Review
Biochemistry & Molecular Biology
Stefano Turolo, Alberto Edefonti, Alessandra Mazzocchi, Marie Louise Syren, William Morello, Carlo Agostoni, Giovanni Montini
Summary: Research on the role of arachidonic acid and its metabolites in kidney disease, particularly idiopathic nephrotic syndrome, is limited. These substances play a significant role in various biological processes related to kidney function, inflammation, and fibrosis. Dietary interventions to maintain balance between arachidonic acid and linoleic acid could potentially help mitigate inflammatory states seen in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pediatrics
Zivile Bekassy, Martin Lindstrom, Therese Rosenblad, Sunna Aradottir, Lisa Sartz, Kjell Tullus
Summary: This study investigated the need for kidney biopsy in children with steroid-sensitive nephrotic syndrome in the Northern European setting. The results showed that kidney biopsy is rarely necessary in steroid-sensitive children without any other complicating factor, and therefore, the liberal policy of kidney biopsy in the Nordic countries can be safely changed.
Review
Urology & Nephrology
Eugene Yu-hin Chan, Desmond Yat-hin Yap, Manuela Colucci, Alison Lap-tak Ma, Rulan S. Parekh, Kjell Tullus
Summary: Rituximab is an established therapy for children with idiopathic nephrotic syndrome, providing short- to medium-term disease remission and avoiding steroid toxicities. Recent trials focus on using rituximab as a first-line agent for milder disease severity. The treatment response to rituximab depends on various factors, including patient characteristics, dosing regimen, and the use of immunosuppression. Repeated treatments lead to an improving response overall, but relapse eventually occurs in 80% of patients, necessitating additional courses of rituximab. The long-term safety profile and the development of reliable predictors for treatment success and side effects are areas of concern.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Developmental Biology
Jitske Jansen, Bartholomeus T. van den Berge, Martijn van den Broek, Rutger J. Maas, Deniz Daviran, Brigith Willemsen, Rona Roverts, Marit van der Kruit, Christoph Kuppe, Katharina C. Reimer, Gianluca Di Giovanni, Fieke Mooren, Quincy Nlandu, Helmer Mudde, Roy Wetzels, Dirk den Braanker, Naomi Parr, James S. Nagai, Vedran Drenic, Ivan G. Costa, Eric Steenbergen, Tom Nijenhuis, Henry Dijkman, Nicole Endlich, Nicole C. A. J. van de Kar, Rebekka K. Schneider, Jack F. M. Wetzels, Anat Akiva, Johan van der Vlag, Rafael Kramann, Michiel F. Schreuder, Bart Smeets
Summary: Using organoid podocytes as a model, this study investigated idiopathic nephrotic syndrome and found that repaired organoids exhibited improved functionality, providing a valuable tool for disease modeling and therapy development.
Article
Nutrition & Dietetics
Turolo Stefano, Edefonti Alberto, Morello William, Bolzan Giulia, Syren M. Louise, Tamburello Chiara, Agostoni Carlo, Montini Giovanni
Summary: Patients with idiopathic nephrotic syndrome (INS) show differences in fatty acid profiles compared to healthy controls, with an increase in the pro-inflammatory omega-6 series. Adherence to the Mediterranean diet was associated with lower levels of linoleic acid and total omega-6 in patients, and a negative correlation was found between proteinuria and the anti-inflammatory omega-3 series.
Article
Urology & Nephrology
Lea Moret, Alexandre Ganea, Myriam Dao, Aurelie Hummel, Bertrand Knebelman, Jean Francois Subra, Johan Noble, Christophe Mariat, Noemie Jourde-Chiche, Fatouma Toure, Cyril Garrouste, Charlotte Laurent, Lacraz Adeline, Yahsou Delmas, Alexandre Cez, Olivier Fritz, Christiane Mousson, Lise Marie Pouteau, Olivier Moranne, Jean-Michel Halimi, Vincent Audard
Summary: This retrospective study showed that apheresis may lead to remission in adult patients with refractory INS, especially in those at risk of renal failure and with limited sensitivity to medical treatments, if apheresis is initiated within a year of diagnosis.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Pediatrics
Anna E. Mason, Moin A. Saleem, Agnieszka Bierzynska
Summary: The post-transplantation recurrence in genetic children with steroid-resistant nephrotic syndrome is rare and mainly driven by an immune-mediated process involving antibody production. Biallelic pathogenic variants in NPHS1 are commonly reported in post-transplantation nephrotic syndrome cases, while the mechanism for recurrence involving other pathogenic variants in NPHS2, WT1 and NUP93 remains unclear.
PEDIATRIC NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Agnieszka Pukajlo-Marczyk, Danuta Zwolinska
Summary: The study evaluated the levels of Hpx in children with INS and suggested its potential role in the pathogenesis of the disease, as well as its usefulness as a marker for disease progression. Hemopexin levels were found to be elevated in INS patients during relapse and remained higher than controls even in remission.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Transplantation
Mai Sato, Kenji Ishikura, Takashi Ando, Kaori Kikunaga, Chikako Terano, Riku Hamada, Shingo Ishimori, Yuko Hamasaki, Yoshinori Araki, Yoshimitsu Gotoh, Koichi Nakanishi, Hitoshi Nakazato, Takeshi Matsuyama, Kazumoto Iijima, Norishige Yoshikawa, Shuichi Ito, Masataka Honda
Summary: This study investigated the epidemiology of idiopathic nephrotic syndrome in children and the complications of INS at initial presentation. The results revealed some risk factors for complications, emphasizing the importance of proper management in order to improve patient outcomes. Although overall survival and renal survival rates were excellent, attention to complications, especially in acute kidney injury and ocular hypertension, is crucial.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Andrzej Badenski, Marta Badenska, Elzbieta Swietochowska, Agnieszka Didyk, Aurelia Morawiec-Knysak, Maria Szczepanska
Summary: Idiopathic nephrotic syndrome (INS) is a chronic disease that affects children in early childhood and is usually diagnosed at an advanced stage of proteinuria. This study suggests that brain-derived neurotrophic factor (BDNF) may be a potential marker for early diagnosis of INS. The study found that BDNF levels in the serum decreased and in the urine increased in INS patients compared to healthy controls. These findings may be related to the loss of BDNF contribution to podocyte structure maintenance and the increase in urine protein concentration. In addition, the ROC curve analysis showed that serum BDNF and urine BDNF levels may be useful markers for INS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Tianxin Chen, Ying Zhou, Xinxin Chen, Bo Chen, Jingye Pan
Summary: This study found that in iMN patients with NS, AKI was often mild and overlooked, but it had a strong association with poor clinical outcomes and was an independent risk factor for CKD progression.
Article
Pediatrics
Peng Peng, Wei Li, Yanyan Jin, Wenqing Xiang, Haidong Fu, Jianhua Mao
Summary: Serum levels of CCL22 and Leptin, detected prior to steroid therapy, were associated with steroid resistance in childhood INS.
FRONTIERS IN PEDIATRICS
(2023)
Article
Urology & Nephrology
Jenny Weinbrand-Goichberg, Efrat Ben Shalom, Choni Rinat, Sapir Choshen, Shimrit Tzvi-Behr, Yaacov Frishberg, Rachel Becker-Cohen
Summary: This study aimed to assess the incidence and severity of COVID-19 in children and young adults with kidney disease, showing that the incidence was similar to the general population and all cases were mild. Risk factors for infection included exposure at home and number of household members.
JOURNAL OF NEPHROLOGY
(2022)
Article
Pediatrics
Shuhan Zeng, Yuanyuan Xu, Cheng Cheng, Nannan Yu, Longshan Liu, Ying Mo, Lizhi Chen, Xiaoyun Jiang
Summary: COQ8B-GN in the Chinese population may initially present with asymptomatic proteinuria, nephrotic syndrome, or steroid-resistant nephrotic syndrome, with most cases occurring before the age of 10. Many patients progress to end-stage renal disease in early adolescence. Focal segmental glomerulosclerosis (FSGS) is the most common renal pathology, and the c.748G>C mutation in the COQ8B gene is frequently observed in Chinese COQ8B-GN patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Andrzej Badenski, Marta Badenska, Elzbieta Swietochowska, Artur Janek, Aleksandra Gliwinska, Aurelia Morawiec-Knysak, Maria Szczepanska
Summary: Idiopathic nephrotic syndrome (INS) is a chronic glomerular disease in children characterized by severe proteinuria, hypoalbuminemia, and/or edema and hyperlipidemia. Interleukin-15 (IL-15), a pro-inflammatory cytokine, may play a role in the pathogenesis of INS. Our study found that the concentration of IL-15 was significantly elevated in both serum and urine of patients with INS compared to healthy controls, suggesting IL-15 may serve as a potential marker for early diagnosis of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Remi Lenain, Etienne Dantan, Magali Giral, Yohann Foucher, Ozgur Asar, Maarten Naesens, Marc Hazzan, Marie-Cecile Fournier
Summary: The study validated the prognostic capacities of DynPG in terms of both discrimination and calibration, despite differences in characteristics of the external validation sample. The area under the ROC curve varied from 0.70 to 0.76 at 1 and 6 years posttransplantation, respectively.
Article
Urology & Nephrology
Y. Foucher, M. Lorent, L. Albano, S. Roux, V. Pernin, M. Le Quintrec, C. Legendre, F. Buron, E. Morelon, S. Girerd, M. Ladriere, D. Glotz, C. Lefaucher, C. Kerleau, J. Dantal, J. Branchereau, M. Giral, Gilles Blancho, Gilles Blancho, Julien Branchereau, Diego Cantarovich, Agnes Chapelet, Jacques Dantal, Clement Deltombe, Lucile Figueres, Claire Garandeau, Magali Giral, Caroline Gourraud-Vercel, Maryvonne Hourmant, Georges Karam, Clarisse Kerleau, Aurelie Meurette, Simon Ville, Christine Kandell, Anne Moreau, Karine Renaudin, Anne Cesbron, Florent Delbos, Alexandre Walencik, Anne Devis, Lucile Amrouche, Dany Anglicheau, Olivier Aubert, Lynda Bererhi, Christophe Legendre, Alexandre Loupy, Frank Martinez, Rebecca Sberro-Soussan, Anne Scemla, Claire Tinel, Julien Zuber, Pascal Eschwege, Luc Frimat, Sophie Girerd, Jacques Hubert, Marc Ladriere, Emmanuelle Laurain, Louis Leblanc, Pierre Lecoanet, Jean-Louis Lemelle, Lionel Badet, Maria Brunet, Fanny Buron, Remi Cahen, Sameh Daoud, Coralie Fournie, Arnaud Gregoire, Alice Koenig, Charlene Levi, Emmanuel Morelon, Claire Pouteil-Noble, Thomas Rimmele, Olivier Thaunat, Sylvie Delmas, Valerie Garrigue, Moglie Le Quintrec, Vincent Pernin, Jean-Emmanuel Serre
Summary: This study found that obesity increased the risk of death and serious bacterial infections and cardiac complications in obese French kidney transplant recipients. However, obesity did not significantly increase the risk of early surgical complications. Further epidemiologic studies comparing obese recipients versus obese candidates remaining on dialysis are needed to improve guidelines for obese patient transplant allocation.
Review
Medicine, General & Internal
Mario Ollero, Dil Sahali
Summary: CMIP is overexpressed in T cell subpopulations of INS patients and in podocytes, as well as in various types of cancer. It has regulatory ties with NF-kappa B and WT1, indicating its potential role in cancer pathology.
Article
Urology & Nephrology
Remi Lenain, Camille Prouteau, Aghiles Hamroun, Yohann Foucher, Magali Giral, Mehdi Maanaoui, Marc Hazzan
Summary: This study examined the impact of deceased donor acute kidney injury (AKI) on long-term graft survival in kidney transplant recipients. The results showed that ongoing AKI, undetermined AKI/CKD, and recovery from AKI were associated with a decreased graft survival.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Health Care Sciences & Services
Etienne Dantan, Florent Le Borgne, Magali Giral, Angelina Dion, Anne-Helene Querard, Yohann Foucher
Summary: The study demonstrated the importance of considering covariates in interpreting the discriminative capacities of a prognostic marker. Results showed that the predictive abilities of KDRI for kidney graft failure risk were mainly influenced by recipient characteristics.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Review
Medicine, General & Internal
Jeanne Simon-Pimmel, Yohann Foucher, Maxime Leger, Fanny Feuillet, Laetitia Bodet-Contentin, Raphael Cinotti, Denis Frasca, Etienne Dantan
Summary: This study aimed to methodologically assess prognostic tools for functional outcomes in severe spontaneous intracranial haemorrhages, and revealed methodological flaws, suggesting that future research should focus on externally validating and updating existing prognostic tools.
Article
Oncology
Shao-Yu Zhang, Qingfeng Fan, Anissa Moktefi, Virginie Ory, Vincent Audard, Andre Pawlak, Mario Ollero, Dil Sahali, Carole Henique
Summary: The study revealed that overproduction of CMIP in podocytes is associated with a downregulation of WT1 via two mechanisms. CMIP prevents the NF-kB-mediated transcriptional activation of WT1 and interacts with WT1 directly through its leucine-rich repeat domain. The E3 ligase activity of CMIP targets WT1 for proteasome degradation, suggesting a potential therapeutic target for podocyte diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Arthur Chatton, Florent Le Borgne, Clemence Leyrat, Yohann Foucher
Summary: This paper extends the G-computation and doubly robust estimators based on discrete-time data to continuous-time settings, showing their higher efficiency compared to the well-known inverse-probability-weighting estimator through a simulation study. The practical implementation of these methods is illustrated using real-world datasets, with the R package RISCA being updated to facilitate their use and dissemination.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Transplantation
Christel Castelli, Yohann Foucher, Julie Boucquemont, Mathilde Prezelin-Reydit, Magali Giral, Emilie Savoye, Marc Hazzan, Remi Lenain
Summary: This study compares the life expectancy of patients who underwent kidney transplantation (KT) versus patients awaiting KT on dialysis. The results suggest that KT is beneficial in terms of life expectancy for patients with a BMI between 30 and 35 kg/m(2). However, for patients with a BMI >= 35 kg/m(2), KT may be questionable and needs to be taken into consideration in organ allocation systems.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Maxime Leger, Denis Frasca, Antoine Roquilly, Philippe Seguin, Raphael Cinotti, Claire Dahyot-Fizelier, Karim Asehnoune, Florent Le Borgne, Thomas Gaillard, Yohann Foucher, Sigismond Lasocki
Summary: The use of barbiturates in treating intracranial hypertension in traumatic brain injury patients remains controversial. This study found that early administration of barbiturates may increase ICU survival, but has no significant association with ventilator-associated pneumonia or the patient's functional status at three months. Due to the lack of clinical trials, the benefit and risk ratio of barbiturates prescription should be carefully evaluated.
Article
Health Care Sciences & Services
Yohann Foucher, Cyrille Loncle, Florent Le Borgne
Summary: This paper discusses the challenges of utilizing observational data for real-world evidence (RWE) and proposes a tool called Plug-Stat (R) to facilitate causal inference analysis of real-world data. The tool features a user-friendly graphical interface and automated statistical modeling steps, providing time and cost reduction.
HEALTH SERVICES AND OUTCOMES RESEARCH METHODOLOGY
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
V. Bonnemains, F. Le Borgne, E. Savoye, C. Legeai, M. Pastural, S. Bayat-Maokei, R. Lenain, K. Leffondre, C. Couchoud, Y. Foucher
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Meeting Abstract
Clinical Neurology
C. Sabathe, R. Casey, S. Vukusic, E. Leray, G. Mathey, J. De Seze, J. Ciron, S. Wiertlewski, A. Ruet, J. Pelletier, H. Zephir, L. Michel, C. Lebrun-Frenay, X. Moisset, E. Thouvenot, J. -P. Camdessanche, S. Bakchine, B. Stankoff, A. Al Khedr, P. Cabre, E. Maillart, E. Berger, O. Heinzlef, K. Hankiewicz, T. Moreau, O. Gout, B. Bourre, A. Wahab, P. Labauge, A. Montcuquet, G. Defer, A. Maurousset, N. Maubeuge, D. Boulos Dalia, H. Ben Nasr, C. Nifle, O. Casez, D. -A. Laplaud, Y. Foucher
MULTIPLE SCLEROSIS JOURNAL
(2021)
Meeting Abstract
Surgery
Anne-Helene Querard, Etienne Dantan, Florent Leborgne, Magali Giral, Angelina Dion, Yohann Foucher
TRANSPLANT INTERNATIONAL
(2021)
Meeting Abstract
Surgery
Remi Lenain, Camille Prouteau, Aghiles Hamroun, Yohann Foucher, Magali Giral, Aurelie Deshayes, Mehdi Maanaoui, Marc Hazzan
TRANSPLANT INTERNATIONAL
(2021)