Article
Biochemistry & Molecular Biology
Hui Hua Chang, Yuan-Shuo Hsueh, Yung Wen Cheng, Huai-Hsuan Tseng
Summary: This study investigated the associations between LEPR gene polymorphisms and treatment response to valproate (VPA) in patients with bipolar disorder (BD). The results showed that LEPR gene polymorphisms significantly affected changes in disease severity after VPA treatment in BD patients, and the LEPR CAGG haplotype was associated with a better treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Livia J. De Picker, Marion Leboyer, John R. Geddes, Manuel Morrens, Paul J. Harrison, Maxime Taquet
Summary: This study suggests that patients with therapeutic levels of lithium have a lower risk of COVID-19 infection, regardless of underlying psychiatric diagnosis or vaccination status, based on electronic health records.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Alla Shnaider, Sarit Uzzan, Ahmad Nassar, Adi Jabarin, Naim Abu-Freha, Karen Meir, Abed N. Azab
Summary: Chronic low-dose aspirin can mitigate the typical renal side effects of standard-dose lithium and enhance the beneficial behavioral effects of low-dose lithium therapy without aggravating its toxicity.
Article
Urology & Nephrology
Nahid Tabibzadeh, Emmanuelle Vidal-Petiot, Lynda Cheddani, Jean -Philippe Haymann, Guillaume Lefevre, Bruno Etain, Frank Bellivier, Emeline Marlinge, Marine Delavest, Francois Vrtovsnik, Martin Flamant
Summary: This study found that patients treated with lithium for over 10 years had lower urine concentration, higher urine output, and higher free water clearance. Higher lithium dose was associated with higher vasopressin levels and urine output, while daily osmolar intake was also related to increased urine output.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Psychiatry
Ole Kohler-Forsberg, Christopher Rohde, Andrew A. Nierenberg, Soren Dinesen Ostergaard
Summary: This study found an increased risk of osteoporosis in individuals with bipolar disorder. However, treatment with lithium was associated with a decreased risk of osteoporosis, suggesting that bone health should be prioritized in the clinical management of bipolar disorder and further research should be conducted on the potential bone-protective properties of lithium.
Article
Clinical Neurology
Lars Vedel Kessing, Simon Christoffer Ziersen, Thomas Gerds, Esben Budtz-Jorgensen
Summary: This nationwide population-based longitudinal register linkage study aimed to investigate the long-term response to lithium in patients with bipolar disorder with and without comorbid epilepsy. The study also aimed to compare differences in responses between lithium, valproate, and lamotrigine within patients with comorbid bipolar disorder and epilepsy. The findings suggest that valproate and lamotrigine should be given priority in these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Health Care Sciences & Services
Lawrence Shih-Hsin Wu, Ming-Chyi Huang, Chih-Ken Chen, Chen-Yang Shen, Cathy Shen-Jang Fann, Chun-Yuan Lin, Chih-Chien Lin, Andrew Tai-Ann Cheng
Summary: Dry mouth is a common adverse drug reaction to lithium treatment in patients with bipolar I disorder, with a specific SNP located in the immunoglobulin heavy chain locus showing the strongest association with dry mouth. This genetic variant could potentially be used for early identification and management of dry mouth in individuals undergoing lithium therapy, ultimately improving medication adherence.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Psychology, Clinical
Franz Hozer, Samuel Sarrazin, Charles Laidi, Pauline Favre, Melissa Pauling, Dara Cannon, Colm McDonald, Louise Emsell, Jean-Francois Mangin, Edouard Duchesnay, Marcella Bellani, Paolo Brambilla, Michele Wessa, Julia Linke, Mircea Polosan, Amelia Versace, Mary L. Phillips, Marine Delavest, Frank Bellivier, Nora Hamdani, Marc-Antoine D'albis, Marion Leboyer, Josselin Houenou
Summary: In this study, it was found that BD patients undergoing lithium treatment had larger cortical GM volume compared to those not receiving treatment. These patients also had greater regional GM volumes in specific brain regions. The results support the hypothesis that lithium may exert neurotrophic and neuroprotective effects in limiting pathological GM atrophy in key brain regions associated with BD.
PSYCHOLOGICAL MEDICINE
(2021)
Letter
Clinical Neurology
Mustafa Akkus
Summary: This case suggests that lithium-induced tardive dyskinesia may be reversible in a dose-dependent manner.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
Ingrid Lieber, Michael Ott, Robert Lundqvist, Mats Eliasson, Mikael Sandlund, Ursula Werneke
Summary: This study investigated the relevance of hyperthyroxinaemia as a risk factor for lithium intoxication and found that hyperthyroxinaemia was associated with a low incidence of unintentional lithium intoxication. There was no direct causal link between hyperthyroxinaemia and altered tubular renal function. Therefore, increasing the frequency of thyroid function tests may not reduce the risk of lithium intoxication.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Erdem Pulcu, Kate E. A. Saunders, Catherine J. Harmer, Paul J. Harrison, Guy M. Goodwin, John R. Geddes, Michael Browning
Summary: The affective variability of bipolar disorder (BD) is different from that of borderline personality disorder (BPD), and lithium treatment increases the volatility of positive affect.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychiatry
Michael J. Spoelma, Joanne Leidreiter, Adam Bayes, Artin Jebejian, Gordon Parker
Summary: This study provides an alternative perspective on the effectiveness of common bipolar disorder maintenance treatments by considering naturalistic data. The findings suggest a preference for lamotrigine in the maintenance treatment of bipolar II disorder, while the side effect profile of lithium remains a concern.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Neurosciences
Lingzhuo Kong, Yuting Shen, Shaohua Hu, Jianbo Lai
Summary: This study investigated the impact of quetiapine monotherapy or combination therapy with lithium on thyroid function in depressed patients with bipolar disorder. The results showed that both treatment methods significantly disturbed thyroid function, with quetiapine monotherapy being associated with immune dysregulation in the thyroid.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark A. Frye, Fred H. Gage, Elliot S. Gershon, Melvin G. McInnis, Caroline M. Nievergelt, John I. Nurnberger, Paul D. Shilling, Ketil J. Oedegaard, Peter P. Zandi, R. Kelsoe John, David K. Welsh, Michael J. McCarthy
Summary: Neuronal circadian rhythm abnormalities are present in patients with bipolar disorder, with the most pronounced deficits observed in individuals who do not respond to lithium treatment. Stimulation of entrainment pathways may partly reverse these rhythm deficits.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Claudia Pisanu, Alessio Squassina
Summary: In this narrative review, the potential use of messenger RNAs and noncoding transcripts as peripheral markers of bipolar disorder (BD) and/or response to lithium and other mood stabilizers are summarized. Studies have investigated specific targets or pathways and there is heterogeneity in the type of cells or biofluids included. However, there is a growing number of hypothesis-free designs and integration of coding and noncoding RNAs data. Studies conducted in cellular models provide promising findings for investigating the molecular determinants of BD and clinical response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Neurosciences
Firoza Mamdani, Adolfo Sequeira
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Developmental
Lea C. Perret, Michel Boivin, Genevieve Morneau-Vaillancourt, Till F. M. Andlauer, Stephane Paquin, Stephanie Langevin, Alain Girard, Gustavo Turecki, Kieran O'Donnell, Richard E. Tremblay, Sylvana M. Cote, Jean-Philippe Gouin, Isabelle Ouellet-Morin, Marie-Claude Geoffroy
Summary: This study examined whether having a genetic predisposition to depression increased the risk of experiencing depressive symptoms in peer victimised youth. The results showed that both self- and teacher-reported peer victimisation were associated with depressive symptoms in adolescence, and this association remained significant when accounting for genetic predisposition. However, there was no significant interaction between genetic predisposition and peer victimisation. The findings suggest that genetic predisposition and exposure to peer victimisation are independently associated with depressive symptoms in adolescence.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
R. J. Scott Lacombe, Mackenzie E. Smith, Kelly Perlman, Gustavo Turecki, Naguib Mechawar, Richard P. Bazinet
Summary: Through analysis of human brain hemispheres, it was found that oleic acid was the most abundant fatty acid in the human brain, and cholesterol and saturated fatty acids were more enriched in C-13 isotope, while polyunsaturated fatty acids were more depleted in C-13 isotope. These findings provide new insights into the origin and concentration of fatty acids in the human brain.
JOURNAL OF NEUROCHEMISTRY
(2023)
Editorial Material
Neurosciences
Abraham Nunes, Katie Scott, Martin Alda
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Clinical Neurology
Irfan Ahmed, Muhammad Shehzad Khan, Victor Ma, Hina Magsi, Renardi Gunawan, Abdul-Mojeed Olabisi Ilyas, Najeeb ur Rehman Lashari, Naveed Wassan, Santosh Paidi, Zulfiqar Ali, Alan W. L. Law, Yanpeng Zhang, William C. C. Cho, Martin Alda, Veerle Bergink, Ishan Barman, Condon Lau
Summary: This study investigated the effects of lithium medication on the offspring of nursing rats and found that lithium can be transferred to the pups through breast milk, leading to long-term effects on their kidneys and thyroid glands. However, these effects were reversed after discontinuation of lithium exposure.
Article
Clinical Neurology
Utkarsh Tripathi, Liron Mizrahi, Martin Alda, Gregory Falkovich, Shani Stern
Summary: This study aimed to improve the prediction of response to lithium and develop a diagnostic algorithm for bipolar disorder using information theory-derived features. The addition of these features significantly improved classification accuracy, distinguishing patients from controls and lithium responders from non-responders.
Review
Psychiatry
Katie Scott, Abraham Nunes, Barbara Pavlova, Sandra Meier, Martin Alda
Summary: This study conducted a systematic review and meta-analysis on familial clinical traits of bipolar disorder (BD), and identified 14 potentially familial traits of BD, such as age of onset, type of bipolar and response to lithium. However, there is still significant heterogeneity and publication bias in the current research.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Alyson Zwicker, Janice M. Fullerton, Niamh Mullins, Frances Rice, Danella M. Hafeman, Neeltje E. M. van Haren, Nikita Setiaman, John A. Merranko, Benjamin I. Goldstein, Alessandra G. Ferrera, Emma K. Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergio Mas Herrero, Gloria Roberts, Claudio Toma, Peter R. Schofield, Howard J. Edenberg, Holly C. Wilcox, Melvin G. McInnis, Victoria Powell, Lukas Propper, Eileen Denovan-Wright, Guy Rouleau, Josefina Castro-Fornieles, Manon H. J. Hillegers, Boris Birmaher, Anita Thapar, Philip B. Mitchell, Cathryn M. Lewis, Martin Alda, John I. Nurnberger, Rudolf Uher
Summary: The authors found that polygenic scores (PGSs) can complement family history to improve identification of risk for major mood and psychotic disorders. PGSs for neuroticism and subjective well-being are significantly associated with the onsets of disorders, and PGSs for psychiatric illness have limited predictive power when family history is known.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Paola Lavin, Soham Rej, Andrew T. Olagunju, Antonio L. Teixeira, Annemieke Dols, Martin Alda, Osvaldo P. Almeida, Kursat Altinbas, Vicent Balanza-Martinez, Izabela G. Barbosa, Hilary P. Blumberg, Farren Briggs, Cynthia Calkin, Kristin Cassidy, Brent P. Forester, Orestes V. Forlenza, Tomas Hajek, Barthomeus C. M. Haarman, Esther Jimenez, Beny Lafer, Benoit Mulsant, Stephen O. Oluwaniyi, Regan Patrick, Joaquim Radua, Sigfried Schouws, Harmehr Sekhon, Christian Simhandl, Jair C. Soares, Shang-Ying Tsai, Eduard Vieta, Luca M. Villa, Martha Sajatovic, Lisa T. Eyler
Summary: By 2030, more than 50% of individuals with bipolar disorder will be aged 50 years or older. However, there is a lack of research on older age bipolar disorder. This study developed initial recommendations for essential dimensions and variables for data collection in older age bipolar disorder, which can guide future research and clinical practice.
Article
Cell Biology
Bruno Mari Fredi, Roger Willian De Labio, Lucas Trevizani Rasmussen, Eduardo Federighi Baisi Chagas, Elizabeth Suchi Chen, Gustavo Turecki, Marilia de Arruda Cardoso Smith, Spencer Luiz Marques Payao
Summary: Alzheimer's disease is a progressive neuroinflammatory and neurodegenerative disorder that affects different regions of the brain. The accumulation of beta-amyloid protein, formation of neurofibrillary tangles, and inflammatory processes contribute to its pathophysiology. CDK10 and CDK11 have high expression in AD patients compared to control, and they present a positive correlation of gene expression in the analyzed groups and tissues, suggesting their important role in the pathogenesis of AD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vipavee Niemsiri, Sara Brin Rosenthal, Caroline M. Nievergelt, Adam X. Maihofer., Maria C. Marchetto., Renata. Santos, Tatyana Shekhtman, Ney Alliey-Rodriguez, Amit Anand, Yokesh Balaraman, Wade H. Berrettini, Holli Bertram, Katherine E. Burdick, Joseph R. Calabrese, Cynthia V. Calkin, Carla Conroy, William H. Coryell, Anna DeModena, Lisa T. Eyler, Scott Feeder, Carrie Fisher, Nicole Frazier, Mark A. Frye, Keming Gao, Julie Garnham, Elliot S. Gershon, Fernando S. Goes, Toyomi Goto, Gloria J. Harrington, Petter Jakobsen, Masoud Kamali, Marisa Kelly, Susan G. Leckband, Falk W. Lohoff, Michael J. McCarthy, Melvin G. McInnis, David Craig, Caitlin E. Millett, Francis Mondimore, Gunnar Morken, John I. Nurnberger, Claire O'Donovan, Ketil J. Oedegaard, Kelly Ryan, Martha Schinagle, Paul D. Shilling, Claire Slaney, Emma K. Stapp, Andrea Stautland, Bruce Tarwater, Peter P. Zandi, Martin Alda, Kathleen M. Fisch, Fred H. Gage, John R. Kelsoe
Summary: This study aims to identify functional genes and pathways that distinguish lithium responders from non-responders in bipolar disorder. Through integrative analysis of transcriptomic and genomic data, several candidate genes and functional networks related to focal adhesion and the extracellular matrix were identified.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Edwin J. C. G. van den Oord, Lin Y. Xie, Min Zhao, Thomas L. Campbell, Gustavo Turecki, Anna K. Kahler, Brian Dean, Ole Mors, Christina M. Hultman, Nicklas H. Staunstrup, Karolina A. Aberg
Summary: Schizophrenia is a disabling disorder with unclear pathophysiology, but a recent study using methylome-wide association analysis found suggestive associations in all cell types and whole blood, as well as significant associations in monocytes, natural killer cells, and B cells. Validation of these methylomic findings in post-mortem brains revealed significant transcriptional differences correlated with schizophrenia, providing potential genes and loci of functional relevance. This unique approach combining pre-disease onset blood data and post-disease onset brain data may lead to the development of methylation-based biomarkers for early detection of schizophrenia susceptibility.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Sean R. McWhinney, Christoph Abe, Martin Alda, Francesco Benedetti, Erlend Boen, Caterina del Mar Bonnin, Tiana Borgers, Katharina Brosch, Erick J. Canales-Rodriguez, Dara M. Cannon, Udo Dannlowski, Ana M. Diaz-Zuluaga, Lorielle M. F. Dietze, Torbjorn Elvsashagen, Lisa T. Eyler, Janice M. Fullerton, Jose M. Goikolea, Janik Goltermann, Dominik Grotegerd, Bartholomeus C. M. Haarman, Tim Hahn, Fleur M. Howells, Martin Ingvar, Neda Jahanshad, Tilo T. J. Kircher, Axel Krug, Rayus T. Kuplicki, Mikael Landen, Hannah Lemke, Benny Liberg, Carlos Lopez-Jaramillo, Ulrik F. Malt, Fiona M. Martyn, Elena Mazza, Colm McDonald, Genevieve McPhilemy, Sandra Meier, Susanne Meinert, Tina Meller, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Nils Opel, Roel A. Ophoff, Bronwyn J. Overs, Julia-Katharina Pfarr, Julian A. Pineda-Zapata, Edith Pomarol-Clotet, Joaquim Radua, Jonathan Repple, Maike Richter, Kai G. Ringwald, Gloria Roberts, Alex Ross, Raymond Salvador, Jonathan Savitz, Simon Schmitt, Peter R. Schofield, Kang Sim, Dan J. Stein, Frederike Stein, Henk S. Temmingh, Katharina Thiel, Sophia I. Thomopoulos, Neeltje E. M. van Haren, Cristian Vargas, Eduard Vieta, Annabel Vreeker, Lena Waltemate, Lakshmi N. Yatham, Christopher R. K. Ching, Ole A. Andreassen, Paul M. Thompson, Tomas Hajek
Summary: This study found that body mass index (BMI) and bipolar disorder (BD) have an impact on brain structure, particularly in cortical thickness. Both BMI and BD negatively affect the same brain regions, and BMI has a greater effect on brain alterations in individuals with BD. It is important to assess the neuroanatomical changes in BD caused by BMI and the effects of psychiatric medications on the brain.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Nicolas Garel, Kyle T. T. Greenway, Le-Anh L. Dinh-Williams, Julien Thibault-Levesque, Didier Jutras-Aswad, Gustavo Turecki, Soham Rej, Stephane Richard-Devantoy
Summary: We provide evidence that sub-anesthetic ketamine infusions can facilitate the discontinuation of long-term benzodiazepine/z-drugs for treatment-resistant depression. In this cohort study, 91% of patients successfully discontinued all benzodiazepine/z-drugs after receiving a course of ketamine infusions. Less than 25% of discontinuers experienced significant worsening of symptoms during the discontinuation phase. During follow-up, 64% of patients remained abstinent from any benzodiazepine/z-drugs. These preliminary results suggest that ketamine infusions may be a novel approach for deprescribing benzodiazepine/z-drugs in patients with treatment-resistant depression.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Alice Morgunova, Pascal Ibrahim, Gary Gang Chen, Sache M. Coury, Gustavo Turecki, Michael J. Meaney, Anthony Gifuni, Ian H. Gotlib, Corina Nagy, Tiffany C. Ho, Cecilia Flores
Summary: Dried blood spots (DBS) are a common method to collect biological samples, especially for newborns and in remote areas. MicroRNAs (miRNAs) play critical roles in diseases and are used as markers and regulators. This protocol provides optimized steps to obtain peripheral miRNA expression profiles from DBS, including key practices and the benefits of standardization.
BIOLOGY METHODS & PROTOCOLS
(2023)