Article
Medicine, General & Internal
Yi-Han Jhuang, Chi-Hsiang Chung, I-Duo Wang, Chung-Kan Peng, En Meng, Wu-Chien Chien, Ping-Ying Chang
Summary: This study investigates the association between obstructive sleep apnea (OSA) and male infertility, finding that OSA is an independent risk factor for male infertility, and untreated OSA patients have a higher risk of infertility.
Article
Andrology
Prafulla S. Ambulkar, Jwalant E. Waghmare, Poonam Verma Shivkumar, Ajay R. Chaudhari, Nitin M. Gangane, Pratibha Narang, Asoke K. Pal
Summary: This study aimed to evaluate the role of variants/mutations in the testis-specific hTAF7L gene in non-obstructive azoospermia and severe oligozoospermia male infertility. The study found that the hTAF7L gene is highly polymorphic and the identified variants are not directly associated with male infertility.
Article
Endocrinology & Metabolism
Zhengyuan Chen, Xiaoqing Shao, Min He, Ming Shen, Wei Gong, Meng Wang, Yichao Zhang, Wenjuan Liu, Zengyi Ma, Zhao Ye, Yongning Lu, Nianqin Yang, Shanwen Chen, Lydia Hu, Yiming Li, Yongfei Wang, Yao Zhao, Zhaoyun Zhang
Summary: The study found that erectile dysfunction in male patients with acromegaly is associated with excessive GH and serum nitric oxide levels, while normalization of GH after treatment is beneficial for short-term recovery of erectile function.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Urology & Nephrology
Andrea Salonia, Carlo Bettocchi, Luca Boeri, Paolo Capogrosso, Joana Carvalho, Nusret Can Cilesiz, Andrea Cocci, Giovanni Corona, Kostantinos Dimitropoulos, Murat Gul, Georgios Hatzichristodoulou, T. Hugh Jones, Ates Kadioglu, Juan Ignatio Martinez Salamanca, Uros Milenkovic, Vaibhav Modgil, Giorgio Ivan Russo, Ege Can Serefoglu, Tharu Tharakan, Paolo Verze, Suks Minhas
Summary: This study presents a summary of the European Association of Urology (EAU) guidelines on male sexual and reproductive health published in 2021. It covers topics such as late-onset hypogonadism, erectile dysfunction, premature ejaculation, and haemospermia, providing recommendations for diagnosis and treatment of these common conditions in men.
Review
Environmental Sciences
Nelson T. Peterson, Chad M. Vezina
Summary: Lower urinary tract dysfunction (LUTD) is a common condition in men that imposes significant physical, mental, social, and financial burdens on society. However, research on the influence of environmental chemicals on LUTD is lacking. This review provides toxicologists with an overview of the disease process and the role of environmental chemicals in contributing to LUTD, using both men and male mice as research models.
Article
Endocrinology & Metabolism
Yixun Liu, Xuechun Hu, Mengneng Xiong, Jiyan Li, Xiaohua Jiang, Yangyang Wan, Shun Bai, Xiansheng Zhang
Summary: Abnormal body mass index (BMI) is associated with an increased risk of erectile dysfunction (ED), and the relationship between different BMI categories and ED severity has been investigated in this study. Findings suggest that obese men have a higher risk of ED and a positive correlation is found between obesity and moderate/severe ED severity. Clinicians should pay attention to the weight management of moderate/severe ED patients to improve erectile function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Kathrin Jager, Juliane Mensch, Maria Elisabeth Grimmig, Bruno Neuner, Kerstin Gorzelniak, Seval Turkmen, Ilja Demuth, Alexander Hartmann, Christiane Hartmann, Felix Wittig, Anje Sporbert, Andreas Hermann, Georg Fuellen, Steffen Moller, Michael Walter
Summary: Telomeres are repetitive nucleotide sequences at the ends of chromosomes which can silence genes away from them to inhibit tumor growth. A study identified a set of highly conserved genes in replicatively aging animals and discovered that PPP2R2C gene, regulated by TPE-OLD, can suppress tumor-related signaling pathways.
Article
Medicine, General & Internal
Caitlin W. Hicks, Dan Wang, B. Gwen Windham, Elizabeth Selvin
Summary: The study found a significant association between peripheral neuropathy and erectile dysfunction, especially in adult men without diabetes.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Plant Sciences
Yaming Cai, Zhishen Ma, Collins Otieno Ogutu, Lei Zhao, Liao Liao, Beibei Zheng, Ruoxi Zhang, Lu Wang, Yuepeng Han
Summary: This study investigated the mechanisms of male sterility in peach using a combined cytology, physiology, and molecular approach, revealing abnormal changes in anther cells leading to male sterility in peach. The findings suggest that male sterility in peach may be caused by sequence variation in the mitochondrial genome, providing valuable insights for further exploration of the genetic mechanisms underlying male sterility.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Medicine, General & Internal
Ariel Banai, Dana Levit, Samuel Morgan, Itamar Loewenstein, Ilan Merdler, Aviram Hochstadt, Yishay Szekely, Yan Topilsky, Shmuel Banai, Yacov Shacham
Summary: C-reactive protein velocity (CRPv) is associated with both systolic and diastolic dysfunction in patients with ST elevation myocardial infarction (STEMI). Higher CRPv is related to lower left ventricular ejection fraction (LVEF) and more severe diastolic dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Marie-Agnes Dragon-Durey, Xiaoyi Chen, Amos Kirilovsky, Nadine Ben Hamouda, Carine El Sissy, Jules Russick, Etienne Charpentier, Yannick Binois, Florence Marliot, Maxime Meylan, Clemence Granier, Helene Pere, Antonin Saldmann, Bastien Rance, Anne Sophie Jannot, Stephanie Baron, Mouna Chebbi, Antoine Fayol, Nathalie Josseaume, Claire Rives-Lange, Pierre-Louis Tharaux, Bernard Cholley, Jean-Luc Diehl, Jean-Benoit Arlet, Michel Azizi, Alexandre Karras, Sebastien Czernichow, David M. Smadja, Jean-Sebastien Hulot, Isabelle Cremer, Eric Tartour, Elie Mousseaux, Franck Pages
Summary: This study investigated the mechanisms underlying SARS-CoV-2 infection severity in patients with obesity. It found specific associations between inflammatory cytokines and liver, renal, and endothelial dysfunctions in obese patients, and independent correlations between early lung damage and obesity with cytokine levels. These findings highlight distinct pathophysiological mechanisms associated with SARS-CoV-2 infection in obese patients.
Review
Medicine, General & Internal
Zhaoqi Yan, Yifeng Xu, Keke Li, Liangji Liu
Summary: This study used Mendelian randomization to investigate the causal associations between HMGCR inhibitor and male sex hormone levels and related diseases, finding that the inhibitor could reduce testosterone levels and the risk of prostate cancer without increasing the risk of erectile dysfunction. Additionally, obesity-related factors were found to mediate these associations.
Article
Biology
Hui Zheng, Robert E. Gerszten, Kathleen E. Corey
Summary: The visualization approach presented in this study allows for rapid identification of biomarkers and marker clusters that are more closely associated with clinical outcomes. The method effectively reduces the dimensionality of the data and presents it in 2-D plots, showing the inter-correlations of biomarkers and their relationships with clinical outcomes.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Obstetrics & Gynecology
U. Ezeh, M. D. Pisarska, R. Azziz
Summary: In women with hyperandrogenic polycystic ovary syndrome (PCOS), the severity of menstrual cyclicity is related to the risk of hyperinsulinemia and dysglycemia. Women with amenorrhea have a higher risk of post-challenge hyperinsulinemia and dysglycemia compared to those with oligomenorrhea or eumenorrhea.
HUMAN REPRODUCTION
(2022)
Review
Endocrinology & Metabolism
Juncen Guo, Kai Sheng, Sixian Wu, Hanxiao Chen, Wenming Xu
Summary: Since the outbreak of the COVID-19 pandemic, the number of global infection cases has exceeded 200 million, with a male bias in morbidity and mortality. COVID-19 has been associated with adverse effects on male reproductive system, such as infertility and sexual dysfunction, raising concerns among couples intending to conceive or undergo assisted reproduction. Numerous studies have explored the impact of SARS-CoV-2 on male reproduction, aiming to provide a panoramic view for further research in reproductive medicine and science.
FRONTIERS IN ENDOCRINOLOGY
(2021)