaykh, Hailey Choi, Kevin Junus, John Grady, Michael Song, Emily A. Leven, Jung Yum, Vrushab Gowda, Manaf Alsudaney, Perla Hernandez, Nirmal Desai, Neehar D. Parikh
Summary: There is a wide variation in recall patterns for patients with subcentimeter liver lesions on ultrasound. The low risk of primary liver cancer (PLC) in these patients supports short-interval ultrasound follow-up in 3-6 months, but high-risk subgroups may require diagnostic CT/MRI.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Swathi Eluri, Sumana Reddy, Corey C. Ketchem, Manaswita Tappata, Hanna G. Nettles, Ariel E. Watts, Cary C. Cotton, Evan S. Dellon, Nicholas J. Shaheen
Summary: This study found that only 39% of eligible patients for Barrett's esophagus screening underwent upper esophagogastroduodenoscopy (EGD), with most of the examinations being triggered by refractory symptoms. Improved dissemination and implementation of BE screening are needed.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Seyed Aria Nejadghaderi, Shahin Roshani, Esmaeil Mohammadi, Moein Yoosefi, Negar Rezaei, Zahra Esfahani, Sina Azadnajafabad, Naser Ahmadi, Sarvenaz Shahin, Ameneh Kazemi, Alireza Namazi Shabestari, Ardeshir Khosravi, Ali H. Mokdad, Bagher Larijani, Farshad Farzadfar
Summary: This study aimed to evaluate the inequity and healthcare quality regarding colorectal cancer (CRC) by sex and location using a comprehensive measure called the quality of care index (QCI). The study found heterogeneity in QCI between socio-demographic index (SDI) quintiles and highlighted the importance of paying attention to individuals aged over 75 years due to lower quality of care in this age group.
Article
Gastroenterology & Hepatology
Yuemin Nan, Xiaoyuan Xu, Shiming Dong, Ming Yang, Ling Li, Suxian Zhao, Zhongping Duan, Jidong Jia, Lai Wei, Hui Zhuang, Chinese Med Assoc
Summary: To prevent recurrence and improve the prognosis of primary liver cancer patients, the Chinese Society of Hepatology developed the Consensus on the Tertiary Prevention of Primary Liver Cancer, which provides current guidelines based on scientific advances to prevent recurrence, monitor, and diagnose primary liver cancer.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Lauren Bifulco, Daren R. Anderson, Mary L. Blankson, Veena Channamsetty, Jacquelyn W. Blaz, Tam T. Nguyen-Louie, Sarah Hudson Scholle
Summary: This study evaluated a 2-step process for chronic pain screening and follow-up in primary care, finding that this systematic screening method can help identify patients with previously undocumented chronic pain.
