Article
Health Care Sciences & Services
Chin-Han Chang, Chi-Hua Chang, Jui-Pin Lai, Shiu-Shiung Lin, Yu-Jen Chang
Summary: This study investigated the prevalence of tooth agenesis, tooth malformation, and eruption patterns of upper canines/first premolars in Taiwanese children. The results suggest a strong correlation between the patterns of dental anomalies and the cleft sites in cleft lip and cleft palate patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Jose Ruben Herrera-Atoche, Nieves Aime Huerta-Garcia, Mauricio Escoffie-Ramirez, Fernando Javier Aguilar-Perez, Fernando Javier Aguilar-Ayala, Eduardo Andres Lizarraga-Colome, Gabriel Eduardo Colome-Ruiz, Ivan Daniel Zuniga-Herrera
Summary: This study compared the prevalence of dental anomalies (DA) between patients with cleft lip and palate (CLP) and a control group, finding a higher prevalence of DAs in CLP patients, especially for anomalies outside the cleft. The results suggest that environmental factors play a major role in the high prevalence of DAs in CLP subjects.
Article
Chemistry, Multidisciplinary
Mohammad Khursheed Alam, Ahmed Ali Alfawzan, Fatema Akhter, Haytham Jamil Alswairki, Prabhat Kumar Chaudhari
Summary: This study investigated the variation between non-syndromic cleft lip and/or palate (NSCLP) and non-cleft (NC) subjects in relation to lip morphology (LM) and nasolabial angle (NLA). The results showed significant disparities in LM-1 and NLA between NSCLP and NC individuals.
APPLIED SCIENCES-BASEL
(2022)
Review
Dentistry, Oral Surgery & Medicine
Robert Frederick, Amy Claire Hogan, Natalie Seabolt, Rose Mary S. Stocks
Summary: This article emphasizes the benefits of a multidisciplinary team approach in the systemic management of patients with cleft lip and cleft palate, and suggests the addition of a registered dietitian to the care team. An ideal cleft palate care team should focus on a comprehensive, collaborative, and family-centered approach. While care teams may vary depending on context and location, there are still some key principles.
Article
Chemistry, Multidisciplinary
Natalia Kaczorowska, Marcin Mikulewicz
Summary: This paper examines cephalometric parameters in patients with cleft lip and palate and cleft lip, and compares the differences between these patient groups. The results show that cleft palate surgery has an effect on the forward growth of the maxilla.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Xiaofeng Li, Yu Tian, Ling Qiu, Shu Lou, Guirong Zhu, Yue Gao, Lan Ma, Yongchu Pan
Summary: This study utilized an expression quantitative trait locus (eQTL) dataset to identify multiple associations with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). Functional annotation analysis showed that these risk loci were significantly enriched in transcription regulation and chromatin open regions on the genome. Additionally, these susceptible genes were closely related to cell fate determination, the pluripotency of stem cells, and Wnt signaling pathways.
Article
Dentistry, Oral Surgery & Medicine
Liesa Heidi Moeller, Winnie Pradel, Tomasz Gedrange, Ute Ulrike Botzenhart
Summary: The prevalence of hypodontia and supernumerary teeth among cleft patients varies significantly depending on the cleft type, with hypodontia becoming more common with the extent of the cleft while the prevalence of supernumerary teeth decreases.
Review
Genetics & Heredity
Arwa Babai, Melita Irving
Summary: Orofacial clefting is a common birth defect worldwide, presenting as cleft lip only, isolated cleft palate or cleft lip and palate. It has a diverse genetic background influenced by gene-gene and gene-environment interaction, resulting in syndromic and nonsyndromic orofacial clefts. Orofacial clefts cause significant physiological difficulties, impacting feeding, speech and language development, and other developmental aspects, leading to increased social and financial burden. The management of orofacial clefts requires a multidisciplinary team approach.
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article provides an overview of characteristics of unilateral cleft lip and nasal deformity, as well as its management options including presurgical orthopedics, operative techniques, and postsurgical care. Specific surgical techniques such as rotation-advancement and straightline repairs are discussed in detail, along with current concepts in primary cleft nose repair.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Chihiro Iwaya, Akiko Suzuki, Junichi Iwata
Summary: Cleft lip and palate is a common congenital birth defect with varied causes. Recent studies suggest that non-coding RNAs, specifically microRNAs, may play a role in the development of cleft lip and palate. This review examines the potential of microRNAs as causative mechanisms in humans and mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
David O'Neil Danis, Kevin Bachrach, Jacquelyn Piraquive, Alexander P. Marston, Jessica R. Levi
Summary: The study found an association between neonatal abstinence syndrome (NAS) and cleft lip and/or cleft palate (CLP), specifically isolated cleft palate, suggesting that prenatal exposure to opioids may be an environmental risk factor in the development of CLP.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Genetics & Heredity
Benjamin L. Green, Grace-Ann Fasaye, Sarah G. Samaranayake, Anna Duemler, Lauren A. Gamble, Jeremy L. Davis
Summary: Pathogenic and likely pathogenic variants in the CDH1 gene are associated with increased risk of gastric and breast cancers, as well as hereditary cleft lip and palate (CLP). This study aimed to determine the prevalence of CLP in families with these variants. The results showed a high prevalence of CLP in families carrying CDH1 variants, with no clear genotype-phenotype pattern. Genetic testing for CDH1 should be considered in families with CLP and a history of gastric or lobular breast cancer.
FRONTIERS IN GENETICS
(2022)
Article
Surgery
Amy S. Xue, Edward P. Buchanan, Larry H. Hollier
Summary: This article describes the characteristics and management of bilateral cleft lip and nasal deformity, including presurgical orthopedics, operative techniques, and postsurgical care.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Anne M. Sescleifer, Caitlin A. Francoisse, Tamara A. Osborn, Jeffrey D. Rector, Alexander Y. Lin
Summary: By modifying patients' postoperative photographs, the study found that lip angle has a smaller impact on appearance ratings compared to scar severity. Although families are more concerned about scarring, clinically, the angle of the cleft lip repair is more likely to influence the perception of the surgical result.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Nader Salari, Niloofar Darvishi, Mohammadbagher Heydari, Shadi Bokaee, Fateme Darvishi, Masoud Mohammadi
Summary: This study conducted a systematic review and meta-analysis to determine the overall prevalence of cleft palate, lip, and cleft lip and palate. The findings revealed a high prevalence of these oral clefts among infants. Health system policymakers need to implement measures to reduce the number of patients and mitigate the impact on children through preventive and therapeutic measures.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tsun M. Choi, Gem J. C. Kramer, Jacqueline A. C. Goos, Irene M. J. Mathijssen, Eppo B. Wolvius, Edwin M. Ongkosuwito
Summary: The study revealed that dental development was delayed by one year in patients with Muenke syndrome and Saethre-Chotzen syndrome compared to children without syndromes in the control group. These findings can help orthodontists determine whether growth disturbances related to dental development need to be considered.
EUROPEAN JOURNAL OF ORTHODONTICS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Wenying Kuang, Miranda Aarts, Anne Marie Kuijpers-Jagtman, Hong He, Edwin M. Ongkosuwito
Summary: The study assessed treatment outcomes for complete bilateral cleft lip and palate patients and found that most treatment centers had good results, but with moderate to high risk of bias and very low quality of evidence. Future clinical research should focus on methodological designs to improve treatment outcomes for BCLP patients.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ruben Houkes, Johannes Smit, Peter Mossey, Peter Don Griot, Martin Persson, Amanda Neville, Edwin Ongkosuwito, Tom Sitzman, Corstiaan Breugem
Summary: This study investigated the commonly used classification systems by cleft providers worldwide and their perceived indications and limitations. The results showed a great variety in the use of classification systems among craniofacial specialists, and recommended the usage of the LAHSHAL classification system due to its comprehensiveness and potential to overcome deficiencies in other systems.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
T. M. Choi, O. W. Lijten, I. M. J. Mathijssen, E. B. Wolvius, E. M. Ongkosuwito
Summary: This study found that patients with Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis have hypoplastic midfaces compared to a Dutch control group. Additionally, the maxillary rotation and craniofacial buildup are significantly different in these three craniosynostosis syndromes compared to controls.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Public, Environmental & Occupational Health
Mika Gissler, Melanie Durox, Lucy Smith, Beatrice Blondel, Lisa Broeders, Ashna Hindori-Mohangoo, Karen Kearns, Rumyana Kolarova, Marzia Loghi, Urelija Rodin, Katarzyna Szamotulska, Petr Velebil, Guy Weber, Oscar Zurriaga, Jennifer Zeitlin
Summary: Routine stillbirth data in European countries are not comparable and should not be used for benchmarking or surveillance without careful verification. Recommendations for improvement include using gestational age as a cut-off, excluding late terminations of pregnancy, and linking multiple sources to improve the quality of national databases.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Olivier de Waard, Robin Bruggink, Frank Baan, Hendrikus A. J. Reukers, Ewald M. Bronkhorst, Anne Marie Kuijpers-Jagtman, Edwin M. Ongkosuwito
Summary: The study aimed to investigate the operator performance of digital orthodontic setups integrated into cone beam computed tomography (CBCT) scans. The results showed significant errors in the construction of digital orthodontic setups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Robin Bruggink, Frank Baan, Sander Brons, Tom G. J. Loonen, Anne Marie Kuijpers-Jagtman, Thomas J. J. Maal, Edwin M. Ongkosuwito
Summary: This study developed a semi-automatic technique to evaluate normative facial growth in healthy children between the age of 1.5 and 5.0 years using three-dimensional stereophotogrammetric images. The results show that this technique can be used for objective clinical evaluation of facial growth.
Article
Environmental Sciences
Vinoj H. Sewberath Misser, Ashna D. Hindori-Mohangoo, Arti Shankar, Jeffrey K. Wickliffe, Maureen Y. Lichtveld, Dennis R. A. Mans
Summary: Globally, prenatal exposure to environmental contaminants such as mercury, manganese, and lead is increasingly linked to adverse birth outcomes. This study in Suriname found no statistically significant relationship between blood levels of mercury, manganese, or lead and stillbirth, preterm birth, low birth weight, and low Apgar score. However, diabetes mellitus was independently associated with preterm birth and hypertension with low birth weight.
Review
Dentistry, Oral Surgery & Medicine
Edwin M. Ongkosuwito, Mette A. R. Kuijpers
Summary: An orofacial cleft (OC) is a congenital cleft that affects the lip, alveolus, hard and soft palate, causing physical and functional problems. Patient reported Outcome (PRO) and experience (PRE) measures are important to improve care for OC patients. The current framework for OC assessment should include social network support and focus on enhancing experiences. Combining traditional indicators with PROMs can provide better understanding and enable shared decision making for OC patients, empowering them.
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2023)
Article
Environmental Sciences
Sheila A. R. Kort, Jeffrey Wickliffe, Arti Shankar, Martin Shafer, Ashna D. Hindori-Mohangoo, Hannah H. Covert, Maureen Lichtveld, Wilco Zijlmans
Summary: This study assessed the effects of exposure to mercury and lead on liver and kidney functions in pregnant women, finding a potential harmful impact of high blood mercury levels on liver and kidney function.
Article
Environmental Sciences
Cecilia S. Alcala, Maureen Y. Lichtveld, Jeffrey K. Wickliffe, Wilco Zijlmans, Arti Shankar, Ellen Rokicki, Hannah Covert, Firoz Z. Abdoel Wahid, Ashna D. Hindori-Mohangoo, Alies Van Sauers-Muller, Carmen van Dijk, Jimmy Roosblad, John Codrington, Mark J. Wilson
Summary: This study assessed pesticide exposure among pregnant women in different agricultural practices in Suriname. The participants from the Nickerie region had the highest urinary concentrations of pesticide metabolites, possibly due to residential use and heavy rice production.
Article
Pediatrics
Aloysius Ph. Koendjbiharie, Ashna D. Hindori-Mohangoo, Wilco C. W. R. Zijlmans, Jeffrey K. Wickliffe, Arti Shankar, Hannah H. Covert, Maureen Y. Lichtveld, Antoon W. Gruenberg, Stacy S. Drury
Summary: The aim of this study was to investigate the effects of prenatal exposure to perceived stress, probable depression, and lead on toddlers' neurodevelopment. The results showed that prenatal lead exposure was associated with lower communication scores, while maternal probable depression was associated with lower motor scores. However, prenatal stress was not found to have an impact. Furthermore, the combined exposure to stress, depression, and lead was found to predict fine motor scores in toddlers.
Article
Environmental Sciences
Firoz Abdoel Z. Wahid, Ashna D. Hindori-Mohangoo, Hannah H. Covert, Maryam Karimi, Samain Sabrin, Martin Shafer, Anisma R. Gokoel, Arti Shankar, Wilco Zijlmans, Maureen Lichtveld, Jeffrey K. Wickliffe
Summary: This study assessed the exposure to metals and essential elements in pregnant women in Suriname and found that pregnant women are exposed to levels of mercury and lead that exceed public health concern levels. The findings highlight the importance of developing, implementing, and monitoring environmental health policies.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Environmental Sciences
Arioene Vreedzaam, Paul Ouboter, Ashna D. Hindori-Mohangoo, Ryan Lepak, Samantha Rumschlag, Sarah Janssen, Gwen Landburg, Arti Shankar, Wilco Zijlmans, Maureen Y. Lichtveld, Jeffrey K. Wickliffe
Summary: In Suriname, the use of mercury has increased due to gold mining, putting fish-reliant communities, such as Indigenous and Tribal communities, at risk of higher mercury exposure. However, the study found no significant increase in fish mercury levels over time or based on proximity to gold mining sites. Instead, remote unmined sites were found to be more susceptible to gaseous elemental mercury deposition, leading to increased contamination risk. This highlights the potential impact of mercury releases from gold mining on fish-reliant communities far away from the mining sites.
ENVIRONMENTAL POLLUTION
(2023)
Article
Dentistry, Oral Surgery & Medicine
M. Aarts, S. Mettenberger, E. M. Bronkhorst, E. M. Ongkosuwito
Summary: This study investigated the impact of oligodontia on appearance and on the functional and psychosocial aspects of oral health-related quality of life (OHrQoL) in patients aged 8-29 years. It was found that patients with oligodontia scored lower in the domain of 'eating and drinking' and that the number of congenitally missing teeth, age, and gender had significant effects on OHrQoL.
JOURNAL OF DENTISTRY
(2023)
