Review
Biochemistry & Molecular Biology
Cassandra Millet-Boureima, Stephanie He, Thi Bich Uyen Le, Chiara Gamberi
Summary: RCC and ADPKD share similarities in tumor cell growth, cyst formation, and angiogenesis, with involvement of pathways like PI3K/AKT/mTOR and Ras/Raf/ERK. Hypoxia triggers HIF-alpha activation, potentially involving primary cilia and altered cell metabolism in disease progression. Drosophila model shows potential for accelerating disease mechanism understanding and drug screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Conor F. Underwood, Simon McMullan, Ann K. Goodchild, Jacqueline K. Phillips, Cara M. Hildreth
Summary: This study reveals that multiple independent mechanisms contribute to hypertension in polycystic kidney disease, including high plasma osmolality, angiotensin II type I receptor activation, and a hyperactive subfornical organ to paraventricular nucleus glutamatergic pathway.
CARDIOVASCULAR RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Jessica Kearney, Luigi Gnudi
Summary: The diabetes epidemic and increasing number of patients with diabetic chronic vascular complications present a major challenge to healthcare providers. Diabetic kidney disease, a serious complication of diabetes, not only leads to end-stage renal disease but is also associated with an increased risk of cardiovascular morbidity and mortality. Interventions to delay the progression of diabetic kidney disease are crucial in reducing the cardiovascular burden.
Article
Urology & Nephrology
Rainjade Chung, Jane T. Kurtzman, Anton Gillespie, Luis P. Martina, Connie Wang, James M. McKiernan, Christopher B. Anderson
Summary: This study evaluates the utility of renal mass biopsy in shared decision-making for renal mass treatment. The results show that patients perceive the biopsy results as useful and that these results can impact treatment preferences.
Review
Biochemistry & Molecular Biology
L. Lucchetti, M. Chinali, F. Emma, L. Massella
Summary: Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are the most common cystic kidney diseases, with significant differences in genetics and clinical manifestations. Hypertension is a main symptom in both diseases, but the age of onset and secondary cardiovascular complications differ. Systematic screening and monitoring of hypertension and secondary cardiovascular damage in childhood can help manage the disease early and limit the burden in adulthood.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Endocrinology & Metabolism
Andrew H. Nguyen, Michael P. O'Leary, James P. De Andrade, Philip H. G. Ituarte, Jonathan Kessler, Daneng Li, Gagandeep Singh, Sue Chang
Summary: Renal neuroendocrine neoplasms are rare and their natural history is poorly understood. The study found that patients with earlier stage and favorable histologies had increased survival rates.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Arnaud Delezire, Marianne Terrasse, Julien Bouet, Maxence Laot, Vanessa Brun, Emmanuel Oger, Cecile Vigneau
Summary: This study evaluated the association between clinical and radiological features at diagnosis and long-term outcomes in patients with acute renal infarction. Age, acute development of hypertension, and AKI at diagnosis were associated with long term CKD, while no factor was correlated with long-term hypertension after acute renal infarction.
JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Junayd Hussain, Haris Imsirovic, Mark Canney, Edward G. Clark, Meghan J. Elliott, Pietro Ravani, Peter Tanuseputro, Ayub Akbari, Gregory L. Hundemer, Tim Ramsay, Navdeep Tangri, Greg A. Knoll, Manish M. Sood
Summary: This study found that subclinical reductions in kidney function in young adults are associated with an increased cardiovascular risk. The relative risk of major adverse cardiovascular events (MACE) and MACE plus heart failure (MACE+) was higher in young adults with eGFR below age-expected values. Age-appropriate risk stratification, proactive monitoring, and timely intervention are warranted.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Urology & Nephrology
Tatsuya Suwabe, Yoshifumi Ubara, Yuki Oba, Hiroki Mizuno, Daisuke Ikuma, Masayuki Yamanouchi, Akinari Sekine, Kiho Tanaka, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa
Summary: This study investigated the frequency, causative factors, and effects of acute renal cyst bleeding on the enlargement of polycystic kidneys in ADPKD patients on dialysis. The results showed that the total volume of acute renal cyst bleeding was significantly associated with total kidney volume and was greater in younger patients. These findings suggest that renal cyst bleeding and renal artery blood flow may synergistically accelerate the enlargement of polycystic kidneys in ADPKD patients on dialysis.
JOURNAL OF NEPHROLOGY
(2023)
Article
Oncology
Shohei Fukuda, Kazutaka Saito, Yosuke Yasuda, Toshiki Kijima, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Yukio Kageyama, Yasuhisa Fujii
Summary: The study found that the CRP flare-response group among mRCC patients was associated with significant tumor shrinkage and improved survival outcomes compared to the other two groups. Early CRP kinetics may be useful for evaluating the efficacy of nivolumab treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Shohei Kaneko, Katsunori Yanai, Hiroki Ishii, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita
Summary: The role of exogenous miRNAs in renal fibrosis was investigated using a mouse model. miR-122-5p was found to be downregulated in the kidneys of mice with renal fibrosis. Overexpression of miR-122-5p promoted fibrosis, while inhibition of miR-122-5p suppressed fibrosis. miR-122-5p regulated the expression of fibrosis-related mRNAs, including pro-fibrotic TGFBR2 and anti-fibrotic FOXO3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Transplantation
Bart J. Kramers, Iris W. Koorevaar, Rudolf De Boer, Ewout J. Hoorn, Michelle J. Pena, Ron T. Gansevoort, Esther Meijer
Summary: This study found that the use of thiazide diuretics in ADPKD patients does not have a detrimental effect on disease progression rate, suggesting that these drugs can be prescribed as second-line antihypertensives. Users of thiazide diuretics may have higher vasopressin concentrations and RAAS activity, but this difference disappears after adjustment for age and sex.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Pathology
Heba W. Z. Khella, Andreas Scorilas, Roy Mozes, Lorna Mirham, Evi Lianidou, Sergey N. Krylov, Jason Y. Lee, Michael Ordon, Robert Stewart, Michael A. S. Jewett, George M. Youseff
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Article
Pathology
Sara Samaan, Heba W. Z. Khella, Andrew Girgis, Andreas Scorilas, Evi Lianidou, Manal Gabril, Sergey N. Krylov, Michael Jewett, Georg A. Bjarnason, La El-said, George M. Yousef
JOURNAL OF MOLECULAR DIAGNOSTICS
(2015)
Article
Biotechnology & Applied Microbiology
Heba W. Z. Khella, Henriett Butz, Qiang Ding, Fabio Rotondo, Kenneth R. Evans, Peter Kupchak, Moyez Dharsee, Ashraf Latif, Maria D. Pasic, Evi Lianidou, Georg A. Bjarnason, George M. Yousef
Article
Oncology
Henriett Butz, Peter M. Szabo, Heba W. Z. Khella, Roy Nofech-Mozes, Attila Patocs, George M. Yousef
Article
Oncology
Roy Nofech-Mozes, Heba W. Z. Khella, Andreas Scorilas, Leza Youssef, Sergey N. Krylov, Evi Lianidou, Konstantinos G. Sidiropoulos, Manal Gabril, Andrew Evans, George M. Yousef
Article
Pathology
Heba W. Z. Khella, Nicole Daniel, Leza Youssef, Andreas Scorilas, Roy Nofech-Mozes, Lorna Mirham, Sergey N. Krylov, Evi Liandeau, Adriana Krizova, Antonio Finelli, Yufeng Cheng, George M. Yousef
JOURNAL OF CLINICAL PATHOLOGY
(2017)
Article
Oncology
Ashley Di Meo, Rola Saleeb, Samantha J. Wala, Heba W. Khella, Qiang Ding, Haiyan Zhai, Kalra Krishan, Adriana Krizova, Manal Gabril, Andrew Evans, Fadi Brimo, Maria D. Pasic, Antonio Finelli, Eleftherios P. Diamandis, George M. Yousef
Article
Oncology
H. W. Z. Khella, M. Bakhet, G. Allo, M. A. S. Jewett, A. H. Girgis, A. Latif, H. Girgis, I. Von Both, G. A. Bjarnason, G. M. Yousef
Article
Pathology
Hala Faragalla, Youssef M. Youssef, Andreas Scorilas, Bishoy Khalil, Nicole M. A. White, Salvador Mejia-Guerrero, Heba Khella, Michael A. S. Jewett, Andrew Evans, Zsuzsanna Lichner, Georg Bjarnason, Linda Sugar, Magdy I. Attalah, George M. Yousef
JOURNAL OF MOLECULAR DIAGNOSTICS
(2012)
Article
Oncology
Heba W. Z. Khella, George M. Yousef
CANCER CYTOPATHOLOGY
(2018)
Article
Oncology
Rola Saleeb, Sung Sun Kim, Qiang Ding, Andreas Scorilas, Sicheng Lin, Heba W. Z. Khella, Carl Boulos, Gena Ibrahim, George M. Yousef
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2019)
Article
Biology
Julita A. Teodorczyk-Injeyan, Heba Khella, H. Stephen Injeyan
Summary: The study investigates the role of HMGB1 in chronic non-specific LBP and finds that the levels of extracellular HMGB1 are elevated in LBP patients. It also shows a correlation between HMGB1 levels and pain intensity.
Article
Medicine, Research & Experimental
Mohamed H. ElSayed, Huda M. Atif, Mohamed Ahmed Eladl, Samah M. Elaidy, Ahmed M. N. Helaly, Fatma Azzahraa Hisham, Noha E. Farag, Noura M. S. Osman, Afaf T. Ibrahiem, Heba W. Z. Khella, Shymaa E. Bilasy, Marzough Aziz Albalawi, Mohamed A. Helal, Wafa Ali Alzlaiq, Sawsan A. Zaiton
Summary: In this study, the neuroprotective effect of betanin was investigated in a rotenone-induced Parkinson-like mouse model. Results showed that betanin improved motor function and reduced oxidative stress and inflammation. Therefore, betanin has the potential to be used as a therapeutic agent for Parkinson's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Urology & Nephrology
Henriett Butz, Roy Nofech-Mozes, Qiang Ding, Heba W. Z. Khella, Peter M. Szabo, Michael Jewett, Antonio Finelli, Jason Lee, Michael Ordon, Robert Stewart, Sergey Krylov, George M. Yousef
EUROPEAN UROLOGY FOCUS
(2016)
