Article
Multidisciplinary Sciences
Shuliang Zhou, Sulin Mi, Xin Rao, Qi Zhang, Shiwen Wei, Meng Xiao, Zhiyong Peng, Jing Wang
Summary: This study evaluated the role of individualized active surveillance using Xpert Carba-R in reducing the risk of carbapenem-resistant microorganisms (CRO) in ICU. The use of Xpert Carba-R for monitoring the presence of carbapenem resistance genes was associated with a lower CRO risk. Among the 3,765 patients admitted to Zhongnan Hospital of Wuhan University, 390 manifested the presence of CRO, indicating a prevalence of 10.36%. Individualized active surveillance using Xpert Carba-R may be effective in reducing the overall incidence of CRO in ICU.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Hamzah J. J. Aldali, Azra Khan, Abdullah A. A. Alshehri, Jehad A. A. Aldali, Sultan Ayoub Meo, Ali Hindi, Emadeldin M. M. Elsokkary
Summary: Globally, hospital-acquired infections (HAIs) are increasing and causing high mortality and morbidity rates. This study focused on the analysis of carbapenem-resistant E. coli and K. pneumoniae in UK hospitals from 2009 to 2021. The study also examined the best approaches to patient management for controlling the spread of carbapenem-resistant Enterobacteriaceae (CRE).
Article
Microbiology
Jin Young Ahn, Sang Min Ahn, Jung Ho Kim, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon Sup Yeom, Je Eun Song
Summary: This study aimed to analyze the characteristics, outcomes, and risk factors of mortality in adult patients with carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infection (BSI), and to elucidate the differences between carbapenemase-producing (CP)-CRE BSI and non-CP-CRE BSI. The results showed that mortality was related to the severity of the infection rather than carbapenemase production or antibiotic treatment, suggesting that efforts to prevent CRE acquisition would be more effective at reducing mortality.
Article
Infectious Diseases
Ziv Dadon, Eli Ben-Chetrit, Ofer Benjaminov, Louay Taha, Yonit Wiener-Well, Daniel Belman, Phillip D. Levin
Summary: The study assessed the role of CT scans in cross-transmission of CRAB between hospitalized patients and found that undergoing a CT scan within 6 hours of a CRAB-positive patient's scan was an independent predictor of CRAB acquisition, approximately tripling the risk.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Environmental Sciences
S. Araujo, M. Sousa, M. Tacao, R. A. Barauna, A. Silva, R. Ramos, A. Alves, C. M. Manaia, I. Henriques
Summary: Although urban wastewater treatment plants play a crucial role in eliminating antibiotic resistance, they still struggle to produce effluents free of resistance. UV-C radiation significantly reduces the abundance and prevalence of carbapenem-resistant bacteria (CRB), but CRB numbers increased after incubation in the dark. Carbapenem-resistant Enterobacteriaceae (CRE) with bla(GES-5), integrons, and plasmids were detected in samples, raising concerns about potential horizontal gene transfer within these systems. Surveillance of carbapenem resistance in UWWTPs is essential for timely mitigation measures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Infectious Diseases
Yan Gao, Meilian Chen, Meng Cai, Kun Liu, Yimin Wang, Chunlian Zhou, Zhigang Chang, Qi Zou, Shirou Xiao, Yang Cao, Weihua Wang, Zhuang Liu, Linfang Lv, Yajun Luo, Yinghong Wu
Summary: This study aimed to explore the high-risk factors for carbapenem-resistant Enterobacteriaceae (CRE) infection in hospitalized patients in high-risk departments. The results showed that renal disease, granulocytosis, invasive procedures, and CRE detection time were the risk factors for CRE infection. The rate of CRE infection and exacerbation or death was higher in the invasive group.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Sarah S. L. Tang, Enqing Chee, Jocelyn Q. Teo, Maciej P. Chlebicki, Andrea L. H. Kwa
Summary: The study found that the incidence of subsequent infections in patients with prior CP-CRE colonisation was low. Patients with initial infections originating from intra-abdominal or respiratory sources were more likely to develop subsequent infections, while most rectal carriers remained colonised.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Wenwen Chu, Xiubing Hang, Xin Li, Naifang Ye, Wei Tang, Yafei Zhang, Xiyao Yang, Min Yang, Yansheng Wang, Zhou Liu, Qiang Zhou
Summary: The study found that intestinal CRE colonization was prevalent among hospitalized patients, especially in ICU patients, with potential rapid horizontal transmission. This suggests that CRE bloodstream infections in hospitalized patients may be caused by their colonized strains, indicating a correlation between intestinal colonization and BSI.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Li-Peng Liu, Qing-Song Lin, Wen-Yu Yang, Xiao-Juan Chen, Fang Liu, Xia Chen, Yuan-Yuan Ren, Min Ruan, Yu-Mei Chen, Li Zhang, Yao Zou, Ye Guo, Xiao-Fan Zhu
Summary: This study aimed to investigate the clinical characteristics, antimicrobial susceptibility, and outcomes of carbapenem-resistant enterobacteriaceae (CRE) blood-stream infection (BSI) in neutropenic children with hematological diseases. The study found that CRE colonizers were more likely to develop CRE-BSI, which was associated with lower 30-day survival probability. Additionally, individualized antimicrobial therapy should be considered due to the different features of patients with different CRE strains.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
Paula Eckardt, Kelsi Canavan, Rachel Guran, Elizabeth George, Nancimae Miller, Dianeysis H. Avendano, Myeongji Kim, Khaled Himed, Karen Heidi Gonzalez Ramirez
Summary: This study reports on an outbreak investigation and containment strategy for a carbapenem-resistant Acinetobacter baumannii outbreak in a community hospital's COVID intensive care unit. The study emphasizes the importance of prevention strategies and maintaining infection control best practices to reduce the spread of multidrug resistant organisms.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Environmental Sciences
Cai-Hong Guo, Yu-Qing Liu, Yan Li, Xiao-Xiao Duan, Ting-Yu Yang, Fang-Yu Li, Ming Zou, Bao-Tao Liu
Summary: The widespread presence of carbapenem-resistant Enterobacteriaceae (CRE) and mcr-positive Escherichia coli (MCREC) in large-scale rivers in China poses a significant threat to animal and human health. A study conducted in Shandong Province sampled 86 rivers and found a prevalence of 16.3% for CRE and 27.9% for MCREC. Multiple antibiotic-resistant isolates were obtained, including those carrying blaKPC-2, blaNDM, and mcr-1 genes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Infectious Diseases
Wei-Hua Wang, Ying-Hong Wu, Yi-Min Wang, Chun-Lei Wang, Yun Liu, Peng Gao, Xiao-Jing Wu, Jiao-Qian Ying
Summary: The study found that an increased number of fiberoptic bronchoscopic examinations is highly correlated with the risk of nosocomial infection/colonization of CRE.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Zhile Xiong, Chao Zhang, Kurosh Sarbandi, Zhuwei Liang, Jialiang Mai, Bingshao Liang, Hao Cai, Xiantang Chen, Fei Gao, Fangjun Lan, Xiaochun Liu, Shuyan Liu, Zhenwen Zhou
Summary: Carbapenem-resistant Enterobacteriaceae (CRE) colonization in pediatric inpatients in Guangzhou, China was evaluated in this study. The molecular and clinical characteristics of CRE colonization were described, and risk factors for fecal CRE colonization were identified. The study highlights the importance of implementing infection control and prevention measures to reduce CRE colonization.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Victor Band, Sarah W. Satola, Richard D. Smith, David A. Hufnagel, Chris Bower, Andrew B. Conley, Lavanya Rishishwar, Suzanne E. Dale, Dwight J. Hardy, Roberto L. Vargas, Ghinwa Dumyati, Marion A. Kainer, Erin C. Phipps, Rebecca Pierce, Lucy E. Wilson, Matthew Sorensen, Erik Nilsson, I. King Jordan, Eileen M. Burd, Monica M. Farley, Jesse T. Jacob, Robert K. Ernst, David S. Weiss
Summary: The study revealed varying levels of colistin heteroresistance among highly drug-resistant carbapenem-resistant Enterobacterales (CRE), with most heteroresistant isolates being misclassified as colistin susceptible by clinical diagnostic testing. The findings from the 2015 study suggest a high frequency of colistin heteroresistance in CRE.
Article
Multidisciplinary Sciences
Sayran Hamad Haji, Fattma A. Ali, Safaa Toma Hanna Aka
Summary: This study investigates the potential of nanotechnology in improving nanomedicine for human health by studying the antibacterial activity of silver nanoparticles (Ag NPs) biosynthesized by Acinetobacter baumannii on carbapenemase-producing Gram-negative bacilli (CPGB). The results showed that the combination of Ag NPs and antibiotics demonstrated synergistic activity against CPGB, indicating the potential application of this nanomedicine in clinical settings.
SCIENTIFIC REPORTS
(2022)