Article
Cell Biology
Dorota Kostrzewa-Nowak, Alicja Trzeciak-Ryczek, Pawel Wityk, Danuta Cembrowska-Lech, Robert Nowak
Summary: Intense physical exertion increases gene expression related to autophagy and inflammation, with anaerobic effort having a stronger impact compared to aerobic effort. This suggests that the bioenergetic cost of physical activity plays a significant role in the expression of autophagy-related genes, supporting the protective role of autophagy.
Article
Multidisciplinary Sciences
Kevin Cheeseman, Guillaume Jannot, Nelly Lourenco, Marie Villares, Jeremy Berthelet, Teresa Calegari-Silva, Juliette Hamroune, Franck Letourneur, Fernando Rodrigues-Lima, Jonathan B. Weitzman
Summary: Lysine methylation plays a crucial role in gene expression and differentiation stages in Theileria parasites, with H3K18me1 emerging as a key epigenetic mark. A parasite SET-domain methyltransferase, TaSETup1, is identified to be involved in this modification process.
NATURE COMMUNICATIONS
(2021)
Article
Reproductive Biology
A. R. Guadagnin, D. A. Velasco-Acosta, S. L. Stella, D. Luchini, F. C. Cardoso
Summary: Feeding rumen-protected methionine during the peripartal period and early lactation can enhance uterine immune response and metabolism in Holstein cows, as indicated by favorable gene expressions related to uterine immunometabolism during this challenging period.
Article
Biochemistry & Molecular Biology
Sourav Panja, John T. Benjamin, Bibhash C. Paria
Summary: Maternal infection-induced early pregnancy complications are linked to perturbation of the immune environment at the uterine early blastocyst implantation site. Research found that exposure to LPS can lead to defects in the implantation site, possibly involving the activation of the Tlr4-MyD88 dependent inflammatory pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Philipp von Hundelshausen, Kanin Wichapong, Hans-Joachim Gabius, Kevin H. Mayo
Summary: The trafficking and local activity of leukocytes are essential for various physiological processes. Microenvironments are complex due to the multiple mediators from diverse cell types playing regulated roles. Chemokines and galectins represent important effector molecules involved in inflammatory processes and have the capacity to form various molecular interactions in response to inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Medicine, General & Internal
Dijoia B. Darden, Gabriela L. Ghita, Zhongkai Wang, Julie A. Stortz, Maria-Cecilia Lopez, Michael C. Cox, Russell B. Hawkins, Jaimar C. Rincon, Lauren S. Kelly, Brittany P. Fenner, Tezcan Ozrazgat-Baslanti, Christiaan Leeuwenburgh, Azra Bihorac, Tyler J. Loftus, Frederick A. Moore, Scott C. Brakenridge, Henry Baker, Rhonda Bacher, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron
Summary: The study found that sepsis survivors have unique blood leukocyte transcriptomes in late sepsis, indicating ongoing immune dyscrasia which could help understand the prognosis of sepsis patients with CCI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Gijsje J. L. J. Snijders, Welmoed van Zuiden, Marjolein A. M. Sneeboer, Amber Berdenis van Berlekom, Astrid T. van der Geest, Tatiana Schnieder, Donald J. MacIntyre, Elly M. Hol, Rene S. Kahn, Lot D. de Witte
Summary: The density and morphology of microglial cells in schizophrenia patients were found to be unchanged, while the expression of several microglial-specific genes was decreased. This indicates a change in microglial phenotype rather than density, which could provide a crucial molecular hallmark for future research into the role of microglia in schizophrenia and other psychiatric disorders.
Article
Gastroenterology & Hepatology
Tanay Kaymak, Berna Kaya, Philipp Wuggenig, Sandro Nuciforo, Andreas Goldi, Franz Oswald, Julien Roux, Mario Noti, Hassan Melhem, Petr Hruz, Jan Hendrik Niess
Summary: This study illustrates the importance of the IL-20 subfamily in maintaining the barrier function of the esophagus in the context of EoE. The dysregulation of IL-20 subfamily signaling disrupts the integrity of the esophageal epithelial barrier and promotes the development of EoE. Targeting the IL-20 subfamily signaling pathway may provide a novel strategy for the treatment of EoE.
Article
Cell Biology
Keliane Liberman, Rose Njemini, Louis Nuvagah Forti, Wilfried Cools, Florence Debacq-Chainiaux, Ron Kooijman, Ingo Beyer, Ivan Bautmans
Summary: In this study, we investigated the changes in inflammation-related gene expression in peripheral mononuclear blood cells (PBMC) induced by strength training. We found that intensive strength training (IST) and strength endurance training (SET) altered the expression of different genes and related pathways, with some genes showing similar changes and others showing opposite changes when compared to the control group (CON). Changes in gene expression affected multiple canonical pathways related to chronic inflammation, and no overlapping pathways were observed between IST and SET.
Review
Immunology
Jacinta B. Smith, Jason J. Herbert, Naomi R. Truong, Anthony L. Cunningham
Summary: Herpes simplex viruses (HSV) types 1 and 2 are common infections in humans, causing oral and genital herpes. There is currently no vaccine or immunotherapy available for these diseases, making it crucial to understand the immunopathogenesis of HSV infections to develop preventive and therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf Panzer
Summary: CD4(+) IL-17A-producing TH17 cells play a crucial role in autoimmune and chronic inflammatory diseases of the kidney, skin, and gut. The IL-17RA/IL-17RC complex is highly expressed in these cells and controls the TH17 response, potentially offering new insights for more efficient treatment strategies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cell Biology
Damian Tanski, Agnieszka Skowronska, Malgorzata Tanska, Ewa Lepiarczyk, Mariusz T. Skowronski
Summary: The research shows that estradiol, progesterone, and arachidonic acid regulate the expression of AQP1 and AQP5 in porcine luminal epithelial cells through the PKA and MAPK signaling pathways.
Article
Immunology
Raquel Freitas Zambonatto, Renata Nakata Teixeira, Sarah de Oliveira Poma, Eliane Borges da Silva, Mariana Mendes de Almeida, Gerson dos Santos Leite, Cesar Miguel Momesso dos Santos, Heloisa Helena de Oliveira Alves, Renata Gorjao, Tania Cristina Pithon-Curi, Celso R. F. Carvalho, Rui Curi, Adriana Cristina Levada-Pires
Summary: The study found that neutrophils from atopic elite runners exhibited lower responses to LPS stimulation compared to non-atopic runners. Both groups responded similarly to fMLP stimulation. Training hours and volume were not associated with neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
David A. Simon A. Davis, Melissa Ritchie, Dillon Hammill, Jessica Garrett, Robert O. O. Slater, Naomi Otoo, Anna Orlov, Katharine Gosling, Jason Price, Desmond Yip, Kylie Jung, Farhan M. M. Syed, Ines I. I. Atmosukarto, Ben J. C. Quah
Summary: Blood immune cell signatures can serve as biomarkers for cancer progression, aiding in detection and characterization of different types of cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Jie Yu, Sarah L. Berga, Qingying Meng, Mingjing Xia, Trudy A. Kohout, Marcel van Duin, Robert N. Taylor
Summary: The study demonstrated the important regulatory role of dopamine receptor type 2 in endometrial tissue and cells, showing that dopamine agonists like cabergoline can promote decidualization in vitro, potentially serving as therapeutic agents for infertility due to inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Microbiology
Medini K. Annavajhala, Sabrina D. Khan, Sean B. Sullivan, Jayesh Shah, Lauren Pass, Karolina Kister, Heather Kunen, Victor Chiang, Gwennaelle C. Monnot, Christopher L. Ricupero, Rebecca A. Mazur, Peter Gordon, Annemieke de Jong, Sunil Wadhwa, Michael T. Yin, Ryan T. Demmer, Anne-Catrin Uhlemann
Article
Immunology
Sarah Nicolai, Marcin Wegrecki, Tan-Yun Cheng, Elvire A. Bourgeois, Rachel N. Cotton, Jacob A. Mayfield, Gwennaelle C. Monnot, Jerome Le Nours, Ildiko Van Rhijn, Jamie Rossjohn, D. Branch Moody, Annemieke de Jong
SCIENCE IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Rachel N. Cotton, Tan-Yun Cheng, Marcin Wegrecki, Jerome Le Nours, Dennis P. Orgill, Bohdan Pomahac, Simon G. Talbot, Richard A. Willis, John D. Altman, Annemieke de Jong, Graham Ogg, Ildiko Van Rhijn, Jamie Rossjohn, Rachael A. Clark, D. Branch Moody
Summary: CD1a-autoreactive T cells play a role in skin disease, with the antigenic target being CD1a itself. T cells can bind various lipid ligands carried by CD1a proteins, and CD1a-specific T cells are a normal component of the human skin T cell repertoire, making CD1a tetramers a simple method to track them in tissues and clinical diseases.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Annemieke de Jong, Graham Ogg
Summary: The high expression of CD1a on Langerhans cells in normal human skin indicates its crucial role in skin homeostasis and immunity. While the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin are still not fully understood. Recent research provides insights into the functions of CD1a, CD1a-restricted T cells, and lipid antigens in inflammatory and allergic skin diseases.
MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Qin Li, Torsten B. Meissner, Fang Wang, Ziming Du, Sai Ma, Sarika Kshirsagar, Tamara Tilburgs, Jason D. Buenrostro, Motonari Uesugi, Jack L. Strominger
Summary: HLA-C emerged during the evolution of pregnancy in great apes such as gorillas around 10 to 15 million years ago, playing a dual role in tolerance and immunity at the maternal-fetal interface. ELF3 is a key regulator of HLA-C, forming an autoregulatory feedback loop to establish their expression in trophoblasts. Wrenchnolol disrupts this positive-feedback loop by blocking the binding of MED23 to ELF3, resulting in down-regulation of HLA-C expression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Nadia M. Ikumi, Komala Pillay, Tamara Tilburgs, Thokozile R. Malaba, Sonwabile Dzanibe, Elizabeth Ann L. Enninga, Rana Chakraborty, Mohammed Lamorde, Landon Myer, Saye Khoo, Heather B. Jaspan, Clive M. Gray
Summary: The study found T-cell imbalances in the placenta of HIV-infected pregnant women who initiated ART late in pregnancy, which were related to the blood circulation status of the mother. This may be a causal link to immune changes in newborn infants.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Correction
Multidisciplinary Sciences
Tove Lekva, Marie Cecilie Paasche Roland, Mette E. Estensen, Errol R. Norwitz, Tamara Tilburgs, Tore Henriksen, Jens Bollerslev, Kjersti R. Normann, Per Magnus, Ole Kristoffer Olstad, Pal Aukrust, Thor Ueland
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
T. Lekva, M. C. P. Roland, M. E. Estensen, E. R. Norwitz, T. Tilburgs, T. Henriksen, J. Bollerslev, K. R. Normann, P. Magnus, O. K. Olstad, P. Aukrust, T. Ueland
Summary: This study found that the expression of TERC in PBMC was decreased in pregnant women who subsequently developed preeclampsia, suggesting a potential involvement of dysfunctional telomerase biology in the pathophysiology of preeclampsia. Additionally, senescence markers like CAMP and beta-galactosidase were increased in preeclamptic pregnancies, with CAMP remaining elevated even at 5-year follow-up, indicating a continued dysregulation of cellular senescence in PE.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Ashley L. Severance, Jeremy M. Kinder, Lijun Xin, Ashley R. Burg, Tzu-Yu Shao, Giang Pham, Tamara Tilburgs, Wendy A. Goodman, Sam Mesiano, Sing Sing Way
Summary: During pregnancy, progesterone stimulates the expansion of regulatory T cells to promote immune tolerance, ensuring fetal growth and preventing rejection from the mother's immune system. This study reveals the role of progesterone in promoting fetal tolerance and establishes a molecular link between immune and other physiological adaptations during pregnancy.
Article
Immunology
Gwennaelle C. Monnot, Marcin Wegrecki, Tan-Yun Cheng, Yi-Ling Chen, Brigitte N. Sallee, Reka Chakravarthy, Ioanna Maria Karantza, Shin Yi Tin, Alexandra E. Khaleel, Isha Monga, Laura N. Uwakwe, Alice Tillman, Bin Cheng, Soundos Youssef, Soo Weei Ng, Adam Shahine, Javier A. Garcia-Vilas, Anne-Catrin Uhlemann, Lindsey A. Bordone, Arnold Han, Christine H. Rohde, Graham Ogg, D. Branch Moody, Jamie Rossjohn, Annemieke de Jong
Summary: CD1a presents a range of self-lipid antigens found within the skin. The study identifies CD1a-dependent T cell responses to bacterial membrane phospholipids and suggests a link between PG-based lipid-activated T cells and atopic dermatitis pathogenesis. The expansion of CD4(+) CD1a-(lysyl)PG tetramer(+) T cells in patients with atopic dermatitis supports the involvement of bacteria-associated lipids in the development of this condition.
Article
Biochemical Research Methods
Ira Hamilton, Nadia M. Ikumi, Sarika Kshirsagar, Wendy A. Goodman, Tamara Tilburgs
Summary: This study presents a protocol for purifying and culturing HLA-G+ EVTs, the most invasive cells of the placenta that play a crucial role in modulating maternal immune responses. The protocol includes steps for tissue dissection, digestion, centrifugation, and cell sorting, as well as methods for determining EVT function. It provides a comprehensive approach for investigating maternal immune interactions with HLA-G+ EVTs.
Article
Biochemical Research Methods
Nadia M. Ikumi, Zachary Koenig, Shweta Mahajan, Clive M. Gray, Tamara Tilburgs
Summary: This article presents detailed methods for purifying, culturing, and functionally analyzing human placental decidual leukocytes, including dNK, dTreg, dTem, and dM ɸ, from different parts of the placenta. These methods have high clinical relevance in understanding the development of diseases such as villitis and chorioamnionitis.
Article
Medicine, Research & Experimental
Shweta Mahajan, Aria Alexander, Zachary Koenig, Nicholas Saba, Nina Prasanphanich, David A. Hildeman, Claire A. Chougnet, Emily Defranco, Sandra Andorf, Tamara Tilburgs
Summary: Decidual CD8(+) T cells play a critical role in providing immunity to infection and immune tolerance for fetal and placental antigens. These cells include shared blood T cells and unique decidual T cells, and the specificity of decidual CD8(+) T cells is closely related to their function and tissue residency.
Meeting Abstract
Developmental Biology
Tamara Tilburgs
Meeting Abstract
Obstetrics & Gynecology
Sarika Kshirsagar, Tamara Hagen, Tamara Tilburgs
REPRODUCTIVE SCIENCES
(2021)
