Article
Geriatrics & Gerontology
Thomas J. Wilkinson, Joanne Miksza, Francesco Zaccardi, Claire Lawson, Andrew C. Nixon, Hannah M. L. Young, Kamlesh Khunti, Alice C. Smith
Summary: Frailty is common in individuals with chronic kidney disease (CKD) and is associated with adverse outcomes, including mortality and risk of end-stage kidney disease (ESKD). Preventative interventions should be initiated to mitigate the development of frailty. The use of a simple frailty index, generated electronically from health records, can predict outcomes and may aid prioritization for management of people with frailty.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Multidisciplinary Sciences
Haruna Fukuzaki, Junichiro Nakata, Shuko Nojiri, Yuki Shimizu, Yuka Shirotani, Takuya Maeda, Toshiki Kano, Maiko Mishiro, Nao Nohara, Hiroaki Io, Yusuke Suzuki
Summary: The importance of shared decision-making (SDM) is widely recognized. This study aimed to clarify the effectiveness and long-term medical benefits of SDM in renal replacement therapy (RRT) for patients with end-stage renal disease (ESRD). The findings demonstrate the association between visiting an ESRD clinic, improved survival in ESRD patients, and the choice of different RRT modalities.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Fung-Chang Sung, Ying-Chin Jong, Chih-Hsin Muo, Chih-Cheng Hsu, Wen-Chen Tsai, Yueh-Han Hsu
Summary: Through analyzing insurance claims data from Taiwan, we found that statin therapy may reduce mortality risks for hyperlipidemic patients, especially in those with end-stage renal disease. Hydrophilic statin therapy showed superior effects in reducing all-cause mortality and deaths from cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Kyung-Do Han, YouMi Hwang, Sang Hyun Park
Summary: This study evaluated the effect of differential blood pressure control on the prevalence of atrial fibrillation (AF) in patients with diabetic end-stage renal disease (ESRD). The results showed that the new onset hypertension, controlled hypertension, and uncontrolled hypertension groups had a higher risk of AF.
Article
Medicine, General & Internal
Min-Kuang Tsai, Wayne Gao, Kuo-Liong Chien, Chih-Cheng Hsu, Chi-Pang Wen
Summary: A study found that sustained leisure-time physical activity, particularly with vigorous intensity, significantly lowered the risk of ESRD, even among individuals with comorbidities such as diabetes or hyperlipidemia.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Article
Multidisciplinary Sciences
Yu-Kang Chang, Hueng-Chuen Fan, Chi-Chien Lin, Yuan-Hung Wang, Wan-Ni Tsai, Paik-Seong Lim
Summary: This study evaluated the risk of developing end-stage renal disease (ESRD) in diabetes mellitus (DM) patients with and without atrial fibrillation (AF). The results showed that DM patients with AF had an increased risk of ESRD compared to those without AF, and DM patients with hypertension, chronic kidney disease (CKD), or higher Charlson Comorbidity Index scores also had significantly increased ESRD risks.
Article
Biochemistry & Molecular Biology
Mahmoud M. Zakaria, Safaa A. Derbala, Ayman E. Salem, Amgad E. EL-Agroudy, Fatma M. El-Tantawy
Summary: The study found that ESRD patients have a significantly lower number of T-cell subsets compared to CKD patients, which is related to a higher degree of apoptosis in these cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Infectious Diseases
Jose Molto, Fredzzia Graterol, Adrian Curran, Natalia Ramos, Arkaitz Imaz, Diego Sandoval, Francisco Perez, Lucia Bailon, Saye Khoo, Laura Else, Roger Paredes
Summary: This study evaluated the effect of haemodialysis on doravirine concentrations in people living with HIV (PLWH) undergoing routine haemodialysis. The results showed that despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Therefore, doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Urology & Nephrology
Li Yang, Yanwei He, Xiaoming Li
Summary: This study conducted a meta-analysis to explore the relationship between physical functional performance and all-cause mortality in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) undergoing dialysis. The results showed that poor physical functional performance was significantly associated with higher all-cause mortality in these patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Primary Health Care
Noah Wouk
Summary: End-stage renal disease (ESRD) treatment options include kidney transplantation, dialysis, and palliative care. Prior to dialysis, optimal disease management is essential and initiation should be decided through shared decision-making. Vaccination, blood pressure control, salt restriction, and adequate dialysis are recommended for ESRD patients to optimize treatment outcomes.
AMERICAN FAMILY PHYSICIAN
(2021)
Article
Urology & Nephrology
Ariana J. Noel, Anan Badder Eddeen, Douglas G. Manuel, Emily Rhodes, Navdeep Tangri, Gregory L. Hundemer, Peter Tanuseputro, Gregory A. Knoll, Ranjeeta Mallick, Manish M. Sood
Summary: The study developed and validated a survey-based prediction equation to identify individuals at risk for incident CKD. The results showed that self-reported lifestyle and health behavior information from the survey can help predict the occurrence of CKD.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
John Kenneth Peel, Shaf Keshavjee, David Naimark, Mingyao Liu, Lorenzo Del Sorbo, Marcelo Cypel, Kali Barrett, Eleanor M. Pullenayegum, Beate Sander
Summary: This study compared the institutional costs of lung transplantation before and after the availability of EVLP and determined the health-economic impact of EVLP. The study found that EVLP availability was associated with faster progression to transplantation without significant marginal cost increase.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Morgan E. Grams, Nigel J. Brunskill, Shoshana H. Ballew, Yingying Sang, Josef Coresh, Kunihiro Matsushita, Aditya Surapaneni, Samira Bell, Juan J. Carrero, Gabriel Chodick, Marie Evans, Hiddo J. L. Heerspink, Lesley A. Inker, Kunitoshi Iseki, Philip A. Kalra, H. Lester Kirchner, Brian J. Lee, Adeera Levin, Rupert W. Major, James Medcalf, Girish N. Nadkarni, David M. J. Naimark, Ana C. Ricardo, Simon Sawhney, Manish M. Sood, Natalie Staplin, Nikita Stempniewicz, Benedicte Stengel, Keiichi Sumida, Jamie P. Traynor, Jan van den Brand, Chi-Pang Wen, Mark Woodward, Jae Won Yang, Angela Yee-Moon Wang, Navdeep Tangri
Summary: The kidney failure risk equation (KFRE) accurately predicts kidney failure risk in people with GFR < 60 ml/min per 1.73 m(2) when using the CKD-EPI 2021 creatinine equation. Other modifications to the KFRE did not improve its performance.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
David Z. I. Cherney, Alan Bell, Louis Girard, Philip McFarlane, Louise Moist, Sharon J. J. Nessim, Steven Soroka, Sara Stafford, Andrew Steele, Navdeep Tangri, Jordan Weinstein
Summary: The purpose of this review is to discuss the current evidence for the treatment of diabetic kidney disease (DKD) and to provide practice points. It emphasizes the importance of early identification of DKD to prevent disease progression and associated complications. The review also highlights the individualized treatment decisions based on patients' needs and preferences, as well as the use of renin-angiotensin-aldosterone system blockade, SGLT2 inhibitors, and finerenone to reduce the risk of kidney and cardiovascular events.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2023)
Article
Urology & Nephrology
Vandana Mathur, Nancy L. Reaven, Susan E. Funk, Navdeep Tangri
Summary: Metabolic acidosis, especially eubicarbonatemic metabolic acidosis, is associated with kidney allograft failure in transplant recipients. However, the effects of acidosis in this population are unclear. This retrospective cohort study showed that even small increases in serum bicarbonate levels (1 mEq/L) were significantly associated with reduced risk of graft failure, mortality, cardiovascular events, and hospitalization in US kidney transplant recipients.
Article
Medicine, Research & Experimental
Bartholomeus J. A. Willigers, Mario Ouwens, Andrew Briggs, Hiddo J. L. Heerspink, Carol Pollock, Roberto Pecoits-Filho, Navdeep Tangri, Csaba P. P. Kovesdy, David C. C. Wheeler, Juan Jose Garcia Sanchez
Summary: To minimize uncertainty in projecting long-term outcomes in clinical trials, researchers developed a novel method that incorporates expert opinion in a Bayesian analysis. The results showed that using expert opinion in Bayesian analysis produced a smaller range of survival values compared to frequentist methods.
ADVANCES IN THERAPY
(2023)
Article
Ophthalmology
Tina Felfeli, Bijan Teja, Rafael N. Miranda, Frances Simbulan, Jayanth Sridhar, Beate Sander, David M. Naimark
Summary: This study assesses the cost-effectiveness of three different strategies (PPV, SB, and PnR) for repairing primary noncomplex rhegmatogenous retinal detachment (RRD) from the perspective of healthcare payers. The results indicate that PPV is the most cost-effective primary procedure. It has a higher primary anatomical success rate, more quality-adjusted life years, and lower lifetime costs compared to SB and PnR.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Norhammar, Johan Bodegard, Marc Vanderheyden, Navdeep Tangri, Avraham Karasik, Aldo Pietro Maggioni, Kari Anne Sveen, Tiago Taveira-Gomes, Manuel Botana, Lukas Hunziker, Marcus Thuresson, Amitava Banerjee, Johan Sundstrom, Andreas Bollmann
Summary: The CaReMe HF study collected individual level data from digital healthcare systems in 11 countries to estimate the prevalence, clinical outcomes, and costs of HF. The study found that 1-2% of the contemporary adult population has HF, and these individuals are at significant risk of adverse outcomes and associated costs.
Article
Medicine, General & Internal
Shardool Patel, Derek Pinnell, Joshua Qualls, Anitha Rathod, Wei Chen, Sylvie Boutin, Steven D. Woods, Csaba P. Kovesdy, Navdeep Tangri, Brian C. Sauer
Summary: Untreated chronic hyperkalemia is associated with increased mortality risk. Patiromer, a new potassium binder, is being used by clinicians as a management tool. This study assessed patiromer utilization and its effect on serum potassium in US veterans with prior exposure to sodium polystyrene sulfonate.
Editorial Material
Urology & Nephrology
Nestor Oliva-Damaso, Navdeep Tangri, Pierre Delanaye, Richard J. Glassock
Summary: Optimizing the referral of at-risk patients to nephrologists can enhance their long-term outcomes. Strategies such as incorporating kidney failure risk equations into electronic medical records and actively disseminating clinical practice guidelines could bridge the gap between optimal referral and current clinical practices.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Urology & Nephrology
Krista Rossum, Evelyn Hancock, Stephanie Thompson, Ranveer Brar, Victoria Riehl-Tonn, Eric Garcia, Silvia J. Leon, Monica Sharma, Emilie Ford, Paul Komenda, Claudio Rigatto, Navdeep Tangri, Jennifer M. MacRae, Clara Bohm
Summary: The timing of intradialytic cycling does not affect the rate of intradialytic hypotension. Delaying exercise during hemodialysis can optimize the use of exercise programs and may be a potential treatment for symptoms common in late hemodialysis.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Nancy L. Reaven, Susan E. Funk, Vandana Mathur, Thomas W. Ferguson, Julie Lai, Navdeep Tangri
Summary: This study found that the Kidney Failure Risk Equations (KFRE) can predict healthcare costs for patients with chronic kidney disease (CKD). For the 8-variable KFRE, each 1% increase in risk was associated with a 13.5% and 4.1% increase in monthly costs for CKD stage G3 and G4 patients, respectively. For the 4-variable KFRE, a 1% increase in risk was associated with a 6.7% and 2.9% increase in monthly costs for CKD stage G3 and G4 patients, respectively.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Nancy L. Reaven, Susan E. Funk, Vandana Mathur, Navdeep Tangri
Summary: This study aimed to investigate the impact of metabolic acidosis on healthcare costs and resource utilization in patients with chronic kidney disease (CKD). The results showed that patients with metabolic acidosis had higher rates of adverse kidney outcomes and higher healthcare costs. Each 1-mEq/L increase in serum bicarbonate levels was associated with a decrease in adverse events and costs.
Article
Urology & Nephrology
Reid H. Whitlock, Mohammad Nour-Mohammadi, Sarah Curtis, Paul Komenda, Clara Bohm, David Collister, Navdeep Tangri, Claudio Rigatto
Summary: This study used administrative health databases to identify patients at high risk of Fabry disease and found that 1364 high-risk patients had not been tested. Administrative health databases can assist in identifying high-risk populations and further design screening programs for Fabry disease.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2023)
Review
Urology & Nephrology
Donald E. E. Wesson, Vandana Mathur, Navdeep Tangri
Summary: Research suggests that metabolic derangements of skeletal muscle dysfunction in both chronic kidney disease and aging-related frailty offer potential avenues for identifying new preventive and treatment strategies. Targeting these derangements unique to CKD may help improve quality and quantity of life for patients with CKD.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)