Article
Urology & Nephrology
Jia H. Ng, Jamie S. Hirsch, Azzour Hazzan, Rimda Wanchoo, Hitesh H. Shah, Deepa A. Malieckal, Daniel W. Ross, Purva Sharma, Vipulbhai Sakhiya, Steven Fishbane, Kenar D. Jhaveri
Summary: The study found that COVID-19 patients with AKI had a higher risk of death, but good kidney function recovery among survivors. However, some patients still needed dialysis at discharge.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Nutrition & Dietetics
Jinru Pan, Xiao Xu, Zi Wang, Tiantian Ma, Jie Dong
Summary: This study found that dietary potassium intake was not independently associated with all-cause and cardiovascular mortality in peritoneal dialysis (PD) patients. Initially, unadjusted analyses showed that patients with lower dietary potassium intake had higher mortality rates. However, after adjusting for demographic and laboratory data, this association weakened and even disappeared.
Article
Urology & Nephrology
Ruihua Liu, Hongjian Ye, Yuan Peng, Chunyan Yi, Jianxiong Lin, Haishan Wu, Xiangwen Diao, Haiping Mao, Fengxian Huang, Xiao Yang
Summary: This study aimed to evaluate the association between incremental initiation of peritoneal dialysis and mortality. The study found that patients in the incremental group had better survival and cardiovascular event-free survival during the first 6 years of dialysis compared to the full dose group. However, this advantage disappeared as dialysis vintage became longer. Additionally, the incremental group had lower all-cause and cardiovascular mortality rates compared to the full dose group.
JOURNAL OF NEPHROLOGY
(2023)
Article
Geriatrics & Gerontology
Thomas J. Wilkinson, Joanne Miksza, Francesco Zaccardi, Claire Lawson, Andrew C. Nixon, Hannah M. L. Young, Kamlesh Khunti, Alice C. Smith
Summary: Frailty is common in individuals with chronic kidney disease (CKD) and is associated with adverse outcomes, including mortality and risk of end-stage kidney disease (ESKD). Preventative interventions should be initiated to mitigate the development of frailty. The use of a simple frailty index, generated electronically from health records, can predict outcomes and may aid prioritization for management of people with frailty.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Urology & Nephrology
Essam S. El-Magd, Robbert W. Schouten, Els Nadort, Prataap K. Chandie Shaw, Yves F. C. Smets, Louis-Jean Vleming, Friedo W. Dekker, Birit F. P. Broekman, Adriaan Honig, Carl E. H. Siegert
Summary: Anxiety and depressive symptoms are associated with withdrawal from dialysis therapy in patients. These symptoms increase the risk of withdrawal from dialysis therapy. Understanding the factors related to dialysis withdrawal can help patients and clinicians make informed decisions and develop clinical guidelines.
Article
Economics
Eugene Lin, Khristina Lung, Glenn M. Chertow, Jay Bhattacharya, Darius Lakdawalla
Summary: In a study comparing PD and HD among uninsured patients, starting PD later in the month was associated with increased PD uptake. However, no significant differences were observed in mortality, hospitalization rates, or Medicare spending between PD and HD within the first 12 months of treatment.
Article
Urology & Nephrology
Sibel G. Bek, Simone Marschner, Kamal Sud, David W. Johnson, Clara K. Chow, Carmel Hawley, Helen Pilmore, Germaine Wong, Wai Lim, Vincent W. Lee
Summary: This study found that smoking is associated with increased rates of all-cause mortality, cardiovascular mortality, respiratory failure, chronic lung disease, and malignancy in dialysis patients. It also increases the risk of non-skin cancers, de novo vascular disease, and chronic lung disease.
Article
Urology & Nephrology
Li Jin, Xiaopei Wang, Ying Ma, Jie Zheng, Wanhong Lu, Liyi Xie, Jing Lv
Summary: Based on the results of this study, the improvement of serum albumin level after 1 year of peritoneal dialysis can predict the mortality rate among peritoneal dialysis patients.
Article
Transplantation
Marcelo Barreto Lopes, Angelo Karaboyas, Junhui Zhao, David W. Johnson, Talerngsak Kanjanabuch, Martin Wilkie, Kosaku Nitta, Hideki Kawanishi, Jeffrey Perl, Ronald L. Pisoni
Summary: This study investigates the association between serum phosphorus levels and adverse outcomes in peritoneal dialysis (PD) patients. It finds that higher serum phosphorus levels are associated with increased morbidity and mortality, highlighting the need for improved treatment strategies in this population. The study suggests that serial serum phosphorus measurements should be considered when assessing patients' risks of adverse outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
David A. Jaques, Belen Ponte, Fadi Haidar, Anne Dufey, Sebastian Carballo, Sophie De Seigneux, Patrick Saudan
Summary: This study examines the outcomes of patients initiating dialysis with different modalities, and finds that starting with I-HD is associated with improved survival and can be maintained for a significant amount of time. Diabetes is identified as a risk factor for transitioning to TW-HD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Simon J. Davies, Junhui Zhao, Hal Morgenstern, Jarcy Zee, Brian Bieber, Douglas S. Fuller, James A. Sloand, Andreas Vychytil, Hideki Kawanishi, David W. Johnson, Angela Yee-Moon Wang, Talerngsak Kanjananbuch, Sarinya Boongird, Thyago P. Moraes, Sunil Badve, Ronald L. Pisoni, Jeffrey Perl
Summary: This study investigated international variation in hypokalemia and found that persistent hypokalemia is associated with higher mortality and peritonitis rates, even after extensive adjustment for patient factors. Further research is needed to understand the mechanisms of these poorer outcomes and modifiable risk factors for persistent hypokalemia.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Nutrition & Dietetics
Limin Wei, Fanfan Gao, Lei Chen, Jie Li, Xue Zhao, Ning Qu, Xinmei Huang, Hongli Jiang, Meng Wei
Summary: The concurrent presence of malnutrition and ADL dependence has significant detrimental impacts on the health of incident dialysis patients, especially in older patients.
CLINICAL NUTRITION
(2022)
Article
Urology & Nephrology
Tian Xu, Zhiyao Bao, Min Zhou, Weiming Wang
Summary: This study provides an academic summary of the clinical characteristics, outcomes, and risk factors associated with prolonged hospital stays among COVID-19 patients with varying renal function statuses during the Omicron pandemic in Shanghai. The study found that hemodialysis-dependent patients had poorer outcomes and higher ICU admission rates, and decreased eGFR and low lymphocyte/platelet counts were important risk factors associated with prolonged Omicron infection.
Article
Pharmacology & Pharmacy
Ching-Chung Hsiao, Jih-Kai Yeh, Yan-Rong Li, Wei-Chiao Sun, Pei-Yi Fan, Chieh-Li Yen, Jung-Sheng Chen, Chihung Lin, Kuan-Hsing Chen
Summary: The study shows that the de novo use of statins in patients with non-dialysis CKD stage V can reduce the incidence of cardiovascular events, hospitalization, and mortality for infectious disease. The results reinforce the benefits of statins in a wide range of patients with renal impairment before maintenance dialysis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Emaad M. Abdel-Rahman, Ernst Casimir, Genevieve R. Lyons, Jennie Z. Ma, Jitendra K. Gautam
Summary: Identifying modifiable predictors of outcomes for acute kidney injury requiring hemodialysis is important for better care of patients. This study found that dialysis-related factors, such as frequency of intradialytic hypotension and net ultrafiltration, are associated with the outcomes of recovery, end stage kidney disease, or death. Optimizing dialysis prescription and close monitoring of outpatient dialysis are crucial in improving outcomes for these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Chandana Guha, Anita van Zwieten, Rabia Khalid, Siah Kim, Amanda Walker, Anna Francis, Madeleine Didsbury, Armando Teixeira-Pinto, Belinda Barton, Chanel Prestidge, Emily Lancsar, Fiona Mackie, Joseph Kwon, Kirsten Howard, Kylie-Ann Mallitt, Martin Howell, Allison Jaure, Alison Hayes, Rakhee Raghunandan, Stavros Petrou, Suncica Lah, Steven McTaggart, Jonathan C. Craig, Germaine Wong
Summary: This multi-center longitudinal cohort study aimed to assess the trajectories of health-related quality of life (HRQoL) in children with chronic kidney disease (CKD) over time. The results showed that the HRQoL scores differed between children with different CKD stages, and the transition from dialysis to transplantation was significantly associated with the improvement in HRQoL. Children with CKD stage 1-5 and transplant recipients at baseline had stable HRQoL over time.
KIDNEY INTERNATIONAL
(2023)
Article
Pediatrics
Chandana Guha, Rabia Khalid, Anita van Zwieten, Anna Francis, Carmel M. Hawley, Allison Jaure, Armando Teixeira-Pinto, Alistair R. Mallard, Amelie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elaine M. Pascoe, Elizabeth G. Ryan, Fiona Mackie, Hugh J. McCarthy, Jonathan C. Craig, Julie Varghese, Charani Kiriwandeniya, Kirsten Howard, Nicholas G. Larkins, Luke Macauley, Amanda Walker, Martin Howell, Michelle Irving, Patrina H. Y. Caldwell, Reginald Woodleigh, Shilpanjali Jesudason, Simon A. Carter, Sean E. Kennedy, Stephen Alexander, Steven McTaggart, Germaine Wong
Summary: This study aims to evaluate the effectiveness of a patient navigator program in children with chronic kidney disease. A total of 162 patients were enrolled and randomized into immediate intervention and waitlisted groups. The results of the study will be completed by October 2022.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Eric H. Au, Germaine Wong, Allison Tong, Armando Teixeira-Pinto, Anita van Zwieten, Ellen Dobrijevic, Curie Ahn, Christopher D. Blosser, Bianca Davidson, Anna Francis, Kenar D. Jhaveri, Jolanta Malyszko, Alejandra Mena-Gutierrez, Kenneth A. Newell, Sarah Palmer, Nicole Scholes-Robertson, Helio Tedesco Silva Junior, Jonathan C. Craig
Summary: This study aimed to assess the range and variability of cancer outcomes in trials involving kidney transplant recipients. The results showed that cancer is an infrequently reported outcome and is inconsistently defined in trials of kidney transplant recipients. Consistent reporting of cancer outcomes would provide important information on the impact of cancer in patients after kidney transplantation.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Katharine Hegerty, Allison Jaure, Nicole Scholes-Robertson, Kirsten Howard, Angela Ju, Nicole Evangelidis, Martin Wolley, Amanda Baumgart, David W. Johnson, Carmel M. Hawley, Donna Reidlinger, Laura Hickey, Alyssa Welch, Yeoungjee Cho, Peter G. Kerr, Matthew A. Roberts, Jenny I. Shen, Jonathan Craig, Rathika Krishnasamy, Andrea K. Viecelli
Summary: This study aimed to explore patients' perspectives on incremental hemodialysis (HD) and their priorities and concerns regarding HD. The study found that patients with kidney failure preferred incremental initiation of HD to minimize disruption to daily living and improve quality of life. The top prioritized outcomes were quality of life, residual kidney function, and mortality.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Health Policy & Services
K. J. Mrklas, J. M. Boyd, S. Shergill, S. Merali, M. Khan, L. Nowell, A. Goertzen, L. M. Pfadenhauer, K. Paul, K. M. Sibley, L. Swain, M. Vis-Dunbar, M. D. Hill, S. Raffin-Bouchal, M. Tonelli, I. D. Graham
Summary: The objective of this study was to identify and assess valid, reliable, and acceptable tools for evaluating outcomes and impacts of health research partnerships worldwide. A total of 48 studies and 58 tools were analyzed, with most tools consisting of surveys, questionnaires, and scales. While many tools had empirical validity, there were inconsistencies in the assessment and reporting of psychometric characteristics. The study also identified a subset of tools with empirical evidence, pragmatic strength, and moderate study quality.
HEALTH RESEARCH POLICY AND SYSTEMS
(2023)
Review
Transplantation
Gregory J. Wilson, Kim Van, Emma O'Lone, Allison Tong, Jonathan C. Craig, Benedicte Sautenet, Klemens Budde, Derek Forfang, John Gill, William G. Herrington, Tazeen H. Jafar, David W. Johnson, Vera Krane, Adeera Levin, Jolanta Malyszko, Patrick Rossignol, Deirdre Sawinski, Nicole Scholes-Robertons, Giovanni Strippoli, Angela Wang, Wolfgang C. Winkelmayer, Carmel M. Hawley, Andrea K. Viecelli
Summary: This study aimed to assess the range and consistency of cardiovascular outcomes reported by contemporary trials in kidney transplant recipients, revealing substantial heterogeneity in cardiovascular outcome reporting.
TRANSPLANTATION DIRECT
(2023)
Review
Peripheral Vascular Disease
Patrizia Natale, Jia Yi Ni, David Martinez-Martin, Ayano Kelly, Clara K. Chow, Aravinda Thiagalingam, Corinne Caillaud, Benjamin Eggleton, Nicole Scholes-Robertson, Jonathan C. Craig, Giovanni F. M. Strippoli, Allison Jaure
Summary: This study explored the perspectives and experiences of self-monitoring of blood pressure in patients with hypertension. The findings revealed that self-monitoring of blood pressure can empower patients, provide reassurance and convenience, and complement medical diagnosis and treatment. However, there are challenges such as inadequate knowledge and understanding of blood pressure targets and interpretation, limited access to monitoring devices, and psychological burdens associated with self-monitoring.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Urology & Nephrology
Chanel H. Chong, Eric H. Au, Christopher E. Davies, Allison Jaure, Martin Howell, Wai H. Lim, Jonathan C. Craig, Armando Teixeira-Pinto, Germaine Wong
Summary: The risk of infection-related death has decreased significantly over time for patients on dialysis, but it still remains more than 20 times higher than the general population. Female gender, older age, and being Aboriginal and/or Torres Strait Islander or Māori are associated with infection-related mortality.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Review
Urology & Nephrology
Patrizia Natale, Jing Zhang, Nicole Scholes-Robertson, Rosanna Cazzolli, David White, Germaine Wong, Chandana Guha, Jonathan Craig, Giovanni Strippoli, Giovanni Stallone, Loreto Gesualdo, Allison Jaure
Summary: The study revealed that COVID-19 exacerbated vulnerability and distress among individuals with chronic kidney disease and their caregivers, leading to uncertainty in accessing healthcare and reduced capacity for self-management. Optimizing telehealth services and providing more educational and psychosocial support may help improve self-management and the quality of care for this population during a pandemic.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Yingxin Lin, Armando Teixeira-Pinto, Jonathan C. Craig, Helen Opdam, Jeremy C. Chapman, Henry Pleass, Angus Carter, Natasha M. Rogers, Christopher E. Davies, Stephen McDonald, Jean Yang, Wai H. Lim, Germaine Wong
Summary: The trajectory of blood pressure decline in kidneys donated after circulatory death can predict the risk of delayed graft function. The assessment of haemodynamic changes in donors during the agonal phase may be useful for determining donor suitability and post-transplant outcomes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Jack DeLacy, Leonie Burgess, Mandy Cutmore, Simone Sherriff, Susan Woolfenden, Kathleen Falster, Emily Banks, Alison Purcell, Kelvin Kong, Harvey Coates, John Curotta, Markeeta Douglas, Kym Slater, Aleathia Thompson, Jacqueline Stephens, Juanita Sherwood, Peter McIntyre, Jean Tsembis, Michelle Dickson, Jonathan Craig, Hasantha Gunasekera
Summary: The study found that half of the urban Aboriginal children had otitis media, and two-thirds of children with hearing impairment also had otitis media. This highlights the importance of early detection and support for ear health, especially in preschool-aged children with risk factors.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
(2023)
Article
Economics
Rakhee Raghunandan, Kirsten Howard, Sarah Smith, Anagha Killedar, Erin Cvejic, Martin Howell, Stavros Petrou, Emily Lancsar, Germaine Wong, Jonathan Craig, Alison Hayes
Summary: This study evaluated the psychometric properties of the PedsQL GCS and CHU9D in children and adolescents with common chronic health problems. Both instruments showed strong internal consistency, but weak convergent validity. Known group validity was demonstrated for PedsQL GCS, while CHU9D was only able to discriminate between certain health conditions.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Article
Medicine, General & Internal
Marcello Tonelli, Natasha Wiebe, Meg Lunney, Maoliosa Donald, Tanis Howarth, Julie Evans, Scott W. Klarenbach, David Nicholas, Tiffany Boulton, Stephanie Thompson, Kara Schick Makaroff, Braden Manns, Brenda Hemmelgarn
Summary: Hearing loss is a common disability worldwide and is associated with a wide range of adverse clinical outcomes. This population-based cohort study in Alberta, Canada, found that individuals with hearing loss had higher rates of hospitalization, falls, adverse drug events, and emergency visits compared to those without hearing loss. They also had increased risks of death, cardiovascular events, depression, dementia, and other health issues.
Review
Medicine, General & Internal
Edmund Y. M. Chung, Suetonia C. Palmer, Valeria M. Saglimbene, Jonathan C. Craig, Marcello Tonelli, Giovanni F. M. Strippoli
Summary: This update of the Cochrane review found that erythropoiesis-stimulating agents (ESAs) may be more effective than placebo in treating anaemia in patients with chronic kidney disease, but their use may also increase the risk of cardiovascular events and hypertension. The comparative effects of different ESAs and their effects on other outcomes such as cardiovascular death and kidney failure remain uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Review
Urology & Nephrology
Andrea C. Cowan, Kristin K. Clemens, Jessica M. Sontrop, Stephanie N. Dixon, Lauren Killin, Sierra Anderson, Rey R. Acedillo, Amit Bagga, Clara Bohm, Pierre Antoine Brown, Brenden Cote, Varun Dev, Claire Harris, Swapnil Hiremath, Mercedeh Kiaii, Eduardo Lacson Jr, Amber O. Molnar, Matthew J. Oliver, Malvinder S. Parmar, Jennifer M. McRae, Bharat Nathoo, Kathleen Quinn, Nikhil Shah, Samuel A. Silver, Daniel J. Tascona, Stephanie Thompson, Robert H. Ting, Marcello Tonelli, Hans Vorster, Davinder B. Wadehra, Ron Wald, Myles Wolf, Amit X. Garg
Summary: This review examines the impact of magnesium intake on bone metabolism and fracture risk, revealing that sufficient magnesium intake can improve bone density and reduce fracture risk in individuals with normal kidney function. However, the relationship between magnesium concentration and bone-related outcomes in patients receiving dialysis is still poorly understood.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2023)