Clinical delineation and natural history of thePIK3CA-related overgrowth spectrum

Megalencephaly Syndromes and Activating Mutations in the PI3K-AKT Pathway: MPPH and MCAP

(2013) GHAYDA M. MIRZAA et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab

(2013) M Cizkova et al.   BRITISH JOURNAL OF CANCER

Aspirin extends life of some patients with colorectal cancer

(2013) Carrie Printz   CANCER

AKT1 Gene Mutation Levels Are Correlated with the Type of Dermatologic Lesions in Patients with Proteus Syndrome

(2013) Marjorie J. Lindhurst et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aspirin, PIK3CA Mutation, and Colorectal-Cancer Survival

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ

(2013) Matthew D. Shirley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Mosaic Activating Mutations in PIK3CA Cause CLOVES Syndrome

(2012) Kyle C. Kurek et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Megalencephaly-capillary malformation (MCAP) and megalencephaly-polydactyly-polymicrogyria-hydrocephalus (MPPH) syndromes: Two closely related disorders of brain overgrowth and abnormal brain and body morphogenesis

(2012) Ghayda M. Mirzaa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly

(2012) Jonathan J. Rios et al.   HUMAN MOLECULAR GENETICS

Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells

(2012) Andrea E. Lo Ré et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

(2012) Kathryn M. Kinross et al.   JOURNAL OF CLINICAL INVESTIGATION

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

(2012) Marjorie J Lindhurst et al.   NATURE GENETICS

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

(2012) Jean-Baptiste Rivière et al.   NATURE GENETICS

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations

(2012) Annapurna Poduri et al.   NEURON

Next generation sequencing--implications for clinical practice

(2011) E. Raffan et al.   BRITISH MEDICAL BULLETIN

Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation

(2011) J. R. Adams et al.   CANCER RESEARCH

Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors

(2011) D. S. Meyer et al.   CANCER RESEARCH

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome

(2011) Marjorie J. Lindhurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Activating Mutation of AKT2 and Human Hypoglycemia

(2011) K. Hussain et al.   SCIENCE

Assessment and management of the orthopedic and other complications of Proteus syndrome

(2011) Laura L. Tosi et al.   Journal of Childrens Orthopaedics

CLOVES syndrome with thoracic and central phlebectasia: Increased risk of pulmonary embolism

(2010) Ahmad I. Alomari et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

More than just a big thumb

(2010) C. Tziotzios et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Aberrant FGF signaling, independent of ectopic hedgehog signaling, initiates preaxial polydactyly in Dorking chickens

(2009) Cortney M. Bouldin et al.   DEVELOPMENTAL BIOLOGY

Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome

(2008) Ahmad I. Alomari   CLINICAL DYSMORPHOLOGY

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

(2008) Jeffrey A Engelman et al.   NATURE MEDICINE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE