Article
Chemistry, Multidisciplinary
Bong Kyun Kim, Sang-A Lee, Minju Park, Eui Ju Jeon, Mi Jung Kim, Jung Min Kim, Heesuk Kim, Seungwon Jung, Sang Kyung Kim
Summary: This article introduces a photonic PCR platform using hydrogel microparticles, which utilizes photothermal nanomaterials as heating elements for rapid and portable POCT. The researchers successfully demonstrate the ability to perform multiplex assays by loading multiple encoded pPIN microparticles in a single reaction.
Article
Multidisciplinary Sciences
O. Y. Olivia Tse, Peiyong Jiang, Suk Hang Cheng, Wenlei Peng, Huimin Shang, John Wong, Stephen L. Chan, Liona C. Y. Poon, Tak Y. Leung, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo
Summary: The study developed a methodology for direct detection of S-Methylcytosine, achieving genome-wide SmC detection at single-base resolution in various biological samples with high sensitivity and specificity. It also allowed for the measurement of allele-specific methylation patterns in imprinted genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Jose Roberto Tenorio Filho, Yawar Abbas, Jos Oudenhoven, Stijn Matthys
Summary: Concrete is a widely used construction material, and the durability and lifespan of concrete structures depend on the characteristics of fresh and early age concrete, which are strongly influenced by the curing process. Current electrical resistivity-based sensors used for quality control and monitoring tend to be costly or limited to a single location within the concrete cover. This study introduces a novel printed circuit board (PCB)-based array of electrodes capable of measuring concrete resistivity profiles across the concrete cover, showing promising performance in monitoring concrete curing efficiency and evaluating the effectiveness of internal curing.
Article
Environmental Sciences
Maria-Sofia Vidali, Stefanos Dailianis, Dimitris Vlastos, Panagiotis Georgiadis
Summary: The study found that under conditions of exposure to PCB, there was a significant dose-dependent hypomethylation in the human lymphocyte methylome, even at low concentrations. However, all compounds tested did not show significant genotoxic effects during the testing period.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Walid Hossain, Mohabbat Hossain, Khalid Arafath, Subarna Sayed Ety, Mahade Hasan Shetu, Mazbahul Kabir, Farjana Akther Noor, Kalissar Mannoor
Summary: The study aimed to reduce the run time of multiplex RT-PCR for detecting SARS CoV-2 N1 and N2 sequences and human RNase P (RP) sequence. By optimizing the Fast PCR protocol and comparing it with conventional PCR, the researchers found that Fast PCR significantly shortened the run time while yielding comparable results to conventional PCR.
Article
Chemistry, Analytical
Yuwei Qiu, Kunlun Jiang, Jingrui Wu, Yung-Kang Peng, Jeong-Wook Oh, Jung- Hoon Lee
Summary: A plasmonic photothermal quantitative immuno-PCR (PPT-qiPCR) assay is developed for biomarker detection using multifunctional plasmonic immunomagnetic nanoparticles (PIMNs). This assay has real-time and end-point dual readout and is simple, time-saving, and inexpensive compared to conventional iPCR platforms. It can quickly discriminate target proteins and improve assay sensitivity with in-situ end-point fluorescence or colorimetric detection using only the human eye.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Jing Tu, Yi Qiao, Yuhan Luo, Naiyun Long, Zuhong Lu
Summary: DNA quantification is crucial in life sciences research, and real-time MDA technology can provide template amount information during whole-genome amplification with a very low detection limit, offering a promising tool to quantify entire DNA without sacrificing sample completeness or introducing redundant steps.
Article
Chemistry, Multidisciplinary
Byoung-Hoon Kang, Youngseop Lee, Eun-Sil Yu, Hamin Na, Minhee Kang, Hee Jae Huh, Ki-Hun Jeong
Summary: The rapid and accurate molecular diagnostics are crucial in the face of pandemic diseases, and the nanoplasmonic PCR provides a new solution for rapid and quantitative molecular diagnostics at point-of-care level.
Article
Chemistry, Analytical
Liang Gong, Siyue Yao, Yidong He, Chengliang Liu
Summary: A new qPCR data analysis method called AERKM is proposed to achieve more accurate results by introducing amplification efficiency (AE) for error correction. It has been verified to have higher precision and stability in 5-point 10-fold gradient qPCR tests of 63 genes.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Byoung-Hoon Kang, Kyung-Won Jang, Eun-Sil Yu, Hamin Na, Yun-Jae Lee, Woong-Yeol Ko, NamHo Bae, Donggee Rho, Ki -Hun Jeong
Summary: This study presents a rapid and compact real-time RT-PCR system for decentralized molecular diagnostics. It utilizes plasmonic nucleic acid amplification and quantification, and features an ultrafast plasmonic thermocycler, a disposable plastic-on-metal cartridge, and a compact fluorescence microscope. The system successfully enables 10-minute diagnosis of COVID-19 with high amplification efficiency, classification accuracy, and total percent agreement for clinical diagnostic tests.
Article
Chemistry, Multidisciplinary
Byoung-Hoon Kang, Kyung-Won Jang, Eun-Sil Yu, Hamin Na, Yun-Jae Lee, Woong-Yeol Ko, NamHo Bae, Donggee Rho, Ki-Hun Jeong
Summary: This study presents an ultrafast plasmonic nucleic acid amplification and real-time quantification system for decentralized molecular diagnostics. The system features ultrafast photothermal cycling, rapid heat transfer, and efficient PCR quantification, along with high-contrast fluorescence microscopic imaging. It enables decentralized point-of-care molecular diagnostic testing in primary care and developing countries.
Article
Chemistry, Analytical
Kazuyuki Nobusawa, Huan-Wen Han, Fumie Takei, Ting-Chieh Chu, Noriyasu Hashida, Ichiro Yamashita
Summary: We developed a new electrochemical method for real-time detection of polymerase chain reactions, using a DNA intercalator to enhance charge transfer and monitoring the changes in charge transfer resistance. This simple method has the potential to be a cost-effective and portable PCR device.
ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
D. Cristiano, M. F. Peruzy, M. Aponte, A. Mancusi, Y. T. R. Proroga, F. Capuano, N. Murru
Summary: The study investigated the detection methods for Yersinia enterocolitica in leafy greens, finding that only ddPCR technology could detect the pathogen in leafy greens contaminated at low levels. Additionally, the incubation time and temperature were shown to significantly impact the survival and concentration of Yersinia enterocolitica in vegetables.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Chemistry, Analytical
Kazuyuki Nobusawa, Huan-Wen Han, Fumie Takei, Ting-Chieh Chu, Noriyasu Hashida, Ichiro Yamashita
Summary: We developed a new electrochemical impedimetric method for real-time detection of PCR. By adding a specific DNA intercalator and redox mediator, the progress of PCR reaction can be accurately monitored using impedance measurement. This simple method enables cost-effective and portable PCR devices.
ANALYTICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Saiful Arefeen Sazed, Mohammad Golam Kibria, Mohammad Shafiul Alam
Summary: The real-time PCR method established in this study efficiently detects and distinguishes five human Plasmodium species with a single protocol, improving sensitivity and specificity. This method can be considered as an alternative to existing molecular diagnosis lineup for malaria in endemic countries.
Article
Psychology, Developmental
Emma Sciberras, Pooja Patel, Mark A. Stokes, David Coghill, Christel M. Middeldorp, Mark A. Bellgrove, Stephen P. Becker, Daryl Efron, Argyris Stringaris, Stephen V. Faraone, Susannah T. Bellows, Jon Quach, Tobias Banaschewski, Jane McGillivray, Delyse Hutchinson, Tim J. Silk, Glenn Melvin, Amanda G. Wood, Anna Jackson, George Loram, Lidia Engel, Alicia Montgomery, Elizabeth Westrupp
Summary: The study found that COVID-19 restrictions had negative impacts on children with ADHD, leading to reduced physical activity and outdoor time, decreased enjoyment in activities, and increased screen time and negative emotions. However, some parents reported positive changes in their children, such as increased family time during this period.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Psychology, Developmental
Ann C. Childress, Henry C. Foehl, Jeffrey H. Newcorn, Stephen Faraone, Benjamin Levinson, Akwete L. Adjei
Summary: The study on the long-term safety and symptom control of extended-release methylphenidate in children aged 4 to <6 years showed that most treatment-emergent adverse events were of mild or moderate severity, weight and height z scores as well as obesity rates decreased significantly, with insomnia reported in 9% and hypertension in 6.7%, while ADHD symptom control was maintained.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Stephen Faraone, Jeffrey H. Newcorn, Andrea Cipriani, Daniel Brandeis, Anna Kaiser, Sarah Hohmann, Alexander Haege, Samuele Cortese
Summary: The study analyzed the placebo and nocebo effects in ADHD medications, finding significant impact of placebo effects on efficacy and negative effects on tolerability. It also discovered a positive correlation between baseline to endpoint placebo effects and drug effects.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychology, Developmental
Timothy E. Wilens, Stephen Faraone, Paul G. Hammerness, Steven R. Pliszka, Cassandra L. Uchida, Norberto J. DeSousa, Floyd R. Sallee, Bev Incledon, Jeffrey H. Newcorn
Summary: By using established criteria for clinically meaningful improvements, it was found that delayed-release and extended-release methylphenidate (DR/ER-MPH) significantly improved early morning and late afternoon/evening functional impairment in children with ADHD, particularly compared to placebo.
JOURNAL OF ATTENTION DISORDERS
(2022)
Review
Behavioral Sciences
Sarah Kittel-Schneider, Gara Arteaga-Henriquez, Alejandro Arias Vasquez, Phil Asherson, Tobias Banaschewski, Isabell Brikell, Jan Buitelaar, Bru Cormand, Stephen Faraone, Christine M. Freitag, Ylva Ginsberg, Jan Haavik, Catharina A. Hartman, Jonna Kuntsi, Henrik Larsson, Silke Matura, Rhiannon McNeill, J. Antoni Ramos-Quiroga, Marta Ribases, Marcel Romanos, Isabella Vainieri, Barbara Franke, Andreas Reif
Summary: There is a correlation between ADHD and non-mental diseases, possibly due to shared pathologic mechanisms and genetic risk factors. Neglecting these co-occurring conditions may result in missed diagnoses and suboptimal treatment.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Developmental
Corentin J. Gosling, Samuele Cortese, Eric Konofal, Michel Lecendreux, Stephen V. Faraone
Summary: This study examined the association between sleep disturbances and ADHD symptoms over a 9-year period, finding that sleep disturbances at age 13 predicted increased ADHD symptoms at age 18, while ADHD symptoms at age 9 predicted increased sleep disturbances at age 13. The findings highlight the importance of identifying these issues for preventive interventions.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Alessio Bellato, John Perna, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Samuele Cortese, Stephen Faraone
Summary: This study conducted a systematic review and meta-analysis to investigate the association between attention-deficit/hyperactivity disorder (ADHD) and eye disorders as well as altered visual function. The findings suggest that ADHD is associated with an increased risk of certain vision problems and visual function impairments, but not with structural changes in the eye.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Developmental
Yanli Zhang-James, Ali Shervin Razavi, Martine Hoogman, Barbara Franke, Stephen V. Faraone
Summary: This systematic review examines the literature on the development of magnetic resonance imaging (MRI)-based diagnostic classifiers for attention-deficit/hyperactivity disorder (ADHD) using machine learning (ML). It found variations in MRI modalities, ML models, cross-validation and testing methods, and sample sizes among the studies. The review also highlights the importance of large multi-modal imaging datasets and the potential combination with other types of data to develop clinically useful imaging classification tools for ADHD in the future.
JOURNAL OF ATTENTION DISORDERS
(2023)
Biographical-Item
Neurosciences
Stephen V. Faraone
BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Nevena V. Radonjic, Alessio Bellato, Nayla M. Khoury, Samuele Cortese, Stephen V. Faraone
Summary: This study conducted a systematic review and meta-analysis to assess the efficacy, acceptability, and tolerability of nonstimulants in adults with ADHD. The results showed that atomoxetine, guanfacine, and viloxazine ER were significantly more effective than placebo in treating ADHD. However, atomoxetine had poorer tolerability compared to placebo.
Article
Psychology, Developmental
Elisabeth F. Callen, Tarin L. Clay, Jillian Alai, David W. Goodman, Lenard A. Adler, Joel Shields, Stephen V. Faraone
Summary: This study aimed to assess the changes in quality care for adults with ADHD from 2010 to 2020. The results showed an increase in the achievement of quality measures over time, but none of the patients achieved more than six out of ten measures in any year. Small but significant effects were observed for sex, race, ethnicity, practice ownership, practice type, and age.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Endocrinology & Metabolism
Ali Zare Dehnavi, Yanli Zhang-James, Dan Draytsel, Ben Carguello, Stephen V. Faraone, Ruth S. Weinstock
Summary: This study found that approximately 49.2% of adults with type 2 diabetes (T2D) met the diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD). However, there was no direct association between these symptoms and cardiovascular diseases or diabetic control. Further research is needed to clarify the relationship between ADHD symptoms, diabetic control, and comorbidities.
JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
John Perna, Alessio Bellato, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Stephen V. Faraone, Samuele Cortese
Summary: This study conducted a systematic review and meta-analysis to investigate the association between vision and/or eye disorders and Autism Spectrum Disorder (ASD). The findings suggest that ASD is associated with functional vision problems and structural alterations of the eye. However, further research is needed to clarify the causal relationship between ASD and vision problems.
MOLECULAR PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
John Perna, Alessio Bellato, Preethi S. Ganapathy, Marco Solmi, Andrea Zampieri, Stephen V. Faraone, Samuele Cortese
MOLECULAR PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Lisa O'Connor, Stephanie Carbone, Anthony Gobbo, Hilary Gamble, Stephen Faraone
Summary: This article provides an overview of pharmacological treatment options for pediatric attention-deficit disorder (ADHD), including stimulant and non-stimulant medications. It offers detailed information on new medication options, such as anesthetic agents, extended-release forms, and novel adjunctive medications. These additions are beneficial for clinicians in their treatment toolbox.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
