Floating-Harbor Syndrome and Intramedullary Spinal Cord Ganglioglioma: Case Report and Observations From the Literature

We report on a 5-year-old male with expressive language delay, developmental delay, short stature, and facial anomalies consistent with Floating-Harbor syndrome (FHS). In addition, he developed an intramedullary ganglioglioma. This is the first reported case of a tumor associated with FHS, and may represent an as yet undefined genetic link between spinal cord tumors and FHS, adding this syndrome to the growing list of disorders with a predisposition for tumor development. (C) 2009 Wiley-Liss, Inc.