Article
Urology & Nephrology
Ronald D. Perrone, Kaleab Z. Abebe, Terry J. Watnick, Andrew D. Althouse, Kenneth R. Hallows, Christina M. Lalama, Dana C. Miskulin, Stephen L. Seliger, Cheng Tao, Peter C. Harris, Kyongtae Ty Bae
Summary: Metformin was found to be safe and tolerable in adults with ADPKD, slightly reducing estimated GFR decline but not significantly. Larger trials are needed to evaluate efficacy.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Martine G. E. Knol, Bart J. Kramers, Ron T. Gansevoort, Maatje D. A. van Gastel
Summary: This study examined the relationship between endogenous glucagon and disease severity/progression in ADPKD patients. The results showed that glucagon concentration was associated with patient characteristics and blood markers, but not with declines in kidney function or growth in kidney volume. Further intervention studies are needed to explore the relationship between glucagon and ADPKD.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Environmental Sciences
Nan Zhao, Xinxin Fang, Shiwen Zhang, Yuting Zhu, Lei Ding, Caihong Xu
Summary: This study found that male serum total short-chain CP and medium-chain CP concentrations were associated with kidney function, specifically with elevated risk of glomerular hyperfiltration (GH), while no such associations were observed in females.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Gustavo Laham, Juan Pablo Ponti, Gervasio Soler Pujol
Summary: Kidney transplantation is the preferred treatment for end-stage kidney disease, but the shortage of deceased donors has led to an increase in living donor transplants. Studies suggest that living donors may have a higher risk of developing kidney disease after donation. Proper evaluation of donors is crucial to avoid rejecting suitable donors and accepting those at higher risk. Assessing glomerular filtration rate (GFR) is an important aspect of donor evaluation, but there is ongoing debate on the methods for measuring GFR.
FRONTIERS IN MEDICINE
(2022)
Article
Transplantation
Charles J. Blijdorp, David Severs, Usha M. Musterd-Bhaggoe, Ronald T. Gansevoort, Robert Zietse, Ewout J. Hoorn
Summary: In patients with ADPKD, lower serum bicarbonate levels within the normal range are associated with worse kidney outcomes, independent of established prognostic factors for ADPKD and urine ammonium excretion. This suggests that serum bicarbonate may be a valuable addition to prognostic models for ADPKD and should be further explored as a potential treatment target.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Rosa Miquel Rodriguez, Sergio Luis-Lima, Juan Manuel Fernandez, Maria Vanesa Perez Gomez, Beatriz Gonzalez Toledo, Marian Cobo, Patricia Delgado-Mallen, Beatriz Escamilla, Cristina Oramas Marco, Sara Estupinan, Coriolano Cruz Perera, Natalia Negrin Mena, Laura Diaz Martin, Sergio Pitti Reyes, Ibrahim Hernandez Gonzalez, Federico Gonzalez-Rinne, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Begona Lopez-Botet Zulueta, Armando Torres, Jose Carlos Rodriguez Perez, Flavio Gaspari, Alberto Ortiz, Esteban Porrini
Summary: The study evaluated the agreement between measured GFR and estimated GFR by different formulas in ADPKD patients. Results showed that none of the formulas had acceptable agreement with measured GFR, indicating significant deviation from real renal function.
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Gyuyeong Rah, Hwayeon Cha, Joohee Kim, Jieun Song, Hyunho Kim, Yun Kyu Oh, Curie Ahn, Minyong Kang, Jongmin Kim, Kyung Hyun Yoo, Min Jung Kim, Hyuk Wan Ko, Je Yeong Ko, Jong Hoon Park
Summary: CILK1 deficiency in renal collecting ducts leads to PKD and promotes ciliary trafficking via increased KLC3.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Max Taubert, Elke Schaeffner, Peter Martus, Markus van der Giet, Uwe Fuhr, Amina Loesment, Natalie Ebert
Summary: In this study, the impact of a Bayesian estimation procedure on iohexol clearance estimates was evaluated, and an optimal sampling strategy was identified based on data in individuals aged 70+. A simplified three-compartment model was found to be optimal for estimating iohexol clearance in elderly patients with reduced GFR.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Adrian Cordido, Marta Vizoso-Gonzalez, Miguel A. Garcia-Gonzalez
Summary: ARPKD is a rare disorder linked to the PKHD1 and DZIP1L genes, with research elucidating molecular pathways involved in disease progression. However, understanding of the function of ARPKD proteins and the disease's molecular mechanism remains incomplete.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Pierre J. Saulnier, Helen C. Looker, Michael Mauer, Behzad Najafian, Elise Gand, Stephanie Ragot, Robert G. Nelson, Petter Bjornstad
Summary: In patients with type 2 diabetes, intraglomerular hemodynamic parameters are strongly associated with incident end-stage kidney disease (ESKD) and correlate with structural lesions of diabetic kidney disease (DKD).
Article
Medicine, General & Internal
Elisabet Van Loon, Wanqiu Zhang, Maarten Coemans, Maarten De Vos, Marie-Paule Emonds, Irina Scheffner, Wilfried Gwinner, Dirk Kuypers, Aleksandar Senev, Claire Tinel, Amaryllis H. Van Craenenbroeck, Bart De Moor, Maarten Naesens
Summary: A deep learning model was developed and validated to predict the patient-specific expected reference range of eGFR after kidney transplant, showing promising results in accurately forecasting individual trajectories within the first 3 months post-transplant.
Article
Urology & Nephrology
Kathrin Burgmaier, Leonie Brinker, Florian Erger, Bodo B. Beck, Marcus R. Benz, Carsten Bergmann, Olivia Boyer, Laure Collard, Claudia Dafinger, Marc Fila, Claudia Kowalewska, Baerbel Lange-Sperandio, Laura Massella, Antonio Mastrangelo, Djalila Mekahli, Monika Miklaszewska, Nadina Ortiz-Bruechle, Ludwig Patzer, Larisa Prikhodina, Bruno Ranchin, Nadejda Ranguelov, Raphael Schild, Tomas Seeman, Lale Sever, Przemyslaw Sikora, Maria Szczepanska, Ana Teixeira, Julia Thumfart, Barbara Uetz, Lutz Thorsten Weber, Elke Wuehl, Klaus Zerres, Joerg Doetsch, Franz Schaefer, Max Christoph Liebau
Summary: ARPKD is a severe disease characterized by fibrocystic changes in kidneys and liver, caused by variants in the PKHD1 gene. A study identified new genotype-phenotype correlations, showing that different regions of the gene affect disease severity and outcomes, potentially guiding personalized treatment approaches.
KIDNEY INTERNATIONAL
(2021)
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Adriana Gregory, Fouad T. Chebib, Bhavya Poudyal, Heather L. Holmes, Alan S. L. Yu, Douglas P. Landsittel, Kyongtae T. Bae, Arlene B. Chapman, Rahbari-Oskoui Frederic, Michal Mrug, William M. Bennett, Peter C. Harris, Bradley J. Erickson, Vicente E. Torres, Timothy L. Kline
Summary: New image-derived biomarkers are needed to improve the management of autosomal dominant polycystic kidney disease. A new technique to individually segment cysts and quantify biometric parameters has been developed. Total cyst number and cyst parenchyma surface area showed superior prediction of kidney function decline and disease stages compared to the measurement of total kidney volume.
KIDNEY INTERNATIONAL
(2023)
Article
Physiology
Nuria M. Pastor-Soler, Hui Li, Jessica Pham, Daniel Rivera, Pei-Yin Ho, Valeria Mancino, Biagio Saitta, Kenneth R. Hallows
Summary: This study tested the effectiveness of metformin as a therapy for ADPKD in a relevant mouse model and found that metformin reduced kidney cysts, improved kidney function, lowered blood pressure and urea nitrogen levels, and reduced inflammation and injury markers. These findings have implications for new ADPKD therapies in patients.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Transplantation
Franka van Luijk, Ron T. Gansevoort, Hans Blokzijl, Gerbrand J. Groen, Robbert J. de Haas, Anna M. Leliveld, Esther Meijer, Joke M. Perdok, Ruud Stellema, Andreas P. Wolff, Niek F. Casteleijn
Summary: This study analyzed the long-term efficacy of an innovative multidisciplinary treatment protocol in managing chronic refractory pain in ADPKD patients. The results showed that this protocol effectively reduced pain symptoms in the majority of patients and postponed or avoided surgical interventions such as nephrectomy in most cases.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Crissy F. Rudolphi, Charles J. Blijdorp, Hester van Willigenburg, Mahdi Salih, Ewout J. Hoorn
Summary: Urinary extracellular vesicles (uEVs) offer a noninvasive approach to study tubular transport in health and disease. They have been applied to both rare and common diseases, but challenges in technical and biological aspects still need to be addressed.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Agnes Trautmann, Olivia Boyer, Elisabeth Hodson, Arvind Bagga, Debbie S. Gipson, Susan Samuel, Jack Wetzels, Khalid Alhasan, Sushmita Banerjee, Rajendra Bhimma, Melvin Bonilla-Felix, Francisco Cano, Martin Christian, Deirdre Hahn, Hee Gyung Kang, Koichi Nakanishi, Hesham Safouh, Howard Trachtman, Hong Xu, Wendy Cook, Marina Vivarelli, Dieter Haffner
Summary: Idiopathic nephrotic syndrome is a common pediatric glomerular disease, and patients who are sensitive to steroids have a risk of relapse and may require long-term medication to maintain remission. The optimal dose and duration of steroid treatment to prolong time between relapses are still debated, and there is variation in practice regarding drug selection and timing. Therefore, international evidence-based clinical practice recommendations are needed to guide treatment and reduce practice variation.
PEDIATRIC NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dirk J. W. den Braanker, Rutger J. H. Maas, Guido van Mierlo, Naomi M. J. Parr, Marinka Bakker-van Bebber, Jeroen K. J. Deegens, Pascal W. T. C. Jansen, Jolein Gloerich, Brigith Willemsen, Henry B. B. Dijkman, Alain J. J. van Gool, Jack F. M. Wetzels, Markus M. M. Rinschen, Michiel Vermeulen, Tom Nijenhuis, Johan van der Vlag
Summary: This study aimed to investigate the possible factors and mechanisms leading to recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation. It was found that a protein called perilipin-2 was significantly increased in infiltrating cells of patients' glomeruli and was associated with lipid droplet accumulation, suggesting it as a potential biomarker. Further research should focus on understanding how these factors alter lipid metabolism in podocytes and provide new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Ben Sprangers, Ute Hegenbart, Jack F. M. Wetzels
Summary: MGRS refers to kidney diseases caused by monoclonal immunoglobulins produced by B-cell or plasma-cell clones, which do not meet current hematologic criteria for therapy. The diseases can lead to end stage kidney disease. The decision of kidney transplantation in MGRS patients should be personalized, considering factors such as the subtype of MGRS-associated kidney disease, patient age and comorbidity, extrarenal complications, waiting time, living kidney donor availability, and previous hematological treatment.
Article
Urology & Nephrology
Coralien H. Vink, Anne-Els van de Logt, Renate G. van der Molen, Julia M. Hofstra, Jack F. M. Wetzels
Summary: An antibody-guided treatment schedule is effective in the treatment of primary membranous nephropathy, providing individualized therapy with many patients responding well to 8 weeks of treatment.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Medicine, General & Internal
Darko Mitrovic, Margriet van Elp, Loes Visser, Nienke van Rein, Patricia van den Bemt, Marinus van Hulst, Albert Dreijer, Heleen Lameijer, Nic Veeger, Karina Meijer, Eric van Roon
Summary: This study aimed to evaluate the adherence to protocols for the use of reversal agents in Dutch hospitals. The results showed that overall adherence to the protocol for bleeding under DOAC was moderate, but it was low for patients needing an urgent procedure.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Review
Emergency Medicine
Linda J. De Vries, Nic J. G. M. Veeger, Eric N. Van Roon, Heleen Lameijer
Summary: This systematic review compared low-dose ketamine and propofol with opioids and propofol for procedural sedation in the emergency department. The results showed differences in analgesic efficacy, sedation depth, and recovery time between the two combinations. However, due to limited studies, there is insufficient evidence to support the superiority of low-dose ketamine and propofol combination therapy in emergency procedural sedation.
EUROPEAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Valentina Carotti, Wouter H. van Megen, Juan P. Rigalli, Eric R. Barros, Vera Sommers, Luco Rutten, Nico Sommerdijk, Dorien J. M. Peters, Jenny van Asbeck-van der Wijst, Joost G. J. Hoenderop
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of fluid-filled cysts within the kidney due to mutations in PKD1 or PKD2. EVs released from PKD1 knockout cells can stimulate cyst growth through effects on recipient cells, indicating their potential role in intersegmental communication and cyst growth.
Article
Oncology
Johanne Rozema, Jetske Graafsma, Mels Hoogendoorn, Robby Kibbelaar, Nic Veeger, Eric van Roon
Summary: This study analyzed the treatment patterns and outcomes in a cohort of patients with myelodysplastic syndromes (MDS). The study found that treatment options for MDS are limited and there is a lack of understanding of consecutive treatments. The duration of treatment and median overall survival after treatment discontinuation were relatively limited. There is an urgent need for new treatment options and strategies to optimize the duration of existing treatments, especially for older, higher-risk patients with MDS with a poor prognosis.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Cell Biology
Suzanne Bezstarosti, Soufian Meziyerh, Marlies E. J. Reinders, Kim Voogt-Bakker, Koen E. E. Groeneweg, Dave L. L. Roelen, Jesper Kers, Johan W. W. de Fijter, Sebastiaan Heidt
Summary: Recently, a randomized phase-II Triton study found that mesenchymal stromal cell (MSC) therapy could help living donor kidney transplant recipients withdraw tacrolimus early. This sub-study analyzed the formation of de novo donor-specific HLA antibodies (dnDSA) in relation to HLA eplet mismatches. Results showed that dnDSA occurred more frequently in the MSC group compared to the control group, but the long-term kidney function and rejection episodes were similar between the two groups. The study also suggested exploring HLA molecular mismatch load as a biomarker for personalized immunosuppression in kidney transplantation.
Article
Urology & Nephrology
Frank Geurts, Laixi Xue, Bart J. Kramers, Robert Zietse, Ron T. Gansevoort, Robert A. Fenton, Esther Meijer, Mahdi Salih, Ewout J. Hoorn, DIPAK Consortium
Summary: This study found that higher urinary excretions of PGE2 and PGEM in patients with ADPKD are associated with impaired osmoregulation, disease severity, and progression.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Hematology
Tessa Elling, Eelko Hak, Jens H. Bos, Vladimir Y. I. G. Tichelaar, Nic J. G. M. Veeger, Karina Meijer
Summary: Previous INR control during VKA therapy is not associated with subsequent DOAC nonadherence and nonpersistence. This study suggests that INR control on VKA cannot, and therefore should not, be used for predicting DOAC adherence or persistence.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
J. Joep van der Harst, Jan Willem J. Elting, Reinoud P. H. Bokkers, Nic J. G. M. Veeger, Carlina E. van Donkelaar, Walter M. van den Bergh, Jan D. M. Metzemaekers, Rob J. M. Groen, Aryan Mazuri, Gert-Jan R. Luijckx, J. Marc C. van Dijk, Maarten Uyttenboogaart
Summary: NIRS rSO2 monitoring in patients with SAH may improve prediction of DCI and clinical outcome after SAH.
WORLD NEUROSURGERY
(2023)
Article
Health Care Sciences & Services
Seye Abimbola, Hueiming Liu
Summary: Efforts to promote the adoption and scale-up of health system innovations must consider the existing institutional context. The 'four-by-four' framework, which focuses on different types of institutions and entrepreneurial strategies, can help understand the influence of context and mechanism on adoption and scale-up outcomes. It provides a scaffold to generate narratives, a tool to map out contingencies, and a matrix to synthesize narratives and experiences.
HEALTH POLICY AND PLANNING
(2023)