4.6 Article

Exertional Fatigue in Patients With CKD

期刊

AMERICAN JOURNAL OF KIDNEY DISEASES
卷 60, 期 6, 页码 930-939

出版社

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2012.06.021

关键词

Activities of daily living; anemia; exercise capacity; hemoglobin; oxygen delivery; perceived exertion; quality of life

资金

  1. North West Wales National Health Service Trust Research & Development Grants Committee [07/WNo01/21]

向作者/读者索取更多资源

Background: Fatigue is one of the most prevalent symptoms in chronic kidney disease (CKD). However, fatigue mechanisms are poorly understood due in part to nonspecific definitions. This study investigates exertional fatigue during simulated activities of daily living, focusing on oxygen delivery and utilization. Study Design: Explanatory matched-cohort study. Participants & Setting: 13 patients with CKD (stages 3b-4; mean age, 62 +/- 13 [SD] years) and 13 healthy controls, mean matched for age, height, body mass and composition, and physical activity level. Participants completed an incremental cycle ergometer test to simulate energy expenditure of typical activities of daily living. Factor: 4 exercise intensities: 1, 1.8, 2.4, and 3.1 metabolic equivalent tasks (METs). Outcomes: The primary outcome was exertional fatigue by rating of perceived exertion (RPE) on a 6-20 scale. Measurements: Other multidimensional measures of fatigue: UK Short Form Health Survey 36 (UK SF-36) Vitality and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue) subscales. Physiologic measures of the oxygen transport and utilization chain (expired gas analysis, cardiac output, and arterial oxygen content) and blood lactate. Results: RPE was increased in patients compared with controls at 2.4 (10.5 [ie, light] +/- 2.7 vs 8.7 [very light] +/- 1.7 units) and 3.1 (12.5 [somewhat hard] +/- 2.6 vs 10.2 [light] +/- 1.7 units) METs (interaction P = 0.03), which was consistent with higher chronic fatigue in patients by both the UK SF-36 Vitality (P = 0.01) and FACIT-Fatigue (P = 0.004) subscales. Arterial oxygen content was decreased in patients (P = 0.001), but cardiac output and oxygen extraction ratio were unchanged, decreasing oxygen delivery (P = 0.04). Respiratory exchange ratio (P = 0.004) and blood lactate production (P = 0.002) were increased. Limitations: Those inherent to a matched-cohort study. Conclusions: Using a novel application of the outcome measure RPE, patients with non-dialysis-dependent CKD reported considerable exertional fatigue during simulated activities of daily living. Poor compensation for mild anemia contributed to this symptom. In addition to anemia, the entire oxygen transport chain needs to be targeted to treat fatigue in patients with CKD. Am J Kidney Dis. 60(6): 930-939. (C) 2012 by the National Kidney Foundation, Inc.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Correction Geriatrics & Gerontology

Effect of a Mediterranean type diet on inflammatory and cartilage degradation biomarkers in patients with osteoarthritis (vol 21, pg 562, 2017)

J. Dyer, G. Davison, S. M. Marcora, Alexis R. Mauger

JOURNAL OF NUTRITION HEALTH & AGING (2023)

Review Sport Sciences

Development of a Revised Conceptual Framework of Physical Training for Use in Research and Practice

Annie C. Jeffries, Samuele M. Marcora, Aaron J. Coutts, Lee Wallace, Alan McCall, Franco M. Impellizzeri

Summary: The text explains the importance of conceptual framework in scientific research and introduces an updated conceptual framework for physical training, including new measurable components, training effect measures, and a continuum of sport performance outcomes.

SPORTS MEDICINE (2022)

Article Physiology

Ischemic preconditioning of the muscle reduces the metaboreflex response of the knee extensors

Luca Angius, Benjamin Pageaux, Antonio Crisafulli, James Hopker, Samuele Maria Marcora

Summary: The study showed that IP significantly reduced mean arterial pressure during metaboreflex activation, likely due to a reduced end diastolic volume. MP was significantly higher during IP compared to SHAM treatment, while PPT showed no significant differences. MP remained unchanged during exercise but was significantly lower during PEMI following IP.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2022)

Letter Sport Sciences

Authors' Response to Comment on: Development of a Revised Conceptual Framework of Physical Training for Use in Research

Annie Jeffries, Samuele Marcora, Aaron Coutts, Lee Wallace, Alan McCall, Franco Impellizzeri

SPORTS MEDICINE (2022)

Article Physiology

Sleep Deprivation Training to Reduce the Negative Effects of Sleep Loss on Endurance Performance: A Single Case Study

Chiara Gattoni, Michele Girardi, Barry Vincent O'Neill, Samuele Maria Marcora

Summary: This study describes the application of SDT as a potential strategy to reduce the negative effects of sleep deprivation on ultraendurance performance. Although further research is needed, preliminary results suggest that SDT may have beneficial effects on sleepiness and perceived mental effort during prolonged running.

INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE (2022)

Article Hospitality, Leisure, Sport & Tourism

Short and Sweet: A Randomized Controlled Initial Investigation of Brief Online Psychological Interventions With Endurance Athletes

Carla Meijen, Alister McCormick, Paul A. Anstiss, Samuele M. Marcora

Summary: This study investigates the potential of delivering brief, educational interventions online for recreational athletes. The findings suggest that online interventions, particularly those involving implementation intentions, can improve one's perception of stress controllability in endurance participants.

SPORT PSYCHOLOGIST (2022)

Review Sport Sciences

Pharmacological Blockade of Muscle Afferents and Perception of Effort: A Systematic Review with Meta-analysis

Maxime Bergevin, James Steele, Marie Payen de la Garanderie, Camille Feral-Basin, Samuele M. Marcora, Pierre Rainville, Jeffrey G. Caron, Benjamin Pageaux

Summary: This meta-analysis investigates the effect of pharmacologically blocking muscle afferents on the perception of effort. The results reveal heterogeneity between different groups, suggesting that the inclusion of perceptions other than effort influences the ratings of perceived effort. The group with effort dissociated showed a slight increase in perceived effort with reduced muscle afferent feedback, while the group with effort not dissociated and the unclear group did not show conclusive results.

SPORTS MEDICINE (2023)

Editorial Material Physiology

Louis Passfield-A Role Model for the Mission of IJSPP

Oyvind Sandbakk, Mark Burnley, James Hopker, Athanasios Pappous, Samuele Maria Marcora, Gary Brickley

INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE (2023)

Article Psychology, Multidisciplinary

Building a transdisciplinary expert consensus on the cognitive drivers of performance under pressure: An international multi-panel Delphi study

Lucy Albertella, Rebecca Kirkham, Amy B. Adler, John Crampton, Sean P. A. Drummond, Gerard J. Fogarty, James J. Gross, Leonard Zaichkowsky, Judith P. Andersen, Paul T. Bartone, Danny Boga, Jeffrey W. Bond, Tad T. Brunye, Mark J. Campbell, Liliana G. Ciobanu, Scott R. Clark, Monique F. Crane, Arne Dietrich, Tracy J. Doty, James E. Driskell, Ivar Fahsing, Stephen M. Fiore, Rhona Flin, Joachim Funke, Justine M. Gatt, P. A. Hancock, Craig Harper, Andrew Heathcote, Kristin J. Heatown, Werner F. Helsen, Erika K. Hussey, Robin C. Jackson, Sangeet Khemlani, William D. S. Killgore, Sabina Kleitman, Andrew M. Lane, Shayne Loft, Clare MacMahon, Samuele M. Marcora, Frank P. McKenna, Carla Meijen, Vanessa Moulton, Gene M. Moyle, Eugene Nalivaiko, Donna O'Connor, Dorothea O'Conor, Debra Patton, Mark D. Piccolo, Coleman Ruiz, Linda Schuecker, Ron A. Smith, Sarah J. R. Smith, Chava Sobrino, Melba Stetz, Damien Stewart, Paul Taylor, Andrew J. Tucker, Haike van Stralen, Joan N. Vickers, Troy A. W. Visser, Rohan Walker, Mark W. Wiggins, Andrew Mark Williams, Leonard Wong, Eugene Aidman, Murat Yuecel

Summary: This study aims to integrate existing knowledge in the performance field and determine the cognitive mechanisms underlying performance under pressure through expert consensus. The results identify ten important constructs, including attention, cognitive control, arousal and regulatory systems, and working memory. The expert consensus highlights the importance of standardizing cognitive assessment and informing interventions in optimizing human performance.

FRONTIERS IN PSYCHOLOGY (2023)

Meeting Abstract Psychology, Biological

Effects of running style on perception of effort, energy cost and performance in competitive runners

S. Marcor, B. M. Gonzalez, G. Toffoli, F. Nigro, S. Ciacci

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2023)

Editorial Material Physiology

Do We Ask the Right Questions and Use Appropriate Methodologies to Answer Them?

Oyvind Sandbakk

INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE (2023)

Article Medicine, General & Internal

Assessing Cognitive-Motor Interference in Military Contexts: Validity and Reliability of Two Dual-tasking Tests

Chiara Gattoni, Borja Martinez-Gonzalez, Caroline Li, Samuele Maria Marcora

Summary: The aim of this study was to investigate the construct validity and test-retest reliability of two cognitive-motor interference tests in military contexts. The results showed significant impairments on running distance and number of words recalled in the dual-task condition. Additionally, shorter step length and higher step frequency were found during loaded marching in the dual-task condition. In conclusion, the Running + Word Recall Task test is a valid and reliable dual-tasking test for assessing cognitive-motor interference in military contexts.

MILITARY MEDICINE (2023)

Editorial Material Physiology

Work-Life Balance Among Sport Scientists and Coaches: Do As I Say, Not As I Do

Oyvind Sandbakk

INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE (2023)

Article Physiology

The Evolution of World-Class Endurance Training: The Scientist's View on Current and Future Trends

Oyvind Sandbakk, David B. Pyne, Kerry McGawley, Carl Foster, Rune Kjosen Talsnes, Guro Strom Solli, Gregoire P. Millet, Stephen Seiler, Paul B. Laursen, Thomas Haugen, Espen Tonnessen, Randy Wilber, Teun van Erp, Trent Stellingwerff, Hans-Christer Holmberg, Silvana Bucher Sandbakk

Summary: This commentary provides insights into current and future trends in world-class endurance training, focusing on the accessibility of scientific knowledge for coaches and athletes, integration of practical and scientific exchange, and utilization of new technological advances. Future improvements are expected in the extensive use of advanced technology for monitoring and prescribing training and recovery, more precise use of environmental and nutritional interventions, better understanding of athlete-equipment interactions, and greater emphasis on injury and illness prevention.

INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE (2023)

Review Sport Sciences

Limits of Ultra: Towards an Interdisciplinary Understanding of Ultra-Endurance Running Performance

Nicolas J. A. Berger, Russ Best, Andrew W. Best, Andrew M. Lane, Guillaume Y. Millet, Martin Barwood, Samuele Marcora, Patrick Wilson, Shawn Bearden

Summary: This paper reviews the major limitations in ultra-endurance running (UER) and discusses factors such as thermoregulation, oxygen delivery and utilization, running economy and biomechanics, fatigue, digestive system, and psychology. It provides guidance and suggestions for practitioners and future research in these areas.

SPORTS MEDICINE (2023)

暂无数据