Article
Medicine, General & Internal
Chih-Yuan Lee, Meng-Kun Tsai, Yi-Ting Chen, Yu-Jun Zhan, Min-Ling Wang, Chien-Chia Chen
Summary: Creating a musculofascial tunnel during peritoneal dialysis catheter implantation can help maintain the catheter's position in the pelvis, reduce migration, and prevent catheter dysfunction.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Medicine, General & Internal
Victoria R. Briggs, Richard M. Jacques, James Fotheringham, Ravi Maheswaran, Michael Campbell, Martin E. Wilkie
Summary: This review evaluates the association between PD catheter insertion technique and associated differences in PD catheter function and post-PD catheter insertion complications. The meta-analyses of randomized controlled trials have found that different insertion techniques have certain effects on catheter function and complications.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Review
Urology & Nephrology
Vivekanand Jha, Alferso C. Abrahams, Abdullah Al-Hwiesh, Edwina A. Brown, Brett Cullis, Frank J. M. F. Dor, Mallika Mendu, Daniela Ponce, Jose Carolino Divino-Filho
Summary: This article provides a comprehensive analysis of PD catheter insertion procedures worldwide, discussing the barriers to the procedure and the impact of COVID-19, and proposes policy solutions to improve access to PD catheter insertion.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Hematology
Hong-chang Zou, Ming-ming Gao, Yan-xia Chen, Cheng-yun Xu, Wei-ping Tu, Xiao-hua Qin
Summary: This study evaluated the impact of peritoneal dialysis catheter (PDC) tail-end design variations on PDC-related complications. The analysis revealed that the straight-tailed catheter was superior to the curled-tailed catheter in minimizing catheter displacement and complication-induced catheter removal.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Surgery
Hao-Wei Kou, Chun-Nan Yeh, Chun-Yi Tsai, Chao-Wei Lee, Jun-Te Hsu, Shang-Yu Wang, Ming-Chin Yu, Wen-Hsin Chen, Chien-Chih Chiu, Tsann-Long Hwang
Summary: Sutureless omentopexy is a safe and reliable technique that reduces the risk of catheter dysfunction caused by omental wrapping, providing clinical benefits.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Urology & Nephrology
Elaine Ku, Timothy Copeland, Charles E. Mcculloch, Christopher Freise, Sabrina Legaspi, Eric Weinhandl, Karen Woo, Kirsten L. Johansen
Summary: The study compared initial outcomes after PD catheter placement by different types of operators. The study found that interventionalists had a higher probability of needing a follow-up procedure, while general surgeons had the lowest probability.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Michael Sayer, Christian Thiel, Martin Schenk, Alfred Koenigsrainer, Nils Heyne, Andreas L. Birkenfeld, Ferruh Artunc, Karolin Thiel
Summary: By using a PD catheter with an intraperitoneal extension, PD catheter implantation can be relocated to the upper abdomen in patients with obesity, providing optimal position and easy surgical access. Over a follow-up period lasting up to 51 months, the postoperative course was unremarkable, with low complication rates, and the catheter survival rates matched patient survival rates.
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Bruno Legendre, Thierry Lobbedez, Cecile Couchoud, Mathilde Lassalle, Isabelle Kazes, Antoine Lanot, Annabel Boyer, Clemence Bechade
Summary: The duration of hemodialysis before transfer to peritoneal dialysis affects the outcomes and survival of patients on peritoneal dialysis.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Jennifer M. Kaplan, Jingbo Niu, Vivian Ho, Wolfgang C. Winkelmayer, Kevin F. Erickson
Summary: The study shows that for patients over 67 years old, peritoneal dialysis (PD) has a significant advantage over in-center hemodialysis in terms of Medicare expenditures, although there is no significant difference in the dialysis modality. Over time, the gap in dialysis expenditures gradually narrowed, while the gap in nondialysis expenditures widened.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Tong Wu, Yuanyuan Qi, Shuang Ma, Lijie Zhang, Xinyu Pu, Kui Chen, Ying Zhao, Shenghua Sang, Jing Xiao
Summary: This study demonstrates that Roxadustat treatment can effectively and safely improve renal anemia and delay the decline of residual renal function (RRF) in patients new to peritoneal dialysis (PD).
Article
Urology & Nephrology
Joaquim Barreto, Cynthia Borges, Tais Betoni Rodrigues, Daniel C. Jesus, Alessandra M. Campos-Staffico, Wilson Nadruz, Jose Luiz da Costa, Rodrigo Bueno de Oliveira, Andrei C. Sposito
Summary: The study aimed to evaluate the effects of SGLT2 inhibitors on cardiovascular outcomes in patients with conservatively managed CKD. It was found that dapagliflozin was well tolerated and had nonaccumulating pharmacokinetic properties in patients with kidney failure on dialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Lijuan Zhao, Jun Yang, Ming Bai, Fanfan Dong, Shiren Sun, Guoshuang Xu
Summary: This study retrospectively analyzed the risk factors and management of catheter malfunction in urgent-start peritoneal dialysis patients, finding higher BMI, lower surgeon count, and higher serum potassium levels as independent risk factors for catheter malfunction, while older age and colonic dialysis were protective factors.
FRONTIERS IN MEDICINE
(2021)
Review
Obstetrics & Gynecology
Zatul Akmar Ahmad, Fathi Ramly, Akmal Zulayla Mohd Zahid, Bahiyah Abdullah, Muhammad Iqbal Abdul Hafidz
Summary: This case report describes a successful laparoscopic management of an endometrioma in a patient on peritoneal dialysis, with good post-operative recovery and early resumption of peritoneal dialysis. Laparoscopy is considered a safe and advantageous surgical approach for ovarian endometrioma in peritoneal dialysis patients, but careful surgical strategies are necessary to ensure the longevity of the Tenckhoff catheter and early resumption of peritoneal dialysis post-operatively.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2021)
Article
Urology & Nephrology
Xingzhe Gao, Zhiguo Peng, Engang Li, Jun Tian
Summary: This study evaluated a new technique for peritoneal dialysis catheter placement and found that the modified minimally invasive laparoscopic approach was superior to conventional open surgery in terms of intraoperative and postoperative conditions. The laparoscopic group had shorter incision length, less intraoperative blood loss, lower catheter migration rates, and lower incidence of complications after 6 months compared to the conventional group.
Article
Urology & Nephrology
Annie-Claire Nadeau-Fredette, Nidhi Sukul, Mark Lambie, Jeffrey Perl, Simon Davies, David W. Johnson, Bruce Robinson, Wim Van Biesen, Anneke Kramer, Kitty J. Jager, Rajiv Saran, Ronald Pisoni, Christopher T. Chan
Summary: This multinational study found that mortality rates were highest in the first month after transitioning from peritoneal dialysis to hemodialysis, and gradually declined afterwards. Older age, earlier initiation of peritoneal dialysis, and longer peritoneal dialysis duration were associated with increased risk of death.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Win Hlaing Than, Jack Kit-Chung Ng, Gordon Chun-Kau Chan, Winston Wing-Shing Fung, Kai-Ming Chow, Cheuk-Chun Szeto
Summary: The prevalence of obesity has significantly increased in incident Chinese peritoneal dialysis patients in Hong Kong over the past 25 years, regardless of diabetes status. New PD patients with preexisting obesity or overweight have a higher incidence of new-onset diabetes compared to those without obesity. Further studies are needed to explore the prognostic implications and impacts on healthcare systems.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Endocrinology & Metabolism
Gordon Chun -Kau Chan, Jack Kit-Chung Ng, Kai-Ming Chow, Cheuk-Chun Szeto
Summary: A retrospective observational cohort study found that SGLT2 inhibitors had significant efficacy in improving glycemic profile, kidney function, and preventing adverse kidney and cardiovascular events in diabetic patients with advanced CKD, with good safety profile.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Benjamin Y. F. So, Chun Ka Wong, Gordon Chun Kau Chan, Jack Kit Chung Ng, Grace Chung Yan Lui, Cheuk Chun Szeto, Ivan Fan Ngai Hung, Hung Fat Tse, Sydney C. W. Tang, Tak Mao Chan, Kai Ming Chow, Desmond Y. H. Yap
Summary: Hypernatraemia is common in COVID-19 patients, especially during the Omicron era. Patients with hypernatraemia have higher 30-day mortality and longer hospital stays. This study provides insights into the epidemiology and clinical outcomes of hypernatraemia in COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Gordon Chun Kau Chan, Chun Ka Wong, Benjamin Y. F. So, Jack Kit Chung Ng, Grace Chung Yan Lui, Cheuk Chun Szeto, Ivan Fan Ngai Hung, Hung Fat Tse, Sydney C. W. Tang, Tak Mao Chan, Kai Ming Chow, Desmond Y. H. Yap
Summary: This study investigates the epidemiology and outcomes of COVID-19 patients with hyponatremia. The results show that hyponatremic patients have higher 30-day mortality, prolonged hospitalization, and increased ICU admissions. Hyponatremia may serve as a prognostic indicator for unfavorable outcomes in COVID-19.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Win Hlaing Than, Jack Kit-Chung Ng, Gordon Chun-Kau Chan, Winston Wing-Shing Fung, Kai-Ming Chow, Cheuk-Chun Szeto
Summary: This study examined the change in body weight of 954 consecutive PD patients during the first 2 years of treatment and analyzed its impact on subsequent clinical outcomes. The results showed that weight loss >5% was significantly associated with a worse patient survival subsequently, while weight gain had no significant impact on patient survival.
Article
Urology & Nephrology
Lingfeng Zeng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Jack Kit-Chung Ng, Kai-Ming Chow, Cheuk-Chun Szeto
Summary: Diabetic kidney diseases (DKD) are the most common cause of dialysis-dependent kidney disease worldwide. Previous studies have shown that the urinary levels of podocyte-associated molecules may predict the prognosis of DKD. This study found that intrarenal podocalyxin level was an independent predictor of dialysis-free survival, while urinary podocin level was associated with the rate of kidney function decline.
Article
Urology & Nephrology
Win Hlaing Than, Gordon Chun-Kau Chan, Bonnie Ching-Ha Kwan, Ka-Bik Lai, Ronald Cheong-Kin Chan, Jeromy Yuen Chun Teoh, Jack Kit -Chung Ng, Winston Wing-Shing Fung, Kai-Ming Chow, Phyllis Mei-Shan Cheng, Philip Kam -Tao Li, Cheuk-Chun Szeto
Summary: This study investigated the prognostic role of plasma omentin-1 levels in incident peritoneal dialysis patients. The results showed that higher plasma omentin-1 levels were weakly correlated with fewer hospital admissions and shorter duration of hospitalization. However, there was no significant association between plasma omentin-1 levels and patient survival or technique survival.
Article
Physiology
Lik Fung Sam Lau, Jack K. C. Ng, Winston W. S. Fung, Gordon C. K. Chan, Phyllis M. S. Cheng, Kai-Ming Chow, Chi-Bon Leung, Philip Kam-To Li, Cheuk-Chun Szeto
Summary: This study found that serial monitoring of serum neutrophil-lymphocyte ratio (NLR) is associated with cardiovascular (CV) burden and all-cause mortality in peritoneal dialysis (PD) patients. Patients with high baseline NLR and persistently elevated NLR values had higher all-cause mortality. However, NLR did not show a significant relationship with CV mortality. Regular monitoring of serial serum NLR may help identify patients at risk of adverse outcomes.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Urology & Nephrology
Kai Ming Chow, Philip Kam-Tao Li, Yeoungjee Cho, Ali Abu-Alfa, Sunita Bavanandan, Edwina A. Brown, Brett Cullis, Dawn Edwards, Isabelle Ethier, Helen Hurst, Yasuhiko Ito, Thyago Proenca de Moraes, Johann Morelle, Naomi Runnegar, Anjali Saxena, Simon Wai-Yin So, Na Tian, David W. Johnson
Summary: Peritoneal dialysis (PD) catheter-related infections are significant risk factors for catheter loss and peritonitis. The 2023 updated recommendations provide revised definitions and classifications of exit site infection and tunnel infection. The new target for the overall exit site infection rate is recommended to be no more than 0.40 episodes per year at risk. Changes have been made to the recommendation of topical antibiotic cream or ointment, and new recommendations include clarified suggestions for exit site dressing cover and updated antibiotic treatment duration with emphasis on early clinical monitoring. Additional catheter interventions such as external cuff removal or shaving and exit site relocation are also suggested.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Win Hlaing Than, Gordon Chun-Kau Chan, Bonnie Ching-Ha Kwan, Ka-Bik Lai, Ronald Cheong-Kin Chan, Jeromy Yuen Chun Teoh, Jack Kit -Chung Ng, Winston Wing-Shing Fung, Kai-Ming Chow, Phyllis Mei-Shan Cheng, Man-Ching Law, Philip Kam-Tao Li, Cheuk-Chun Szeto
Summary: This study investigated the clinical and prognostic value of plasma adiponectin level and its adipose tissue mRNA expression in peritoneal dialysis (PD) patients. The results showed that plasma adiponectin level was negatively correlated with obesity, but it did not predict patient survival.
Article
Immunology
Gordon Chun Kau Chan, Grace Chung Yan Lui, Candy Ngai Sze Wong, Sindy Sin Ting Yip, Timothy Chun Man Li, Catherine Siu King Cheung, Ryan Kin Ho Sze, Cheuk Chun Szeto, Kai Ming Chow
Summary: The study aimed to evaluate the safety and virological outcomes of nirmatrelvir-ritonavir in patients with chronic kidney disease. The results showed that the modified dosage of the drug is well-tolerated and effective in suppressing the SARS-CoV-2 viral load in mild COVID-19 cases among patients with chronic kidney disease.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Urology & Nephrology
Yeoungjee Cho, Kai-Ming Chow, Philip Kam-Tao Li, Naomi Runnegar, David W. Johnson
Summary: Peritoneal dialysis is an important treatment option for patients with kidney failure, providing various benefits such as enhanced participation in daily activities, flexibility in schedules, cost savings, and improved quality of life. However, the utilization of peritoneal dialysis has remained static or declining in certain regions due to concerns about PD-related infections. This review aims to provide an overview of the definition, epidemiology, risk factors, prevention, and treatment of PD-related infections based on current evidence.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheuk-Chun Szeto, Ho So, Peter Yam-Kau Poon, Cathy Choi-Wan Luk, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Fernand Mac-Moune Lai, Lai-Shan Tam
Summary: Through the study of three cohorts of lupus nephritis patients and controls, we identified specific lncRNA targets in urine that are associated with the severity and histological classification of lupus nephritis. These urinary lncRNA levels may serve as biomarkers for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Lingfeng Zeng, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Cheuk-Chun Szeto
Summary: The levels of GSK3 beta were higher in the kidneys and urine of DKD patients compared to non-diabetic CKD patients. However, only the ratio of pY216-GSK3 total GSK3 in the kidneys was associated with the progression rate of DKD. Further studies on the pathophysiological roles of GSK3 beta in kidney diseases are needed.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Nutrition & Dietetics
Gordon Chun-Kau Chan, Jack Kit-Chung Ng, Phyllis Mei-Shan Cheng, Kai-Ming Chow, Cheuk-Chun Szeto, Philip Kam-Tao Li
Summary: The study revealed a high prevalence of dietary inadequacy and micronutrient deficiency among PD patients. Dietary zinc intake was found to be independently associated with improved nutrition, physical condition, and reduced inflammatory state.