Article
Medicine, General & Internal
Muriel Coupaye, Karlijn Pellikaan, Anthony P. Goldstone, Antonino Crino, Graziano Grugni, Tania P. Markovic, Charlotte Hoybye, Assumpta Caixas, Helena Mosbah, Laura C. G. De Graaff, Maithe Tauber, Christine Poitou
Summary: Hyponatremia in PWS is rare but potentially fatal, with causes including desmopressin treatment and excessive fluid intake. Monitoring sodium levels and avoiding desmopressin treatment should be included in routine follow-ups for patients with PWS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Lena K. Tran, Kaylee K. Marino, Jeremy R. DeGrado, Paul M. Szumita, Kevin M. Dube
Summary: This study evaluated the effects of different hyponatremia management strategies on sodium correction in critically ill patients. The results showed that patients receiving DDAVP in addition to 3HS had a higher percentage of achieving goal sodium correction at 24 hours. However, there was no significant difference in duration and total amount of 3HS infusion between the two patient groups.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Pediatrics
Ankit Kumar Meena, Pamali Mahasweta Nanda, Rajni Sharma, Biswaroop Chakrabarty, Sheffali Gulati
Summary: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of euvolemic hyponatremia in hospitalized children. It is characterized by increased serum ADH, leading to water retention through V2 receptors in the distal renal tubules. The conventional treatment for SIADH includes fluid restriction and salt supplementation, but pharmacological therapy may be required in some cases. Limited experience exists with the use of V2-receptor antagonists in the pediatric population. In this case report, a girl with corpus callosum agenesis and severe symptomatic hyponatremia due to SIADH was successfully managed with the V2-receptor antagonist tolvaptan.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Immunology
Wen Li, Shu Teng, Shi-Yong Zhao, Zheng-Hong Qi
Summary: This article reports a case of SIADH secondary to varicella in a 9-year-old girl with remarkable hyponatremia. The patient's serum sodium returned to the normal level under appropriate treatment and no evidence of hyponatremia was found at a 3-month follow-up. The authors suggest that the existence of SIADH should be considered when treating patients with varicella who present with severe hyponatremia.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Medicine, General & Internal
Toru Hamada, Katsuyuki Matsuki, Seiji Kondou, Shinya Furukawa, Morikazu Onji
Summary: Duloxetine can cause syndrome of inappropriate secretion of antidiuretic hormone (SIADH), leading to hyponatremia. Elderly patients are more susceptible, with lower doses and earlier onset. Duloxetine-induced SIADH should be considered in high-risk elderly patients when hyponatremia occurs.
Article
Biochemistry & Molecular Biology
Yanhua Wang, Lauren M. LaRocque, Joseph A. Ruiz, Eva L. Rodriguez, Jeff M. Sands, Janet D. Klein
Summary: Hyponatremia is a water balance disorder due to abnormal renal diluting capacity. Vasopressin escape is a mechanism that limits the decrease in serum sodium concentration. Aldosterone and calcineurin play roles in regulating vasopressin escape through changes in UT-A1 and AQP2 proteins. Knockout mice lacking aldosterone synthase and rats treated with spironolactone or tacrolimus showed impaired vasopressin escape and altered protein abundances of UT-A1 and AQP2.
Article
Medicine, Research & Experimental
Alvin Estilo, Linda McCormick, Mirza Rahman
Summary: This study evaluated the use of tolvaptan in hospitalized patients with hyponatremia due to SIADH, finding that it effectively increased patient sodium levels and reduced symptoms. However, careful monitoring of sodium levels is needed to prevent rapid correction of hyponatremia.
ADVANCES IN THERAPY
(2021)
Article
Urology & Nephrology
Helbert Rondon-Berrios, Richard H. Sterns
Summary: This article discusses the use of hypertonic saline in the treatment of hyponatremia, including administration modality, dosing, concomitant use of desmopressin, etc. The authors provide some recommendations based on the latest evidence.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Review
Medicine, General & Internal
Pajaree Krisanapan, Supawit Tangpanithandee, Charat Thongprayoon, Pattharawin Pattharanitima, Andrea Kleindienst, Jing Miao, Iasmina M. Craici, Michael A. Mao, Wisit Cheungpasitporn
Summary: This meta-analysis evaluates the safety and efficacy of vaptans in treating chronic hyponatremia in adult SIADH patients. The results indicate that vaptans effectively raise serum sodium concentration in the short-term, but caution is needed due to the risk of overcorrection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Marcus Skribek, Benedek Bozoky, Georgios Tsakonas
Summary: Asian patients with EGFR-mutated NSCLC have a higher prevalence and may develop SIADH with osimertinib treatment, which can be significantly improved after discontinuation. Further studies are needed to evaluate the potential mechanisms of osimertinib-induced SIADH.
Article
Pharmacology & Pharmacy
Hui Tang, Changjing Xu, Piao Zhang, Taimin Luo, Yilan Huang, Xuping Yang
Summary: Hyponatremia is a common electrolyte disorder that can have life-threatening complications. It is associated with increased hospital stays, costs, morbidity, and mortality. Recent studies have shown that oral administration of SGLT 2i is an effective treatment for hyponatremia.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Haruka Takenouchi, Takatoshi Anno, Yukiko Kimura, Fumiko Kawasaki, Ryo Shirai, Hideaki Kaneto, Katsumi Kurokawa, Koichi Tomoda
Summary: This case report describes a coma case of NMS complicated with water intoxication, SIADH syndrome and rhabdomyolysis. The patient had severe cerebral edema and hyponatremia, but the condition improved rapidly after correction of hyponatremia within a few days.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Mari Mori, Satoru Takeshita, Nami Nakamura, Yuki Mizuno, Akiko Tomita, Mineyoshi Aoyama, Hiroki Kakita, Yasumasa Yamada
Summary: This report demonstrates the safety and efficacy of tolvaptan in an infant with HPE-associated SIADH.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Medicine, General & Internal
Lynette Mei Yi Lee, Sarah Ying Tse Tan, Wann Jia Loh
Summary: This article presents two cases of severe hyponatremia caused by syndrome of inappropriate secretion of antidiuretic hormone (SIADH) with very high urine sodium concentrations. Fluid administration and/or consumption worsened the hyponatremia in both cases.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Martin Kieninger, Christina Kerscher, Elisabeth Bruendl, Sylvia Bele, Martin Proescholdt, Florian Zeman, Bernhard Graf, Nils-Ole Schmidt, Karl-Michael Schebesch
Summary: This study examined the frequency of hyponatremic episodes and treatment in 180 patients with acute aneurysmal subarachnoid hemorrhage during ICU treatment. Results showed that patients with hyponatremia were more likely to have a good outcome at 6 months after SAH. Tolvaptan therapy was associated with a lower rate of poor outcome in patients with hyponatremia.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)