Article
Psychiatry
Antonija Ruzic Barsic, Lea Gudelj, Ronald Antulov, Damir Miletic, Koraljka Knezevic, Gordana Rubesa
Summary: The study found that grey matter (GM) is reduced in various regions in patients with schizophrenia, with the most significant reduction in the frontal cortex and cerebellum. The decrease in GM volume (GMV) is more pronounced in patients with a higher number of psychotic episodes and an earlier onset of the disease.
PSYCHIATRIA DANUBINA
(2021)
Article
Clinical Neurology
Gregor Broessner, Isabel Ellerbrock, Mareike M. Menz, Florian Frank, Michael Verius, Christian Gaser, Arne May
Summary: Voxel-based morphometry (VBM) is a widely used tool to study brain plasticity, development, and disease, but the source of T-1 signal changes is not fully understood. This study found significant gray matter volume changes in pain processing areas following pain stimulation, yet similar changes were observed in a control group without pain input. The results highlight the need for further research and control groups in longitudinal imaging studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Food Science & Technology
Yeonjae (Angel) Lee, Sungjin Yoon, SangYun Kim, Young Chul Youn
Summary: Vitamin D is crucial for brain function, and its deficiency can accelerate cognitive impairment. This study aimed to evaluate the association between blood 25-hydroxyvitamin D levels and structural changes in the brain. Lower 25(OH)D levels were linked to reduced volumes in olfactory and hippocampal regions in elderly patients with cognitive decline, providing insights into the neurological pathophysiology of vitamin D.
FOOD SCIENCE & NUTRITION
(2021)
Article
Geriatrics & Gerontology
Ryuzo Orihashi, Yoshito Mizoguchi, Yoshiomi Imamura, Shigeto Yamada, Akira Monji
Summary: This study aimed to investigate the association between serum levels of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) and brain volume in older adults. However, the results showed no correlation between serum sTREM2 levels and volume of different brain regions closely related to cognitive function in older adults aged 65 years and above.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Shota Nishitani, Ryoko Kasaba, Daiki Hiraoka, Koji Shimada, Takashi X. Fujisawa, Hidehiko Okazawa, Akemi Tomoda
Summary: The study suggests that increasing reproductive efforts are associated with decelerated aging in mothers with one to four children, mediated by structural changes in the precuneus.
FRONTIERS IN GENETICS
(2022)
Article
Neuroimaging
Youling Bai, Li Zhang, Chengwei Liu, Xiaobing Cui, Dan Li, Huazhan Yin
Summary: The study investigated the association between white matter volume and sleep quality, finding a negative correlation between global PSQI score and white matter volume in specific brain regions. This suggests that exploring brain white structure in relation to sleep may help to explain the mechanisms underlying the association between sleep quality and brain function, behavior, and cognition, as well as the networks responsible for variations in sleep.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Geriatrics & Gerontology
Wei-Ling Chen, Yukiko Nishita, Akinori Nakamura, Takashi Kato, Takeshi Nakagawa, Shu Zhang, Hiroshi Shimokata, Rei Otsuka, Kuan-Pin Su, Hidenori Arai
Summary: This study found a positive correlation between hemoglobin concentration and hippocampal volume in middle-aged and older adults, highlighting the importance of monitoring hemoglobin concentration to decrease the possibility of neurodegeneration.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Neurosciences
Cindy H. Lee, Kristi L. Bartholomay, Matthew J. Marzelli, Jonas G. Miller, Jennifer L. Bruno, Amy A. Lightbody, Allan L. Reiss
Summary: This study investigated neuroanatomical differences in young females with fragile X syndrome compared to a matched control group. The results showed larger total gray and white matter volumes in girls with fragile X syndrome, as well as differences in specific brain regions. These findings provide insights into the gene-brain-behavior relationships underlying the fragile X syndrome phenotype in females and expand our understanding of the neurodevelopmental mechanisms in this condition.
Article
Multidisciplinary Sciences
Qian Zhang, XiaoLi Yang, ZhongKui Sun
Summary: This study explores the importance of classification features and experimental algorithms in early detection and diagnosis of Alzheimer's disease. The results indicate that the combination of gray matter volume and lateralization index is an effective feature, and different classifier algorithms have varying performances in different subject groups. Combining the lateralization index with gray matter volume can significantly improve classification accuracy.
Article
Neurosciences
Feifei Zhang, Song Wang, Yang Feng, Kun Qin, Huiru Li, Baolin Wu, Zhiyun Jia, Qiyong Gong
Summary: The study highlights the potential risk of exercise dependence (EXD) due to excessive exercise and the role of stress in its onset and development. The findings suggest that gray matter volume (GMV) in specific brain regions may mediate the relationship between stress and EXD, even after controlling for various factors such as sex, age, and psychological conditions.
HUMAN BRAIN MAPPING
(2021)
Article
Neuroimaging
Hirotsugu Kawashima, Shimpei Yamasaki, Manabu Kubota, Masaaki Hazama, Yasutaka Fushimi, Jun Miyata, Toshiya Murai, Taro Suwa
Summary: ECT is effective for treating depression and schizophrenia, but the interpretation of GMV changes after ECT is complicated. This study compares longitudinal MRI data in two diagnostic groups and finds that GMV changes can be related to treatment effects and intervention-dependent.
NEUROIMAGE-CLINICAL
(2023)
Article
Multidisciplinary Sciences
Sergio Leonardo Mendes, Walter Hugo Lopez Pinaya, Pedro Mario Pan, Andrea Parolin Jackowski, Rodrigo Affonseca Bressan, Joao Ricardo Sato
Summary: Recently, studies have investigated the neurodevelopment of psychiatric disorders using structural magnetic resonance imaging (sMRI) data. This study explores the reliability and consistency of a model trained on different datasets with varying stages of neurodevelopment and mental health conditions. The models used 3D convolutional neural networks (CNN) to assess autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), brain age, and dimensional psychopathology. Despite demographic and phenotypic differences, the models showed significant age estimations within and between datasets, with moderate to high correlation. The findings provide insights into youth neurodevelopmental structural changes and highlight the importance of less confounded training datasets for model generalization.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Hiraku Watanabe, Sho Kojima, Kazuaki Nagasaka, Ken Ohno, Noriko Sakurai, Naoki Kodama, Naofumi Otsuru, Hideaki Onishi
Summary: This study found that although there is small variability in gray matter volumes in the short term, it is influenced by within-subject factors such as gender and BDNF genotype.
Article
Neurosciences
Lin Song, Xiaodong Han, Yuanjing Li, Xiaolei Han, Mingqing Zhao, Chunyan Li, Pin Wang, Jiafeng Wang, Yi Dong, Lin Cong, Xiaojuan Han, Tingting Hou, Keke Liu, Yongxiang Wang, Chengxuan Qiu, Yifeng Du
Summary: The KIBRA rs17070145 C-allele is associated with a reduced likelihood of olfactory impairment among older adults, partly mediated through left thalamic gray matter volume.
Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Lara M. Wierenga, Gaelle E. Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A. Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Vince D. Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Vincent P. Clark, Patricia J. Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G. Davey, Erin W. Dickie, Stefan Ehrlich, Dennis Van't Ent, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Paola Fuentes-Claramonte, Eco J. C. de Geus, Annabella Di Giorgio, David C. Glahn, Ian H. Gotlib, Hans J. Grabe, Oliver Gruber, Patricia Gruner, Raquel E. Gur, Ruben C. Gur, Tiril P. Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J. Harrison, Catharina A. Hartman, Sean N. Hatton, Dirk J. Heslenfeld, Odile A. van den Heuvel, Ian B. Hickie, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony C. James, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Andrew J. Kalnin, Marieke Klein, Laura Koenders, Knut K. Kolskar, Bernd Kramer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S. Lebedeva, Phil H. Lee, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Brenna C. McDonald, Colm McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Dennis van der Meer, Jose M. Menchon, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Joaquim Radua, Andreas Reif, Genevieve Richard, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Kang Sim, Andrew Simmons, Jordan W. Smoller, Iris E. Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Philip R. Szeszko, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Julian N. Trollor, Anne Uhlmann, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Volzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather C. Whalley, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Margaret J. Wright, Yuliya N. Yoncheva, Marcus Zanetti, Georg C. Ziegler, Greig de Zubicaray, Paul M. Thompson, Eveline A. Crone, Sophia Frangou, Christian K. Tamnes
Summary: Males exhibit greater variability than females in many traits, which may have implications for understanding sex differences in health and disease. A mega-analysis of brain structure variability based on MRI data of 16,683 healthy individuals spanning nine decades of life reveals significant patterns of greater male than female between-subject variance in subcortical volumes, cortical surface area, and cortical thickness. These sex differences are present in childhood and may be influenced by early life genetic or gene-environment interaction mechanisms. The findings underscore the importance of individual differences within each sex, which may contribute to sex-specific vulnerability to disorders.
HUMAN BRAIN MAPPING
(2022)
Review
Psychology, Clinical
E. Frawley, M. Cowman, M. Lepage, G. Donohoe
Summary: This study aimed to evaluate the effectiveness of psychosocial interventions in improving functioning in early psychosis. The results indicated that psychosocial interventions, particularly when provided as part of a multi-component intervention model in community-based settings, are associated with significant improvements in social and occupational function. Different intervention approaches showed varying levels of effectiveness, with cognitive remediation training outperforming symptom-focused cognitive behavioural therapy interventions and multi-component interventions associated with the largest gains.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Aoibheann Rainford, S. Moran, Eimear McMahon, Yvonne Patricia Fahy, Colm McDonald, Brian Hallahan
Summary: The impact of the COVID-19 pandemic on individuals with treatment-resistant psychotic disorders was modest 12 months after their initial study engagement. Anxiety symptoms showed a minor increase, while depressive symptoms had a minimal increase. Some participants had positive views regarding vaccination and were optimistic about the future.
IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Emma Frawley, Caroline Heary, Clio Berry, Matteo Cella, David Fowler, Til Wykes, Gary Donohoe
Summary: This study explores a psychosocial intervention combining cognitive remediation and social recovery therapy for early psychosis. Through qualitative research methods, four themes were identified and pragmatic feedback for improving the therapy was provided. The findings suggest that this intervention is acceptable and helpful for early psychosis patients.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Antoine Lefrere, Guillaume Auzias, Pauline Favre, Irene Kaltenmark, Josselin Houenou, Camille Piguet, Mircea Polosan, Lisa T. Eyler, Mary L. Phillips, Amelia Versace, Michele Wessa, Colm McDonald, Dara M. Cannon, Paolo Brambilla, Marcella Bellani, Christine Deruelle, Raoul Belzeaux
Summary: This study explores the cortical folding in relation to neuro-developmental disorders, focusing on a neurodevelopmental subtype of bipolar disorders (BD-ND). It finds that BD-ND is associated with specific brain morphology revealed by the analysis of sulcal pits, suggesting potential insights into the neurodevelopment process and stratification of patients based on pathophysiological hypothesis.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Correction
Biochemistry & Molecular Biology
Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun, Benedicto Crespo-Facorro, Nicolas A. Crossley, Udo Dannlowski, Erin Dickie, Lorielle M. F. Dietze, Gary Donohoe, Stefan Du Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C. Glahn, Alfonso Gonzalez-Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T. J. Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadic, Nils Opel, Julia-Katharina Pfarr, Amanda L. Rodrigue, Kelly Rootes-Murdy, Alex J. Ross, Kang Sim, Antonin Skoch, Filip Spaniel, Frederike Stein, Patrik Svancer, Diana Tordesillas-Gutierrez, Juan Undurraga, Javier Vaquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Paul M. Thompson, Theo G. M. van Erp, Jessica A. Turner, Tomas Hajek
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Megan Cowman, Emmet Godfrey, Talissa Walsh, Emma Frawley, David Fowler, Mario Alvarez-Jimenez, Karen O'Connor, Til Wykes, Max Birchwood, Gary Donohoe
Summary: This study conducted a systematic review and meta-analysis of functioning measures in psychosis. The results showed that more specific measures of social and occupational function were better at detecting changes over time and in response to treatment.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Jiayue-Clara Jiang, Chenwen Hu, Andrew M. McIntosh, Sonia Shah
Summary: Observational studies and randomized controlled trials have shown inconsistent findings on the effects of cholesterol-lowering statins on depression. It is still uncertain whether statins have any beneficial effects on depression, and if so, what the underlying molecular mechanisms are. Genomic approaches were used to investigate this further.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Sinead King, David Mothersill, Laurena Holleran, Saahithh Redddi Patlola, Tom Burke, Ross McManus, Marcus Kenyon, Colm McDonald, Brian Hallahan, Aiden Corvin, Derek W. W. Morris, John P. P. Kelly, Declan P. P. McKernan, Gary Donohoe
Summary: Childhood trauma is associated with lower cognitive and social cognitive function in schizophrenia. Recent research suggests that the relationship between childhood trauma and cognition is mediated by low-grade systemic inflammation and reduced connectivity of the default mode network (DMN) during resting state. This study aimed to determine if the same pattern of associations was observed for DMN connectivity during task based activity. Results showed that patients with schizophrenia or schizoaffective disorder exhibited evidence of low-grade systemic inflammation and increased connectivity between specific brain regions compared to healthy participants. Furthermore, the inflammatory marker IL-6 mediated the relationship between childhood physical neglect and DMN connectivity. These findings provide the first evidence that higher plasma IL-6 mediates the association between childhood neglect and increased DMN connectivity during task based activity, contributing to our understanding of the biological mechanisms underlying the relationship between childhood trauma and cognitive function in schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Genetics & Heredity
Muhammad Kamran, Aodan Laighneach, Farhana Bibi, Gary Donohoe, Naveed Ahmed, Asim Ur Rehman, Derek W. Morris
Summary: This study identifies associations between SORCS3 and various brain-related disorders and traits, and reveals that SNPs related to neurodevelopment and cognitive function are associated with SORCS3. The study also shows that the SORCS3 gene-set contributes significantly to the heritability of schizophrenia, bipolar disorder, intelligence, and education attainment. Furthermore, functional annotation reveals the enrichment of synapse-related ontologies in the SORCS3 gene-set.
Article
Psychiatry
A. McLoughlin, K. Mulholland, E. McMahon, R. Plunkett, K. Hennigan, C. McDonald, B. Hallahan
Summary: This study investigated the psychological and social impact of the COVID-19 pandemic on patients with established anxiety disorders over a 2-year period in Ireland. The results showed no significant overall change in symptoms or functioning for individuals with pre-existing anxiety disorders. However, there was variability among individuals, with some experiencing ongoing anxiety, social isolation, and concern for the future. The study suggests the use of tailored supports, including tele-psychiatry, to help those who experience increased anxiety with the removal of societal restrictions during the reopening process.
IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE
(2023)
Article
Behavioral Sciences
Emma Corley, Laura Fahey, Joan Fitzgerald, Laurena Holleran, Esther Walton, Derek W. W. Morris, Gary Donohoe
Summary: Cognitive ability is a powerful predictor of occupational achievement, quality of life, and physical health. However, little is known about how genetic variation, brain morphology, early life adversity, and education interact to explain this variation in cognition.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Health Care Sciences & Services
Amy Joanne Lynham, Ian R. Jones, James T. R. Walters
Summary: This study developed a web-based cognitive assessment tool (CONCA) to measure the core cognitive domains affected in people with psychiatric disorders. The results showed that CONCA can provide a valid measure of cognitive ability (g) within 15 minutes and demonstrated associations with demographic characteristics and current depression and anxiety symptoms.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Psychiatry
K. Mulholland, A. McLoughlin, C. McDonald, B. Hallahan
Summary: Zooanthropy, a rare psychiatric phenomenon, is characterized by delusional beliefs of turning into an animal. This case study focuses on kynanthropic delusions, where the patient believes they have transformed into a dog. The presence of additional psychotic symptoms, including delusions of vampirism, was also observed. The patient exhibited behavioral changes such as growling and barking, and in some cases, expressed a desire to bite people's necks and consume human blood. Higher doses of antipsychotic medications provided some relief, and short-term admissions to a psychiatric unit helped alleviate symptoms by removing environmental stressors.
IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE
(2023)
Article
Cell Biology
Eduardo A. Maury, Maxwell A. Sherman, Giulio Genovese, Thomas G. Gilgenast, Tushar Kamath, S. J. Burris, Prashanth Rajarajan, Erin Flaherty, Schahram Akbarian, Andrew Chess, Steven A. McCarroll, Po-Ru Loh, Jennifer E. Phillips-Cremins, Kristen J. Brennand, Evan Z. Macosko, James T. R. Walters, Michael O'Donovan, Patrick Sullivan, Jonathan Sebat, Eunjung A. Lee, Christopher A. Walsh
Summary: This study suggests that somatic copy-number variants (sCNVs) may play a potential role in the risk of schizophrenia (SCZ). Early-developmental sCNVs were more common in SCZ cases, including recurrent somatic deletions in the NRXN1 gene. Additionally, recurrent intragenic deletions of the ABCB11 gene were observed in treatment-resistant SCZ cases.
