Article
Cardiac & Cardiovascular Systems
Paloma Jorda, Laurens P. Bosman, Alessio Gasperetti, Andrea Mazzanti, Jean-Baptiste Gourraud, Brianna Davies, Tanja Charlotte Frederiksen, Zoraida Moreno Weidmann, Andrea Di Marco, Jason D. Roberts, Ciorsti MacIntyre, Colette Seifer, Antoine Deliniere, Wael Alqarawi, Deni Kukavica, Damien Minois, Alessandro Trancuccio, Marine Arnaud, Mattia Targetti, Annamaria Martino, Giada Oliviero, Daniel C. Pipilas, Corrado Carbucicchio, Paolo Compagnucci, Antonio Dello Russo, Iacopo Olivotto, Leonardo Calo, Steven A. Lubitz, Michael J. Cutler, Philippe Chevalier, Elena Arbelo, Silvia Giuliana Priori, Jeffrey S. Healey, Hugh Calkins, Michela Casella, Henrik Kjaerulf Jensen, Claudio Tondo, Rafik Tadros, Cynthia A. James, Andrew D. Krahn, Julia Cadrin-Tourigny
Summary: This study validated a 5-year risk prediction model for ARVC patients, demonstrating its superior performance in guiding ICD implantation decisions compared to other published guidelines and consensus statements. The findings support the use of this model for shared decision making in the primary prevention of SCD in ARVC patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Cadrin-Tourigny, Laurens P. Bosman, Anna Nozza, Weijia Wang, Rafik Tadros, Aditya Bhonsale, Mimount Bourfiss, Annik Fortier, Oyvind H. Lie, Ardan M. Saguner, Anneli Svensson, Antoine Andorin, Crystal Tichnell, Brittney Murray, Katja Zeppenfeld, Maarten P. van den Berg, Folkert W. Asselbergs, Arthur A. M. Wilde, Andrew D. Krahn, Mario Talajic, Lena Rivard, Stephen Chelko, Stefan L. Zimmerman, Ihab R. Kamel, Jane E. Crosson, Daniel P. Judge, Sing-Chien Yap, Jeroen F. van der Heijden, Harikrishna Tandri, Jan D. H. Jongbloed, Marie-Claude Guertin, J. Peter van Tintelen, Pyotr G. Platonov, Firat Duru, Kristina H. Haugaa, Paul Khairy, Richard N. W. Hauer, Hugh Calkins, Anneline S. J. M. te Riele, Cynthia A. James
Summary: We developed a prediction model for incident VA/SCD in ARVC patients using readily available clinical parameters, which accurately distinguished patients with and without events and showed superior clinical benefit compared to current ICD placement algorithms.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Sayed Al-Aidarous, Alexandros Protonotarios, Perry M. Elliott, Pier D. Lambiase
Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterized by myocardial fibrofatty replacement due to specific mutations, resulting in ventricular arrhythmias and sudden cardiac death. Treating this condition is challenging due to fibrosis progression, phenotypic variations, and limited clinical trials. While beta-blockers are theoretically effective, their efficacy in reducing arrhythmic risk is not strong. Emerging evidence suggests that combining flecainide and bisoprolol may be effective. Radiofrequency ablation and stereotactic radiotherapy show potential in disrupting ventricular circuits and modifying myocardial fibrosis. Future therapies, such as adenoviruses and GSk3b modulation, are still in early-stage research. Implantable cardioverter-defibrillator implantation reduces arrhythmic death but comes with risks.
Article
Cardiac & Cardiovascular Systems
Ishan Lakhani, Jiandong Zhou, Sharen Lee, Ka Hou Christien Li, Keith Sai Kit Leung, Jeremy Man Ho Hui, Yan Hiu Athena Lee, Guoliang Li, Tong Liu, Wing Tak Wong, Ian Chi Kei Wong, Ngai Shing Mok, Chloe Miu Mak, Qingpeng Zhang, Gary Tse
Summary: Clinical and electrocardiographic parameters are important for assessing prognosis in ARVC/D patients and can aid risk stratification in the hospital setting.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Makiko Nakamura, Teruhiko Imamura, Takuya Fukui, Naoya Kataoka, Koichiro Kinugawa
Summary: Myocarditis may have a profound pathophysiological association with arrhythmogenic right ventricular cardiomyopathy (ARVC).
Review
Cardiac & Cardiovascular Systems
Alessio Gasperetti, Cynthia A. James, Marina Cerrone, Mario Delmar, Hugh Calkins, Firat Duru
Summary: Physical exercise can influence the progression and arrhythmia risk of arrhythmogenic right ventricular cardiomyopathy (ARVC), guidelines currently recommend individuals with ARVC to avoid competitive or high-intensity endurance exercise, as exercise-induced physiological changes may mimic classic features of ARVC.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Chiara Cappelletto, Caterina Gregorio, Giulia Barbati, Simona Romani, Antonio De Luca, Marco Merlo, Luisa Mestroni, Davide Stolfo, Gianfranco Sinagra
Summary: The study found that in ARVC patients with long-term follow-up, only beta-blockers administered at >50% target dose were associated with lower risk of SCD/recurrent MVA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Nixiao Zhang, Chuangshi Wang, Alessio Gasperetti, Yanyan Song, Hongxia Niu, Min Gu, Firat Duru, Liang Chen, Shu Zhang, Wei Hua
Summary: The study validated the good fitness of the novel risk-prediction model in predicting arrhythmic risk in Asian ARVC patients for primary prevention, and for secondary prevention patients after recalibration of the baseline risk. The performance of the prediction model in secondary prevention patients was improved after recalibration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Y. Liu, J. Yu, J. Liu, B. Wu, Q. Cui, W. Shen, S. Xia
Summary: The meta-analysis suggests that late gadolinium enhancement (LGE) in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients is a significant predictor of all-cause mortality and major adverse cardiovascular events (MACE).
CLINICAL RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Rolland, Nicolas Badenco, Carole Maupain, Guillaume Duthoit, Xavier Waintraub, Mikael Laredo, Caroline Himbert, Robert Frank, Francoise Hidden-Lucet, Estelle Gandjbakhch
Summary: The combination of flecainide and beta-blockers is complementary in treating ventricular arrhythmias (VA) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), and it is safe and effective in reducing the burden of premature ventricular contractions and preventing sustained VA.
Article
Cardiac & Cardiovascular Systems
Shehab Anwer, Francesca Guastafierro, Ladina Erhart, Sarah Costa, Deniz Akdis, Manuel Schuermann, Sara Hosseini, Neria E. Winkler, Nazar Kuzo, Alessio Gasperetti, Corinna Brunckhorst, Firat Duru, Ardan M. Saguner, Felix C. Tanner
Summary: This study examines right atrial (RA) deformation in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) and its association with cardiovascular (CV) outcomes. The results show that ARVC patients exhibit impaired RA strain, and reservoir and pump strain are associated with an increased risk of CV events.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Bernard Belhassen, Mikael Laredo, Rob W. Roudijk, Giovanni Peretto, Guy Zahavi, Srijita Sen-Chowdhry, Nicolas Badenco, Anneline S. J. M. Te Riele, Simone Sala, Guillaume Duthoit, J. Peter van Tintelen, Gabriele Paglino, Jean-Marc Sellal, Alessio Gasperetti, Elena Arbelo, Antoine Andorin, Sandro Ninni, Anne Rollin, Petr Peichl, Xavier Waintraub, Laurens P. Bosman, Bertrand Pierre, Eyal Nof, Chris Miles, Jacob Tfelt-Hansen, Alexandros Protonotarios, Carla Giustetto, Frederic Sacher, Jean-Sylvain Hermida, Stepan Havranek, Leonardo Calo, Ruben Casado-Arroyo, Giulio Conte, Konstantinos P. Letsas, Esther Zorio, Francisco J. Bermudez-Jimenez, Elijah R. Behr, Roy Beinart, Laurent Fauchier, Josef Kautzner, Philippe Maury, Dominique Lacroix, Vincent Probst, Josep Brugada, Firat Duru, Christian de Chillou, Paolo Della Bella, Estelle Gandjbakhch, Richard Hauer, Anat Milman
Summary: The study found that RBBB-VT accounts for a significant proportion of sustained VTs in ACM patients. Sex and type of pathogenic mutations are associated with VT type, with female sex associated with LBBB + RBBB-VT and DSP mutation associated with RBBB-VT.
Article
Cardiac & Cardiovascular Systems
A. M. Saguner, D. Lunk, M. Mohsen, Sven Knecht, Deniz Akdis, S. Costa, A. Gasperetti, F. Duru, V. A. Rossi, C. B. Brunckhorst
Summary: This study investigated the use of contact-force sensing catheters (CFSC) in endocardial electroanatomical mapping (EAM) to diagnose arrhythmogenic right ventricular cardiomyopathy (ARVC). The results showed that ARVC patients had lower RV voltage amplitudes compared to controls, particularly in the subtricuspid region and RV apex. EAM using CFSC was found to be a promising tool for diagnosing ARVC.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Laurens P. Bosman, Claire L. Nielsen Gerlach, Julia Cadrin-Tourigny, Gabriela Orgeron, Crystal Tichnell, Brittney Murray, Mimount Bourfiss, Jeroen F. van der Heijden, Sing-Chien Yap, Katja Zeppenfeld, Maarten P. van den Berg, Arthur A. M. Wilde, Folkert W. Asselbergs, Hariskrishna Tandri, Hugh Calkins, J. Peter van Tintelen, Cynthia A. James, Anneline S. J. M. te Riele
Summary: This study aimed to validate and compare the performance of four different algorithms in ARVC patients. The ITFC and mITFC algorithms showed higher sensitivity and protection rates, while the AHA and HRS algorithms reduced unnecessary ICD placements.
Article
Genetics & Heredity
Jia Chen, Yuting Ma, Hong Li, Zhuo Lin, Zhe Yang, Qin Zhang, Feng Wang, Yanping Lin, Zebing Ye, Yubi Lin
Summary: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a condition associated with ventricular arrhythmia, heart failure, and sudden death. Thromboembolism is also a serious complication of ARVC/D. This study identified a Chinese Han family with ARVC/D and characterized their genetic mutations. The LMNA and LAMA4 gene variants were found to be potentially pathogenic and associated with the manifestation of ARVC/D and related symptoms.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Bradley S. Marino, David J. Goldberg, Adam L. Dorfman, Eileen King, Heidi Kalkwarf, Babette S. Zemel, Margaret Smith, Jesse Pratt, Mark A. Fogel, Amanda J. Shillingford, Barbara J. Deal, Anitha S. John, Caren S. Goldberg, Timothy M. Hoffman, Marshall L. Jacobs, Asher Lisec, Susan Finan, Lazaros K. Kochilas, Thomas W. Pawlowski, Kathleen Campbell, Clinton Joiner, Stuart L. Goldstein, Paul Stephens, Alvin J. Chin
CARDIOLOGY IN THE YOUNG
(2017)
Editorial Material
Genetics & Heredity
Joseph T. C. Shieh, John L. Jefferies, Alvin J. Chin
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
(2013)
Article
Cardiac & Cardiovascular Systems
Lazaros K. Kochilas, Charles W. Shepard, James M. Berry, Alvin J. Chin
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2014)
Meeting Abstract
Cardiac & Cardiovascular Systems
Bradley S. Marino, David Goldberg, Adam L. Dorfman, Heidi Kalkwarf, Babette Zemel, Margaret Smith, Jesse Pratt, Eileen King, Mark Fogel, Amanda J. Shillingford, Barbara Deal, Anitha S. John, Caren Goldberg, Timothy Hoffman, Marshall Jacobs, Asher Lisec, Susan Finan, Lazaros Kochilas, Tom Pawlowski, Kathleen Campbell, Clinton Joiner, Stuart Goldstein, Paul Stephens, Alvin Chin
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2011)
Review
Developmental Biology
Alvin J. Chin, Jean-Pierre Saint-Jeannet, Cecilia W. Lo
MECHANISMS OF DEVELOPMENT
(2012)
Article
Cardiac & Cardiovascular Systems
Alvin J. Chin, P. Stephens, E. Goldmuntz, M. B. Leonard
PEDIATRIC CARDIOLOGY
(2009)
Article
Cardiac & Cardiovascular Systems
Maria Batsis, Lazaros Kochilas, Alvin J. Chin, Michael Kelleman, Eric Ferguson, Matthew E. Oster
Summary: The study found that the use of digoxin during the interstage period is associated with better preservation of RV volume and tricuspid valve measurements, leading to less adverse remodeling of the single ventricle. These results suggest a possible mechanism explaining the survival benefit of digoxin during the interstage period.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Raymond L. Watrous, Alvin J. Chin
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2017)
Article
Cardiac & Cardiovascular Systems
Alvin J. Chin, Raymond L. Watrous
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Raymond L. Watrous, Alvin J. Chin
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2014)
Article
Anatomy & Morphology
B Chatterjee, AJ Chin, G Valdimarsson, C Finis, JM Sonntag, BY Choi, L Tao, K Balasubramanian, C Bell, A Krufka, DJ Kozlowski, RG Johnson, CW Lo
DEVELOPMENTAL DYNAMICS
(2005)
Article
Oncology
JP Ginsberg, A Cnaan, HQ Zhao, BJ Clark, SM Paridon, AJ Chin, J Rychik, AN Hogarty, G Barber, M Rutkowski, TR Kimball, C DeLaat, LJ Steinherz, JH Silber
JOURNAL OF CLINICAL ONCOLOGY
(2004)
Article
Oncology
JH Silber, A Cnaan, BJ Clark, SM Paridon, AJ Chin, J Rychik, AN Hogarty, MI Cohen, G Barber, M Rutkowski, TR Kimball, C Delaat, LJ Steinherz, HQ Zhao
JOURNAL OF CLINICAL ONCOLOGY
(2004)
Review
Cardiac & Cardiovascular Systems
Alvin J. Chin, Kevin K. Whitehead, Raymond L. Watrous
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2010)
