Article
Genetics & Heredity
Dev Paudel, Rocheteau Dareus, Julia Rosenwald, Maria Munoz-Amatriain, Esteban F. Rios
Summary: Cowpea, a major crop used for human consumption and livestock feed, has been studied for its genetic basis of flowering time through genome-wide association studies, revealing seven reliable SNP markers and candidate genes associated with flowering time, which could facilitate breeding efforts and knowledge transfer to other legume species.
FRONTIERS IN GENETICS
(2021)
Article
Biology
Yunfeng Zhao, Jin Gao, Xiugang Guo, Baofeng Su, Haijie Wang, Runqing Yang, Li Jiang
Summary: This study proposes an efficient gene-based GWAS method for studying economic traits in maize. By comparing different statistical methods, many candidate genes related to maize traits were identified, supporting the reliability of the method. These findings are significant for maize breeding.
Article
Plant Sciences
Chuan Zhang, Liwen Cui, Jinggui Fang
Summary: This study identified candidate genes related to grape berry shape through genome-wide association analysis, with some genes controlling multiple berry shape traits simultaneously.
Article
Genetics & Heredity
Zheng Chang Wu, Yifu Wang, Xiaoguo Huang, Shenglong Wu, Wenbin Bao
Summary: Improving the reproductive efficiency of sows is a major challenge in the swine industry. This study identified genetic markers associated with reproductive traits in Large White pigs and suggested the use of marker-assisted selection for genetic improvement.
Review
Biochemistry & Molecular Biology
Bi-jun Wang, Jun-yi Chen, Yu Guan, Da-chao Liu, Zi-chuan Cao, Jin Kong, Zheng-Sheng Wu, Wen-Yong Wu
Summary: The meta-analysis conducted in this study found no significant association between P2RX7 rs3751143 polymorphism and the risk of cancer across different models.
BIOSCIENCE REPORTS
(2021)
Article
Genetics & Heredity
Qing Wang, Ning Yan, Hao Chen, Sirui Li, Haiyan Hu, Yu Lin, Haoran Shi, Kunyu Zhou, Xiaojun Jiang, Shifan Yu, Caixia Li, Guangdeng Chen, Zisong Yang, Yaxi Liu
Summary: This study identified two subpopulations within 223 Aegilops tauschii accessions and discovered 66 significant markers associated with kernel traits on a genome-wide level using population structure analysis and genome-wide association analysis.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Hamza Dallali, Meriem Hechmi, Imane Morjane, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Abdelmajid Abid, Afef Bahlous, Abdelhamid Barakat, Henda Jamoussi, Sonia Abdelhak, Rym Kefi
Summary: This study excluded the association between HNF1A gene variants and susceptibility to MetS in the Tunisian population. However, it emphasized the role of these variants in cholesterol homeostasis with sex-specific differences.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Agriculture, Dairy & Animal Science
Mohammad Zahangir Alam, Md Azizul Haque, Asif Iqbal, Yun-Mi Lee, Jae-Jung Ha, Shil Jin, Byoungho Park, Nam-Young Kim, Jeong Il Won, Jong-Joo Kim
Summary: This study aimed to identify genetic variants and genomic regions associated with carcass traits in Korean Hanwoo cattle using genome-wide association study (GWAS). By utilizing a large sample size and different response variables, such as deregressed genomic estimated breeding value (DGEBV), genomic estimated breeding value (GEBV), and residual values, common single nucleotide polymorphisms (SNPs) were identified on chromosomes 6, 13, and 14, demonstrating their significant associations with carcass traits. These findings provide valuable insights into the genetic and biological mechanisms underlying carcass traits in the Hanwoo population.
Article
Clinical Neurology
Vilma Liaugaudaite, Nijole Raskauskiene, Rima Naginiene, Narseta Mickuviene, Leo Sher
Summary: The study found a positive association between lithium levels in drinking water and the incidence of affective disorders. Higher incidence rates of affective disorders were observed in municipalities with a lithium level in drinking water above median compared to those below median, while suicide mortality rates were inversely associated with lithium levels in municipalities with higher levels of lithium and a high rate of affective disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Gordana Stanic, Snezana Marinkovic, Jelena Milin Lazovic, Dragana Ignjatovic Ristic
Summary: This study found differences in affective temperament and levels of psychosomatic symptoms between patients with Hashimoto's thyroiditis (HT) and healthy individuals. Patients with HT had higher levels of psychosomatic symptoms compared to the control group, and their affective temperament was associated with these symptoms. Further research is needed to better understand the relationship between affective temperament and psychosomatic symptoms.
Article
Psychology, Clinical
Judith Allardyce, Anna-Clara Hollander, Syed Rahman, Christina Dalman, Stan Zammit
Summary: This study examines the temporal relationships between traumatic events, post-traumatic stress disorder (PTSD), and non-affective psychotic disorders (NAPD). The results suggest that trauma and PTSD are associated with an increased risk of NAPD, indicating that trauma may be a component cause of psychotic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Seong-Hoon Kim, Rupesh Tayade, Byeong-Hee Kang, Bum-Soo Hahn, Bo-Keun Ha, Yoon-Ha Kim
Summary: This study conducted a genome-wide association study (GWAS) on 357 soybean landraces to analyze root traits. It identified 112 significant SNP loci and 55 putative candidate genes. These findings suggest that the combined approach of SNP array and GWAS can be used to understand the genetic basis of soybean root traits and improve soybean breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Yajun Shang, Xinjie Chen, Mingda Ai, Xiaoran Gao, Shujuan Dai, Mingjie Zhao, Cen Yang, Liangfeng Wang, Junyan Zhang, Lianmei Zhong, Tianhao Bao, Xiaolei Liu
Summary: This meta-analysis found that cognitive impairments and affective disorders are common in patients with essential tremor (ET). Patients with ET showed lower scores on Mini-Mental State Examination (MMSE) and higher scores on depressive and anxiety symptoms scale compared to non-ET group. The risk for dementia and affective disorders was significantly higher in individuals with ET. However, the causal relationship between ET and dementia, depression, and anxiety remains unclear.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Toshimitsu Suzuki, Yoshinao Koike, Kyota Ashikawa, Nao Otomo, Atsushi Takahashi, Tomomi Aoi, Naoyuki Kamatani, Yusuke Nakamura, Michiaki Kubo, Yoichiro Kamatani, Yukihide Momozawa, Chikashi Terao, Kazuhiro Yamakawa
Summary: Through a genome-wide association study on a Japanese population, a novel region on chromosome 12q24 was identified as a risk factor for epilepsy. This region harbors multiple transcripts including genes expressed in the brain, and the associated SNPs are correlated with differential expression of genes at 12q24. These findings suggest a contribution of genes in this region to the pathology of epilepsy in the Japanese population.
Article
Agriculture, Dairy & Animal Science
Manuel More, Eudosio Veli, Alan Cruz, Juan Pablo Gutierrez, Gustavo Gutierrez, F. Abel Ponce de Leon
Summary: This study aims to identify candidate genomic regions associated with fiber diameter in alpacas using whole genome association analysis. Four candidate regions were identified, and the genetic heritability and selection signature of SNPs were analyzed using different association methods.
Article
Psychiatry
Alexander Refisch, Shoko Komatsuzaki, Martin Ungelenk, Ha-Yeun Chung, Andy Schumann, Susann S. Schilling, Wibke Jantzen, Sabine Schroeder, Thomas W. Muehleisen, Markus M. Noethen, Christian A. Huebner, Karl-Jurgen Baer
Summary: This study found associations between CHRM2 polymorphisms and heart rate variability in patients with schizophrenia, suggesting a potential role for these genetic variations in cardiac autonomic dysfunction in schizophrenia.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Gehlen, Anja Stundl, Radoslaw Debiec, Federica Fontana, Markus Krane, Dinara Sharipova, Christopher P. Nelson, Baravan Al-Kassou, Ann Sophie Giel, Jan Malte Sinning, Christopher M. H. Bruenger, Carolin F. Zelck, Laura L. Koebbe, Peter S. Braund, Thomas R. Webb, Simon Hetherington, Stephan Ensminger, Buntaro Fujita, Salah A. Mohamed, Malakh Shrestha, Heike Krueger, Matthias Siepe, Fabian Alexander Kari, Peter Nordbeck, Larissa Buravezky, Malte Kelm, Verena Veulemans, Matti Adam, Stephan Baldus, Karl Ludwig Laugwitz, Yannick Haas, Matthias Karck, Uwe Mehlhorn, Lars Oliver Conzelmann, Ingo Breitenbach, Corinna Lebherz, Paul Urbanski, Won Keun Kim, Joscha Kandels, David Ellinghaus, Ulrike Nowak-Goettl, Per Hoffmann, Felix Wirth, Stefanie Doppler, Harald Lahm, Martina Dressen, Moritz von Scheidt, Katharina Knoll, Thorsten Kessler, Christian Hengstenberg, Heribert Schunkert, Georg Nickenig, Markus M. Noethen, Aidan P. Bolger, Salim Abdelilah-Seyfried, Nilesh J. Samani, Jeanette Erdmann, Teresa Trenkwalder, Johannes Schumacher
Summary: This study provides deeper insights into the genetic risk architecture of bicuspid aortic valve (BAV) disease, including both single-marker and polygenic levels. The study identified a new risk locus and confirmed previously reported risk loci. Additionally, the study revealed that the transcriptome profile in endothelial cells plays a major role in the pathology of BAV.
CARDIOVASCULAR RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Julia Schroeder, Laura Chegwidden, Carlo Maj, Jan Gehlen, Jan Speller, Anne C. Boehmer, Oleg Borisov, Timo Hess, Nicole Kreuser, Marino Venerito, Hakan Alakus, Andrea May, Christian Gerges, Thomas Schmidt, Rene Thieme, Dominik Heider, Axel M. Hillmer, Julian Reingruber, Orestis Lyros, Arne Dietrich, Albrecht Hoffmeister, Matthias Mehdorn, Florian Lordick, Gertraud Stocker, Michael Hohaus, Daniel Reim, Jennis Kandler, Michaela Mueller, Alanna Ebigbo, Claudia Fuchs, Christiane J. Bruns, Arnulf H. Holscher, Hauke Lang, Peter P. Grimminger, Dani Dakkak, Yogesh Vashist, Sandra May, Siegfried Gorg, Andre Franke, David Ellinghaus, Sara Galavotti, Lothar Veits, Josef Weismuller, Jens Dommermuth, Udo Benner, Thomas Roesch, Helmut Messmann, Brigitte Schumacher, Horst Neuhaus, Carsten Schmidt, Thaddaus T. Wissinowski, Markus M. Noethen, Jing Dong, Jue-Sheng Ong, Matthew F. Buas, Aaron P. Thrift, Thomas L. Vaughan, Ian Tomlinson, David C. Whiteman, Rebecca Claire Fitzgerald, Janusz Jankowski, Michael Vieth, Andreas Mayr, Puya Gharahkhani, Stuart MacGregor, Ines Gockel, Claire Palles, Johannes Schumacher
Summary: This study utilized GWAS, genetic correlation analysis, and polygenic risk modeling to investigate the genetic causes of BE/EA. The findings identified new risk loci and candidate genes associated with BE/EA development. The study also revealed differences in the etiology of BE and EA and demonstrated improved risk prediction models when combining PRS with risk factors. These findings provide valuable insights into the mechanisms underlying BE/EA and improve our understanding of the disease.
Article
Nutrition & Dietetics
Christina-Alexandra Schulz, Leonie Weinhold, Matthias Schmid, Markus M. Noethen, Ute Noethlings
Summary: This study aimed to investigate the influence of diet on fluid intelligence and whether this association is modified by individual genetic disposition. The results showed no significant association between diet score and fluid intelligence, even after stratification by polygenic score.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Dermatology
Nicole Cesarato, Agnes Schwieger-Briel, Yasmina Gossmann, Sabrina K. Henne, Kathrin Hillmann, Leonie H. Frommherz, Maria Wehner, Xing Xiong, Holger Thiele, Vinzenz Oji, Donatella Milani, Iliana Tantcheva-Poor, Kathrin Giehl, Regina Foelster-Holst, Anne Teichler, Delphine Braeckmans, Peter H. Hoeger, Gabriela Jones, Jorge Frank, Lisa Weibel, Ulrike Blume-Peytavi, Henning Hamm, Markus M. Noethen, Matthias Geyer, Stefanie Heilmann-Heimbach, F. Buket Basmanav, Regina C. Betz
Summary: Short anagen hair (SAH) is a rare pediatric hair disorder characterized by a short anagen phase. Pathogenic variants in the WNT10A gene were found to be associated with SAH, and there is a genetic overlap between SAH and male pattern hair loss (MPHL).
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemical Research Methods
Andreas Glaessner, Gerda Wurpts, Stefanie Roeseler, Amir S. Yazdi, Christine Kraemer, Amol Fatangare, Albert Sickmann, Per Hoffmann, Markus Noethen, Bernhardt Sachs
Summary: The lymphocyte transformation test (LTT) is used to detect drug sensitization in allergic patients. However, the specificity of LTT has not been analyzed in relation to specific drugs in a larger control group. This study investigated the impact of amoxicillin, cefuroxime, and clindamycin on the specificity of LTT with ELISA read-out in control persons.
JOURNAL OF IMMUNOLOGICAL METHODS
(2023)
Article
Genetics & Heredity
Wenqianglong Li, Hang Zhou, Johan H. Thygesen, Mathis Heydtmann, Iain Smith, Franziska Degenhardt, Markus Noethen, Marsha Y. Morgan, Henry R. Kranzler, Joel Gelernter, Nicholas Bass, Andrew McQuillin
Summary: This study identifies a chromosome 15 variant that is associated with the diagnostic criteria of ASPD and explores the pleiotropic associations of ASPD with other disorders and traits. It suggests that SLCO3A1 may be a genetic risk factor for ASPD and provides insight into the genetic architecture of ASPD.
PSYCHIATRIC GENETICS
(2023)
Article
Multidisciplinary Sciences
Ashley Budu-Aggrey, Anna Kilanowski, Maria K. Sobczyk, Suyash S. Shringarpure, Ruth Mitchell, Kadri Reis, Anu Reigo, Reedik Maegi, Mari Nelis, Nao Tanaka, Ben M. Brumpton, Laurent F. Thomas, Pol Sole-Navais, Christopher Flatley, Antonio Espuela-Ortiz, Esther Herrera-Luis, Jesus V. T. Lominchar, Jette Bork-Jensen, Ingo Marenholz, Aleix Arnau-Soler, Ayoung Jeong, Katherine A. Fawcett, Hansjorg Baurecht, Elke Rodriguez, Alexessander Couto Alves, Ashish Kumar, Patrick M. Sleiman, Xiao Chang, Carolina Medina-Gomez, Chen Hu, Cheng-jian Xu, Cancan Qi, Sarah El-Heis, Philip Titcombe, Elie Antoun, Joao Fadista, Carol A. Wang, Elisabeth Thiering, Baojun Wu, Sara Kress, Dilini M. Kothalawala, Latha Kadalayil, Jiasong Duan, Hongmei Zhang, Sabelo Hadebe, Thomas Hoffmann, Eric Jorgenson, Helene Choquet, Neil Risch, Pal Njolstad, Ole A. Andreassen, Stefan Johansson, Catarina Almqvist, Tong Gong, Vilhelmina Ullemar, Robert Karlsson, Patrik K. E. Magnusson, Agnieszka Szwajda, Esteban G. Burchard, Jacob P. Thyssen, Torben Hansen, Line L. Karhus, Thomas M. Dantoft, Alexander C. S. N. Jeanrenaud, Ahla Ghauri, Andreas Arnold, Georg Homuth, Susanne Lau, Markus M. Noethen, Norbert Huebner, Medea Imboden, Alessia Visconti, Mario Falchi, Veronique Bataille, Pirro Hysi, Natalia Ballardini, Dorret I. Boomsma, Jouke J. Hottenga, Martina Mueller-Nurasyid, Tarunveer S. Ahluwalia, Jakob Stokholm, Bo Chawes, Ann-Marie M. Schoos, Ana Esplugues, Mariona Bustamante, Benjamin Raby, Syed Arshad, Chris German, Tonu Esko, Lili A. Milani, Andres Metspalu, Chikashi Terao, Katrina Abuabara, Mari Loset, Kristian Hveem, Bo Jacobsson, Maria Pino-Yanes, David P. Strachan, Niels Grarup, Allan Linneberg, Young-Ae Lee, Nicole Probst-Hensch, Stephan Weidinger, Marjo-Riitta Jarvelin, Erik Melen, Hakon Hakonarson, Alan D. Irvine, Deborah Jarvis, Tamar Nijsten, Liesbeth Duijts, Judith M. Vonk, Gerard H. Koppelmann, Keith M. Godfrey, Sheila J. Barton, Bjarke Feenstra, Craig E. Pennell, Peter D. Sly, Patrick G. Holt, L. Keoki Williams, Hans Bisgaard, Klaus Bonnelykke, John Curtin, Angela Simpson, Clare Murray, Tamara Schikowski, Supinda Bunyavanich, Scott T. Weiss, John W. Holloway, Josine L. Min, Sara J. Brown, Marie Standl, Lavinia Paternoster
Summary: This study conducted the largest genome-wide association study (GWAS) on atopic dermatitis (AD) to date, identifying 81 replicated AD-associated loci in Europeans and 10 additional loci in a multi-ancestry analysis. The implicated genes are predominantly involved in immune pathways relevant to atopic inflammation and may offer drug repurposing opportunities.
NATURE COMMUNICATIONS
(2023)
Review
Psychiatry
Gunter Schumann, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, Jianfeng Feng, Soeren Hese, Esther Hitchen, Per Hoffmann, Tianye Jia, Viktor Jirsa, Andre F. Marquand, Frauke Nees, Markus M. Noethen, Gaia Novarino, Elli Polemiti, Markus Ralser, Michael Rapp, Kerstin Schepanski, Tamara Schikowski, Mel Slater, Peter Sommer, Bernd Carsten Stahl, Paul M. Thompson, Sven Twardziok, Dennis van der Meer, Henrik Walter, Lars Westlye
Summary: This article introduces a research strategy that leverages innovative tools and techniques such as data federation, geospatial observation, and data integration to understand the impact of environmental factors on the brain and mental illness. The presented example demonstrates the potential of this research to identify brain mechanisms underlying mental health symptoms related to environmental adversity and develop targeted interventions. The development of objective biomarkers and evidence-based interventions can greatly improve outcomes of environment-related mental illness.
Article
Neurosciences
Kosma Sakrajda, Karolina Bilska, Piotr M. Czerski, Beata Narozna, Monika Dmitrzak-Weglarz, Stefanie Heilmann-Heimbach, Felix F. Brockschmidt, Stefan Herms, Markus M. Noethen, Sven Cichon, Barbara Wieckowska, Janusz K. Rybakowski, Joanna Pawlak, Aleksandra Szczepankiewicz
Summary: This study suggests the involvement of AHI1 in the mode of action of lithium, as well as the association between mood-stabilizing treatment and innate immunity-related gene expression in BD patients.
PSYCHOPHARMACOLOGY
(2023)
Article
Cell Biology
Eduardo A. Maury, Maxwell A. Sherman, Giulio Genovese, Thomas G. Gilgenast, Tushar Kamath, S. J. Burris, Prashanth Rajarajan, Erin Flaherty, Schahram Akbarian, Andrew Chess, Steven A. McCarroll, Po-Ru Loh, Jennifer E. Phillips-Cremins, Kristen J. Brennand, Evan Z. Macosko, James T. R. Walters, Michael O'Donovan, Patrick Sullivan, Jonathan Sebat, Eunjung A. Lee, Christopher A. Walsh
Summary: This study suggests that somatic copy-number variants (sCNVs) may play a potential role in the risk of schizophrenia (SCZ). Early-developmental sCNVs were more common in SCZ cases, including recurrent somatic deletions in the NRXN1 gene. Additionally, recurrent intragenic deletions of the ABCB11 gene were observed in treatment-resistant SCZ cases.
Meeting Abstract
Biochemistry & Molecular Biology
Axel Schmidt, Eva C. Schulte, Susanne Motameny, Nicolas Casadei, Fabian Brand, Michael Nothnagel, Elaheh Vojgani, German Demidov, Kerstin Becker, Janine Altmueller, Andre Heimbach, Markus M. Noethen, Peter Nuernberg, Stephan Ossowski, Olaf Riess, Kerstin Ludwig
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Lisa Sindermann, Udo Dannlowski, Susanne Meinert, Elisabeth Johanna Leehr, Lena Waltemate, Hannah Lemke, Alexandrea Winter, Katharina Thiel, Katharina Brosch, Tina Meller, Frederike Stein, Per Hoffmann, Axel Krug, Tilo Kircher, Till Andlauer, Eva Beins, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Angelina Vogelsang, Man Long Chung, Lisa Sindermann, Friederike David, Christina Elling, Laura-Effi Seib-Pfeifer, Stefanie Heilmann-Heimbach, Per Hoffmann, Stefan Herms, Boerge Schmidt, Katharina Domschke, Vanessa Nieratschker, Udo Dannlowski, Elisabeth Johanna Leehr, Eric Leibing, Markus M. Noethen, Franziska Geiser, Johannes Schumacher, Carlo Maj, Rupert Conrad, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Friederike David, Fabian Streit, Josef Frank, Lea Sirignano, Lea Zillich, Stefan Herms, Per Hoffmann, Till Andlauer, Tilo Kircher, Udo Dannlowski, Stephanie Witt, Marcella Rietschel, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)