期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 159B, 期 5, 页码 560-566出版社
WILEY
DOI: 10.1002/ajmg.b.32062
关键词
BDNF; Val66Met; geriatric; depression; meta-analysis
资金
- National Natural Science Foundation of China [81071102]
- National Institute of Mental Health [MH085806]
Depression has been associated with reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced inconsistent results. A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls. A total of five studies involving 523 cases with geriatric depression and 1,220 psychiatrically healthy controls was included. Met allele carriers had an increased risk for geriatric depression when compared to Val/Val homozygotes (P?=?0.004, OR?=?1.48, 95% CI?=?1.131.93). Our findings suggest the BDNF Met allele may confer increased risk for depression as individual age. (C) 2012 Wiley Periodicals, Inc.
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