Article
Urology & Nephrology
Naeun Kwak, Min Ji Park, Hea Min Jang, Hee Sun Baek, Sang In Lee, Man Hoon Han, Yong-Jin Kim, Min Hyun Cho
Summary: This study analyzed the incidence and clinical outcomes of children who showed normal histopathological findings in their percutaneous renal biopsies (PRBs). The results showed that most children with normal PRB histopathologic findings had improved urinary abnormalities during the follow-up period, and none of them developed end-stage renal disease.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Medicine, General & Internal
Antonio Granata, Giulio Distefano, Francesco Pesce, Yuri Battaglia, Paola Suavo Bulzis, Massimo Venturini, Stefano Palmucci, Vito Cantisani, Antonio Basile, Loreto Gesualdo
Summary: Ultrasound-guided percutaneous renal biopsy (PRB) has greatly impacted nephrology clinical practice, being essential for diagnosis, prognosis, and therapeutics of renal diseases. This study reviews the different applications and evidence on periprocedural management. PRB should be performed in patients with specific symptoms, with pre- and post-procedural ultrasound scans recommended for early detection of complications, as most occur within 24 hours of biopsy.
Article
Immunology
Dita Maixnerova, Petra Hruba, Michaela Neprasova, Kamila Bednarova, Janka Slatinska, Miloslav Suchanek, Marek Kollar, Jan Novak, Vladimir Tesar, Ondrej Viklicky
Summary: This study evaluated clinical parameters and histological findings of 313 IgAN patients, identifying risk factors affecting the course of IgAN after kidney transplantation, such as histological recurrence of IgAN, antibody-mediated rejection, and the onset of microscopic hematuria and proteinuria within 1 year after kidney transplant. These factors were associated with worse graft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Bikash Khatri, Anil Baral, Suresh Maharjan, Bijay Khatri
Summary: This study aimed to determine the prevalence of primary focal segmental glomerulosclerosis among patients with glomerular diseases undergoing kidney biopsy in a tertiary care centre. The results showed that out of 213 patients, 22 (10.33%) were diagnosed with primary focal segmental glomerulosclerosis. This prevalence was slightly lower than in other similar studies.
JOURNAL OF NEPAL MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Bethany C. Birkelo, Sharidan K. Parr, Amy M. Perkins, Robert A. Greevy Jr, Adriana M. Hung, Shailja C. Shah, Juan Pablo Arroyo, Jason Denton, Andrew J. Vincz, Michael E. Matheny, Edward D. Siew
Summary: This study found that acute kidney injury is more common and severe among patients hospitalized with COVID-19 compared to influenza, potentially driven largely by illness severity. More resources may be needed to manage the severe kidney damage caused by COVID-19.
KIDNEY INTERNATIONAL
(2021)
Article
Rheumatology
Gavin B. Chapman, Tariq E. Farrah, Fiona A. Chapman, Dan Pugh, Christopher O. C. Bellamy, Rashmi Lahiri, Eve Miller-Hodges, David C. Kluth, Robert W. Hunter, Neeraj Dhaun
Summary: This study assessed the potential utility of interval kidney biopsy in ANCA-associated vasculitis (AAV). The results showed that interval kidney biopsy is useful for determining treatment-response and subsequent disease management in AAV, and may provide better prognostic information than initial kidney biopsy.
Review
Urology & Nephrology
Chanaka Muthukuda, Vindika Suriyakumara, Cherine Sosai, Thilina Samarathunga, Maithili Laxman, Arjuna Marasinghe
Summary: This study aimed to provide a record of the spectrum of renal diseases in Sri Lanka. The most common indication for renal biopsy was nephrotic range proteinuria, and the most prevalent histopathological diagnosis was FSGS. Therefore, a renal biopsy registry is needed in Sri Lanka to document the changing disease pattern.
Review
Medicine, General & Internal
Marilia Dagnon da Silva, Sidney Marcel Domingues, Stevan Oluic, Milan Radovanovic, Pratyusha Kodela, Terri Nordin, Margaret R. Paulson, Bojan Joksimovic, Omobolanle Adetimehin, Devender Singh, Cristian Madrid, Milena Cardozo, Marko Baralic, Igor Dumic
Summary: Unlike other adverse drug reactions, DRESS syndrome involves visceral organ involvement and is linked to mortality. This study reviewed cases from PubMed-indexed journals to explore renal injury in patients with DRESS syndrome. Findings showed that acute kidney injury was the most common renal manifestation, and antibiotics, particularly vancomycin, were the most common medication class associated with renal injury. Mortality was 13%, higher than previously reported. More research and disease-specific biomarkers are needed to understand the risks and distinguish DRESS with renal involvement from other eosinophilic diseases affecting the kidney.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Roman Gunthner, Lea Knipping, Stefanie Jeruschke, Robin Satanoskij, Bettina Lorenz-Depiereux, Clara Hemmer, Matthias C. Braunisch, Korbinian M. Riedhammer, Jasmina Comic, Burkhard Tonshoff, Velibor Tasic, Nora Abazi-Emini, Valbona Nushi-Stavileci, Karin Buiting, Nikola Gjorgjievski, Ana Momirovska, Ludwig Patzer, Martin Kirschstein, Oliver Gross, Adrian Lungu, Stefanie Weber, Lutz Renders, Uwe Heemann, Thomas Meitinger, Anja K. Buscher, Julia Hoefele
Summary: X-inactivation does not correlate with the clinical phenotype of females with X-linked Alport syndrome (AS). In urine-derived cells, the degree of X-inactivation shows a moderate association with age.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Tingli Wang, Junlin Zhang, Yiting Wang, Lijun Zhao, Yucheng Wu, Honghong Ren, Yutong Zou, Rui Zhang, Huan Xu, Zhonglin Chai, Mark E. Cooper, Jie Zhang, Fang Liu
Summary: This study aimed to investigate whether renal pathology is an independent predictor for end-stage renal disease (ESRD) in diabetic kidney diseases (DKD) with nephrotic range proteinuria. The results showed that glomerular pathology class III was the most common type, and hemoglobin and e-GFR were significantly associated with a higher risk of ESRD. Therefore, histopathological damage is not associated with poor renal outcomes in patients with DKD, but hemoglobin and e-GFR could predict poor renal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Fatma Yazilitas, Evrim Kargin cakici, Eda Didem Kurt Sukur, Semanur Ozdel, Tulin Gungor, Esra Baglan, Evra Celikkaya, Deniz Karakaya, Diclehan Orhan, Mehmet Bulbul
Summary: This study identified risk factors associated with renal involvement in children with IgA vasculitis, including older age, presence of hematuria and/or proteinuria in urine examination, and disease onset in the spring season. The optimal timing for predicting renal involvement in the sixth month was found to be the urine examination conducted in the first month after diagnosis. Patients with IgA vasculitis who show abnormal urine findings in the first month should receive closer follow-up.
POSTGRADUATE MEDICINE
(2022)
Article
Pathology
Marco Delsante, Jose M. Monroy-Trujillo, Naima Carter-Monroe, Douglas W. Ball, Avi Z. Rosenberg
Summary: Tyrosine kinase inhibitors, such as lenvatinib, are commonly used in cancer treatment but can lead to renal thrombotic microangiopathy (TMA). Managing lenvatinib-induced renal TMA remains challenging, with uncertainty about the best therapy. Early adjustment of drug dosages may help prevent further damage and treatment discontinuation.
Article
Hematology
Lanbo Teng, Wenxiu Chang
Summary: This study evaluated the incidence, clinical characteristics, and risk factors of kidney involvement in patients with the Omicron variant infection in Tianjin, China. The majority of patients had mild or ordinary symptoms, with the primary kidney involvement being hematuria and proteinuria. Age, hypertension, higher CRP levels, and higher BMI were linked with kidney involvement.
BLOOD PURIFICATION
(2023)
Article
Urology & Nephrology
Hernando Trujillo, Justo Sandino, Teresa Cavero, Fernando Caravaca-Fontan, Eduardo Gutierrez, Angel M. Sevillano, Amir Shabaka, Gema Fernandez-Juarez, Pablo Rodriguez Doyaguez, Rocio Gimena Munoz, Leonardo Calle Garcia, Virginia Cabello, Jose Manuel Munoz-Terol, Ana Garcia Santiago, Oscar Toldos, Juan Antonio Moreno, Manuel Praga
Summary: This study evaluated the underlying kidney pathology in patients on oral anticoagulants who developed ARN. The most common underlying kidney disease in ARN was IgA nephropathy. However, only 24% of patients achieved complete kidney recovery after 12 weeks of follow-up.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Pharmacology & Pharmacy
Mian-Na Luo, Yanqing Yin, Shangmei Li, Junfeng Hao, Cuiwei Yao, Yong-Zhi Xu, Hua-feng Liu, Lawei Yang
Summary: The present study aimed to prove the progression of Immunoglobulin A nephropathy (IgAN) patients with isolated hematuria by analyzing repeat renal biopsy data. The results showed that IgAN patients with isolated hematuria had better clinical indicators compared to those without isolated hematuria. However, persistent deposits of IgA and C3 in the glomerulus, as well as cell inflammation and proliferation, indicated ongoing pathological changes and irreversible chronic progression. This study provides a strong basis for understanding the progression of IgAN with isolated hematuria and emphasizes the importance of early treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
